3HMRA

Crystal structure of the n-terminal fragment (31-127) of the mouse hepatocyte growth factor/scatter factor
Total Genus 23
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
23
sequence length
90
structure length
90
Chain Sequence
NTLHEFKKSAKTTLTKEDPLLKIKTKKVNSADECANRCIRNRGFTFTCKAFVFDKSRKRCYWYPFNSMSSGVKKGFGHEFDLYENKDYIR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for agonism and antagonism of hepatocyte growth factor.
pubmed doi rcsb
molecule tags Hormone
source organism Mus musculus
molecule keywords Hepatocyte growth factor
total genus 23
structure length 90
sequence length 90
ec nomenclature
pdb deposition date 2009-05-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00024 PAN_1 PAN domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.50.4.10 Alpha Beta 3-Layer(bba) Sandwich Hepatocyte Growth Factor Hepatocyte Growth Factor 3hmrA00
1YXEA 3MKPA 4UAOA 3HMRA 2K13X 1W8KA 5CT2A 4Z0DA 2Y8RA 2F83A 4APLA 4A5TS 5EODA 1W81A 4DURA 5CSQA 1Z40A 3HMSA 2YILA 5CS9A 2LL4M 4R1AA 5COEA 5EOKA 4IUAA 4R19A 5I25A 2J8LA 3ZLEA 3HN4A 2Z8WA 3SRIA 5CT1A 5CP9A 5CS3A 3SRJA 1GP9A 2QJ4A 4R1BA 5CT3A 2J8JA 3HMTA 4R1CA 2HGFA 1HKYA 1NK1A 2X2ZA 1GMOA 5CS1A 4Z0FA 1BHTA 2Z8VA 4Z09A 2QJ2A 2LL3A 4Z0EA 2Q8AA 1GMNA 1I8NA 2YIOA 4APMA 2YIPA 5CS5A 3SP8A 2Q8BA 3ZWZA 4UV6A
chains in the Genus database with same CATH superfamily
1YXEA 3MKPA 4UAOA 3HMRA 2K13X 1W8KA 5CT2A 4Z0DA 2Y8RA 2F83A 4APLA 4A5TS 5EODA 1W81A 4DURA 5CSQA 1Z40A 3HMSA 4YIZA 2YILA 5CS9A 2LL4M 4R1AA 5COEA 2KL5A 5EOKA 4IUAA 4R19A 5I25A 2J8LA 4YIVA 3ZLEA 3HN4A 2Z8WA 3SRIA 5CT1A 5CP9A 5CS3A 3SRJA 1GP9A 2QJ4A 4R1BA 5CT3A 2J8JA 3HMTA 4R1CA 2HGFA 1HKYA 1NK1A 2X2ZA 1GMOA 5CS1A 4Z0FA 1BHTA 2Z8VA 4Z09A 2QJ2A 2LL3A 4Z0EA 2Q8AA 1GMNA 1I8NA 2YIOA 4APMA 2YIPA 5CS5A 3SP8A 2Q8BA 3ZWZA 4UV6A
chains in the Genus database with same CATH topology
1YXEA 3MKPA 4UAOA 3HMRA 2K13X 1W8KA 5CT2A 4Z0DA 2Y8RA 2F83A 4APLA 4A5TS 5EODA 1W81A 4DURA 5CSQA 1Z40A 3HMSA 4YIZA 2YILA 5CS9A 2LL4M 4R1AA 5COEA 2KL5A 5EOKA 4IUAA 4R19A 5I25A 2J8LA 4YIVA 3ZLEA 3HN4A 2Z8WA 3SRIA 5CT1A 5CP9A 5CS3A 3SRJA 1GP9A 2QJ4A 4R1BA 5CT3A 2J8JA 3HMTA 4R1CA 2HGFA 1HKYA 1NK1A 2X2ZA 1GMOA 5CS1A 4Z0FA 1BHTA 2Z8VA 4Z09A 2QJ2A 2LL3A 4Z0EA 2Q8AA 1GMNA 1I8NA 