4R5GA

Crystal structure of the dnak c-terminus with the inhibitor pet-16
Total Genus 40
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
40
sequence length
220
structure length
218
Chain Sequence
MHHHHHHIEGRLLDVTPLSLGIETMGGVMTTLIAKNTTIPTKHSQVFSTAEDNQSAVTIHVLQGERKRAADNKSLGQFNLDGINPAPRGMPQIEVTFDIDADGILHVSAKDKNSGKEQKITIKASSGLNEDEIQKMVRDAEANAEADRKFEELVQTRNQGDHLLHSTRKQVEEAGDKLPADDKTAIESALTALETALKGEDKAAIEAKMQELAQVSQK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket.
pubmed doi rcsb
molecule tags Chaperone/chaperone inhibitor
source organism Escherichia coli
molecule keywords Chaperone protein DnaK
total genus 40
structure length 218
sequence length 220
chains with identical sequence B
ec nomenclature
pdb deposition date 2014-08-21
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1270.10 Mainly Alpha Up-down Bundle Substrate Binding Domain Of Dnak; Chain:A; Domain 2 Substrate Binding Domain Of Dnak; Chain:A; Domain 2 4r5gA02
2.60.34.10 Mainly Beta Sandwich Substrate Binding Domain Of DNAk; Chain A, domain 1 Substrate Binding Domain Of DNAk; Chain A, domain 1 4r5gA01
4JNEA 4HYBA 3H0XA 4H6HA 2BPRA 1CKRA 1U00A 5E84A 4R5GA 3DQGA 4E81A 4EZPA 4PO2A 2QFFA 3T47A 4WV5A 2KHOA 3D2EA 4JN4A 4EZWA 3QNJA 3L3OM 3T4AG 4EZSA 3N8EA 2WINM 5TKYA 4H6IA 4EZQA 2OP6A 2QXLA 3DPQA 4EZXA 3T48A 3T49A 3C7NB 1Q5LA 3DPOA 3DPPA 3DOBA 1DG4A 3D2FA 2V7YA 3C7NA 4EZNA 4EZYA 4HY9A 4B9QA 3OHXM 4R5JA 3T46A 4JNFA 4JWEA 1BPRA 1YUWA 1DKYA 4R5KA 4F00A 4WV7A 4R5LA 4EZZA 4EZRA 4FL9A 1DKZA 1DKXA 4EZOA 4F01A 4EZTA 4JWDA 4JWCA 4EZVA 4EZUA 7HSCA 4JWIA 4R5IA
chains in the Genus database with same CATH superfamily
3UITA 3HAHA 5FLEX 2F7OA 2F7RA 1DG4A 4JWEA 1I4DA 3ACOA 4AZGA 4JWCA 3I04A 4IM2A 3DX1A 2WYIA 3EJSA 4EZPA 1R33A 4NPHA 4EZQA 4IW0A 2Z0OA 2YIVX 3CVRA 1HTYA 2ZXQA 4BNEA 2F18A 2YL5A 1GNTA 1DKYA 4WPCA 2LXYA 1SU8A 1R34A 2OZNB 4DYLA 4H6HA 2BPRA 1U00A 1TQTA 3EJQA 1TQSA 2WYHA 3QA8A 2KHOA 4JN4A 1OA0A 2YL9A 2QXLA 2EX3B 3O3NB 3DPPA 2F7PA 1E9VA 2OW7A 3KAVA 4R5KA 2YI8A 1DKZA 1QX1A 4EZOA 2OW6A 3ZEDA 4AZBA 3N8EA 4R5IA 2ALWA 4AZCA 2ELBA 3EJUA 2FYVA 2X5CA 3D52A 2QFFA 