4PO2A

Crystal structure of the stress-inducible human heat shock protein hsp70 substrate-binding domain in complex with peptide substrate
Total Genus 71
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
71
sequence length
228
structure length
228
Chain Sequence
ENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Chaperone
molecule keywords Heat shock 70 kDa protein 1A/1B
publication title Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with Peptide substrate.
pubmed doi rcsb
source organism Homo sapiens
total genus 71
structure length 228
sequence length 228
chains with identical sequence B
ec nomenclature
pdb deposition date 2014-02-24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1270.10 Mainly Alpha Up-down Bundle Substrate Binding Domain Of Dnak; Chain:A; Domain 2 Substrate Binding Domain Of Dnak; Chain:A; Domain 2 4po2A02
2.60.34.10 Mainly Beta Sandwich Substrate Binding Domain Of DNAk; Chain A, domain 1 Substrate Binding Domain Of DNAk; Chain A, domain 1 4po2A01
4EZRA 4R5IA 5TKYA 3T48A 4E81A 4R5LA 2QXLA 4JWDA 4R5KA 4EZPA 4F01A 1DG4A 3DPQA 4F00A 1YUWA 4JN4A 4JWIA 4H6IA 4EZYA 3T49A 3N8EA 1DKZA 4EZWA 3T47A 3C7NB 4EZXA 2OP6A 4HY9A 3T46A 4JWEA 1DKYA 2QFFA 3D2FA 3L3OM 3QNJA 4JNEA 4R5GA 4EZZA 1Q5LA 3DQGA 4WV7A 1CKRA 4HYBA 1BPRA 1DKXA 4EZVA 3H0XA 3D2EA 4FL9A 4EZOA 3DPPA 4WV5A 4B9QA 4H6HA 4PO2A 1U00A 3OHXM 2KHOA 4EZQA 4EZUA 5E84A 3DPOA 4JWCA 3C7NA 4EZNA 4EZSA 4EZTA 3DOBA 2V7YA 4JNFA 3T4AG 4R5JA 7HSCA 2WINM 2BPRA
chains in the Genus database with same CATH superfamily
4AVMA 4AZ5A 3EJRA 1QX1A 4EZXA 4HY9A 2ND0A 3ERCC 1OAOA 3DPPA 4WV5A 3DPOA 3ZEDA 1YUWA 3I01A 3BVVA 4NQIA 1GNLA 3C7NB 2X3WA 4FM3A 4AZHA 4IW0A 4JLCA 2ELBA 1PS3A 1UPXA 2N3KA 1TQTA 2YIAA 3T47A 3D51A 1ZWWA 4WV7A 4EZUA 1I49A 3ACOA 4R5JA 3DDGA 4WPCA 3BVWA 4F01A 3DX0A 3D4YA 1HXKA 1LQ7A 3VEBA 3HAIA 4JWIA 2RAIA 3T49A 3N8EA 3BLBA 3SBTB 2WYHA 3DYTA 2X5CA 2ALWA 2MI7A 4AZ6A 3EJQA 3QNJA 3SBSA 2OZNB 4H6HA 4EZQA 3CZSA 3F7WA 2PY6A 1ZYLA 3Q84A 2D4CA 4R5LA 4F00A 1QWUA 