2W3OA

Crystal structure of the human pnkp fha domain in complex with an xrcc1-derived phosphopeptide
Total Genus 19
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
19
sequence length
100
structure length
100
Chain Sequence
GRLWLESPPGEAPPIFLPSDGQALVLGRGPLTQVTDRKCSRTQVELVADPETRTVAVKQLGVNPSTTGTQELKPGLEGSLGVGDTLYLVNGEHPLTLRWE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Specific Recognition of a Multiply Phosphorylated Motif in the DNA Repair Scaffold Xrcc1 by the Fha Domain of Human Pnk.
pubmed doi rcsb
molecule tags Hydrolase,transferase/peptide
source organism Homo sapiens
molecule keywords BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE
total genus 19
structure length 100
sequence length 100
chains with identical sequence B
ec nomenclature ec 2.7.1.78: Polynucleotide 5'-hydroxyl-kinase.
pdb deposition date 2008-11-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF17913 FHA_2 FHA domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.60.200.20 Mainly Beta Sandwich Tumour Suppressor Smad4 Tumour Suppressor Smad4 2w3oA00
2EH0A 1WV3A 2JQJA 3PO8A 3ELSA 2W3OA 3I6WA 3MDBA 2KB4A 2XT9B 3UNMA 5E50A 4H87A 2BRFA 2AFFA 5DJOA 1FHRA 3ELVA 1MZKA 2KKLA 3FM8A 4A0EA 3UMZA 1K2NA 1J4PA 2LC1A 3HUEA 3VA4A 3UNNA 3HX1A 1G6GA 1J4KA 1GXCA 1WLNA 1YJMA 1K3JA 4QCJA 5A8IA 3UOTA 2CSWA 3GQSA 3I0MA 1FHQA 1K3QA 1J4OA 3HUFA 2PIEA 2A0TA 2G1LA 1J4LA 3I6UA 1DMZA 1UJXA 4EGXA 3POAA 1K3NA 2KFUA 4G2SA 4EJQA 1YJ5C 1LGQA 1G3GA 1QU5A 3VPYA 2JKDA 1LGPA 3VA1A 4JONA 2JQIA 2JPEA 1R21A 2FEZA 3KT9A 2KB3A 2JQLA 1J4QA 2FF4A 3OUNA 1K2MA 3UV0A 4D9VA 3UN0A 3I0NA 1UHTA
chains in the Genus database with same CATH superfamily
2EH0A 5BVIA 3S40A 1U7VA 1MJSA 1WV3A 2AN1A 4HAOA 2JQJA 3PO8A 3ELSA 5EJHA 5JEMA 2W3OA 3VZCA 1G88A 3I6WA 3MDBA 5JEOA 2QVLA 1QWTA 2KB4A 2XT9B 3PFNA 3UNMA 3V7YA 2I2BA 2I1WA 3VZDA 5E50A 2I2AA 1ZOQA 2Q5FA 4H87A 2BRFA 1SUWA 2AFFA 4V24A 5DJOA 1FHRA 3ELVA 1MZKA 2KKLA 3FM8A 4DY6A 3A77A 4A0EA 5JELA 5EJIA 5DHQA 3UMZA 3V8PA 2QV7A 3DITA 1K2NA 1J4PA 2LC1A 3HUEA 3VA4A 3V8NA 1Z0SA 1DEVA 3UNNA 4R9PA 3HX1A 5DHSA 1G6GA 1J4KA 1GXCA 1WLNA 1YJMA 5JEJA 1K3JA 5DHPA 4QCJA 5A8IA 5DHUA 3V7WA 1U7FB 2JGRA 3UOTA 5C4VA 2CSWA 3DSHA 3GQSA 3I0MA 1FHQA 4L02A 2I2FA 4KU0D 1K3QA 3VZBA 1J4OA 1YGSA 3HUFA 2PIEA 2A0TA 1MK2A 1Y3IA 2G1LA 1U0RA 5EJFA 2I29A 3V8RA 4A4YA 1MR1A 3V8MA 1J4LA 1U0TA 3I6UA 1DMZA 1UJXA 4EGXA 3POAA 1U7FA 5DHRA 5JEKA 1K3NA 2KFUA 2P1RA 2I2CA 4G2SA 5DHTA 4EJQA 1YJ5C 1LGQA 1Z0UA 1G3GA 1QU5A 3AFOA 3VPYA 2JKDA 4JIVD 1LGPA 1YT5A 3T5PA 1KHUA 3VA1A 2I2DA 4JONA 1U7VB 2JQIA 4JIWD 2JPEA 3GMJA 1DD1A 1J2FA 1R21A 3V80A 1Y3HA 2FEZA 3KT9A 2BONA 2KB3A 2XXSA 3V8QA 1Z0ZA 4WRRA 2JQLA 1J4QA 2FF4A 3OUNA 4WERA 5JERA 3UV0A 1KHXA 1K2MA 4D9VA 3UN0A 3V7UA 5EJGA 3I0NA 1UHTA
