3DITA

Crystal structure of mad mh2 domain
Total Genus 42
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
42
sequence length
188
structure length
186
Chain Sequence
AFWASIAYYELNCRVGEVFHCNNNSVIVDGFTNNNSDRCCLGQLSNVNRNSTIENTRRHIGKGVHLYYVTGEVYAECLSDSAIFVQSRNCNYHHGFHPSTVCKIPPGCSLKIFNNQEFAQLLSQSVNNGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure of Drosophila Mad MH2 domain.
pubmed doi rcsb
molecule tags Signaling protein
source organism Drosophila melanogaster
molecule keywords Protein mothers against dpp
total genus 42
structure length 186
sequence length 188
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2008-06-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03166 MH2 MH2 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.60.200.10 Mainly Beta Sandwich Tumour Suppressor Smad4 Tumour Suppressor Smad4 3ditA00
3GMJA 3DSHA 1KHUA 1MK2A 5JERA 1QWTA 5JEKA 1YGSA 5JEOA 1MR1A 1U7FA 1ZOQA 5BVIA 1U7VA 5JELA 5JEJA 1KHXA 3DITA 1DEVA 5C4VA 1J2FA 1MJSA 1G88A 4R9PA 1U7FB 1U7VB 1DD1A 5JEMA 3A77A
chains in the Genus database with same CATH superfamily
3V8QA 1K2MA 1UJXA 3PFNA 3ELSA 3DSHA 1Z0UA 3V8NA 1G3GA 2JQLA 5DHUA 4JONA 5DHQA 2JQJA 2QV7A 4DY6A 2G1LA 2QVLA 4EGXA 3V80A 5JEOA 1MR1A 3S40A 3VA4A 2I29A 1J4KA 1KHXA 3ELVA 2FEZA 5DHSA 2KFUA 5C4VA 5EJGA 2I2DA 3VZCA 1MJSA 2XT9B 4JIVD 2Q5FA 2PIEA 3VZBA 1J4PA 3A77A 4QCJA 5EJFA 1J4OA 4G2SA 3PO8A 3I0MA 3HUFA 1KHUA 4A0EA 3UNMA 2FF4A 4A4YA 1LGQA 4L02A 2JPEA 3AFOA 3UN0A 1U0TA 1GXCA 5JERA 1QWTA 1YGSA 5DJOA 1U7FA 2JGRA 5DHRA 5JELA 5JEJA 1DEVA 2I2FA 2BONA 1K2NA 2I2AA 1K3JA 1J2FA 3V8PA 2AN1A 4H87A 4R9PA 1U7VB 3UOTA 1YJMA 2CSWA 5DHTA 5JEMA 3I6UA 3POAA 5EJIA 4V24A 1UHTA 2LC1A 1WV3A 1K3NA 1G6GA 3VA1A 2I2BA 4WRRA 2W3OA 1SUWA 5JEKA 3HUEA 1R21A 1ZOQA 5A8IA 5BVIA 3I6WA 4HAOA 3UV0A 2A0TA 3V8RA 2JQIA 5E50A 4WERA 1G88A 1J4QA 3FM8A 4JIWD 3VZDA 1Z0SA 1DMZA 1K3QA 1DD1A 2I2CA 2I1WA 2EH0A 3V7WA 3I0NA 3GMJA 1Y3IA 3V7UA 3GQSA 2JKDA 3UMZA 3V7YA 1MK2A 2XXSA 4D9VA 3T5PA 5DHPA 1J4LA 2KB4A 2AFFA 5EJHA 1FHQA 1WLNA 1U7VA 2BRFA 3VPYA 3OUNA 3DITA 1YJ5C 1Z0ZA 3HX1A 1LGPA 3MDBA 3UNNA 4EJQA 3V8MA 1U0RA 4KU0D 1U7FB 1Y3HA 1QU5A 2KB3A 2KKLA 2P1RA 1MZKA 3KT9A 1YT5A 1FHRA
