4Z0FA

Crystal structure of fvo strain plasmodium falciparum ama1 in complex with the ron2hp [phe2038(6cw)] peptide
Total Genus 75
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
75
sequence length
332
structure length
278
Chain Sequence
GNPWTEYMAKYDIEEVHGSGIRVDLGEDAEVAGTQYRLPSGKCPVFGKGIIIENSNTTFLKPVATLKDGGFAFPPTNPLISPMTLNGMRDFYKNNEYVKNLDELTLCSRHAGNMNPDNKNSNYKYPAVYDYNDKKCHILYIAAQENNFCFRPAKDKLFENYTYLSKNVVDNWEEVCPRKNLENAKFGLWVDGNCEDIPHVNEFSANDLFECNKLVFELSASDQPKQYDRYKSHGKGYNWGNYNRETQKCEIFNVKPTCLINNSSYIATTALSHPIEVE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure-Activity Studies of beta-Hairpin Peptide Inhibitors of the Plasmodium falciparum AMA1-RON2 Interaction.
pubmed doi rcsb
molecule tags Cell invasion
source organism Plasmodium falciparum vietnam oak-knoll (fvo)
molecule keywords Apical membrane antigen 1
total genus 75
structure length 278
sequence length 332
ec nomenclature
pdb deposition date 2015-03-26
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.50.4.10 Alpha Beta 3-Layer(bba) Sandwich Hepatocyte Growth Factor Hepatocyte Growth Factor 4z0fA01
2LL4M 3HN4A 5CS3A 3SP8A 3HMRA 5COEA 4R19A 4APLA 5I25A 1HKYA 5CS5A 1NK1A 4Z0EA 3SRIA 4Z0FA 4Z09A 4DURA 3HMTA 1GMNA 2Y8RA 2Q8AA 4IUAA 5EODA 3ZWZA 4UV6A 2Z8VA 3ZLEA 5CS9A 1I8NA 2J8LA 5CS1A 2F83A 1YXEA 4UAOA 4R1AA 2X2ZA 5CT1A 1Z40A 1GP9A 4Z0DA 1W81A 2YIOA 1BHTA 2J8JA 2HGFA 5CP9A 4A5TS 2QJ4A 4R1BA 1W8KA 2QJ2A 3MKPA 2Q8BA 2YIPA 5EOKA 4R1CA 5CT3A 5CT2A 2Z8WA 1GMOA 2LL3A 4APMA 3HMSA 3SRJA 5CSQA 2K13X 2YILA
chains in the Genus database with same CATH superfamily
2LL4M 3HN4A 5CS3A 3SP8A 3HMRA 5COEA 4R19A 4APLA 5I25A 1HKYA 5CS5A 1NK1A 4Z0EA 3SRIA 4Z0FA 4Z09A 4DURA 3HMTA 1GMNA 2Y8RA 2Q8AA 4IUAA 5EODA 3ZWZA 4UV6A 2Z8VA 3ZLEA 5CS9A 1I8NA 2J8LA 5CS1A 2F83A 1YXEA 4UAOA 4R1AA 2X2ZA 5CT1A 1Z40A 1GP9A 4Z0DA 1W81A 2KL5A 1BHTA 2YIOA 4YIZA 2J8JA 2HGFA 5CP9A 4YIVA 4A5TS 2QJ4A 4R1BA 1W8KA 2QJ2A 3MKPA 2Q8BA 2YIPA 5EOKA 4R1CA 5CT3A 5CT2A 2Z8WA 1GMOA 2LL3A 4APMA 3HMSA 3SRJA 5CSQA 2K13X 2YILA
chains in the Genus database with same CATH topology
