3DITA

Crystal structure of mad mh2 domain
Total Genus 42
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
42
sequence length
188
structure length
186
Chain Sequence
AFWASIAYYELNCRVGEVFHCNNNSVIVDGFTNNNSDRCCLGQLSNVNRNSTIENTRRHIGKGVHLYYVTGEVYAECLSDSAIFVQSRNCNYHHGFHPSTVCKIPPGCSLKIFNNQEFAQLLSQSVNNGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure of Drosophila Mad MH2 domain.
pubmed doi rcsb
molecule tags Signaling protein
source organism Drosophila melanogaster
molecule keywords Protein mothers against dpp
total genus 42
structure length 186
sequence length 188
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2008-06-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03166 MH2 MH2 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.60.200.10 Mainly Beta Sandwich Tumour Suppressor Smad4 Tumour Suppressor Smad4 3ditA00
1KHUA 5JEJA 1QWTA 1DEVA 5BVIA 4R9PA 5C4VA 5JEKA 5JELA 1MK2A 3DITA 5JEMA 1G88A 5JEOA 3DSHA 1YGSA 3GMJA 1DD1A 1KHXA 3A77A 1U7VA 1MR1A 1U7FA 1MJSA 1ZOQA 1U7VB 5JERA 1U7FB 1J2FA
chains in the Genus database with same CATH superfamily
5JEJA 1Y3HA 1DEVA 2I2CA 5EJIA 3V7YA 3DITA 2KB3A 3UNMA 3I0MA 3PFNA 3I0NA 2FF4A 1MZKA 2W3OA 2AFFA 1U0TA 2BRFA 4JONA 3ELVA 3UOTA 3UNNA 3GMJA 4JIVD 5DHQA 2KB4A 3T5PA 1Z0UA 3A77A 4HAOA 3AFOA 1Z0SA 1WLNA 3VZBA 4H87A 4WRRA 1U7VB 2G1LA 3V8QA 1UJXA 1Z0ZA 4G2SA 3V7UA 1LGPA 3V8RA 3PO8A 3VA1A 1QWTA 1WV3A 2JQIA 1K2NA 2AN1A 3UMZA 5BVIA 2PIEA 4DY6A 2XT9B 2I2FA 2Q5FA 5JELA 5JEKA 2JQLA 1K3QA 1U0RA 3ELSA 2I2BA 5JEMA 3S40A 2BONA 1G88A 5DHTA 2I2DA 1DMZA 5DHRA 3DSHA 2FEZA 4QCJA 1DD1A 1KHXA 1YJMA 4A0EA 1J4OA 1YJ5C 2EH0A 1U7VA 1K3NA 1J4KA 5DHPA 1MR1A 3HUFA 3VPYA 2JGRA 2XXSA 3HUEA 1J2FA 3V8MA 2QVLA 3VZCA 3V80A 4L02A 1G3GA 5C4VA 4V24A 2A0TA 3GQSA 1Y3IA 1YT5A 1LGQA 1GXCA 3VZDA 3FM8A 2I29A 2KFUA 4JIWD 2LC1A 5A8IA 2JPEA 3V8NA 1QU5A 5EJHA 3UN0A 3OUNA 3POAA 1ZOQA 2P1RA 1J4QA 2I1WA 1U7FB 1KHUA 1SUWA 5E50A 1FHQA 3UV0A 3KT9A 5EJFA 4R9PA 3VA4A 1R21A 1G6GA 1MK2A 2KKLA 3V7WA 2QV7A 5JEOA 4EGXA 5EJGA 1YGSA 5DHUA 3HX1A 3I6UA 1K3JA 1FHRA 5DJOA 4WERA 1UHTA 4EJQA 4D9VA 4KU0D 1U7FA 1MJSA 2JQJA 2CSWA 5DHSA 1J4PA 3V8PA 3I6WA 4A4YA 5JERA 1J4LA 1K2MA 3MDBA 2JKDA 2I2AA
