2J8JA

Solution structure of the a4 domain of blood coagulation factor xi
Total Genus 18
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
18
sequence length
90
structure length
90
Chain Sequence
FCHSSFYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKILHGRGGISGYTLRLCKMDNE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Solution Structure of the A4 Domain of Factor Xi Sheds Light on the Mechanism of Zymogen Activation.
pubmed doi rcsb
molecule keywords COAGULATION FACTOR XI
molecule tags Hydrolase
total genus 18
structure length 90
sequence length 90
chains with identical sequence B
ec nomenclature ec 3.4.21.27: Coagulation factor XIa.
pdb deposition date 2006-10-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00024 PAN_1 PAN domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.50.4.10 Alpha Beta 3-Layer(bba) Sandwich Hepatocyte Growth Factor Hepatocyte Growth Factor 2j8jA00
4R1BA 3HMRA 2QJ4A 1Z40A 4IUAA 1GP9A 2K13X 5CS1A 5CSQA 4DURA 1NK1A 2J8JA 2YIPA 1GMNA 3HN4A 5CT3A 5CT1A 2Z8WA 5CS9A 4APLA 3ZWZA 2LL4M 4R1CA 2Q8AA 1I8NA 2J8LA 2X2ZA 2Y8RA 2YILA 4UAOA 5CS3A 5CT2A 3SP8A 3HMSA 1GMOA 1BHTA 1W81A 1YXEA 4APMA 4A5TS 2Q8BA 2LL3A 5I25A 3ZLEA 3MKPA 4R1AA 1W8KA 3HMTA 3SRJA 2YIOA 5EODA 1HKYA 3SRIA 2Z8VA 2QJ2A 4R19A 4Z09A 5COEA 4Z0DA 2F83A 4Z0FA 2HGFA 4UV6A 4Z0EA 5EOKA 5CP9A 5CS5A
chains in the Genus database with same CATH superfamily
4R1BA 3HMRA 2QJ4A 1Z40A 4IUAA 1GP9A 2K13X 5CS1A 5CSQA 4DURA 1NK1A 4YIZA 2J8JA 2KL5A 2YIPA 1GMNA 3HN4A 5CT3A 5CT1A 2Z8WA 5CS9A 4APLA 3ZWZA 2LL4M 4R1CA 2Q8AA 1I8NA 2J8LA 2X2ZA 2Y8RA 2YILA 4UAOA 5CS3A 5CT2A 3SP8A 4YIVA 3HMSA 1GMOA 1BHTA 1W81A 1YXEA 4APMA 4A5TS 2Q8BA 2LL3A 5I25A 3ZLEA 3MKPA 4R1AA 1W8KA 3HMTA 3SRJA 2YIOA 5EODA 1HKYA 3SRIA 2Z8VA 2QJ2A 4R19A 4Z09A 5COEA 4Z0DA 2F83A 4Z0FA 2HGFA 4UV6A 4Z0EA 5EOKA 5CP9A 5CS5A
chains in the Genus database with same CATH topology
4R1BA 3HMRA 2QJ4A 1Z40A 4IUAA 1GP9A 2K13X 5CS1A 5CSQA 4DURA 1NK1A 4YIZA 2J8JA 2KL5A 2YIPA 1GMNA 3HN4A 5CT3A 5CT1A 2Z8WA 5CS9A 4APLA 3ZWZA 2LL4M 4R1CA 2Q8AA 1I8NA 2J8LA 2X2ZA 2Y8RA 2YILA 4UAOA 5CS3A 5CT2A 3SP8A 4YIVA 3HMSA 1GMOA 1BHTA 1W81A 1YXEA 4APMA 4A5TS 2Q8BA 2LL3A 5I25A 3ZLEA 3MKPA 4R1AA 1W8KA 3HMTA 3SRJA 2YIOA 5EODA 1HKYA 3SRIA 2Z8VA 2QJ2A 4R19A 