4Z0FA

Crystal structure of fvo strain plasmodium falciparum ama1 in complex with the ron2hp [phe2038(6cw)] peptide
Total Genus 75
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
75
sequence length
332
structure length
278
Chain Sequence
GNPWTEYMAKYDIEEVHGSGIRVDLGEDAEVAGTQYRLPSGKCPVFGKGIIIENSNTTFLKPVATLKDGGFAFPPTNPLISPMTLNGMRDFYKNNEYVKNLDELTLCSRHAGNMNPDNKNSNYKYPAVYDYNDKKCHILYIAAQENNFCFRPAKDKLFENYTYLSKNVVDNWEEVCPRKNLENAKFGLWVDGNCEDIPHVNEFSANDLFECNKLVFELSASDQPKQYDRYKSHGKGYNWGNYNRETQKCEIFNVKPTCLINNSSYIATTALSHPIEVE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure-Activity Studies of beta-Hairpin Peptide Inhibitors of the Plasmodium falciparum AMA1-RON2 Interaction.
pubmed doi rcsb
molecule tags Cell invasion
source organism Plasmodium falciparum vietnam oak-knoll (fvo)
molecule keywords Apical membrane antigen 1
total genus 75
structure length 278
sequence length 332
ec nomenclature
pdb deposition date 2015-03-26
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.50.4.10 Alpha Beta 3-Layer(bba) Sandwich Hepatocyte Growth Factor Hepatocyte Growth Factor 4z0fA01
5I25A 4APLA 2LL4M 3HN4A 3MKPA 1BHTA 2Q8AA 5CS9A 1Z40A 5EOKA 2J8JA 2LL3A 5CS5A 5EODA 2Q8BA 4A5TS 5CT1A 4Z0EA 4UV6A 4APMA 3HMRA 3SP8A 3ZLEA 2X2ZA 5CP9A 4Z0FA 4Z0DA 2YILA 5CSQA 1HKYA 1GP9A 4UAOA 3SRJA 1YXEA 1NK1A 2YIOA 2K13X 2Y8RA 1GMOA 4Z09A 4R1AA 4DURA 5CS1A 5CS3A 4R19A 2J8LA 2YIPA 2Z8WA 2HGFA 3HMSA 2F83A 1W8KA 4IUAA 5CT2A 5CT3A 3SRIA 3ZWZA 1GMNA 2Z8VA 5COEA 4R1BA 1I8NA 2QJ2A 4R1CA 2QJ4A 3HMTA 1W81A
chains in the Genus database with same CATH superfamily
5I25A 4APLA 2LL4M 3HN4A 4YIZA 3MKPA 1BHTA 2KL5A 2Q8AA 5CS9A 1Z40A 5EOKA 2J8JA 2LL3A 5CS5A 5EODA 2Q8BA 4A5TS 5CT1A 4Z0EA 4UV6A 4APMA 3HMRA 3SP8A 3ZLEA 2X2ZA 5CP9A 4Z0FA 4Z0DA 2YILA 5CSQA 1HKYA 1GP9A 4UAOA 3SRJA 1YXEA 1NK1A 2YIOA 2K13X 2Y8RA 1GMOA 4Z09A 4R1AA 4DURA 5CS1A 5CS3A 4R19A 2J8LA 2YIPA 4YIVA 2Z8WA 2HGFA 3HMSA 2F83A 1W8KA 4IUAA 5CT2A 5CT3A 3SRIA 3ZWZA 1GMNA 2Z8VA 5COEA 4R1BA 1I8NA 2QJ2A 4R1CA 2QJ4A 3HMTA 1W81A
chains in the Genus database with same CATH topology