chains in the Genus database with same CATH topology
5JEJA 1DEVA 3DITA 2KB3A 3UNMA 3I0MA 3I0NA 2FF4A 1MZKA 2W3OA 2AFFA 2BRFA 4JONA 3ELVA 3UOTA 3UNNA 3GMJA 4JIVD 2KB4A 3T5PA 3A77A 1WLNA 3VZBA 4H87A 4WRRA 1U7VB 2G1LA 1UJXA 4G2SA 1LGPA 3PO8A 3VA1A 1QWTA 1WV3A 2JQIA 1K2NA 3UMZA 5BVIA 2PIEA 2XT9B 5JEKA 5JELA 2JQLA 1K3QA 3ELSA 5JEMA 3S40A 2BONA 1G88A 1DMZA 3DSHA 2FEZA 4QCJA 1DD1A 1KHXA 1YJMA 4A0EA 1J4OA 1YJ5C 2EH0A 1U7VA 1K3NA 1J4KA 1MR1A 3HUFA 3VPYA 2JGRA 2XXSA 3HUEA 1J2FA 2QVLA 3VZCA 4L02A 1G3GA 5C4VA 4V24A 2A0TA 3GQSA 1LGQA 1GXCA 3VZDA 3FM8A 2KFUA 4JIWD 2LC1A 5A8IA 2JPEA 1QU5A 3UN0A 3OUNA 3POAA 1ZOQA 2P1RA 1J4QA 1U7FB 1KHUA 5E50A 1FHQA 3UV0A 3KT9A 4R9PA 3VA4A 1R21A 1G6GA 1MK2A 2KKLA 2QV7A 5JEOA 4EGXA 1YGSA 3HX1A 3I6UA 1K3JA 1FHRA 5DJOA 4WERA 1UHTA 4EJQA 4D9VA 4KU0D 1U7FA 1MJSA 2JQJA 2CSWA 1J4PA 4A4YA 3I6WA 5JERA 1J4LA 1K2MA 3MDBA 2JKDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1KHU A;  5JEJ A;  1QWT A;  1DEV A;  5BVI A;  4R9P A;  5C4V A;  5JEK A;  5JEL A;  1MK2 A;  3DIT A;  5JEM A;  1G88 A;  5JEO A;  3DSH A;  1YGS A;  3GMJ A;  1DD1 A;  1KHX A;  3A77 A;  1U7V A;  1MR1 A;  1U7F A;  1MJS A;  1ZOQ A;  1U7V B;  5JER A;  1U7F B;  1J2F A; 
#chains in the Genus database with same CATH topology
 5JEJ A;  1Y3H A;  1DEV A;  2I2C A;  5EJI A;  3V7Y A;  3DIT A;  2KB3 A;  3UNM A;  3I0M A;  3PFN A;  3I0N A;  2FF4 A;  1MZK A;  2W3O A;  2AFF A;  1U0T A;  2BRF A;  4JON A;  3ELV A;  3UOT A;  3UNN A;  3GMJ A;  4JIV D;  5DHQ A;  2KB4 A;  3T5P A;  1Z0U A;  3A77 A;  4HAO A;  3AFO A;  1Z0S A;  1WLN A;  3VZB A;  4H87 A;  4WRR A;  1U7V B;  2G1L A;  3V8Q A;  1UJX A;  1Z0Z A;  4G2S A;  3V7U A;  1LGP A;  3V8R A;  3PO8 A;  3VA1 A;  1QWT A;  1WV3 A;  2JQI A;  1K2N A;  2AN1 A;  3UMZ A;  5BVI A;  2PIE A;  4DY6 A;  2XT9 B;  2I2F A;  2Q5F A;  5JEL A;  5JEK A;  2JQL A;  1K3Q A;  1U0R A;  3ELS A;  2I2B A;  5JEM A;  3S40 A;  2BON A;  1G88 A;  5DHT A;  2I2D A;  1DMZ A;  5DHR A;  3DSH A;  2FEZ A;  4QCJ A;  1DD1 A;  1KHX A;  1YJM A;  4A0E A;  1J4O A;  1YJ5 C;  2EH0 A;  1U7V A;  1K3N A;  1J4K A;  5DHP A;  1MR1 A;  3HUF A;  3VPY A;  2JGR