4Z09A 5COEA 4Z0DA 2F83A 4Z0FA 2HGFA 4UV6A 4Z0EA 5EOKA 5CP9A 5CS5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4R1B A;  3HMR A;  2QJ4 A;  1Z40 A;  4IUA A;  1GP9 A;  2K13 X;  5CS1 A;  5CSQ A;  4DUR A;  1NK1 A;  2J8J A;  2YIP A;  1GMN A;  3HN4 A;  5CT3 A;  5CT1 A;  2Z8W A;  5CS9 A;  4APL A;  3ZWZ A;  2LL4 M;  4R1C A;  2Q8A A;  1I8N A;  2J8L A;  2X2Z A;  2Y8R A;  2YIL A;  4UAO A;  5CS3 A;  5CT2 A;  3SP8 A;  3HMS A;  1GMO A;  1BHT A;  1W81 A;  1YXE A;  4APM A;  4A5T S;  2Q8B A;  2LL3 A;  5I25 A;  3ZLE A;  3MKP A;  4R1A A;  1W8K A;  3HMT A;  3SRJ A;  2YIO A;  5EOD A;  1HKY A;  3SRI A;  2Z8V A;  2QJ2 A;  4R19 A;  4Z09 A;  5COE A;  4Z0D A;  2F83 A;  4Z0F A;  2HGF A;  4UV6 A;  4Z0E A;  5EOK A;  5CP9 A;  5CS5 A; 
#chains in the Genus database with same CATH topology
 4R1B A;  3HMR A;  2QJ4 A;  1Z40 A;  4IUA A;  1GP9 A;  2K13 X;  5CS1 A;  5CSQ A;  4DUR A;  1NK1 A;  4YIZ A;  2J8J A;  2KL5 A;  2YIP A;  1GMN A;  3HN4 A;  5CT3 A;  5CT1 A;  2Z8W A;  5CS9 A;  4APL A;  3ZWZ A;  2LL4 M;  4R1C A;  2Q8A A;  1I8N A;  2J8L A;  2X2Z A;  2Y8R A;  2YIL A;  4UAO A;  5CS3 A;  5CT2 A;  3SP8 A;  4YIV A;  3HMS A;  1GMO A;  1BHT A;  1W81 A;  1YXE A;  4APM A;  4A5T S;  2Q8B A;  2LL3 A;  5I25 A;  3ZLE A;  3MKP A;  4R1A A;  1W8K A;  3HMT A;  3SRJ A;  2YIO A;  5EOD A;  1HKY A;  3SRI A;  2Z8V A;  2QJ2 A;  4R19 A;  4Z09 A;  5COE A;  4Z0D A;  2F83 A;  4Z0F A;  2HGF A;  4UV6 A;  4Z0E A;  5EOK A;  5CP9 A;  5CS5 A; 
#chains in the Genus database with same CATH homology
 4R1B A;  3HMR A;  2QJ4 A;  1Z40 A;  4IUA A;  1GP9 A;  2K13 X;  5CS1 A;  5CSQ A;  4DUR A;  1NK1 A;  4YIZ A;  2J8J A;  2KL5 A;  2YIP A;  1GMN A;  3HN4 A;  5CT3 A;  5CT1 A;  2Z8W A;  5CS9 A;  4APL A;  3ZWZ A;  2LL4 M;  4R1C A;  2Q8A A;  1I8N A;  2J8L A;  2X2Z A;  2Y8R A;  2YIL A;  4UAO A;  5CS3 A;  5CT2 A;  3SP8 A;  4YIV A;  3HMS A;  1GMO A;  1BHT A;  1W81 A;  1YXE A;  4APM A;  4A5T S;  2Q8B A;  2LL3 A;  5I25 A;  3ZLE A;  3MKP A;  4R1A A;  1W8K A;  3HMT A;  3SRJ A;  2YIO A;  5EOD A;  1HKY A;  3SRI A;  2Z8V A;  2QJ2 A;  4R19 A;  4Z09 A;  5COE A;  4Z0D A;  2F83 A;  4Z0F A;  2HGF A;  4UV6 A;  4Z0E A;  5EOK A;  5CP9 A;  5CS5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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