4AZ7A 3D2EA 3HAJA 3T49A 2Z0VA 2JNSA 4MQDA 3EJTA 3DYTA 2YIAA 4AZHA 4FZSA 4EZRA 1WDZA 3DDGA 4JNEA 1HXKA 2X3WA 3FD9A 2PMRA 2GA9D 3SBTB 4DCNC 3CKDA 3T4AG 3EJPA 5C5BB 4M0MA 3D4YA 3O3OB 3D2FA 4I43A 2D4CA 3CZSA 4JL9A 4UDYX 4H8SA 2FICA 3LLLA 4KIKB 4EZUA 2JNKA 3CV5A 3ER8C 1CKRA 3I39X 3BUPA 2YI9A 2OO2A 3PLTA 4B9QA 2YKTA 1YUWA 4WV7A 3GI7A 4R5LA 3QWEA 1Y2OA 3SBSA 2RAIA 2X3VA 2YIBA 2GF4A 4NQIA 2C08A 2O0I1 3OK8A 3C7NB 3DOBA 1OAOA 5KBPA 3Q0KA 1E2UA 4ILHB 2F7QA 4E3CA 2Q12A 4AZ5A 3H0XA 1OA1A 1ZYLA 2V0OA 1GN9A 3QNJA 3DPQA 3ER9B 4EZYA 4HY9A 3T46A 3LMFA 2F1AA 3BLBA 3BUQA 1X03A 3M3WA 4F00A 2N3KA 4FZOA 2ND1A 4R5GA 3B53X 3DQGA 4FM3A 3T47A 2RAKA 4AKVA 2QKWA 3BVXA 1PS3A 4EZXA 5C5BA 4D8JA 4ILIA 2OBLA 4IWQA 4JLCA 1BPRA 4G6QA 3BUDA 3ABHA 1Q5LA 2LM0A 3D51A 4KIKA 3DDFA 3QE6A 3CAZA 2X3XA 2Q13A 3BVUA 1X04A 4E81A 3I2WA 4AZ6A 4H6IA 3VKHA 3B51X 3L3PA 1E1DA 4I1QA 4HR1B 3QNIA 3RV1A 1DKXA 1O7DB 4JWDA 1I49A 4NSWA 3F7WA 3BVTA 4IWOA 3ZEFA 2YL8A 2EFLA 1LQ7A 3RPMA 1JQKA 3OWGA 3DX3A 3I01A 2YLLA 1TQUA 3C7NA 4FZPA 4R5JA 1URUA 1SUFA 4FL9A 4EZVA 4EZTA 1QWNA 3DX4A 3Q84A 2EFKA 1YWMA 5E84A 1SU6A 4PO2A 1GNLA 2RT6A 1UPXA 1I4LA 1W9MA 3ERCC 2V7YA 2RAJA 4IM3A 4ATMA 1QWUA 3KDRA 4F01A 7HSCA 2GAFD 1SU7A 2YLAA 2ND0A 3BVWA 3D4ZA 3DPOA 2Z8YA 1ZWWA 4EZNA 1R5EA 3BVVA 4IWPA 3OHXM 3EJRA 1O7DC 5FIGA 4HYBA 2D1LA 4EZWA 3L3OM 2WINM 3B52X 2OP6A 1TQVA 2MI7A 4IM0A 3T48A 3KAWA 4AZIA 3G9GA 1I4TA 1TQWA 4HR1A 4EZZA 2OBMA 3O3MB 4JWIA 4AVMA 2PY6A 3BUIA 2YL6A 4WPEA 4EZSA 5TKYA 3LVTA 4JNFA 3VEBA 3VEAA 2F1BA 3SOGA 4AZCB 3DX0A 4WV5A 4ILGA 3D50A 2EWFA 3SYVA 3DX2A 2NCZA 4UDXX 1MJGA 3CZNA 3A98A 1HWWA 3BUBA 3HAIA 3RV0A 2Z0NA
chains in the Genus database with same CATH topology
4JNEA 3UITA 3FD9A 2ND1A 4R5GA 2GA9D 3B53X 2GAFD 3SBTB 3DQGA 1SU7A 4FM3A 3T47A 2ND0A 3T4AG 5FLEX 4EZXA 4M0MA 3DPOA 3O3OB 1DG4A 3D2FA 4D8JA 2Z8YA 4I43A 4EZNA 4IWPA 4ILIA 2OBLA 3OHXM 4IWQA 4JL9A 4JLCA 4UDYX 4JWEA 1BPRA 4G6QA 4KIKB 5FIGA 4JWCA 1Q5LA 3I04A 4EZUA 2LM0A 4IM2A 4HYBA 4KIKA 3ER8C 1CKRA 4E81A 4EZPA 4EZWA 4NPHA 3I39X 3L3OM 2WINM 3B52X 4H6IA 4EZQA 2OP6A 3VKHA 2YI9A 4IM0A 3T48A 3KAWA 4IW0A 3B51X 1E1DA 2YIVX 4HR1B 4B9QA 