2J8JA

Solution structure of the a4 domain of blood coagulation factor xi
Total Genus 18
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
18
sequence length
90
structure length
90
Chain Sequence
FCHSSFYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKILHGRGGISGYTLRLCKMDNE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
publication title Solution Structure of the A4 Domain of Factor Xi Sheds Light on the Mechanism of Zymogen Activation.
pubmed doi rcsb
molecule keywords COAGULATION FACTOR XI
total genus 18
structure length 90
sequence length 90
chains with identical sequence B
ec nomenclature ec 3.4.21.27: Coagulation factor XIa.
pdb deposition date 2006-10-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00024 PAN_1 PAN domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.50.4.10 Alpha Beta 3-Layer(bba) Sandwich Hepatocyte Growth Factor Hepatocyte Growth Factor 2j8jA00
2Q8BA 5CS3A 2YIOA 2J8JA 1NK1A 1Z40A 5CP9A 4UV6A 2QJ2A 2Y8RA 2J8LA 2Q8AA 3ZLEA 5CSQA 2LL3A 4R19A 5EODA 5CT3A 2QJ4A 1BHTA 2Z8WA 5CT2A 3SP8A 4A5TS 5I25A 4Z0EA 4DURA 1W81A 3MKPA 5CS5A 4APMA 3HN4A 2K13X 4R1CA 1GMNA 1GP9A 2YILA 4Z0DA 1GMOA 3SRIA 4R1BA 4R1AA 5CS9A 5EOKA 4IUAA 4Z09A 1I8NA 2YIPA 4APLA 3HMTA 5CT1A 1HKYA 4Z0FA 3ZWZA 2Z8VA 3HMRA 1W8KA 2HGFA 4UAOA 3SRJA 5CS1A 2X2ZA 3HMSA 5COEA 2F83A 2LL4M 1YXEA
chains in the Genus database with same CATH superfamily
2Q8BA 5CS3A 2YIOA 2J8JA 1NK1A 1Z40A 2KL5A 5CP9A 4UV6A 2QJ2A 2Y8RA 2J8LA 2Q8AA 3ZLEA 5CSQA 2LL3A 4R19A 5EODA 5CT3A 2QJ4A 1BHTA 2Z8WA 5CT2A 3SP8A 4A5TS 5I25A 4Z0EA 4DURA 1W81A 3MKPA 5CS5A 4APMA 3HN4A 2K13X 4R1CA 4YIZA 1GMNA 1GP9A 2YILA 4Z0DA 1GMOA 3SRIA 4R1BA 4R1AA 5CS9A 4YIVA 5EOKA 4IUAA 4Z09A 1I8NA 2YIPA 4APLA 3HMTA 5CT1A 1HKYA 4Z0FA 3ZWZA 2Z8VA 3HMRA 1W8KA 2HGFA 4UAOA 3SRJA 5CS1A 2X2ZA 3HMSA 5COEA 2F83A 2LL4M 1YXEA
chains in the Genus database with same CATH topology
2Q8BA 5CS3A 2YIOA 2J8JA 1NK1A 1Z40A 2KL5A 5CP9A 4UV6A 2QJ2A 2Y8RA 2J8LA 2Q8AA 3ZLEA 5CSQA 2LL3A 4R19A 5EODA 5CT3A 2QJ4A 1BHTA 2Z8WA 5CT2A 3SP8A 4A5TS 5I25A 4Z0EA 4DURA 1W81A 3MKPA 5CS5A 4APMA 3HN4A 2K13X 4R1CA 4YIZA 1GMNA 1GP9A 2YILA 4Z0DA 1GMOA 3SRIA 4R1BA 4R1AA 5CS9A 4YIVA 5EOKA 4IUAA 4Z09A 1I8NA 2YIPA 4APLA 3HMTA 5CT1A 1HKYA 4Z0FA 3ZWZA 2Z8VA 3HMRA 