2HGFA

Hairpin loop containing domain of hepatocyte growth factor, nmr, minimized average structure
Total Genus 14
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
14
sequence length
97
structure length
97
Chain Sequence
GQRKRRNTIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The solution structure of the N-terminal domain of hepatocyte growth factor reveals a potential heparin-binding site.
pubmed doi rcsb
molecule tags Hepatocyte growth factor
source organism Homo sapiens
molecule keywords HEPATOCYTE GROWTH FACTOR
total genus 14
structure length 97
sequence length 97
ec nomenclature
pdb deposition date 1997-12-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00024 PAN_1 PAN domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.50.4.10 Alpha Beta 3-Layer(bba) Sandwich Hepatocyte Growth Factor Hepatocyte Growth Factor 2hgfA00
3HMTA 5CS1A 5CS5A 3SRIA 1BHTA 2YILA 4APMA 5CS9A 5CSQA 4Z0EA 2YIOA 3SRJA 2Z8WA 2YIPA 2Y8RA 1W8KA 1W81A 1GP9A 1GMOA 3HMSA 2K13X 5CS3A 4Z0FA 5EOKA 1GMNA 2HGFA 4R1BA 3MKPA 4Z09A 2F83A 1HKYA 3ZWZA 2LL4M 2J8LA 2Q8BA 4R19A 1YXEA 5CT1A 5EODA 2Z8VA 3HMRA 5CP9A 5I25A 2QJ4A 5COEA 4DURA 4UV6A 4Z0DA 2QJ2A 4IUAA 1I8NA 2LL3A 2J8JA 3ZLEA 4UAOA 1Z40A 4A5TS 1NK1A 4R1CA 4R1AA 5CT3A 3HN4A 4APLA 3SP8A 5CT2A 2Q8AA 2X2ZA
chains in the Genus database with same CATH superfamily
3HMTA 5CS1A 5CS5A 3SRIA 1BHTA 2YILA 4APMA 5CS9A 5CSQA 4Z0EA 2KL5A 2YIOA 2Z8WA 3SRJA 2YIPA 2Y8RA 1W8KA 1W81A 1GP9A 1GMOA 3HMSA 2K13X 5CS3A 4Z0FA 5EOKA 1GMNA 2HGFA 4R1BA 3MKPA 4YIVA 4Z09A 2F83A 1HKYA 3ZWZA 2LL4M 2J8LA 2Q8BA 4R19A 1YXEA 5CT1A 5EODA 2Z8VA 3HMRA 5CP9A 5I25A 2QJ4A 5COEA 4DURA 4UV6A 4Z0DA 2QJ2A 4IUAA 1I8NA 2LL3A 2J8JA 3ZLEA 4UAOA 1Z40A 4A5TS 1NK1A 4R1CA 4R1AA 5CT3A 3HN4A 4YIZA 4APLA 3SP8A 5CT2A 2Q8AA 2X2ZA
chains in the Genus database with same CATH topology
3HMTA 5CS1A 5CS5A 3SRIA 1BHTA 2YILA 4APMA 5CS9A 5CSQA 4Z0EA 2KL5A 2YIOA 2Z8WA 3SRJA 2YIPA 2Y8RA 1W8KA 1W81A 1GP9A 1GMOA 3HMSA 2K13X 5CS3A 4Z0FA 5EOKA 1GMNA 2HGFA 4R1BA 3MKPA 4YIVA 4Z09A 2F83A 1HKYA 3ZWZA 2LL4M 2J8LA 2Q8BA 4R19A 1YXEA 5CT1A 5EODA 2Z8VA 3HMRA 5CP9A 5I25A 2QJ4A 5COEA 4DURA 4UV6A 4Z0DA 2QJ2A 4IUAA 1I8NA 2LL3A 2J8JA 3ZLEA 4UAOA 1Z40A 4A5TS 1NK1A 4R1CA 4R1AA 5CT3A 