3T46A 1I4LA 3EJSA 3Q0KA 1TQSA 2F18A 4B9QA 3D4ZA 4NPHA 3RV1A 3HAJA 3ER9B 4IWQA 4EZPA 3CAZA 4AKVA 3B53X 3DX1A 3I39X 3DDFA 4M0MA 1DKYA 1SUFA 2OW7A 3L3OM 4R5GA 1CKRA 2YIBA 4UDXX 1BPRA 4EZOA 2YL6A 2EFKA 4G6QA 3LVTA 4EZNA 1E9VA 1X04A 4JNFA 1TQUA 2JNSA 4R5IA 3DX3A 5TKYA 2LM0A 4R5KA 1DG4A 4IWOA 2Q12A 2X3XA 4PO2A 4I1QA 3CVRA 2O0I1 4NSWA 3BUDA 3L3PA 5C5BA 2OP6A 3DX4A 3H0XA 4IM2A 1DKXA 4ATMA 4ILGA 3ZEFA 2KHOA 1Y2OA 3CKDA 4MQDA 3RV0A 2F7RA 2BPRA 2OBMA 3M3WA 1YWMA 3DX2A 3BUPA 5KBPA 4EZWA 1TQWA 3O3NB 4DCNC 2NCZA 4JWEA 4IWPA 1Q5LA 4EZZA 2RT6A 2FICA 3CV5A 4FL9A 2Z8YA 4AZ7A 2YKTA 5E84A 4EZSA 3I2WA 2Z0NA 1SU8A 3T48A 1GN9A 4JWDA 3B51X 4H6IA 4IM0A 2JNKA 2QKWA 3QNIA 3VEAA 3VKHA 1SU7A 2FYVA 3D2FA 4JNEA 2D1LA 4FZOA 3D2EA 3KAWA 3OK8A 3SOGA 2OBLA 4H8SA 4JWCA 3ABHA 2YIVX 5C5BB 4EZRA 2YLAA 5FIGA 3RPMA 3B52X 3OWGA 4KIKA 1W9MA 3BUIA 1I4DA 2F1BA 3DQGA 2F7PA 3HAHA 4D8JA 2V0OA 4BNEA 4DYLA 1MJGA 1R33A 4AZCA 3EJUA 1R5EA 3KAVA 2WINM 2Q13A 4UDYX 1E1DA 1HTYA 4ILIA 3EJPA 1R34A 2YI9A 1E2UA 2F7OA 2YLLA 2GF4A 2RAKA 3QE6A 1TQVA 3OHXM 2EX3B 1X03A 3BVUA 3SYVA 4HR1A 4E81A 3CZNA 4I43A 4ILHB 4JN4A 2GAFD 3QA8A 3KDRA 3ER8C 3O3MB 2C08A 4IM3A 2ND1A 4HYBA 2PMRA 1U00A 1HWWA 1O7DC 4WPEA 4KIKB 3BUQA 2QXLA 2YL9A 3BVTA 3BUBA 2F1AA 1DKZA 1O7DB 4FZSA 4AZCB 2OO2A 4FZPA 2GA9D 2WYIA 2YL8A 3D50A 3PLTA 4EZTA 2EWFA 2V7YA 2YI8A 7HSCA 4AZIA 2Z0OA 1WDZA 2Z0VA 3FD9A 3G9GA 3LMFA 4AZBA 2F7QA 3O3OB 4HR1B 3EJTA 3BVXA 4E3CA 1SU6A 3C7NA 3I04A 3DOBA 3T4AG 3UITA 1OA1A 1I4TA 4EZYA 3QWEA 2EFLA 3D52A 1OA0A 3DPQA 1GNTA 1JQKA 2QFFA 2RAJA 2ZXQA 4JL9A 4EZVA 2X3VA 3LLLA 1URUA 4AZGA 3GI7A 2OW6A 2LXYA 1QWNA 5FLEX 2YL5A 3A98A
chains in the Genus database with same CATH topology
3F7WA 4HR1A 2OBMA 2PY6A 4E81A 1ZYLA 4R5LA 4I43A 4ILHB 4F00A 4JN4A 2GAFD 3QA8A 4EZWA 3O3NB 3KDRA 3ER8C 4EZXA 2NCZA 4HY9A 3T46A 4JWEA 2ND0A 4IWPA 3ERCC 1Q5LA 4EZZA 1OAOA 3O3MB 4IM3A 2RT6A 2ND1A 4HYBA 4FL9A 2Z8YA 3DPPA 4WV5A 4B9QA 1U00A 4NPHA 5E84A 3DPOA 3RV1A 4EZSA 3ZEDA 3ER9B 1YUWA 1SU8A 4KIKB 3T48A 3I01A 4IWQA 1GN9A 4EZPA 2QXLA 4JWDA 3B53X 