1W8KA 2HGFA 4UAOA 3SRJA 5CS1A 2X2ZA 3HMSA 5COEA 2F83A 2LL4M 1YXEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2Q8B A;  5CS3 A;  2YIO A;  2J8J A;  1NK1 A;  1Z40 A;  5CP9 A;  4UV6 A;  2QJ2 A;  2Y8R A;  2J8L A;  2Q8A A;  3ZLE A;  5CSQ A;  2LL3 A;  4R19 A;  5EOD A;  5CT3 A;  2QJ4 A;  1BHT A;  2Z8W A;  5CT2 A;  3SP8 A;  4A5T S;  5I25 A;  4Z0E A;  4DUR A;  1W81 A;  3MKP A;  5CS5 A;  4APM A;  3HN4 A;  2K13 X;  4R1C A;  1GMN A;  1GP9 A;  2YIL A;  4Z0D A;  1GMO A;  3SRI A;  4R1B A;  4R1A A;  5CS9 A;  5EOK A;  4IUA A;  4Z09 A;  1I8N A;  2YIP A;  4APL A;  3HMT A;  5CT1 A;  1HKY A;  4Z0F A;  3ZWZ A;  2Z8V A;  3HMR A;  1W8K A;  2HGF A;  4UAO A;  3SRJ A;  5CS1 A;  2X2Z A;  3HMS A;  5COE A;  2F83 A;  2LL4 M;  1YXE A; 
#chains in the Genus database with same CATH topology
 2Q8B A;  5CS3 A;  2YIO A;  2J8J A;  1NK1 A;  1Z40 A;  2KL5 A;  5CP9 A;  4UV6 A;  2QJ2 A;  2Y8R A;  2J8L A;  2Q8A A;  3ZLE A;  5CSQ A;  2LL3 A;  4R19 A;  5EOD A;  5CT3 A;  2QJ4 A;  1BHT A;  2Z8W A;  5CT2 A;  3SP8 A;  4A5T S;  5I25 A;  4Z0E A;  4DUR A;  1W81 A;  3MKP A;  5CS5 A;  4APM A;  3HN4 A;  2K13 X;  4R1C A;  4YIZ A;  1GMN A;  1GP9 A;  2YIL A;  4Z0D A;  1GMO A;  3SRI A;  4R1B A;  4R1A A;  5CS9 A;  4YIV A;  5EOK A;  4IUA A;  4Z09 A;  1I8N A;  2YIP A;  4APL A;  3HMT A;  5CT1 A;  1HKY A;  4Z0F A;  3ZWZ A;  2Z8V A;  3HMR A;  1W8K A;  2HGF A;  4UAO A;  3SRJ A;  5CS1 A;  2X2Z A;  3HMS A;  5COE A;  2F83 A;  2LL4 M;  1YXE A; 
#chains in the Genus database with same CATH homology
 2Q8B A;  5CS3 A;  2YIO A;  2J8J A;  1NK1 A;  1Z40 A;  2KL5 A;  5CP9 A;  4UV6 A;  2QJ2 A;  2Y8R A;  2J8L A;  2Q8A A;  3ZLE A;  5CSQ A;  2LL3 A;  4R19 A;  5EOD A;  5CT3 A;  2QJ4 A;  1BHT A;  2Z8W A;  5CT2 A;  3SP8 A;  4A5T S;  5I25 A;  4Z0E A;  4DUR A;  1W81 A;  3MKP A;  5CS5 A;  4APM A;  3HN4 A;  2K13 X;  4R1C A;  4YIZ A;  1GMN A;  1GP9 A;  2YIL A;  4Z0D A;  1GMO A;  3SRI A;  4R1B A;  4R1A A;  5CS9 A;  4YIV A;  5EOK A;  4IUA A;  4Z09 A;  1I8N A;  2YIP A;  4APL A;  3HMT A;  5CT1 A;  1HKY A;  4Z0F A;  3ZWZ A;  2Z8V A;  3HMR A;  1W8K A;  2HGF A;  4UAO A;  3SRJ A;  5CS1 A;  2X2Z A;  3HMS A;  5COE A;  2F83 A;  2LL4 M;  1YXE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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