3HMTA

Crystal structure of the n-terminal fragment (28-126) of the human hepatocyte growth factor/scatter factor, trigonal crystal form
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
91
structure length
91
Chain Sequence
RNTIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for agonism and antagonism of hepatocyte growth factor.
pubmed doi rcsb
molecule tags Hormone
source organism Homo sapiens
molecule keywords Hepatocyte growth factor
total genus 25
structure length 91
sequence length 91
chains with identical sequence B
ec nomenclature
pdb deposition date 2009-05-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00024 PAN_1 PAN domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.50.4.10 Alpha Beta 3-Layer(bba) Sandwich Hepatocyte Growth Factor Hepatocyte Growth Factor 3hmtA00
2YIPA 2YIOA 4Z0EA 1GP9A 2YILA 3SRIA 2J8JA 2LL3A 3HN4A 4UAOA 4Z0FA 2QJ4A 5CT2A 5EOKA 1HKYA 3HMTA 2J8LA 5CS3A 1GMOA 2Q8AA 4APMA 4Z0DA 3SP8A 3ZLEA 2QJ2A 3ZWZA 2Z8VA 1GMNA 2Y8RA 2Q8BA 3SRJA 5CT1A 2K13X 5CS1A 5CP9A 1BHTA 4R1BA 1NK1A 1W81A 4APLA 4DURA 5CSQA 2HGFA 1I8NA 1Z40A 5CS5A 2LL4M 4IUAA 4R1AA 4R1CA 4UV6A 3HMRA 4Z09A 1YXEA 5CS9A 5CT3A 5COEA 4A5TS 5I25A 2Z8WA 3HMSA 4R19A 5EODA 3MKPA 1W8KA 2X2ZA 2F83A
chains in the Genus database with same CATH superfamily
2YIPA 2YIOA 4Z0EA 1GP9A 2YILA 3SRIA 2J8JA 2LL3A 3HN4A 4UAOA 4Z0FA 2QJ4A 5CT2A 5EOKA 1HKYA 3HMTA 2J8LA 5CS3A 2KL5A 1GMOA 2Q8AA 4APMA 4Z0DA 3SP8A 3ZLEA 2QJ2A 3ZWZA 2Z8VA 1GMNA 2Y8RA 2Q8BA 3SRJA 5CT1A 2K13X 5CS1A 5CP9A 1BHTA 4R1BA 1NK1A 1W81A 4YIVA 4APLA 5CSQA 4DURA 2HGFA 1I8NA 1Z40A 5CS5A 2LL4M 4IUAA 4R1AA 4R1CA 4UV6A 3HMRA 4YIZA 4Z09A 1YXEA 5CS9A 5CT3A 5COEA 4A5TS 5I25A 2Z8WA 3HMSA 4R19A 5EODA 3MKPA 1W8KA 2X2ZA 2F83A
chains in the Genus database with same CATH topology
2YIPA 2YIOA 4Z0EA 1GP9A 2YILA 3SRIA 2J8JA 2LL3A 3HN4A 4UAOA 4Z0FA 2QJ4A 5CT2A 5EOKA 1HKYA 3HMTA 2J8LA 5CS3A 2KL5A 1GMOA 2Q8AA 4APMA 4Z0DA 3SP8A 3ZLEA 2QJ2A 3ZWZA 2Z8VA 1GMNA 2Y8RA 2Q8BA 3SRJA 5CT1A 2K13X 5CS1A 5CP9A 1BHTA 4R1BA 1NK1A 1W81A 4YIVA 4APLA 5CSQA 4DURA 2HGFA 1I8NA 1Z40A 5CS5A 2LL4M 4IUAA 4R1AA 4R1CA 4UV6A 3HMRA 4YIZA 4Z09A 1YXEA 5CS9A 5CT3A 5COEA 4A5TS 5I25A 2Z8WA 3HMSA 4R19A 5EODA 3MKPA 