2J8LA

Fxi apple 4 domain loop-out conformation
Total Genus 17
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
17
sequence length
90
structure length
90
Chain Sequence
FCHSSFYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKILHGRGGISGYTLRLCKMDNE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Solution Structure of the A4 Domain of Factor Xi Sheds Light on the Mechanism of Zymogen Activation.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords COAGULATION FACTOR XI
total genus 17
structure length 90
sequence length 90
chains with identical sequence B
ec nomenclature ec 3.4.21.27: Coagulation factor XIa.
pdb deposition date 2006-10-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00024 PAN_1 PAN domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.50.4.10 Alpha Beta 3-Layer(bba) Sandwich Hepatocyte Growth Factor Hepatocyte Growth Factor 2j8lA00
2YILA 2Q8BA 1W8KA 5CS5A 4R1BA 5CT2A 4Z09A 1GMOA 1YXEA 3SRJA 3HMRA 5CS9A 4APLA 5EOKA 2J8JA 2Y8RA 4A5TS 3SP8A 2YIPA 5CS1A 5CT3A 1BHTA 3MKPA 1HKYA 4R1AA 3HMTA 4R19A 4DURA 2X2ZA 5CS3A 4R1CA 4IUAA 5CP9A 5CT1A 2HGFA 4APMA 2YIOA 1NK1A 3HN4A 4Z0DA 2QJ4A 4Z0EA 3SRIA 4UV6A 4Z0FA 5I25A 5COEA 1GMNA 1GP9A 2F83A 2K13X 1Z40A 3HMSA 4UAOA 2LL4M 5CSQA 3ZLEA 2LL3A 1W81A 2Q8AA 2Z8VA 2J8LA 3ZWZA 2Z8WA 5EODA 2QJ2A 1I8NA
chains in the Genus database with same CATH superfamily
2YILA 2Q8BA 1W8KA 5CS5A 4R1BA 5CT2A 4Z09A 1GMOA 1YXEA 3SRJA 3HMRA 5CS9A 4APLA 5EOKA 2J8JA 2Y8RA 4A5TS 3SP8A 2YIPA 5CS1A 5CT3A 1BHTA 3MKPA 1HKYA 4R1AA 3HMTA 4R19A 2KL5A 2X2ZA 5CS3A 4R1CA 4DURA 4IUAA 5CP9A 5CT1A 2HGFA 4APMA 2YIOA 1NK1A 3HN4A 4Z0DA 2QJ4A 4Z0EA 3SRIA 4UV6A 4Z0FA 5I25A 5COEA 1GMNA 4YIVA 4YIZA 1GP9A 2F83A 2K13X 1Z40A 3HMSA 4UAOA 2LL4M 5CSQA 3ZLEA 2LL3A 1W81A 2Q8AA 2Z8VA 2J8LA 3ZWZA 2Z8WA 5EODA 2QJ2A 1I8NA
chains in the Genus database with same CATH topology
2YILA 2Q8BA 1W8KA 5CS5A 4R1BA 5CT2A 4Z09A 1GMOA 1YXEA 3SRJA 3HMRA 5CS9A 4APLA 5EOKA 2J8JA 2Y8RA 4A5TS 3SP8A 2YIPA 5CS1A 5CT3A 1BHTA 3MKPA 1HKYA 4R1AA 3HMTA 4R19A 2KL5A 2X2ZA 5CS3A 4R1CA 4DURA 4IUAA 5CP9A 5CT1A 2HGFA 4APMA 2YIOA 1NK1A 3HN4A 4Z0DA 2QJ4A 4Z0EA 3SRIA 4UV6A 4Z0FA 5I25A 5COEA 1GMNA 4YIVA 4YIZA 1GP9A 2F83A 2K13X 1Z40A 3HMSA 4UAOA 2LL4M 5CSQA 3ZLEA 2LL3A 