3B51X 4H6IA 3I39X 4IM0A 1GNLA 1DKZA 3VEAA 3VKHA 1SU7A 3C7NB 4FM3A 4M0MA 1DKYA 1SUFA 3D2FA 3L3OM 4JNEA 4R5GA 1CKRA 2YIBA 4UDXX 1BPRA 3D2EA 3KAWA 4IW0A 4EZOA 2GA9D 2BPRA 4JLCA 4G6QA 2OBLA 4JWCA 4EZNA 1UPXA 4EZTA 1E9VA 2EWFA 2V7YA 4JNFA 2YI8A 2YIVX 7HSCA 2JNSA 2N3KA 4EZRA 4R5IA 5TKYA 2LM0A 4R5KA 1DG4A 5FIGA 3B52X 3FD9A 3OWGA 2YIAA 4IWOA 3LMFA 3T47A 4KIKA 1W9MA 3DQGA 4WV7A 3O3OB 4HR1B 4D8JA 4PO2A 4EZUA 4E3CA 1SU6A 3C7NA 3I04A 1MJGA 3DOBA 3T4AG 3UITA 1OA1A 3KAVA 4R5JA 2WINM 4EZYA 4F01A 1OA0A 4UDYX 3VEBA 3DPQA 4JWIA 1E1DA 3T49A 3N8EA 3SBTB 4ILIA 1GNTA 1JQKA 2X5CA 2OP6A 2YI9A 2QFFA 3QNJA 1E2UA 4JL9A 3H0XA 4IM2A 1DKXA 4EZVA 3SBSA 3GI7A 4H6HA 4ILGA 3ZEFA 3OHXM 2EX3B 2KHOA 4EZQA 4MQDA 3RV0A 5FLEX 3A98A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4EZR A;  4R5I A;  5TKY A;  3T48 A;  4E81 A;  4R5L A;  2QXL A;  4JWD A;  4R5K A;  4EZP A;  4F01 A;  1DG4 A;  3DPQ A;  4F00 A;  1YUW A;  4JN4 A;  4JWI A;  4H6I A;  4EZY A;  3T49 A;  3N8E A;  1DKZ A;  4EZW A;  3T47 A;  3C7N B;  4EZX A;  2OP6 A;  4HY9 A;  3T46 A;  4JWE A;  1DKY A;  2QFF A;  3D2F A;  3L3O M;  3QNJ A;  4JNE A;  4R5G A;  4EZZ A;  1Q5L A;  3DQG A;  4WV7 A;  1CKR A;  4HYB A;  1BPR A;  1DKX A;  4EZV A;  3H0X A;  3D2E A;  4FL9 A;  4EZO A;  3DPP A;  4WV5 A;  4B9Q A;  4H6H A;  4PO2 A;  1U00 A;  3OHX M;  2KHO A;  4EZQ A;  4EZU A;  5E84 A;  3DPO A;  4JWC A;  3C7N A;  4EZN A;  4EZS A;  4EZT A;  3DOB A;  2V7Y A;  4JNF A;  3T4A G;  4R5J A;  7HSC A;  2WIN M;  2BPR A; 
#chains in the Genus database with same CATH topology
 4AVM A;  4AZ5 A;  3EJR A;  1QX1 A;  4EZX A;  4HY9 A;  2ND0 A;  3ERC C;  1OAO A;  3DPP A;  4WV5 A;  3DPO A;  3ZED A;  1YUW A;  3I01 A;  3BVV A;  4NQI A;  1GNL A;  3C7N B;  2X3W A;  4FM3 A;  4AZH A;  4IW0 A;  4JLC A;  2ELB A;  1PS3 A;  1UPX A;  2N3K A;  1TQT A;  2YIA A;  3T47 A;  3D51 A;  1ZWW A;  4WV7 A;  4EZU A;  1I49 A;  3ACO A;  4R5J A;  3DDG A;  4WPC A;  3BVW A;  4F01 A;  3DX0 A;  3D4Y A;  1HXK A;  1LQ7 A;  3VEB A;  3HAI A;  4JWI A;  2RAI A;  3T49 A;  3N8E A;  3BLB A;  