2J8JA

Solution structure of the a4 domain of blood coagulation factor xi
Total Genus 18
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
18
sequence length
90
structure length
90
Chain Sequence
FCHSSFYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKILHGRGGISGYTLRLCKMDNE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Solution Structure of the A4 Domain of Factor Xi Sheds Light on the Mechanism of Zymogen Activation.
pubmed doi rcsb
molecule keywords COAGULATION FACTOR XI
molecule tags Hydrolase
total genus 18
structure length 90
sequence length 90
chains with identical sequence B
ec nomenclature ec 3.4.21.27: Coagulation factor XIa.
pdb deposition date 2006-10-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00024 PAN_1 PAN domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.50.4.10 Alpha Beta 3-Layer(bba) Sandwich Hepatocyte Growth Factor Hepatocyte Growth Factor 2j8jA00
5CS9A 2K13X 5CS3A 2F83A 2J8JA 2Q8AA 4IUAA 3ZLEA 2Z8VA 5CP9A 5EODA 1GP9A 1BHTA 2Z8WA 3HMTA 4Z0DA 5I25A 5CSQA 2QJ4A 2J8LA 3HN4A 4R1AA 4UAOA 4UV6A 5CS5A 5CS1A 3SRIA 4APLA 4Z09A 2LL4M 3ZWZA 1W81A 1W8KA 2YIOA 1Z40A 5CT3A 4APMA 5EOKA 1GMOA 1NK1A 5CT2A 4DURA 3HMSA 3SRJA 2X2ZA 4A5TS 3SP8A 1I8NA 3HMRA 4R1BA 1YXEA 5CT1A 2Q8BA 4R19A 3MKPA 1HKYA 4R1CA 2YILA 2HGFA 2QJ2A 2LL3A 2YIPA 4Z0EA 2Y8RA 1GMNA 4Z0FA 5COEA
chains in the Genus database with same CATH superfamily
5CS9A 2K13X 5CS3A 2F83A 2J8JA 2Q8AA 4IUAA 3ZLEA 2Z8VA 5CP9A 5EODA 1GP9A 1BHTA 2Z8WA 3HMTA 4Z0DA 5I25A 5CSQA 2QJ4A 2J8LA 3HN4A 4R1AA 4UAOA 4UV6A 5CS5A 5CS1A 3SRIA 4APLA 4Z09A 2LL4M 3ZWZA 1W81A 1W8KA 2YIOA 4YIVA 1Z40A 5CT3A 4APMA 5EOKA 1GMOA 1NK1A 5CT2A 4DURA 3HMSA 3SRJA 2X2ZA 4A5TS 3SP8A 1I8NA 3HMRA 4R1BA 1YXEA 5CT1A 2Q8BA 4R19A 3MKPA 1HKYA 4R1CA 2YILA 2HGFA 2QJ2A 2LL3A 2YIPA 4Z0EA 4YIZA 2Y8RA 1GMNA 4Z0FA 2KL5A 5COEA
chains in the Genus database with same CATH topology
5CS9A 2K13X 5CS3A 2F83A 2J8JA 2Q8AA 4IUAA 3ZLEA 2Z8VA 5CP9A 5EODA 1GP9A 1BHTA 2Z8WA 3HMTA 4Z0DA 5I25A 5CSQA 2QJ4A 2J8LA 3HN4A 4R1AA 4UAOA 4UV6A 5CS5A 5CS1A 3SRIA 4APLA 4Z09A 2LL4M 3ZWZA 1W81A 1W8KA 2YIOA 4YIVA 1Z40A 5CT3A 4APMA 5EOKA 1GMOA 1NK1A 5CT2A 4DURA 3HMSA 3SRJA 2X2ZA 4A5TS 3SP8A 1I8NA 3HMRA 4R1BA 1YXEA 5CT1A 2Q8BA 4R19A 3MKPA 1HKYA 4R1CA 2YILA 