2YIOA 4APMA 2YIPA 5CS5A 3SP8A 2Q8BA 3ZWZA 4UV6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1YXE A;  3MKP A;  4UAO A;  3HMR A;  2K13 X;  1W8K A;  5CT2 A;  4Z0D A;  2Y8R A;  2F83 A;  4APL A;  4A5T S;  5EOD A;  1W81 A;  4DUR A;  5CSQ A;  1Z40 A;  3HMS A;  2YIL A;  5CS9 A;  2LL4 M;  4R1A A;  5COE A;  5EOK A;  4IUA A;  4R19 A;  5I25 A;  2J8L A;  3ZLE A;  3HN4 A;  2Z8W A;  3SRI A;  5CT1 A;  5CP9 A;  5CS3 A;  3SRJ A;  1GP9 A;  2QJ4 A;  4R1B A;  5CT3 A;  2J8J A;  3HMT A;  4R1C A;  2HGF A;  1HKY A;  1NK1 A;  2X2Z A;  1GMO A;  5CS1 A;  4Z0F A;  1BHT A;  2Z8V A;  4Z09 A;  2QJ2 A;  2LL3 A;  4Z0E A;  2Q8A A;  1GMN A;  1I8N A;  2YIO A;  4APM A;  2YIP A;  5CS5 A;  3SP8 A;  2Q8B A;  3ZWZ A;  4UV6 A; 
#chains in the Genus database with same CATH topology
 1YXE A;  3MKP A;  4UAO A;  3HMR A;  2K13 X;  1W8K A;  5CT2 A;  4Z0D A;  2Y8R A;  2F83 A;  4APL A;  4A5T S;  5EOD A;  1W81 A;  4DUR A;  5CSQ A;  1Z40 A;  3HMS A;  4YIZ A;  2YIL A;  5CS9 A;  2LL4 M;  4R1A A;  5COE A;  2KL5 A;  5EOK A;  4IUA A;  4R19 A;  5I25 A;  2J8L A;  4YIV A;  3ZLE A;  3HN4 A;  2Z8W A;  3SRI A;  5CT1 A;  5CP9 A;  5CS3 A;  3SRJ A;  1GP9 A;  2QJ4 A;  4R1B A;  5CT3 A;  2J8J A;  3HMT A;  4R1C A;  2HGF A;  1HKY A;  1NK1 A;  2X2Z A;  1GMO A;  5CS1 A;  4Z0F A;  1BHT A;  2Z8V A;  4Z09 A;  2QJ2 A;  2LL3 A;  4Z0E A;  2Q8A A;  1GMN A;  1I8N A;  2YIO A;  4APM A;  2YIP A;  5CS5 A;  3SP8 A;  2Q8B A;  3ZWZ A;  4UV6 A; 
#chains in the Genus database with same CATH homology
 1YXE A;  3MKP A;  4UAO A;  3HMR A;  2K13 X;  1W8K A;  5CT2 A;  4Z0D A;  2Y8R A;  2F83 A;  4APL A;  4A5T S;  5EOD A;  1W81 A;  4DUR A;  5CSQ A;  1Z40 A;  3HMS A;  4YIZ A;  2YIL A;  5CS9 A;  2LL4 M;  4R1A A;  5COE A;  2KL5 A;  5EOK A;  4IUA A;  4R19 A;  5I25 A;  2J8L A;  4YIV A;  3ZLE A;  3HN4 A;  2Z8W A;  3SRI A;  5CT1 A;  5CP9 A;  5CS3 A;  3SRJ A;  1GP9 A;  2QJ4 A;  4R1B A;  5CT3 A;  2J8J A;  3HMT A;  4R1C A;  2HGF A;  1HKY A;  1NK1 A;  2X2Z A;  1GMO A;  5CS1 A;  4Z0F A;  1BHT A;  2Z8V A;  4Z09 A;  2QJ2 A;  2LL3 A;  4Z0E A;  2Q8A A;  1GMN A;  1I8N A;  2YIO A;  4APM A;  2YIP A;  5CS5 A;  3SP8 A;  2Q8B A;  3ZWZ A;  4UV6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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