chains in the Genus database with same CATH topology
2EH0A 5BVIA 3S40A 1U7VA 1MJSA 1WV3A 2JQJA 3PO8A 3ELSA 5JEMA 2W3OA 3VZCA 1G88A 3I6WA 3MDBA 5JEOA 2QVLA 1QWTA 2KB4A 2XT9B 3UNMA 3VZDA 5E50A 1ZOQA 4H87A 2BRFA 2AFFA 4V24A 5DJOA 1FHRA 3ELVA 1MZKA 2KKLA 3FM8A 3A77A 4A0EA 5JELA 3UMZA 2QV7A 3DITA 1K2NA 1J4PA 2LC1A 3HUEA 3VA4A 1DEVA 3UNNA 4R9PA 3HX1A 1G6GA 1J4KA 1GXCA 1WLNA 1YJMA 5JEJA 1K3JA 4QCJA 5A8IA 1U7FB 2JGRA 3UOTA 5C4VA 2CSWA 3DSHA 3GQSA 3I0MA 1FHQA 4L02A 4KU0D 1K3QA 3VZBA 1J4OA 1YGSA 3HUFA 2PIEA 2A0TA 1MK2A 2G1LA 4A4YA 1MR1A 1J4LA 3I6UA 1DMZA 1UJXA 4EGXA 3POAA 1U7FA 5JEKA 1K3NA 2KFUA 2P1RA 4G2SA 4EJQA 1YJ5C 1LGQA 1G3GA 1QU5A 3VPYA 2JKDA 4JIVD 1LGPA 3T5PA 1KHUA 3VA1A 4JONA 1U7VB 2JQIA 4JIWD 2JPEA 3GMJA 1DD1A 1J2FA 1R21A 2FEZA 3KT9A 2BONA 2KB3A 2XXSA 4WRRA 2JQLA 1J4QA 2FF4A 3OUNA 4WERA 5JERA 3UV0A 1KHXA 1K2MA 4D9VA 3UN0A 3I0NA 1UHTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2EH0 A;  1WV3 A;  2JQJ A;  3PO8 A;  3ELS A;  2W3O A;  3I6W A;  3MDB A;  2KB4 A;  2XT9 B;  3UNM A;  5E50 A;  4H87 A;  2BRF A;  2AFF A;  5DJO A;  1FHR A;  3ELV A;  1MZK A;  2KKL A;  3FM8 A;  4A0E A;  3UMZ A;  1K2N A;  1J4P A;  2LC1 A;  3HUE A;  3VA4 A;  3UNN A;  3HX1 A;  1G6G A;  1J4K A;  1GXC A;  1WLN A;  1YJM A;  1K3J A;  4QCJ A;  5A8I A;  3UOT A;  2CSW A;  3GQS A;  3I0M A;  1FHQ A;  1K3Q A;  1J4O A;  3HUF A;  2PIE A;  2A0T A;  2G1L A;  1J4L A;  3I6U A;  1DMZ A;  1UJX A;  4EGX A;  3POA A;  1K3N A;  2KFU A;  4G2S A;  4EJQ A;  1YJ5 C;  1LGQ A;  1G3G A;  1QU5 A;  3VPY A;  2JKD A;  1LGP A;  3VA1 A;  4JON A;  2JQI A;  2JPE A;  1R21 A;  2FEZ A;  3KT9 A;  2KB3 A;  2JQL A;  1J4Q A;  2FF4 A;  3OUN A;  1K2M A;  3UV0 A;  4D9V A;  3UN0 A;  3I0N A;  1UHT A; 
#chains in the Genus database with same CATH topology
 2EH0 A;  5BVI A;  3S40 A;  1U7V A;  1MJS A;  1WV3 A;  2AN1 A;  4HAO A;  2JQJ A;  3PO8 A;  3ELS A;  5EJH A;  5JEM A;  2W3O A;  3VZC A;  1G88 A;  3I6W A;  3MDB A;  5JEO A;  2QVL A;  1QWT A;  2KB4 A;  2XT9 B;  3PFN A;  3UNM A;  3V7Y A;  2I2B A;  2I1W A;  3VZD A;  5E50 A;  2I2A A;  1ZOQ A;  2Q5F A;  4H87 A;  2BRF A;  1SUW A;  2AFF A;  4V24 A;  5DJO A;  1FHR A;  3ELV A;  1MZK A;  2KKL A;  3FM8 A;  4DY6 A;  3A77 A;  4A0E A;  5JEL A;  5EJI A;  5DHQ A;  3UMZ A;  3V8P A;  2QV7 A;  