2LL4M 3HN4A 5CS3A 3SP8A 3HMRA 5COEA 4R19A 4APLA 5I25A 1HKYA 5CS5A 1NK1A 4Z0EA 3SRIA 4Z0FA 4Z09A 4DURA 3HMTA 1GMNA 2Y8RA 2Q8AA 4IUAA 5EODA 3ZWZA 4UV6A 2Z8VA 3ZLEA 5CS9A 1I8NA 2J8LA 5CS1A 2F83A 1YXEA 4UAOA 4R1AA 2X2ZA 5CT1A 1Z40A 1GP9A 4Z0DA 1W81A 2KL5A 1BHTA 2YIOA 4YIZA 2J8JA 2HGFA 5CP9A 4YIVA 4A5TS 2QJ4A 4R1BA 1W8KA 2QJ2A 3MKPA 2Q8BA 2YIPA 5EOKA 4R1CA 5CT3A 5CT2A 2Z8WA 1GMOA 2LL3A 4APMA 3HMSA 3SRJA 5CSQA 2K13X 2YILA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2LL4 M;  3HN4 A;  5CS3 A;  3SP8 A;  3HMR A;  5COE A;  4R19 A;  4APL A;  5I25 A;  1HKY A;  5CS5 A;  1NK1 A;  4Z0E A;  3SRI A;  4Z0F A;  4Z09 A;  4DUR A;  3HMT A;  1GMN A;  2Y8R A;  2Q8A A;  4IUA A;  5EOD A;  3ZWZ A;  4UV6 A;  2Z8V A;  3ZLE A;  5CS9 A;  1I8N A;  2J8L A;  5CS1 A;  2F83 A;  1YXE A;  4UAO A;  4R1A A;  2X2Z A;  5CT1 A;  1Z40 A;  1GP9 A;  4Z0D A;  1W81 A;  2YIO A;  1BHT A;  2J8J A;  2HGF A;  5CP9 A;  4A5T S;  2QJ4 A;  4R1B A;  1W8K A;  2QJ2 A;  3MKP A;  2Q8B A;  2YIP A;  5EOK A;  4R1C A;  5CT3 A;  5CT2 A;  2Z8W A;  1GMO A;  2LL3 A;  4APM A;  3HMS A;  3SRJ A;  5CSQ A;  2K13 X;  2YIL A; 
#chains in the Genus database with same CATH topology
 2LL4 M;  3HN4 A;  5CS3 A;  3SP8 A;  3HMR A;  5COE A;  4R19 A;  4APL A;  5I25 A;  1HKY A;  5CS5 A;  1NK1 A;  4Z0E A;  3SRI A;  4Z0F A;  4Z09 A;  4DUR A;  3HMT A;  1GMN A;  2Y8R A;  2Q8A A;  4IUA A;  5EOD A;  3ZWZ A;  4UV6 A;  2Z8V A;  3ZLE A;  5CS9 A;  1I8N A;  2J8L A;  5CS1 A;  2F83 A;  1YXE A;  4UAO A;  4R1A A;  2X2Z A;  5CT1 A;  1Z40 A;  1GP9 A;  4Z0D A;  1W81 A;  2KL5 A;  1BHT A;  2YIO A;  4YIZ A;  2J8J A;  2HGF A;  5CP9 A;  4YIV A;  4A5T S;  2QJ4 A;  4R1B A;  1W8K A;  2QJ2 A;  3MKP A;  2Q8B A;  2YIP A;  5EOK A;  4R1C A;  5CT3 A;  5CT2 A;  2Z8W A;  1GMO A;  2LL3 A;  4APM A;  3HMS A;  3SRJ A;  5CSQ A;  2K13 X;  2YIL A; 
#chains in the Genus database with same CATH homology
 2LL4 M;  3HN4 A;  5CS3 A;  3SP8 A;  3HMR A;  5COE A;  4R19 A;  4APL A;  5I25 A;  1HKY A;  5CS5 A;  1NK1 A;  4Z0E A;  3SRI A;  4Z0F A;  4Z09 A;  4DUR A;  3HMT A;  1GMN A;  2Y8R A;  2Q8A A;  4IUA A;  5EOD A;  3ZWZ A;  4UV6 A;  2Z8V A;  3ZLE A;  5CS9 A;  1I8N A;  2J8L A;  5CS1 A;  2F83 A;  1YXE A;  4UAO A;  4R1A A;  2X2Z A;  5CT1 A;  1Z40 A;  1GP9 A;  4Z0D A;  1W81 A;  2KL5 A;  1BHT A;  2YIO A;  4YIZ A;  2J8J A;  2HGF A;  5CP9 A;  4YIV A;  4A5T S;  2QJ4 A;  4R1B A;  1W8K A;  2QJ2 A;  3MKP A;  2Q8B A;  2YIP A;  5EOK A;  4R1C A;  5CT3 A;  5CT2 A;  2Z8W A;  1GMO A;  2LL3 A;  4APM A;  3HMS A;  3SRJ A;  5CSQ A;  2K13 X;  2YIL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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