4Z0DA

Crystal structure of fvo strain plasmodium falciparum ama1 in complex with the ron2hp [phe2038trp] peptide
Total Genus 74
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
74
sequence length
331
structure length
273
Chain Sequence
NPWTEYMAKYDIEEVHGSGIRVDLGEDAEVAGTQYRLPSGKCPVFGKGIIIETTFLKPVATLKDGGFAFPPTNPLISPMTLNGMRDFYKNNEYVKNLDELTLCSRHAGNMNPDNDKNSNYKYPAVYDYNDKKCHILYIAAQENNFCFRPAKDKLFENYTYLSKNVVDNWEEVCPRKNLENAKFGLWVDGNCEDIPHVNEFSANDLFECNKLVFELSASDQPKDRYKSHGKGYNWGNYNRETQKCEIFNVKPTCLINNSSYIATTALSHPIEVE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure-Activity Studies of beta-Hairpin Peptide Inhibitors of the Plasmodium falciparum AMA1-RON2 Interaction.
pubmed doi rcsb
molecule tags Cell invasion
source organism Plasmodium falciparum vietnam oak-knoll (fvo)
molecule keywords Apical membrane antigen 1
total genus 74
structure length 273
sequence length 331
ec nomenclature
pdb deposition date 2015-03-26
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.50.4.10 Alpha Beta 3-Layer(bba) Sandwich Hepatocyte Growth Factor Hepatocyte Growth Factor 4z0dA01
2YIOA 3SP8A 3ZWZA 4R19A 3SRIA 4APLA 4Z0FA 4R1AA 2Q8AA 5I25A 2YILA 3HMSA 4Z0DA 5CS5A 2F83A 4UAOA 4Z09A 4DURA 2J8JA 3HMTA 5CT2A 2YIPA 3ZLEA 1W8KA 1HKYA 1BHTA 4A5TS 3MKPA 3SRJA 5CSQA 2LL4M 4Z0EA 2QJ4A 2Q8BA 5EOKA 1I8NA 1YXEA 2QJ2A 5CP9A 5CS3A 5CT1A 5CS9A 1GMOA 2Z8VA 2Y8RA 2HGFA 2J8LA 2X2ZA 1GMNA 5CT3A 5EODA 1W81A 4IUAA 2K13X 5COEA 4R1CA 1Z40A 2Z8WA 4R1BA 4UV6A 4APMA 3HN4A 5CS1A 1NK1A 3HMRA 2LL3A 1GP9A
chains in the Genus database with same CATH superfamily
2YIOA 3SP8A 3ZWZA 4R19A 3SRIA 4APLA 4Z0FA 4R1AA 2Q8AA 5I25A 2YILA 3HMSA 4Z0DA 5CS5A 2F83A 4UAOA 4Z09A 4DURA 2J8JA 3HMTA 5CT2A 2YIPA 3ZLEA 1W8KA 1HKYA 1BHTA 2KL5A 4A5TS 3MKPA 3SRJA 5CSQA 2LL4M 4Z0EA 2QJ4A 2Q8BA 5EOKA 1I8NA 1YXEA 2QJ2A 4YIZA 5CP9A 5CS3A 5CT1A 5CS9A 1GMOA 2Z8VA 2Y8RA 4YIVA 2HGFA 2J8LA 2X2ZA 1GMNA 5CT3A 5EODA 1W81A 4IUAA 2K13X 5COEA 4R1CA 1Z40A 2Z8WA 4R1BA 4UV6A 4APMA 3HN4A 5CS1A 1NK1A 3HMRA 2LL3A 1GP9A
chains in the Genus database with same CATH topology