1GNTA 3RV1A 1YUWA 1DKYA 4HR1A 4WV7A 3GI7A 4R5LA 4EZZA 2OBMA 1DKXA 3O3MB 1SU8A 4JWDA 3SBSA 4JWIA 4H6HA 2BPRA 1U00A 3F7WA 4IWOA 3ZEFA 2YIBA 2PY6A 3QA8A 2KHOA 4JN4A 4EZSA 5TKYA 1OA0A 1JQKA 2QXLA 3OWGA 3I01A 2EX3B 3C7NB 3O3NB 3DPPA 1E9VA 3DOBA 1OAOA 3C7NA 4R5JA 3KAVA 4JNFA 3VEBA 4R5KA 1E2UA 3VEAA 1SUFA 2YI8A 4FL9A 1DKZA 4EZOA 4ILHB 4E3CA 4EZTA 4EZVA 3N8EA 3ZEDA 4WV5A 4R5IA 4ILGA 3H0XA 1OA1A 5E84A 1SU6A 2X5CA 1ZYLA 4PO2A 2QFFA 1GNLA 3D2EA 1GN9A 3QNJA 2RT6A 1UPXA 2EWFA 1W9MA 3DPQA 3ER9B 3T49A 3ERCC 2NCZA 2V7YA 4UDXX 1MJGA 4EZYA 4HY9A 3T46A 2JNSA 4IM3A 4MQDA 3LMFA 2YIAA 3A98A 3KDRA 4EZRA 3RV0A 4F01A 4F00A 7HSCA 2N3KA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4JNE A;  4HYB A;  3H0X A;  4H6H A;  2BPR A;  1CKR A;  1U00 A;  5E84 A;  4R5G A;  3DQG A;  4E81 A;  4EZP A;  4PO2 A;  2QFF A;  3T47 A;  4WV5 A;  2KHO A;  3D2E A;  4JN4 A;  4EZW A;  3QNJ A;  3L3O M;  3T4A G;  4EZS A;  3N8E A;  2WIN M;  5TKY A;  4H6I A;  4EZQ A;  2OP6 A;  2QXL A;  3DPQ A;  4EZX A;  3T48 A;  3T49 A;  3C7N B;  1Q5L A;  3DPO A;  3DPP A;  3DOB A;  1DG4 A;  3D2F A;  2V7Y A;  3C7N A;  4EZN A;  4EZY A;  4HY9 A;  4B9Q A;  3OHX M;  4R5J A;  3T46 A;  4JNF A;  4JWE A;  1BPR A;  1YUW A;  1DKY A;  4R5K A;  4F00 A;  4WV7 A;  4R5L A;  4EZZ A;  4EZR A;  4FL9 A;  1DKZ A;  1DKX A;  4EZO A;  4F01 A;  4EZT A;  4JWD A;  4JWC A;  4EZV A;  4EZU A;  7HSC A;  4JWI A;  4R5I A; 
#chains in the Genus database with same CATH topology
 3UIT A;  3HAH A;  5FLE X;  2F7O A;  2F7R A;  1DG4 A;  4JWE A;  1I4D A;  3ACO A;  4AZG A;  4JWC A;  3I04 A;  4IM2 A;  3DX1 A;  2WYI A;  3EJS A;  4EZP A;  1R33 A;  4NPH A;  4EZQ A;  4IW0 A;  2Z0O A;  2YIV X;  3CVR A;  1HTY A;  2ZXQ A;  4BNE A;  2F18 A;  2YL5 A;  1GNT A;  1DKY A;  4WPC A;  2LXY A;  1SU8 A;  1R34 A;  2OZN B;  4DYL A;  4H6H A;  2BPR A;  1U00 A;  1TQT A;  3EJQ A;  1TQS A;  2WYH A;  3QA8 A;  2KHO A;  4JN4 A;  1OA0 A;  2YL9 A;  2QXL A;  2EX3 B;  3O3N B;  3DPP A;  2F7P A;  1E9V A;  2OW7 A;  3KAV A;  4R5K A;  2YI8 A;  1DKZ A;  1QX1 A;  4EZO A;  2OW6 A;  3ZED A;  4AZB A;  3N8E A;  4R5I A;  2ALW A;  4AZC A;  2ELB A;  3EJU A;  2FYV A;  2X5C