chains in the Genus database with same CATH topology
1K2MA 1UJXA 3ELSA 3DSHA 1G3GA 2JQLA 4JONA 2JQJA 2QV7A 2G1LA 2QVLA 4EGXA 5JEOA 1MR1A 3S40A 3VA4A 1J4KA 1KHXA 3ELVA 2FEZA 2KFUA 5C4VA 3VZCA 1MJSA 2XT9B 4JIVD 2PIEA 3VZBA 1J4PA 3A77A 4QCJA 1J4OA 4G2SA 3PO8A 3I0MA 3HUFA 1KHUA 4A0EA 3UNMA 2FF4A 4A4YA 1LGQA 4L02A 2JPEA 3UN0A 5JERA 1GXCA 1QWTA 1YGSA 5DJOA 1U7FA 2JGRA 5JELA 5JEJA 1DEVA 2BONA 1K2NA 1K3JA 1J2FA 4H87A 4R9PA 1U7VB 3UOTA 1YJMA 2CSWA 5JEMA 3I6UA 3POAA 4V24A 1UHTA 2LC1A 1WV3A 1K3NA 1G6GA 3VA1A 4WRRA 2W3OA 5JEKA 3HUEA 1R21A 1ZOQA 5A8IA 5BVIA 3I6WA 3UV0A 2A0TA 2JQIA 5E50A 4WERA 1G88A 1J4QA 3FM8A 4JIWD 3VZDA 1DMZA 1K3QA 1DD1A 2EH0A 3I0NA 3GMJA 3GQSA 2JKDA 3UMZA 1MK2A 2XXSA 4D9VA 3T5PA 1J4LA 2KB4A 2AFFA 1FHQA 1WLNA 1U7VA 2BRFA 3VPYA 3OUNA 3DITA 1YJ5C 3HX1A 1LGPA 3MDBA 3UNNA 4EJQA 4KU0D 1U7FB 2KKLA 1QU5A 2KB3A 2P1RA 1MZKA 3KT9A 1FHRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3GMJ A;  3DSH A;  1KHU A;  1MK2 A;  5JER A;  1QWT A;  5JEK A;  1YGS A;  5JEO A;  1MR1 A;  1U7F A;  1ZOQ A;  5BVI A;  1U7V A;  5JEL A;  5JEJ A;  1KHX A;  3DIT A;  1DEV A;  5C4V A;  1J2F A;  1MJS A;  1G88 A;  4R9P A;  1U7F B;  1U7V B;  1DD1 A;  5JEM A;  3A77 A; 
#chains in the Genus database with same CATH topology
 3V8Q A;  1K2M A;  1UJX A;  3PFN A;  3ELS A;  3DSH A;  1Z0U A;  3V8N A;  1G3G A;  2JQL A;  5DHU A;  4JON A;  5DHQ A;  2JQJ A;  2QV7 A;  4DY6 A;  2G1L A;  2QVL A;  4EGX A;  3V80 A;  5JEO A;  1MR1 A;  3S40 A;  3VA4 A;  2I29 A;  1J4K A;  1KHX A;  3ELV A;  2FEZ A;  5DHS A;  2KFU A;  5C4V A;  5EJG A;  2I2D A;  3VZC A;  1MJS A;  2XT9 B;  4JIV D;  2Q5F A;  2PIE A;  3VZB A;  1J4P A;  3A77 A;  4QCJ A;  5EJF A;  1J4O A;  4G2S A;  3PO8 A;  3I0M A;  3HUF A;  1KHU A;  4A0E A;  3UNM A;  2FF4 A;  4A4Y A;  1LGQ A;  4L02 A;  2JPE A;  3AFO A;  3UN0 A;  1U0T A;  1GXC A;  5JER A;  1QWT A;  1YGS A;  5DJO A;  1U7F A;  2JGR A;  5DHR A;  5JEL A;  5JEJ A;  1DEV A;  2I2F A;  2BON A;  1K2N A;  2I2A A;  1K3J A;  1J2F A;  3V8P A;  2AN1 A;  4H87 A;  4R9P A;  1U7V B;  3UOT A;  1YJM A;  2CSW A;  5DHT A;  5JEM A;  3I6U A;  3POA A;  5EJI A;  4V24 