2YIOA 3SP8A 3ZWZA 4R19A 3SRIA 4APLA 4Z0FA 4R1AA 2Q8AA 5I25A 2YILA 3HMSA 4Z0DA 5CS5A 2F83A 4UAOA 4Z09A 4DURA 2J8JA 3HMTA 5CT2A 2YIPA 3ZLEA 1W8KA 1HKYA 1BHTA 2KL5A 4A5TS 3MKPA 3SRJA 5CSQA 2LL4M 4Z0EA 2QJ4A 2Q8BA 5EOKA 1I8NA 1YXEA 2QJ2A 4YIZA 5CP9A 5CS3A 5CT1A 5CS9A 1GMOA 2Z8VA 2Y8RA 4YIVA 2HGFA 2J8LA 2X2ZA 1GMNA 5CT3A 5EODA 1W81A 4IUAA 2K13X 5COEA 4R1CA 1Z40A 2Z8WA 4R1BA 4UV6A 4APMA 3HN4A 5CS1A 1NK1A 3HMRA 2LL3A 1GP9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2YIO A;  3SP8 A;  3ZWZ A;  4R19 A;  3SRI A;  4APL A;  4Z0F A;  4R1A A;  2Q8A A;  5I25 A;  2YIL A;  3HMS A;  4Z0D A;  5CS5 A;  2F83 A;  4UAO A;  4Z09 A;  4DUR A;  2J8J A;  3HMT A;  5CT2 A;  2YIP A;  3ZLE A;  1W8K A;  1HKY A;  1BHT A;  4A5T S;  3MKP A;  3SRJ A;  5CSQ A;  2LL4 M;  4Z0E A;  2QJ4 A;  2Q8B A;  5EOK A;  1I8N A;  1YXE A;  2QJ2 A;  5CP9 A;  5CS3 A;  5CT1 A;  5CS9 A;  1GMO A;  2Z8V A;  2Y8R A;  2HGF A;  2J8L A;  2X2Z A;  1GMN A;  5CT3 A;  5EOD A;  1W81 A;  4IUA A;  2K13 X;  5COE A;  4R1C A;  1Z40 A;  2Z8W A;  4R1B A;  4UV6 A;  4APM A;  3HN4 A;  5CS1 A;  1NK1 A;  3HMR A;  2LL3 A;  1GP9 A; 
#chains in the Genus database with same CATH topology
 2YIO A;  3SP8 A;  3ZWZ A;  4R19 A;  3SRI A;  4APL A;  4Z0F A;  4R1A A;  2Q8A A;  5I25 A;  2YIL A;  3HMS A;  4Z0D A;  5CS5 A;  2F83 A;  4UAO A;  4Z09 A;  4DUR A;  2J8J A;  3HMT A;  5CT2 A;  2YIP A;  3ZLE A;  1W8K A;  1HKY A;  1BHT A;  2KL5 A;  4A5T S;  3MKP A;  3SRJ A;  5CSQ A;  2LL4 M;  4Z0E A;  2QJ4 A;  2Q8B A;  5EOK A;  1I8N A;  1YXE A;  2QJ2 A;  4YIZ A;  5CP9 A;  5CS3 A;  5CT1 A;  5CS9 A;  1GMO A;  2Z8V A;  2Y8R A;  4YIV A;  2HGF A;  2J8L A;  2X2Z A;  1GMN A;  5CT3 A;  5EOD A;  1W81 A;  4IUA A;  2K13 X;  5COE A;  4R1C A;  1Z40 A;  2Z8W A;  4R1B A;  4UV6 A;  4APM A;  3HN4 A;  5CS1 A;  1NK1 A;  3HMR A;  2LL3 A;  1GP9 A; 
#chains in the Genus database with same CATH homology
 2YIO A;  3SP8 A;  3ZWZ A;  4R19 A;  3SRI A;  4APL A;  4Z0F A;  4R1A A;  2Q8A A;  5I25 A;  2YIL A;  3HMS A;  4Z0D A;  5CS5 A;  2F83 A;  4UAO A;  4Z09 A;  4DUR A;  2J8J A;  3HMT A;  5CT2 A;  2YIP A;  3ZLE A;  1W8K A;  1HKY A;  1BHT A;  2KL5 A;  4A5T S;  3MKP A;  3SRJ A;  5CSQ A;  2LL4 M;  4Z0E A;  2QJ4 A;  2Q8B A;  5EOK A;  1I8N A;  1YXE A;  2QJ2 A;  4YIZ A;  5CP9 A;  5CS3 A;  5CT1 A;  5CS9 A;  1GMO A;  2Z8V A;  2Y8R A;  4YIV A;  2HGF A;  2J8L A;  2X2Z A;  1GMN A;  5CT3 A;  5EOD A;  1W81 A;  4IUA A;  2K13 X;  5COE A;  4R1C A;  1Z40 A;  2Z8W A;  4R1B A;  4UV6 A;  4APM A;  3HN4 A;  5CS1 A;  1NK1 A;  3HMR A;  2LL3 A;  1GP9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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