A;  3D52 A;  2QFF A;  4AZ7 A;  3D2E A;  3HAJ A;  3T49 A;  2Z0V A;  2JNS A;  4MQD A;  3EJT A;  3DYT A;  2YIA A;  4AZH A;  4FZS A;  4EZR A;  1WDZ A;  3DDG A;  4JNE A;  1HXK A;  2X3W A;  3FD9 A;  2PMR A;  2GA9 D;  3SBT B;  4DCN C;  3CKD A;  3T4A G;  3EJP A;  5C5B B;  4M0M A;  3D4Y A;  3O3O B;  3D2F A;  4I43 A;  2D4C A;  3CZS A;  4JL9 A;  4UDY X;  4H8S A;  2FIC A;  3LLL A;  4KIK B;  4EZU A;  2JNK A;  3CV5 A;  3ER8 C;  1CKR A;  3I39 X;  3BUP A;  2YI9 A;  2OO2 A;  3PLT A;  4B9Q A;  2YKT A;  1YUW A;  4WV7 A;  3GI7 A;  4R5L A;  3QWE A;  1Y2O A;  3SBS A;  2RAI A;  2X3V A;  2YIB A;  2GF4 A;  4NQI A;  2C08 A;  2O0I 1;  3OK8 A;  3C7N B;  3DOB A;  1OAO A;  5KBP A;  3Q0K A;  1E2U A;  4ILH B;  2F7Q A;  4E3C A;  2Q12 A;  4AZ5 A;  3H0X A;  1OA1 A;  1ZYL A;  2V0O A;  1GN9 A;  3QNJ A;  3DPQ A;  3ER9 B;  4EZY A;  4HY9 A;  3T46 A;  3LMF A;  2F1A A;  3BLB A;  3BUQ A;  1X03 A;  3M3W A;  4F00 A;  2N3K A;  4FZO A;  2ND1 A;  4R5G A;  3B53 X;  3DQG A;  4FM3 A;  3T47 A;  2RAK A;  4AKV A;  2QKW A;  3BVX A;  1PS3 A;  4EZX A;  5C5B A;  4D8J A;  4ILI A;  2OBL A;  4IWQ A;  4JLC A;  1BPR A;  4G6Q A;  3BUD A;  3ABH A;  1Q5L A;  2LM0 A;  3D51 A;  4KIK A;  3DDF A;  3QE6 A;  3CAZ A;  2X3X A;  2Q13 A;  3BVU A;  1X04 A;  4E81 A;  3I2W A;  4AZ6 A;  4H6I A;  3VKH A;  3B51 X;  3L3P A;  1E1D A;  4I1Q A;  4HR1 B;  3QNI A;  3RV1 A;  1DKX A;  1O7D B;  4JWD A;  1I49 A;  4NSW A;  3F7W A;  3BVT A;  4IWO A;  3ZEF A;  2YL8 A;  2EFL A;  1LQ7 A;  3RPM A;  1JQK A;  3OWG A;  3DX3 A;  3I01 A;  2YLL A;  1TQU A;  3C7N A;  4FZP A;  4R5J A;  1URU A;  1SUF A;  4FL9 A;  4EZV A;  4EZT A;  1QWN A;  3DX4 A;  3Q84 A;  2EFK A;  1YWM A;  5E84 A;  1SU6 A;  4PO2 A;  1GNL A;  2RT6 A;  1UPX A;  1I4L A;  1W9M A;  3ERC C;  2V7Y A;  2RAJ A;  4IM3 A;  4ATM A;  1QWU A;  3KDR A;  4F01 A;  7HSC A;  2GAF D;  1SU7 A;  2YLA A;  2ND0 A;  3BVW A;  3D4Z A;  3DPO A;  2Z8Y A;  1ZWW A;  4EZN A;  1R5E A;  3BVV A;  4IWP A;  3OHX M;  3EJR A;  1O7D C;  5FIG A;  4HYB A;  2D1L A;  4EZW A;  3L3O M;  2WIN M;  3B52 X;  2OP6 A;  1TQV A;  2MI7 A;  4IM0 A;  3T48 A;  3KAW A;  4AZI A;  3G9G A;  1I4T A;  1TQW A;  