3HMSA

Crystal crystal structure of the n-terminal fragment (28-126) of the human hepatocyte growth factor/scatter factor, orthorhombic crystal form
Total Genus 26
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
26
sequence length
91
structure length
91
Chain Sequence
RNTIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for agonism and antagonism of hepatocyte growth factor.
pubmed doi rcsb
molecule tags Hormone
source organism Homo sapiens
molecule keywords Hepatocyte growth factor
total genus 26
structure length 91
sequence length 91
ec nomenclature
pdb deposition date 2009-05-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00024 PAN_1 PAN domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.50.4.10 Alpha Beta 3-Layer(bba) Sandwich Hepatocyte Growth Factor Hepatocyte Growth Factor 3hmsA00
2X2ZA 1HKYA 2LL3A 4DURA 1NK1A 5CP9A 5EODA 2Q8AA 1BHTA 2LL4M 1I8NA 5CS5A 1W81A 4Z0EA 2Y8RA 3SP8A 5COEA 4Z0FA 5CS3A 1GMNA 5CSQA 3HMRA 1W8KA 2J8JA 3SRIA 2QJ4A 1GP9A 4Z09A 4UV6A 5CT1A 2K13X 1YXEA 3ZLEA 3ZWZA 4R1AA 2Z8VA 3HMTA 5I25A 2QJ2A 4A5TS 4R1CA 4R1BA 5CT3A 2J8LA 3HMSA 2F83A 2YIOA 2YIPA 4UAOA 5CS9A 4R19A 4APLA 4APMA 2YILA 3HN4A 5CT2A 1Z40A 2HGFA 3MKPA 4Z0DA 5EOKA 2Z8WA 4IUAA 2Q8BA 5CS1A 1GMOA 3SRJA
chains in the Genus database with same CATH superfamily
2X2ZA 1HKYA 4YIZA 2LL3A 4DURA 1NK1A 5CP9A 5EODA 2Q8AA 1BHTA 2LL4M 1I8NA 5CS5A 1W81A 4Z0EA 2Y8RA 3SP8A 5COEA 4Z0FA 5CS3A 1GMNA 5CSQA 3HMRA 1W8KA 2J8JA 3SRIA 2QJ4A 1GP9A 4Z09A 4UV6A 5CT1A 2K13X 1YXEA 3ZLEA 3ZWZA 4R1AA 2Z8VA 3HMTA 5I25A 2QJ2A 4A5TS 4R1CA 4R1BA 5CT3A 4YIVA 2J8LA 3HMSA 2F83A 2YIOA 2YIPA 2KL5A 4UAOA 4R19A 5CS9A 4APLA 4APMA 2YILA 3HN4A 5CT2A 1Z40A 2HGFA 3MKPA 4Z0DA 5EOKA 2Z8WA 4IUAA 2Q8BA 5CS1A 1GMOA 3SRJA
chains in the Genus database with same CATH topology
2X2ZA 1HKYA 4YIZA 2LL3A 4DURA 1NK1A 5CP9A 5EODA 2Q8AA 1BHTA 2LL4M 1I8NA 5CS5A 1W81A 4Z0EA 2Y8RA 3SP8A 5COEA 4Z0FA 5CS3A 1GMNA 5CSQA 3HMRA 1W8KA 2J8JA 3SRIA 2QJ4A 1GP9A 4Z09A 4UV6A 5CT1A 2K13X 1YXEA 3ZLEA 3ZWZA 4R1AA 2Z8VA 3HMTA 5I25A 2QJ2A 4A5TS 4R1CA 4R1BA 5CT3A 4YIVA 2J8LA 3HMSA 2F83A 2YIOA 2YIPA 2KL5A 4UAOA 4R19A 5CS9A 4APLA 4APMA 2YILA 3HN4A 5CT2A 1Z40A 2HGFA 3MKPA 4Z0DA 5EOKA 2Z8WA 4IUAA 