1W8KA 2X2ZA 2F83A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2YIP A;  2YIO A;  4Z0E A;  1GP9 A;  2YIL A;  3SRI A;  2J8J A;  2LL3 A;  3HN4 A;  4UAO A;  4Z0F A;  2QJ4 A;  5CT2 A;  5EOK A;  1HKY A;  3HMT A;  2J8L A;  5CS3 A;  1GMO A;  2Q8A A;  4APM A;  4Z0D A;  3SP8 A;  3ZLE A;  2QJ2 A;  3ZWZ A;  2Z8V A;  1GMN A;  2Y8R A;  2Q8B A;  3SRJ A;  5CT1 A;  2K13 X;  5CS1 A;  5CP9 A;  1BHT A;  4R1B A;  1NK1 A;  1W81 A;  4APL A;  4DUR A;  5CSQ A;  2HGF A;  1I8N A;  1Z40 A;  5CS5 A;  2LL4 M;  4IUA A;  4R1A A;  4R1C A;  4UV6 A;  3HMR A;  4Z09 A;  1YXE A;  5CS9 A;  5CT3 A;  5COE A;  4A5T S;  5I25 A;  2Z8W A;  3HMS A;  4R19 A;  5EOD A;  3MKP A;  1W8K A;  2X2Z A;  2F83 A; 
#chains in the Genus database with same CATH topology
 2YIP A;  2YIO A;  4Z0E A;  1GP9 A;  2YIL A;  3SRI A;  2J8J A;  2LL3 A;  3HN4 A;  4UAO A;  4Z0F A;  2QJ4 A;  5CT2 A;  5EOK A;  1HKY A;  3HMT A;  2J8L A;  5CS3 A;  2KL5 A;  1GMO A;  2Q8A A;  4APM A;  4Z0D A;  3SP8 A;  3ZLE A;  2QJ2 A;  3ZWZ A;  2Z8V A;  1GMN A;  2Y8R A;  2Q8B A;  3SRJ A;  5CT1 A;  2K13 X;  5CS1 A;  5CP9 A;  1BHT A;  4R1B A;  1NK1 A;  1W81 A;  4YIV A;  4APL A;  5CSQ A;  4DUR A;  2HGF A;  1I8N A;  1Z40 A;  5CS5 A;  2LL4 M;  4IUA A;  4R1A A;  4R1C A;  4UV6 A;  3HMR A;  4YIZ A;  4Z09 A;  1YXE A;  5CS9 A;  5CT3 A;  5COE A;  4A5T S;  5I25 A;  2Z8W A;  3HMS A;  4R19 A;  5EOD A;  3MKP A;  1W8K A;  2X2Z A;  2F83 A; 
#chains in the Genus database with same CATH homology
 2YIP A;  2YIO A;  4Z0E A;  1GP9 A;  2YIL A;  3SRI A;  2J8J A;  2LL3 A;  3HN4 A;  4UAO A;  4Z0F A;  2QJ4 A;  5CT2 A;  5EOK A;  1HKY A;  3HMT A;  2J8L A;  5CS3 A;  2KL5 A;  1GMO A;  2Q8A A;  4APM A;  4Z0D A;  3SP8 A;  3ZLE A;  2QJ2 A;  3ZWZ A;  2Z8V A;  1GMN A;  2Y8R A;  2Q8B A;  3SRJ A;  5CT1 A;  2K13 X;  5CS1 A;  5CP9 A;  1BHT A;  4R1B A;  1NK1 A;  1W81 A;  4YIV A;  4APL A;  5CSQ A;  4DUR A;  2HGF A;  1I8N A;  1Z40 A;  5CS5 A;  2LL4 M;  4IUA A;  4R1A A;  4R1C A;  4UV6 A;  3HMR A;  4YIZ A;  4Z09 A;  1YXE A;  5CS9 A;  5CT3 A;  5COE A;  4A5T S;  5I25 A;  2Z8W A;  3HMS A;  4R19 A;  5EOD A;  3MKP A;  1W8K A;  2X2Z A;  2F83 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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