3HMSA

Crystal crystal structure of the n-terminal fragment (28-126) of the human hepatocyte growth factor/scatter factor, orthorhombic crystal form
Total Genus 26
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
26
sequence length
91
structure length
91
Chain Sequence
RNTIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for agonism and antagonism of hepatocyte growth factor.
pubmed doi rcsb
molecule tags Hormone
source organism Homo sapiens
molecule keywords Hepatocyte growth factor
total genus 26
structure length 91
sequence length 91
ec nomenclature
pdb deposition date 2009-05-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00024 PAN_1 PAN domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.50.4.10 Alpha Beta 3-Layer(bba) Sandwich Hepatocyte Growth Factor Hepatocyte Growth Factor 3hmsA00
2QJ4A 1Z40A 1W8KA 4R1BA 5CS5A 1YXEA 2HGFA 3HMTA 5CS3A 3SRJA 4APLA 1GMOA 1GP9A 4Z09A 2LL3A 4UV6A 4Z0DA 5CT2A 3SRIA 1HKYA 2Z8WA 4A5TS 3HMSA 2QJ2A 4IUAA 4R19A 5CS9A 1I8NA 1BHTA 4R1AA 5CSQA 5EOKA 5EODA 4UAOA 3SP8A 5I25A 4APMA 3ZLEA 4Z0FA 1NK1A 4DURA 5CT1A 2Q8BA 5CP9A 2J8JA 4R1CA 2X2ZA 3HMRA 5COEA 3MKPA 3ZWZA 2Q8AA 2YIPA 5CT3A 1GMNA 1W81A 2Y8RA 2YIOA 2K13X 2Z8VA 2F83A 2LL4M 2J8LA 4Z0EA 5CS1A 3HN4A 2YILA
chains in the Genus database with same CATH superfamily
2QJ4A 1Z40A 1W8KA 4R1BA 5CS5A 1YXEA 2HGFA 3HMTA 5CS3A 3SRJA 4APLA 1GMOA 1GP9A 4Z09A 2LL3A 4UV6A 4Z0DA 5CT2A 3SRIA 1HKYA 2Z8WA 4A5TS 3HMSA 2QJ2A 4IUAA 4R19A 5CS9A 1I8NA 1BHTA 4R1AA 5CSQA 5EOKA 5EODA 4UAOA 3SP8A 5I25A 4APMA 3ZLEA 4Z0FA 1NK1A 2KL5A 4YIVA 4DURA 4YIZA 5CT1A 2Q8BA 5CP9A 2J8JA 4R1CA 2X2ZA 3HMRA 5COEA 3MKPA 3ZWZA 2Q8AA 2YIPA 5CT3A 1GMNA 1W81A 2Y8RA 2YIOA 2K13X 2Z8VA 2F83A 2LL4M 2J8LA 4Z0EA 5CS1A 3HN4A 2YILA
chains in the Genus database with same CATH topology
2QJ4A 1Z40A 1W8KA 4R1BA 5CS5A 1YXEA 2HGFA 3HMTA 5CS3A 3SRJA 4APLA 1GMOA 1GP9A 4Z09A 2LL3A 4UV6A 4Z0DA 5CT2A 3SRIA 1HKYA 2Z8WA 4A5TS 3HMSA 2QJ2A 4IUAA 4R19A 5CS9A 1I8NA 1BHTA 4R1AA 5CSQA 5EOKA 5EODA 4UAOA 3SP8A 5I25A 4APMA 3ZLEA 4Z0FA 1NK1A 2KL5A 4YIVA 4DURA 4YIZA 5CT1A 2Q8BA 5CP9A 2J8JA 4R1CA 2X2ZA 3HMRA 5COEA 3MKPA 3ZWZA 2Q8AA 2YIPA 5CT3A 1GMNA 1W81A 2Y8RA 2YIOA 2K13X 2Z8VA 2F83A 2LL4M 2J8LA 