2HGFA 2QJ2A 2LL3A 2YIPA 4Z0EA 4YIZA 2Y8RA 1GMNA 4Z0FA 2KL5A 5COEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5CS9 A;  2K13 X;  5CS3 A;  2F83 A;  2J8J A;  2Q8A A;  4IUA A;  3ZLE A;  2Z8V A;  5CP9 A;  5EOD A;  1GP9 A;  1BHT A;  2Z8W A;  3HMT A;  4Z0D A;  5I25 A;  5CSQ A;  2QJ4 A;  2J8L A;  3HN4 A;  4R1A A;  4UAO A;  4UV6 A;  5CS5 A;  5CS1 A;  3SRI A;  4APL A;  4Z09 A;  2LL4 M;  3ZWZ A;  1W81 A;  1W8K A;  2YIO A;  1Z40 A;  5CT3 A;  4APM A;  5EOK A;  1GMO A;  1NK1 A;  5CT2 A;  4DUR A;  3HMS A;  3SRJ A;  2X2Z A;  4A5T S;  3SP8 A;  1I8N A;  3HMR A;  4R1B A;  1YXE A;  5CT1 A;  2Q8B A;  4R19 A;  3MKP A;  1HKY A;  4R1C A;  2YIL A;  2HGF A;  2QJ2 A;  2LL3 A;  2YIP A;  4Z0E A;  2Y8R A;  1GMN A;  4Z0F A;  5COE A; 
#chains in the Genus database with same CATH topology
 5CS9 A;  2K13 X;  5CS3 A;  2F83 A;  2J8J A;  2Q8A A;  4IUA A;  3ZLE A;  2Z8V A;  5CP9 A;  5EOD A;  1GP9 A;  1BHT A;  2Z8W A;  3HMT A;  4Z0D A;  5I25 A;  5CSQ A;  2QJ4 A;  2J8L A;  3HN4 A;  4R1A A;  4UAO A;  4UV6 A;  5CS5 A;  5CS1 A;  3SRI A;  4APL A;  4Z09 A;  2LL4 M;  3ZWZ A;  1W81 A;  1W8K A;  2YIO A;  4YIV A;  1Z40 A;  5CT3 A;  4APM A;  5EOK A;  1GMO A;  1NK1 A;  5CT2 A;  4DUR A;  3HMS A;  3SRJ A;  2X2Z A;  4A5T S;  3SP8 A;  1I8N A;  3HMR A;  4R1B A;  1YXE A;  5CT1 A;  2Q8B A;  4R19 A;  3MKP A;  1HKY A;  4R1C A;  2YIL A;  2HGF A;  2QJ2 A;  2LL3 A;  2YIP A;  4Z0E A;  4YIZ A;  2Y8R A;  1GMN A;  4Z0F A;  2KL5 A;  5COE A; 
#chains in the Genus database with same CATH homology
 5CS9 A;  2K13 X;  5CS3 A;  2F83 A;  2J8J A;  2Q8A A;  4IUA A;  3ZLE A;  2Z8V A;  5CP9 A;  5EOD A;  1GP9 A;  1BHT A;  2Z8W A;  3HMT A;  4Z0D A;  5I25 A;  5CSQ A;  2QJ4 A;  2J8L A;  3HN4 A;  4R1A A;  4UAO A;  4UV6 A;  5CS5 A;  5CS1 A;  3SRI A;  4APL A;  4Z09 A;  2LL4 M;  3ZWZ A;  1W81 A;  1W8K A;  2YIO A;  4YIV A;  1Z40 A;  5CT3 A;  4APM A;  5EOK A;  1GMO A;  1NK1 A;  5CT2 A;  4DUR A;  3HMS A;  3SRJ A;  2X2Z A;  4A5T S;  3SP8 A;  1I8N A;  3HMR A;  4R1B A;  1YXE A;  5CT1 A;  2Q8B A;  4R19 A;  3MKP A;  1HKY A;  4R1C A;  2YIL A;  2HGF A;  2QJ2 A;  2LL3 A;  2YIP A;  4Z0E A;  4YIZ A;  2Y8R A;  1GMN A;  4Z0F A;  2KL5 A;  5COE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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