2Q8BA 5CS1A 1GMOA 3SRJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2X2Z A;  1HKY A;  2LL3 A;  4DUR A;  1NK1 A;  5CP9 A;  5EOD A;  2Q8A A;  1BHT A;  2LL4 M;  1I8N A;  5CS5 A;  1W81 A;  4Z0E A;  2Y8R A;  3SP8 A;  5COE A;  4Z0F A;  5CS3 A;  1GMN A;  5CSQ A;  3HMR A;  1W8K A;  2J8J A;  3SRI A;  2QJ4 A;  1GP9 A;  4Z09 A;  4UV6 A;  5CT1 A;  2K13 X;  1YXE A;  3ZLE A;  3ZWZ A;  4R1A A;  2Z8V A;  3HMT A;  5I25 A;  2QJ2 A;  4A5T S;  4R1C A;  4R1B A;  5CT3 A;  2J8L A;  3HMS A;  2F83 A;  2YIO A;  2YIP A;  4UAO A;  5CS9 A;  4R19 A;  4APL A;  4APM A;  2YIL A;  3HN4 A;  5CT2 A;  1Z40 A;  2HGF A;  3MKP A;  4Z0D A;  5EOK A;  2Z8W A;  4IUA A;  2Q8B A;  5CS1 A;  1GMO A;  3SRJ A; 
#chains in the Genus database with same CATH topology
 2X2Z A;  1HKY A;  4YIZ A;  2LL3 A;  4DUR A;  1NK1 A;  5CP9 A;  5EOD A;  2Q8A A;  1BHT A;  2LL4 M;  1I8N A;  5CS5 A;  1W81 A;  4Z0E A;  2Y8R A;  3SP8 A;  5COE A;  4Z0F A;  5CS3 A;  1GMN A;  5CSQ A;  3HMR A;  1W8K A;  2J8J A;  3SRI A;  2QJ4 A;  1GP9 A;  4Z09 A;  4UV6 A;  5CT1 A;  2K13 X;  1YXE A;  3ZLE A;  3ZWZ A;  4R1A A;  2Z8V A;  3HMT A;  5I25 A;  2QJ2 A;  4A5T S;  4R1C A;  4R1B A;  5CT3 A;  4YIV A;  2J8L A;  3HMS A;  2F83 A;  2YIO A;  2YIP A;  2KL5 A;  4UAO A;  4R19 A;  5CS9 A;  4APL A;  4APM A;  2YIL A;  3HN4 A;  5CT2 A;  1Z40 A;  2HGF A;  3MKP A;  4Z0D A;  5EOK A;  2Z8W A;  4IUA A;  2Q8B A;  5CS1 A;  1GMO A;  3SRJ A; 
#chains in the Genus database with same CATH homology
 2X2Z A;  1HKY A;  4YIZ A;  2LL3 A;  4DUR A;  1NK1 A;  5CP9 A;  5EOD A;  2Q8A A;  1BHT A;  2LL4 M;  1I8N A;  5CS5 A;  1W81 A;  4Z0E A;  2Y8R A;  3SP8 A;  5COE A;  4Z0F A;  5CS3 A;  1GMN A;  5CSQ A;  3HMR A;  1W8K A;  2J8J A;  3SRI A;  2QJ4 A;  1GP9 A;  4Z09 A;  4UV6 A;  5CT1 A;  2K13 X;  1YXE A;  3ZLE A;  3ZWZ A;  4R1A A;  2Z8V A;  3HMT A;  5I25 A;  2QJ2 A;  4A5T S;  4R1C A;  4R1B A;  5CT3 A;  4YIV A;  2J8L A;  3HMS A;  2F83 A;  2YIO A;  2YIP A;  2KL5 A;  4UAO A;  4R19 A;  5CS9 A;  4APL A;  4APM A;  2YIL A;  3HN4 A;  5CT2 A;  1Z40 A;  2HGF A;  3MKP A;  4Z0D A;  5EOK A;  2Z8W A;  4IUA A;  2Q8B A;  5CS1 A;  1GMO A;  3SRJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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