5I25A 4APLA 2LL4M 3HN4A 4YIZA 3MKPA 1BHTA 2KL5A 2Q8AA 5CS9A 1Z40A 5EOKA 2J8JA 2LL3A 5CS5A 5EODA 2Q8BA 4A5TS 5CT1A 4Z0EA 4UV6A 4APMA 3HMRA 3SP8A 3ZLEA 2X2ZA 5CP9A 4Z0FA 4Z0DA 2YILA 5CSQA 1HKYA 1GP9A 4UAOA 3SRJA 1YXEA 1NK1A 2YIOA 2K13X 2Y8RA 1GMOA 4Z09A 4R1AA 4DURA 5CS1A 5CS3A 4R19A 2J8LA 2YIPA 4YIVA 2Z8WA 2HGFA 3HMSA 2F83A 1W8KA 4IUAA 5CT2A 5CT3A 3SRIA 3ZWZA 1GMNA 2Z8VA 5COEA 4R1BA 1I8NA 2QJ2A 4R1CA 2QJ4A 3HMTA 1W81A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5I25 A;  4APL A;  2LL4 M;  3HN4 A;  3MKP A;  1BHT A;  2Q8A A;  5CS9 A;  1Z40 A;  5EOK A;  2J8J A;  2LL3 A;  5CS5 A;  5EOD A;  2Q8B A;  4A5T S;  5CT1 A;  4Z0E A;  4UV6 A;  4APM A;  3HMR A;  3SP8 A;  3ZLE A;  2X2Z A;  5CP9 A;  4Z0F A;  4Z0D A;  2YIL A;  5CSQ A;  1HKY A;  1GP9 A;  4UAO A;  3SRJ A;  1YXE A;  1NK1 A;  2YIO A;  2K13 X;  2Y8R A;  1GMO A;  4Z09 A;  4R1A A;  4DUR A;  5CS1 A;  5CS3 A;  4R19 A;  2J8L A;  2YIP A;  2Z8W A;  2HGF A;  3HMS A;  2F83 A;  1W8K A;  4IUA A;  5CT2 A;  5CT3 A;  3SRI A;  3ZWZ A;  1GMN A;  2Z8V A;  5COE A;  4R1B A;  1I8N A;  2QJ2 A;  4R1C A;  2QJ4 A;  3HMT A;  1W81 A; 
#chains in the Genus database with same CATH topology
 5I25 A;  4APL A;  2LL4 M;  3HN4 A;  4YIZ A;  3MKP A;  1BHT A;  2KL5 A;  2Q8A A;  5CS9 A;  1Z40 A;  5EOK A;  2J8J A;  2LL3 A;  5CS5 A;  5EOD A;  2Q8B A;  4A5T S;  5CT1 A;  4Z0E A;  4UV6 A;  4APM A;  3HMR A;  3SP8 A;  3ZLE A;  2X2Z A;  5CP9 A;  4Z0F A;  4Z0D A;  2YIL A;  5CSQ A;  1HKY A;  1GP9 A;  4UAO A;  3SRJ A;  1YXE A;  1NK1 A;  2YIO A;  2K13 X;  2Y8R A;  1GMO A;  4Z09 A;  4R1A A;  4DUR A;  5CS1 A;  5CS3 A;  4R19 A;  2J8L A;  2YIP A;  4YIV A;  2Z8W A;  2HGF A;  3HMS A;  2F83 A;  1W8K A;  4IUA A;  5CT2 A;  5CT3 A;  3SRI A;  3ZWZ A;  1GMN A;  2Z8V A;  5COE A;  4R1B A;  1I8N A;  2QJ2 A;  4R1C A;  2QJ4 A;  3HMT A;  1W81 A; 
#chains in the Genus database with same CATH homology
 5I25 A;  4APL A;  2LL4 M;  3HN4 A;  4YIZ A;  3MKP A;  1BHT A;  2KL5 A;  2Q8A A;  5CS9 A;  1Z40 A;  5EOK A;  2J8J A;  2LL3 A;  5CS5 A;  5EOD A;  2Q8B A;  4A5T S;  5CT1 A;  4Z0E A;  4UV6 A;  4APM A;  3HMR A;  3SP8 A;  3ZLE A;  2X2Z A;  5CP9 A;  4Z0F A;  4Z0D A;  2YIL A;  5CSQ A;  1HKY A;  1GP9 A;  4UAO A;  3SRJ A;  1YXE A;  1NK1 A;  2YIO A;  2K13 X;  2Y8R A;  1GMO A;  4Z09 A;  4R1A A;  4DUR A;  5CS1 A;  5CS3 A;  4R19 A;  2J8L A;  2YIP A;  4YIV A;  2Z8W A;  2HGF A;  3HMS A;  2F83 A;  1W8K A;  4IUA A;  5CT2 A;  5CT3 A;  3SRI A;  3ZWZ A;  1GMN A;  2Z8V A;  5COE A;  4R1B A;  1I8N A;  2QJ2 A;  4R1C A;  2QJ4 A;  3HMT A;  1W81 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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