2J8JA

Solution structure of the a4 domain of blood coagulation factor xi
Total Genus 18
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
18
sequence length
90
structure length
90
Chain Sequence
FCHSSFYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKILHGRGGISGYTLRLCKMDNE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Solution Structure of the A4 Domain of Factor Xi Sheds Light on the Mechanism of Zymogen Activation.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords COAGULATION FACTOR XI
total genus 18
structure length 90
sequence length 90
chains with identical sequence B
ec nomenclature ec 3.4.21.27: Coagulation factor XIa.
pdb deposition date 2006-10-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00024 PAN_1 PAN domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.50.4.10 Alpha Beta 3-Layer(bba) Sandwich Hepatocyte Growth Factor Hepatocyte Growth Factor 2j8jA00
5COEA 4Z0EA 4R1CA 3MKPA 2J8JA 2LL3A 5CS3A 3HMRA 1GMNA 2J8LA 2X2ZA 2YIOA 5CT3A 1NK1A 1BHTA 2YIPA 3HMSA 1W8KA 5I25A 2Z8WA 5CSQA 4APLA 1HKYA 5CT2A 3HMTA 5CP9A 4Z09A 3HN4A 4R19A 4R1BA 4APMA 4Z0FA 2F83A 2LL4M 3SP8A 4Z0DA 2Y8RA 2K13X 5EOKA 5CS1A 2QJ2A 2Q8BA 2QJ4A 4R1AA 1GP9A 2YILA 4UV6A 1W81A 3ZWZA 5CS5A 3ZLEA 4UAOA 1I8NA 4IUAA 1YXEA 5EODA 2HGFA 3SRIA 2Q8AA 4DURA 2Z8VA 3SRJA 5CT1A 5CS9A 4A5TS 1Z40A 1GMOA
chains in the Genus database with same CATH superfamily
5COEA 4Z0EA 4R1CA 3MKPA 2J8JA 2LL3A 5CS3A 3HMRA 1GMNA 2J8LA 2X2ZA 2YIOA 5CT3A 1NK1A 1BHTA 2YIPA 3HMSA 1W8KA 5I25A 2Z8WA 5CSQA 2KL5A 4APLA 1HKYA 5CT2A 3HMTA 5CP9A 4Z09A 3HN4A 4R19A 4R1BA 5CT1A 4APMA 4Z0FA 2F83A 2LL4M 3SP8A 4Z0DA 2Y8RA 2K13X 5EOKA 5CS1A 2QJ2A 2Q8BA 2QJ4A 4R1AA 1GP9A 2YILA 4UV6A 1W81A 3ZWZA 5CS5A 4YIVA 3ZLEA 4UAOA 1I8NA 4IUAA 1YXEA 5EODA 2HGFA 4YIZA 2Q8AA 3SRIA 2Z8VA 3SRJA 4DURA 5CS9A 4A5TS 1Z40A 1GMOA
chains in the Genus database with same CATH topology
5COEA 4Z0EA 4R1CA 3MKPA 2J8JA 2LL3A 5CS3A 3HMRA 1GMNA 2J8LA 2X2ZA 2YIOA 5CT3A 1NK1A 1BHTA 2YIPA 3HMSA 1W8KA 5I25A 2Z8WA 5CSQA 2KL5A 4APLA 1HKYA 5CT2A 3HMTA 5CP9A 4Z09A 3HN4A 4R19A 4R1BA 5CT1A 4APMA 4Z0FA 2F83A 2LL4M 3SP8A 4Z0DA 2Y8RA 2K13X 5EOKA 5CS1A 2QJ2A 2Q8BA 2QJ4A 4R1AA 1GP9A 2YILA 4UV6A 1W81A 3ZWZA 5CS5A 4YIVA 3ZLEA 4UAOA 1I8NA 4IUAA 1YXEA 5EODA 