4Z0EA 5CS1A 3HN4A 2YILA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2QJ4 A;  1Z40 A;  1W8K A;  4R1B A;  5CS5 A;  1YXE A;  2HGF A;  3HMT A;  5CS3 A;  3SRJ A;  4APL A;  1GMO A;  1GP9 A;  4Z09 A;  2LL3 A;  4UV6 A;  4Z0D A;  5CT2 A;  3SRI A;  1HKY A;  2Z8W A;  4A5T S;  3HMS A;  2QJ2 A;  4IUA A;  4R19 A;  5CS9 A;  1I8N A;  1BHT A;  4R1A A;  5CSQ A;  5EOK A;  5EOD A;  4UAO A;  3SP8 A;  5I25 A;  4APM A;  3ZLE A;  4Z0F A;  1NK1 A;  4DUR A;  5CT1 A;  2Q8B A;  5CP9 A;  2J8J A;  4R1C A;  2X2Z A;  3HMR A;  5COE A;  3MKP A;  3ZWZ A;  2Q8A A;  2YIP A;  5CT3 A;  1GMN A;  1W81 A;  2Y8R A;  2YIO A;  2K13 X;  2Z8V A;  2F83 A;  2LL4 M;  2J8L A;  4Z0E A;  5CS1 A;  3HN4 A;  2YIL A; 
#chains in the Genus database with same CATH topology
 2QJ4 A;  1Z40 A;  1W8K A;  4R1B A;  5CS5 A;  1YXE A;  2HGF A;  3HMT A;  5CS3 A;  3SRJ A;  4APL A;  1GMO A;  1GP9 A;  4Z09 A;  2LL3 A;  4UV6 A;  4Z0D A;  5CT2 A;  3SRI A;  1HKY A;  2Z8W A;  4A5T S;  3HMS A;  2QJ2 A;  4IUA A;  4R19 A;  5CS9 A;  1I8N A;  1BHT A;  4R1A A;  5CSQ A;  5EOK A;  5EOD A;  4UAO A;  3SP8 A;  5I25 A;  4APM A;  3ZLE A;  4Z0F A;  1NK1 A;  2KL5 A;  4YIV A;  4DUR A;  4YIZ A;  5CT1 A;  2Q8B A;  5CP9 A;  2J8J A;  4R1C A;  2X2Z A;  3HMR A;  5COE A;  3MKP A;  3ZWZ A;  2Q8A A;  2YIP A;  5CT3 A;  1GMN A;  1W81 A;  2Y8R A;  2YIO A;  2K13 X;  2Z8V A;  2F83 A;  2LL4 M;  2J8L A;  4Z0E A;  5CS1 A;  3HN4 A;  2YIL A; 
#chains in the Genus database with same CATH homology
 2QJ4 A;  1Z40 A;  1W8K A;  4R1B A;  5CS5 A;  1YXE A;  2HGF A;  3HMT A;  5CS3 A;  3SRJ A;  4APL A;  1GMO A;  1GP9 A;  4Z09 A;  2LL3 A;  4UV6 A;  4Z0D A;  5CT2 A;  3SRI A;  1HKY A;  2Z8W A;  4A5T S;  3HMS A;  2QJ2 A;  4IUA A;  4R19 A;  5CS9 A;  1I8N A;  1BHT A;  4R1A A;  5CSQ A;  5EOK A;  5EOD A;  4UAO A;  3SP8 A;  5I25 A;  4APM A;  3ZLE A;  4Z0F A;  1NK1 A;  2KL5 A;  4YIV A;  4DUR A;  4YIZ A;  5CT1 A;  2Q8B A;  5CP9 A;  2J8J A;  4R1C A;  2X2Z A;  3HMR A;  5COE A;  3MKP A;  3ZWZ A;  2Q8A A;  2YIP A;  5CT3 A;  1GMN A;  1W81 A;  2Y8R A;  2YIO A;  2K13 X;  2Z8V A;  2F83 A;  2LL4 M;  2J8L A;  4Z0E A;  5CS1 A;  3HN4 A;  2YIL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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