The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
37
|
sequence length |
149
|
structure length |
145
|
Chain Sequence |
DVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDLSKEEIERMVQEAEKYKAEDEVQRERVSKNALE
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
The novolactone natural product disrupts the allosteric regulation of hsp70.
pubmed doi rcsb |
| molecule tags |
Chaperone/chaperone inhibitor
|
| source organism |
Homo sapiens
|
| molecule keywords |
Heat shock 70 kDa protein 1A/1B
|
| total genus |
37
|
| structure length |
145
|
| sequence length |
149
|
| chains with identical sequence |
B
|
| ec nomenclature | |
| pdb deposition date | 2014-11-04 |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Beta | Sandwich | Substrate Binding Domain Of DNAk; Chain A, domain 1 | Substrate Binding Domain Of DNAk; Chain A, domain 1 |
#chains in the Genus database with same CATH superfamily 4JN4 A; 4EZO A; 3H0X A; 1YUW A; 1DKY A; 1BPR A; 4JNE A; 3DQG A; 3C7N A; 4B9Q A; 3DPQ A; 4R5L A; 1DG4 A; 4EZY A; 4EZQ A; 1CKR A; 4EZV A; 4EZP A; 3C7N B; 4EZX A; 4EZR A; 4HYB A; 4JNF A; 7HSC A; 2V7Y A; 3DPP A; 4EZW A; 4F00 A; 4F01 A; 2KHO A; 4HY9 A; 3D2E A; 4R5K A; 4WV7 A; 1Q5L A; 5TKY A; 1U00 A; 5E84 A; 3D2F A; 2BPR A; 1DKZ A; 3DOB A; 3QNJ A; 4JWD A; 4JWE A; 3N8E A; 2OP6 A; 4R5G A; 4R5J A; 2QXL A; 3DPO A; 4E81 A; 4EZT A; 4EZU A; 4JWI A; 1DKX A; 4EZN A; 4WV5 A; 4EZS A; 4EZZ A; 4FL9 A; 4PO2 A; 4R5I A; 4JWC A; #chains in the Genus database with same CATH topology 4I43 A; 4JN4 A; 3H0X A; 4EZO A; 1YUW A; 1DKY A; 1BPR A; 4JNE A; 3DQG A; 3C7N A; 4B9Q A; 3DPQ A; 4R5L A; 1DG4 A; 4EZY A; 4EZQ A; 1CKR A; 4EZV A; 4EZP A; 3C7N B; 4EZX A; 4EZR A; 4HYB A; 3ZEF A; 4JNF A; 7HSC A; 2V7Y A; 3DPP A; 4EZW A; 3SBT B; 4F00 A; 4F01 A; 2KHO A; 4HY9 A; 3D2E A; 4R5K A; 4WV7 A; 1Q5L A; 5TKY A; 1U00 A; 4ILG A; 4ILH B; 4ILI A; 5E84 A; 3D2F A; 2BPR A; 1DKZ A; 3DOB A; 3QNJ A; 4JWD A; 4JWE A; 3N8E A; 2OP6 A; 4R5G A; 4R5J A; 2QXL A; 3DPO A; 3SBS A; 4E81 A; 4EZT A; 4EZU A; 4JWI A; 4MQD A; 1DKX A; 4EZN A; 4WV5 A; 4EZS A; 4EZZ A; 4FL9 A; 4PO2 A; 4R5I A; 4JWC A; #chains in the Genus database with same CATH homology 4I43 A; 4JN4 A; 3H0X A; 4EZO A; 1YUW A; 1DKY A; 1BPR A; 4JNE A; 3DQG A; 3C7N A; 4B9Q A; 3DPQ A; 4R5L A; 1DG4 A; 4EZY A; 4EZQ A; 1CKR A; 4EZV A; 4EZP A; 3C7N B; 4EZX A; 4EZR A; 4HYB A; 3ZEF A; 4JNF A; 7HSC A; 2V7Y A; 3DPP A; 4EZW A; 3SBT B; 4F00 A; 4F01 A; 2KHO A; 4HY9 A; 3D2E A; 4R5K A; 4WV7 A; 1Q5L A; 5TKY A; 1U00 A; 4ILG A; 4ILH B; 4ILI A; 5E84 A; 3D2F A; 2BPR A; 1DKZ A; 3DOB A; 3QNJ A; 4JWD A; 4JWE A; 3N8E A; 2OP6 A; 4R5G A; 4R5J A; 2QXL A; 3DPO A; 3SBS A; 4E81 A; 4EZT A; 4EZU A; 4JWI A; 4MQD A; 1DKX A; 4EZN A; 4WV5 A; 4EZS A; 4EZZ A; 4FL9 A; 4PO2 A; 4R5I A; 4JWC A;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