A;  2XXS A;  3HUE A;  1J2F A;  3V8M A;  2QVL A;  3VZC A;  3V80 A;  4L02 A;  1G3G A;  5C4V A;  4V24 A;  2A0T A;  3GQS A;  1Y3I A;  1YT5 A;  1LGQ A;  1GXC A;  3VZD A;  3FM8 A;  2I29 A;  2KFU A;  4JIW D;  2LC1 A;  5A8I A;  2JPE A;  3V8N A;  1QU5 A;  5EJH A;  3UN0 A;  3OUN A;  3POA A;  1ZOQ A;  2P1R A;  1J4Q A;  2I1W A;  1U7F B;  1KHU A;  1SUW A;  5E50 A;  1FHQ A;  3UV0 A;  3KT9 A;  5EJF A;  4R9P A;  3VA4 A;  1R21 A;  1G6G A;  1MK2 A;  2KKL A;  3V7W A;  2QV7 A;  5JEO A;  4EGX A;  5EJG A;  1YGS A;  5DHU A;  3HX1 A;  3I6U A;  1K3J A;  1FHR A;  5DJO A;  4WER A;  1UHT A;  4EJQ A;  4D9V A;  4KU0 D;  1U7F A;  1MJS A;  2JQJ A;  2CSW A;  5DHS A;  1J4P A;  3V8P A;  3I6W A;  4A4Y A;  5JER A;  1J4L A;  1K2M A;  3MDB A;  2JKD A;  2I2A A; 
#chains in the Genus database with same CATH homology
 5JEJ A;  1DEV A;  3DIT A;  2KB3 A;  3UNM A;  3I0M A;  3I0N A;  2FF4 A;  1MZK A;  2W3O A;  2AFF A;  2BRF A;  4JON A;  3ELV A;  3UOT A;  3UNN A;  3GMJ A;  4JIV D;  2KB4 A;  3T5P A;  3A77 A;  1WLN A;  3VZB A;  4H87 A;  4WRR A;  1U7V B;  2G1L A;  1UJX A;  4G2S A;  1LGP A;  3PO8 A;  3VA1 A;  1QWT A;  1WV3 A;  2JQI A;  1K2N A;  3UMZ A;  5BVI A;  2PIE A;  2XT9 B;  5JEK A;  5JEL A;  2JQL A;  1K3Q A;  3ELS A;  5JEM A;  3S40 A;  2BON A;  1G88 A;  1DMZ A;  3DSH A;  2FEZ A;  4QCJ A;  1DD1 A;  1KHX A;  1YJM A;  4A0E A;  1J4O A;  1YJ5 C;  2EH0 A;  1U7V A;  1K3N A;  1J4K A;  1MR1 A;  3HUF A;  3VPY A;  2JGR A;  2XXS A;  3HUE A;  1J2F A;  2QVL A;  3VZC A;  4L02 A;  1G3G A;  5C4V A;  4V24 A;  2A0T A;  3GQS A;  1LGQ A;  1GXC A;  3VZD A;  3FM8 A;  2KFU A;  4JIW D;  2LC1 A;  5A8I A;  2JPE A;  1QU5 A;  3UN0 A;  3OUN A;  3POA A;  1ZOQ A;  2P1R A;  1J4Q A;  1U7F B;  1KHU A;  5E50 A;  1FHQ A;  3UV0 A;  3KT9 A;  4R9P A;  3VA4 A;  1R21 A;  1G6G A;  1MK2 A;  2KKL A;  2QV7 A;  5JEO A;  4EGX A;  1YGS A;  3HX1 A;  3I6U A;  1K3J A;  1FHR A;  5DJO A;  4WER A;  1UHT A;  4EJQ A;  4D9V A;  4KU0 D;  1U7F A;  1MJS A;  2JQJ A;  2CSW A;  1J4P A;  4A4Y A;  3I6W A;  5JER A;  1J4L A;  1K2M A;  3MDB A;  2JKD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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