A;  1UHT A;  2LC1 A;  1WV3 A;  1K3N A;  1G6G A;  3VA1 A;  2I2B A;  4WRR A;  2W3O A;  1SUW A;  5JEK A;  3HUE A;  1R21 A;  1ZOQ A;  5A8I A;  5BVI A;  3I6W A;  4HAO A;  3UV0 A;  2A0T A;  3V8R A;  2JQI A;  5E50 A;  4WER A;  1G88 A;  1J4Q A;  3FM8 A;  4JIW D;  3VZD A;  1Z0S A;  1DMZ A;  1K3Q A;  1DD1 A;  2I2C A;  2I1W A;  2EH0 A;  3V7W A;  3I0N A;  3GMJ A;  1Y3I A;  3V7U A;  3GQS A;  2JKD A;  3UMZ A;  3V7Y A;  1MK2 A;  2XXS A;  4D9V A;  3T5P A;  5DHP A;  1J4L A;  2KB4 A;  2AFF A;  5EJH A;  1FHQ A;  1WLN A;  1U7V A;  2BRF A;  3VPY A;  3OUN A;  3DIT A;  1YJ5 C;  1Z0Z A;  3HX1 A;  1LGP A;  3MDB A;  3UNN A;  4EJQ A;  3V8M A;  1U0R A;  4KU0 D;  1U7F B;  1Y3H A;  1QU5 A;  2KB3 A;  2KKL A;  2P1R A;  1MZK A;  3KT9 A;  1YT5 A;  1FHR A; 
#chains in the Genus database with same CATH homology
 1K2M A;  1UJX A;  3ELS A;  3DSH A;  1G3G A;  2JQL A;  4JON A;  2JQJ A;  2QV7 A;  2G1L A;  2QVL A;  4EGX A;  5JEO A;  1MR1 A;  3S40 A;  3VA4 A;  1J4K A;  1KHX A;  3ELV A;  2FEZ A;  2KFU A;  5C4V A;  3VZC A;  1MJS A;  2XT9 B;  4JIV D;  2PIE A;  3VZB A;  1J4P A;  3A77 A;  4QCJ A;  1J4O A;  4G2S A;  3PO8 A;  3I0M A;  3HUF A;  1KHU A;  4A0E A;  3UNM A;  2FF4 A;  4A4Y A;  1LGQ A;  4L02 A;  2JPE A;  3UN0 A;  5JER A;  1GXC A;  1QWT A;  1YGS A;  5DJO A;  1U7F A;  2JGR A;  5JEL A;  5JEJ A;  1DEV A;  2BON A;  1K2N A;  1K3J A;  1J2F A;  4H87 A;  4R9P A;  1U7V B;  3UOT A;  1YJM A;  2CSW A;  5JEM A;  3I6U A;  3POA A;  4V24 A;  1UHT A;  2LC1 A;  1WV3 A;  1K3N A;  1G6G A;  3VA1 A;  4WRR A;  2W3O A;  5JEK A;  3HUE A;  1R21 A;  1ZOQ A;  5A8I A;  5BVI A;  3I6W A;  3UV0 A;  2A0T A;  2JQI A;  5E50 A;  4WER A;  1G88 A;  1J4Q A;  3FM8 A;  4JIW D;  3VZD A;  1DMZ A;  1K3Q A;  1DD1 A;  2EH0 A;  3I0N A;  3GMJ A;  3GQS A;  2JKD A;  3UMZ A;  1MK2 A;  2XXS A;  4D9V A;  3T5P A;  1J4L A;  2KB4 A;  2AFF A;  1FHQ A;  1WLN A;  1U7V A;  2BRF A;  3VPY A;  3OUN A;  3DIT A;  1YJ5 C;  3HX1 A;  1LGP A;  3MDB A;  3UNN A;  4EJQ A;  4KU0 D;  1U7F B;  2KKL A;  1QU5 A;  2KB3 A;  2P1R A;  1MZK A;  3KT9 A;  1FHR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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