1W81A 2Q8AA 2Z8VA 2J8LA 3ZWZA 2Z8WA 5EODA 2QJ2A 1I8NA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2YIL A;  2Q8B A;  1W8K A;  5CS5 A;  4R1B A;  5CT2 A;  4Z09 A;  1GMO A;  1YXE A;  3SRJ A;  3HMR A;  5CS9 A;  4APL A;  5EOK A;  2J8J A;  2Y8R A;  4A5T S;  3SP8 A;  2YIP A;  5CS1 A;  5CT3 A;  1BHT A;  3MKP A;  1HKY A;  4R1A A;  3HMT A;  4R19 A;  4DUR A;  2X2Z A;  5CS3 A;  4R1C A;  4IUA A;  5CP9 A;  5CT1 A;  2HGF A;  4APM A;  2YIO A;  1NK1 A;  3HN4 A;  4Z0D A;  2QJ4 A;  4Z0E A;  3SRI A;  4UV6 A;  4Z0F A;  5I25 A;  5COE A;  1GMN A;  1GP9 A;  2F83 A;  2K13 X;  1Z40 A;  3HMS A;  4UAO A;  2LL4 M;  5CSQ A;  3ZLE A;  2LL3 A;  1W81 A;  2Q8A A;  2Z8V A;  2J8L A;  3ZWZ A;  2Z8W A;  5EOD A;  2QJ2 A;  1I8N A; 
#chains in the Genus database with same CATH topology
 2YIL A;  2Q8B A;  1W8K A;  5CS5 A;  4R1B A;  5CT2 A;  4Z09 A;  1GMO A;  1YXE A;  3SRJ A;  3HMR A;  5CS9 A;  4APL A;  5EOK A;  2J8J A;  2Y8R A;  4A5T S;  3SP8 A;  2YIP A;  5CS1 A;  5CT3 A;  1BHT A;  3MKP A;  1HKY A;  4R1A A;  3HMT A;  4R19 A;  2KL5 A;  2X2Z A;  5CS3 A;  4R1C A;  4DUR A;  4IUA A;  5CP9 A;  5CT1 A;  2HGF A;  4APM A;  2YIO A;  1NK1 A;  3HN4 A;  4Z0D A;  2QJ4 A;  4Z0E A;  3SRI A;  4UV6 A;  4Z0F A;  5I25 A;  5COE A;  1GMN A;  4YIV A;  4YIZ A;  1GP9 A;  2F83 A;  2K13 X;  1Z40 A;  3HMS A;  4UAO A;  2LL4 M;  5CSQ A;  3ZLE A;  2LL3 A;  1W81 A;  2Q8A A;  2Z8V A;  2J8L A;  3ZWZ A;  2Z8W A;  5EOD A;  2QJ2 A;  1I8N A; 
#chains in the Genus database with same CATH homology
 2YIL A;  2Q8B A;  1W8K A;  5CS5 A;  4R1B A;  5CT2 A;  4Z09 A;  1GMO A;  1YXE A;  3SRJ A;  3HMR A;  5CS9 A;  4APL A;  5EOK A;  2J8J A;  2Y8R A;  4A5T S;  3SP8 A;  2YIP A;  5CS1 A;  5CT3 A;  1BHT A;  3MKP A;  1HKY A;  4R1A A;  3HMT A;  4R19 A;  2KL5 A;  2X2Z A;  5CS3 A;  4R1C A;  4DUR A;  4IUA A;  5CP9 A;  5CT1 A;  2HGF A;  4APM A;  2YIO A;  1NK1 A;  3HN4 A;  4Z0D A;  2QJ4 A;  4Z0E A;  3SRI A;  4UV6 A;  4Z0F A;  5I25 A;  5COE A;  1GMN A;  4YIV A;  4YIZ A;  1GP9 A;  2F83 A;  2K13 X;  1Z40 A;  3HMS A;  4UAO A;  2LL4 M;  5CSQ A;  3ZLE A;  2LL3 A;  1W81 A;  2Q8A A;  2Z8V A;  2J8L A;  3ZWZ A;  2Z8W A;  5EOD A;  2QJ2 A;  1I8N A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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