2HGFA 4YIZA 2Q8AA 3SRIA 2Z8VA 3SRJA 4DURA 5CS9A 4A5TS 1Z40A 1GMOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5COE A;  4Z0E A;  4R1C A;  3MKP A;  2J8J A;  2LL3 A;  5CS3 A;  3HMR A;  1GMN A;  2J8L A;  2X2Z A;  2YIO A;  5CT3 A;  1NK1 A;  1BHT A;  2YIP A;  3HMS A;  1W8K A;  5I25 A;  2Z8W A;  5CSQ A;  4APL A;  1HKY A;  5CT2 A;  3HMT A;  5CP9 A;  4Z09 A;  3HN4 A;  4R19 A;  4R1B A;  4APM A;  4Z0F A;  2F83 A;  2LL4 M;  3SP8 A;  4Z0D A;  2Y8R A;  2K13 X;  5EOK A;  5CS1 A;  2QJ2 A;  2Q8B A;  2QJ4 A;  4R1A A;  1GP9 A;  2YIL A;  4UV6 A;  1W81 A;  3ZWZ A;  5CS5 A;  3ZLE A;  4UAO A;  1I8N A;  4IUA A;  1YXE A;  5EOD A;  2HGF A;  3SRI A;  2Q8A A;  4DUR A;  2Z8V A;  3SRJ A;  5CT1 A;  5CS9 A;  4A5T S;  1Z40 A;  1GMO A; 
#chains in the Genus database with same CATH topology
 5COE A;  4Z0E A;  4R1C A;  3MKP A;  2J8J A;  2LL3 A;  5CS3 A;  3HMR A;  1GMN A;  2J8L A;  2X2Z A;  2YIO A;  5CT3 A;  1NK1 A;  1BHT A;  2YIP A;  3HMS A;  1W8K A;  5I25 A;  2Z8W A;  5CSQ A;  2KL5 A;  4APL A;  1HKY A;  5CT2 A;  3HMT A;  5CP9 A;  4Z09 A;  3HN4 A;  4R19 A;  4R1B A;  5CT1 A;  4APM A;  4Z0F A;  2F83 A;  2LL4 M;  3SP8 A;  4Z0D A;  2Y8R A;  2K13 X;  5EOK A;  5CS1 A;  2QJ2 A;  2Q8B A;  2QJ4 A;  4R1A A;  1GP9 A;  2YIL A;  4UV6 A;  1W81 A;  3ZWZ A;  5CS5 A;  4YIV A;  3ZLE A;  4UAO A;  1I8N A;  4IUA A;  1YXE A;  5EOD A;  2HGF A;  4YIZ A;  2Q8A A;  3SRI A;  2Z8V A;  3SRJ A;  4DUR A;  5CS9 A;  4A5T S;  1Z40 A;  1GMO A; 
#chains in the Genus database with same CATH homology
 5COE A;  4Z0E A;  4R1C A;  3MKP A;  2J8J A;  2LL3 A;  5CS3 A;  3HMR A;  1GMN A;  2J8L A;  2X2Z A;  2YIO A;  5CT3 A;  1NK1 A;  1BHT A;  2YIP A;  3HMS A;  1W8K A;  5I25 A;  2Z8W A;  5CSQ A;  2KL5 A;  4APL A;  1HKY A;  5CT2 A;  3HMT A;  5CP9 A;  4Z09 A;  3HN4 A;  4R19 A;  4R1B A;  5CT1 A;  4APM A;  4Z0F A;  2F83 A;  2LL4 M;  3SP8 A;  4Z0D A;  2Y8R A;  2K13 X;  5EOK A;  5CS1 A;  2QJ2 A;  2Q8B A;  2QJ4 A;  4R1A A;  1GP9 A;  2YIL A;  4UV6 A;  1W81 A;  3ZWZ A;  5CS5 A;  4YIV A;  3ZLE A;  4UAO A;  1I8N A;  4IUA A;  1YXE A;  5EOD A;  2HGF A;  4YIZ A;  2Q8A A;  3SRI A;  2Z8V A;  3SRJ A;  4DUR A;  5CS9 A;  4A5T S;  1Z40 A;  1GMO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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