3DIT A;  1K2N A;  1J4P A;  2LC1 A;  3HUE A;  3VA4 A;  3V8N A;  1Z0S A;  1DEV A;  3UNN A;  4R9P A;  3HX1 A;  5DHS A;  1G6G A;  1J4K A;  1GXC A;  1WLN A;  1YJM A;  5JEJ A;  1K3J A;  5DHP A;  4QCJ A;  5A8I A;  5DHU A;  3V7W A;  1U7F B;  2JGR A;  3UOT A;  5C4V A;  2CSW A;  3DSH A;  3GQS A;  3I0M A;  1FHQ A;  4L02 A;  2I2F A;  4KU0 D;  1K3Q A;  3VZB A;  1J4O A;  1YGS A;  3HUF A;  2PIE A;  2A0T A;  1MK2 A;  1Y3I A;  2G1L A;  1U0R A;  5EJF A;  2I29 A;  3V8R A;  4A4Y A;  1MR1 A;  3V8M A;  1J4L A;  1U0T A;  3I6U A;  1DMZ A;  1UJX A;  4EGX A;  3POA A;  1U7F A;  5DHR A;  5JEK A;  1K3N A;  2KFU A;  2P1R A;  2I2C A;  4G2S A;  5DHT A;  4EJQ A;  1YJ5 C;  1LGQ A;  1Z0U A;  1G3G A;  1QU5 A;  3AFO A;  3VPY A;  2JKD A;  4JIV D;  1LGP A;  1YT5 A;  3T5P A;  1KHU A;  3VA1 A;  2I2D A;  4JON A;  1U7V B;  2JQI A;  4JIW D;  2JPE A;  3GMJ A;  1DD1 A;  1J2F A;  1R21 A;  3V80 A;  1Y3H A;  2FEZ A;  3KT9 A;  2BON A;  2KB3 A;  2XXS A;  3V8Q A;  1Z0Z A;  4WRR A;  2JQL A;  1J4Q A;  2FF4 A;  3OUN A;  4WER A;  5JER A;  3UV0 A;  1KHX A;  1K2M A;  4D9V A;  3UN0 A;  3V7U A;  5EJG A;  3I0N A;  1UHT A; 
#chains in the Genus database with same CATH homology
 2EH0 A;  5BVI A;  3S40 A;  1U7V A;  1MJS A;  1WV3 A;  2JQJ A;  3PO8 A;  3ELS A;  5JEM A;  2W3O A;  3VZC A;  1G88 A;  3I6W A;  3MDB A;  5JEO A;  2QVL A;  1QWT A;  2KB4 A;  2XT9 B;  3UNM A;  3VZD A;  5E50 A;  1ZOQ A;  4H87 A;  2BRF A;  2AFF A;  4V24 A;  5DJO A;  1FHR A;  3ELV A;  1MZK A;  2KKL A;  3FM8 A;  3A77 A;  4A0E A;  5JEL A;  3UMZ A;  2QV7 A;  3DIT A;  1K2N A;  1J4P A;  2LC1 A;  3HUE A;  3VA4 A;  1DEV A;  3UNN A;  4R9P A;  3HX1 A;  1G6G A;  1J4K A;  1GXC A;  1WLN A;  1YJM A;  5JEJ A;  1K3J A;  4QCJ A;  5A8I A;  1U7F B;  2JGR A;  3UOT A;  5C4V A;  2CSW A;  3DSH A;  3GQS A;  3I0M A;  1FHQ A;  4L02 A;  4KU0 D;  1K3Q A;  3VZB A;  1J4O A;  1YGS A;  3HUF A;  2PIE A;  2A0T A;  1MK2 A;  2G1L A;  4A4Y A;  1MR1 A;  1J4L A;  3I6U A;  1DMZ A;  1UJX A;  4EGX A;  3POA A;  1U7F A;  5JEK A;  1K3N A;  2KFU A;  2P1R A;  4G2S A;  4EJQ A;  1YJ5 C;  1LGQ A;  1G3G A;  1QU5 A;  3VPY A;  2JKD A;  4JIV D;  1LGP A;  3T5P A;  1KHU A;  3VA1 A;  4JON A;  1U7V B;  2JQI A;  4JIW D;  2JPE A;  3GMJ A;  1DD1 A;  1J2F A;  1R21 A;  2FEZ A;  3KT9 A;  2BON A;  2KB3 A;  2XXS A;  4WRR A;  2JQL A;  1J4Q A;  2FF4 A;  3OUN A;  4WER A;  5JER A;  3UV0 A;  1KHX A;  1K2M A;  4D9V A;  3UN0 A;  3I0N A;  1UHT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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