The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
50
|
sequence length |
225
|
structure length |
195
|
Chain Sequence |
APEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYVDPSGGDRFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQVDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEIHLHRALQLLDEVLHTM
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Structural Mechanism of Smad4 Recognition by the Nuclear Oncoprotein Ski: Insights on Ski-mediated Repression of TGF-beta Signaling
pubmed doi rcsb |
| molecule keywords |
Mothers against decapentaplegic homolog 4
|
| molecule tags |
Signaling protein
|
| source organism |
Homo sapiens
|
| total genus |
50
|
| structure length |
195
|
| sequence length |
225
|
| chains with identical sequence |
B
|
| ec nomenclature | |
| pdb deposition date | 2002-09-17 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF03166 | MH2 | MH2 domain |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Beta | Sandwich | Tumour Suppressor Smad4 | Tumour Suppressor Smad4 |
#chains in the Genus database with same CATH superfamily 1DEV A; 1U7V B; 5JEO A; 1U7F B; 1QWT A; 1YGS A; 1U7V A; 3GMJ A; 5JEM A; 5JEJ A; 1G88 A; 1U7F A; 5BVI A; 1DD1 A; 5C4V A; 1KHU A; 1MR1 A; 1J2F A; 1ZOQ A; 5JER A; 5JEL A; 3A77 A; 1KHX A; 5JEK A; 1MK2 A; 1MJS A; 3DSH A; 4R9P A; 3DIT A; #chains in the Genus database with same CATH topology 4L02 A; 2I2F A; 2G1L A; 3V8Q A; 2I2C A; 2QVL A; 3I6W A; 5JEO A; 2AFF A; 2BRF A; 5EJF A; 1U7F B; 4A4Y A; 3HX1 A; 1YGS A; 1QU5 A; 3V8N A; 1YJM A; 1Z0U A; 3V8R A; 3V8P A; 1FHQ A; 1DD1 A; 3ELS A; 1U0T A; 1Y3H A; 2KKL A; 2QV7 A; 3VZD A; 1K3N A; 3V8M A; 3AFO A; 2CSW A; 5JEL A; 3UOT A; 4A0E A; 2JGR A; 2I29 A; 1UJX A; 1J4K A; 2JPE A; 4EJQ A; 2W3O A; 3VZC A; 3MDB A; 4R9P A; 2JQL A; 2FF4 A; 3DIT A; 1YJ5 C; 2KB4 A; 2PIE A; 3UNM A; 1U7V B; 2KFU A; 2XXS A; 1K3Q A; 1QWT A; 5DHR A; 3GMJ A; 3GQS A; 1G88 A; 1MZK A; 1U7F A; 4V24 A; 1DMZ A; 5BVI A; 4HAO A; 2A0T A; 3I0M A; 5DHQ A; 1KHU A; 2Q5F A; 4H87 A; 4DY6 A; 2I2A A; 3UV0 A; 1ZOQ A; 2I2D A; 3KT9 A; 5E50 A; 1KHX A; 2LC1 A; 5DJO A; 2AN1 A; 1MJS A; 2EH0 A; 3DSH A; 2JKD A; 2I2B A; 3UMZ A; 3V7U A; 1DEV A; 1J4P A; 1K2N A; 1WV3 A; 1WLN A; 3I6U A; 1U0R A; 1U7V A; 5JEM A; 3UNN A; 2JQI A; 4JIW D; 5JEJ A; 5DHS A; 2BON A; 2KB3 A; 4D9V A; 3PO8 A; 4G2S A; 1K2M A; 3POA A; 3PFN A; 3S40 A; 5C4V A; 1YT5 A; 1MR1 A; 4EGX A; 1FHR A; 5DHT A; 5DHP A; 5EJI A; 5JEK A; 1MK2 A; 1G6G A; 3HUE A; 2FEZ A; 1J4Q A; 3ELV A; 4JON A; 5EJG A; 3V80 A; 1SUW A; 2XT9 B; 1J4O A; 2JQJ A; 3VA4 A; 3T5P A; 1K3J A; 1R21 A; 3OUN A; 3VPY A; 4WER A; 1G3G A; 1LGP A; 1GXC A; 2I1W A; 2P1R A; 4WRR A; 3VA1 A; 4JIV D; 1Z0S A; 3HUF A; 3FM8 A; 5A8I A; 1LGQ A; 1J2F A; 4KU0 D; 3VZB A; 5JER A; 3V7Y A; 3A77 A; 1J4L A; 3UN0 A; 1UHT A; 3V7W A; 3I0N A; 5EJH A; 4QCJ A; 1Z0Z A; 1Y3I A; 5DHU A; #chains in the Genus database with same CATH homology 4L02 A; 2G1L A; 2QVL A; 3I6W A; 5JEO A; 2AFF A; 2BRF A; 1U7F B; 4A4Y A; 3HX1 A; 1YGS A; 1QU5 A; 1YJM A; 1FHQ A; 1DD1 A; 3ELS A; 2KKL A; 3VZD A; 2QV7 A; 1K3N A; 2CSW A; 5JEL A; 3UOT A; 4A0E A; 2JGR A; 1UJX A; 1J4K A; 2JPE A; 4EJQ A; 2W3O A; 3VZC A; 3MDB A; 4R9P A; 2JQL A; 2FF4 A; 3DIT A; 1YJ5 C; 2KB4 A; 2PIE A; 3UNM A; 1U7V B; 2KFU A; 2XXS A; 1K3Q A; 1QWT A; 3GMJ A; 3GQS A; 1G88 A; 1MZK A; 1U7F A; 4V24 A; 1DMZ A; 5BVI A; 2A0T A; 3I0M A; 1KHU A; 4H87 A; 3UV0 A; 1ZOQ A; 3KT9 A; 5E50 A; 1KHX A; 2LC1 A; 5DJO A; 1MJS A; 3DSH A; 2EH0 A; 2JKD A; 3UMZ A; 1DEV A; 1J4P A; 1K2N A; 1WV3 A; 1WLN A; 3I6U A; 1U7V A; 5JEM A; 3UNN A; 2JQI A; 4JIW D; 5JEJ A; 2BON A; 2KB3 A; 4D9V A; 3PO8 A; 4G2S A; 1K2M A; 3POA A; 3S40 A; 5C4V A; 1MR1 A; 4EGX A; 1FHR A; 5JEK A; 1MK2 A; 1G6G A; 3HUE A; 2FEZ A; 3ELV A; 1J4Q A; 4JON A; 2XT9 B; 1J4O A; 2JQJ A; 3VA4 A; 3T5P A; 1K3J A; 1R21 A; 3OUN A; 3VPY A; 4WER A; 1G3G A; 1LGP A; 1GXC A; 2P1R A; 4WRR A; 3VA1 A; 4JIV D; 3HUF A; 3FM8 A; 5A8I A; 1LGQ A; 1J2F A; 4KU0 D; 3VZB A; 5JER A; 3A77 A; 1J4L A; 3UN0 A; 1UHT A; 3I0N A; 4QCJ A;
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