3HN4A 4YIZA 4APLA 3SP8A 5CT2A 2Q8AA 2X2ZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3HMT A;  5CS1 A;  5CS5 A;  3SRI A;  1BHT A;  2YIL A;  4APM A;  5CS9 A;  5CSQ A;  4Z0E A;  2YIO A;  3SRJ A;  2Z8W A;  2YIP A;  2Y8R A;  1W8K A;  1W81 A;  1GP9 A;  1GMO A;  3HMS A;  2K13 X;  5CS3 A;  4Z0F A;  5EOK A;  1GMN A;  2HGF A;  4R1B A;  3MKP A;  4Z09 A;  2F83 A;  1HKY A;  3ZWZ A;  2LL4 M;  2J8L A;  2Q8B A;  4R19 A;  1YXE A;  5CT1 A;  5EOD A;  2Z8V A;  3HMR A;  5CP9 A;  5I25 A;  2QJ4 A;  5COE A;  4DUR A;  4UV6 A;  4Z0D A;  2QJ2 A;  4IUA A;  1I8N A;  2LL3 A;  2J8J A;  3ZLE A;  4UAO A;  1Z40 A;  4A5T S;  1NK1 A;  4R1C A;  4R1A A;  5CT3 A;  3HN4 A;  4APL A;  3SP8 A;  5CT2 A;  2Q8A A;  2X2Z A; 
#chains in the Genus database with same CATH topology
 3HMT A;  5CS1 A;  5CS5 A;  3SRI A;  1BHT A;  2YIL A;  4APM A;  5CS9 A;  5CSQ A;  4Z0E A;  2KL5 A;  2YIO A;  2Z8W A;  3SRJ A;  2YIP A;  2Y8R A;  1W8K A;  1W81 A;  1GP9 A;  1GMO A;  3HMS A;  2K13 X;  5CS3 A;  4Z0F A;  5EOK A;  1GMN A;  2HGF A;  4R1B A;  3MKP A;  4YIV A;  4Z09 A;  2F83 A;  1HKY A;  3ZWZ A;  2LL4 M;  2J8L A;  2Q8B A;  4R19 A;  1YXE A;  5CT1 A;  5EOD A;  2Z8V A;  3HMR A;  5CP9 A;  5I25 A;  2QJ4 A;  5COE A;  4DUR A;  4UV6 A;  4Z0D A;  2QJ2 A;  4IUA A;  1I8N A;  2LL3 A;  2J8J A;  3ZLE A;  4UAO A;  1Z40 A;  4A5T S;  1NK1 A;  4R1C A;  4R1A A;  5CT3 A;  3HN4 A;  4YIZ A;  4APL A;  3SP8 A;  5CT2 A;  2Q8A A;  2X2Z A; 
#chains in the Genus database with same CATH homology
 3HMT A;  5CS1 A;  5CS5 A;  3SRI A;  1BHT A;  2YIL A;  4APM A;  5CS9 A;  5CSQ A;  4Z0E A;  2KL5 A;  2YIO A;  2Z8W A;  3SRJ A;  2YIP A;  2Y8R A;  1W8K A;  1W81 A;  1GP9 A;  1GMO A;  3HMS A;  2K13 X;  5CS3 A;  4Z0F A;  5EOK A;  1GMN A;  2HGF A;  4R1B A;  3MKP A;  4YIV A;  4Z09 A;  2F83 A;  1HKY A;  3ZWZ A;  2LL4 M;  2J8L A;  2Q8B A;  4R19 A;  1YXE A;  5CT1 A;  5EOD A;  2Z8V A;  3HMR A;  5CP9 A;  5I25 A;  2QJ4 A;  5COE A;  4DUR A;  4UV6 A;  4Z0D A;  2QJ2 A;  4IUA A;  1I8N A;  2LL3 A;  2J8J A;  3ZLE A;  4UAO A;  1Z40 A;  4A5T S;  1NK1 A;  4R1C A;  4R1A A;  5CT3 A;  3HN4 A;  4YIZ A;  4APL A;  3SP8 A;  5CT2 A;  2Q8A A;  2X2Z A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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