4HR1 A;  4EZZ A;  2OBM A;  3O3M B;  4JWI A;  4AVM A;  2PY6 A;  3BUI A;  2YL6 A;  4WPE A;  4EZS A;  5TKY A;  3LVT A;  4JNF A;  3VEB A;  3VEA A;  2F1B A;  3SOG A;  4AZC B;  3DX0 A;  4WV5 A;  4ILG A;  3D50 A;  2EWF A;  3SYV A;  3DX2 A;  2NCZ A;  4UDX X;  1MJG A;  3CZN A;  3A98 A;  1HWW A;  3BUB A;  3HAI A;  3RV0 A;  2Z0N A; 
#chains in the Genus database with same CATH homology
 4JNE A;  3UIT A;  3FD9 A;  2ND1 A;  4R5G A;  2GA9 D;  3B53 X;  2GAF D;  3SBT B;  3DQG A;  1SU7 A;  4FM3 A;  3T47 A;  2ND0 A;  3T4A G;  5FLE X;  4EZX A;  4M0M A;  3DPO A;  3O3O B;  1DG4 A;  3D2F A;  4D8J A;  2Z8Y A;  4I43 A;  4EZN A;  4IWP A;  4ILI A;  2OBL A;  3OHX M;  4IWQ A;  4JL9 A;  4JLC A;  4UDY X;  4JWE A;  1BPR A;  4G6Q A;  4KIK B;  5FIG A;  4JWC A;  1Q5L A;  3I04 A;  4EZU A;  2LM0 A;  4IM2 A;  4HYB A;  4KIK A;  3ER8 C;  1CKR A;  4E81 A;  4EZP A;  4EZW A;  4NPH A;  3I39 X;  3L3O M;  2WIN M;  3B52 X;  4H6I A;  4EZQ A;  2OP6 A;  3VKH A;  2YI9 A;  4IM0 A;  3T48 A;  3KAW A;  4IW0 A;  3B51 X;  1E1D A;  2YIV X;  4HR1 B;  4B9Q A;  1GNT A;  3RV1 A;  1YUW A;  1DKY A;  4HR1 A;  4WV7 A;  3GI7 A;  4R5L A;  4EZZ A;  2OBM A;  1DKX A;  3O3M B;  1SU8 A;  4JWD A;  3SBS A;  4JWI A;  4H6H A;  2BPR A;  1U00 A;  3F7W A;  4IWO A;  3ZEF A;  2YIB A;  2PY6 A;  3QA8 A;  2KHO A;  4JN4 A;  4EZS A;  5TKY A;  1OA0 A;  1JQK A;  2QXL A;  3OWG A;  3I01 A;  2EX3 B;  3C7N B;  3O3N B;  3DPP A;  1E9V A;  3DOB A;  1OAO A;  3C7N A;  4R5J A;  3KAV A;  4JNF A;  3VEB A;  4R5K A;  1E2U A;  3VEA A;  1SUF A;  2YI8 A;  4FL9 A;  1DKZ A;  4EZO A;  4ILH B;  4E3C A;  4EZT A;  4EZV A;  3N8E A;  3ZED A;  4WV5 A;  4R5I A;  4ILG A;  3H0X A;  1OA1 A;  5E84 A;  1SU6 A;  2X5C A;  1ZYL A;  4PO2 A;  2QFF A;  1GNL A;  3D2E A;  1GN9 A;  3QNJ A;  2RT6 A;  1UPX A;  2EWF A;  1W9M A;  3DPQ A;  3ER9 B;  3T49 A;  3ERC C;  2NCZ A;  2V7Y A;  4UDX X;  1MJG A;  4EZY A;  4HY9 A;  3T46 A;  2JNS A;  4IM3 A;  4MQD A;  3LMF A;  2YIA A;  3A98 A;  3KDR A;  4EZR A;  3RV0 A;  4F01 A;  4F00 A;  7HSC A;  2N3K A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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