3SBT B;  2WYH A;  3DYT A;  2X5C A;  2ALW A;  2MI7 A;  4AZ6 A;  3EJQ A;  3QNJ A;  3SBS A;  2OZN B;  4H6H A;  4EZQ A;  3CZS A;  3F7W A;  2PY6 A;  1ZYL A;  3Q84 A;  2D4C A;  4R5L A;  4F00 A;  1QWU A;  3T46 A;  1I4L A;  3EJS A;  3Q0K A;  1TQS A;  2F18 A;  4B9Q A;  3D4Z A;  4NPH A;  3RV1 A;  3HAJ A;  3ER9 B;  4IWQ A;  4EZP A;  3CAZ A;  4AKV A;  3B53 X;  3DX1 A;  3I39 X;  3DDF A;  4M0M A;  1DKY A;  1SUF A;  2OW7 A;  3L3O M;  4R5G A;  1CKR A;  2YIB A;  4UDX X;  1BPR A;  4EZO A;  2YL6 A;  2EFK A;  4G6Q A;  3LVT A;  4EZN A;  1E9V A;  1X04 A;  4JNF A;  1TQU A;  2JNS A;  4R5I A;  3DX3 A;  5TKY A;  2LM0 A;  4R5K A;  1DG4 A;  4IWO A;  2Q12 A;  2X3X A;  4PO2 A;  4I1Q A;  3CVR A;  2O0I 1;  4NSW A;  3BUD A;  3L3P A;  5C5B A;  2OP6 A;  3DX4 A;  3H0X A;  4IM2 A;  1DKX A;  4ATM A;  4ILG A;  3ZEF A;  2KHO A;  1Y2O A;  3CKD A;  4MQD A;  3RV0 A;  2F7R A;  2BPR A;  2OBM A;  3M3W A;  1YWM A;  3DX2 A;  3BUP A;  5KBP A;  4EZW A;  1TQW A;  3O3N B;  4DCN C;  2NCZ A;  4JWE A;  4IWP A;  1Q5L A;  4EZZ A;  2RT6 A;  2FIC A;  3CV5 A;  4FL9 A;  2Z8Y A;  4AZ7 A;  2YKT A;  5E84 A;  4EZS A;  3I2W A;  2Z0N A;  1SU8 A;  3T48 A;  1GN9 A;  4JWD A;  3B51 X;  4H6I A;  4IM0 A;  2JNK A;  2QKW A;  3QNI A;  3VEA A;  3VKH A;  1SU7 A;  2FYV A;  3D2F A;  4JNE A;  2D1L A;  4FZO A;  3D2E A;  3KAW A;  3OK8 A;  3SOG A;  2OBL A;  4H8S A;  4JWC A;  3ABH A;  2YIV X;  5C5B B;  4EZR A;  2YLA A;  5FIG A;  3RPM A;  3B52 X;  3OWG A;  4KIK A;  1W9M A;  3BUI A;  1I4D A;  2F1B A;  3DQG A;  2F7P A;  3HAH A;  4D8J A;  2V0O A;  4BNE A;  4DYL A;  1MJG A;  1R33 A;  4AZC A;  3EJU A;  1R5E A;  3KAV A;  2WIN M;  2Q13 A;  4UDY X;  1E1D A;  1HTY A;  4ILI A;  3EJP A;  1R34 A;  2YI9 A;  1E2U A;  2F7O A;  2YLL A;  2GF4 A;  2RAK A;  3QE6 A;  1TQV A;  3OHX M;  2EX3 B;  1X03 A;  3BVU A;  3SYV A;  4HR1 A;  4E81 A;  3CZN A;  4I43 A;  4ILH B;  4JN4 A;  2GAF D;  3QA8 A;  3KDR A;  3ER8 C;  3O3M B;  2C08 A;  4IM3 A;  2ND1 A;  4HYB A;  2PMR A;  1U00 A;  1HWW A;  1O7D C;  4WPE A;  4KIK B;  3BUQ A;  2QXL A;  2YL9 A;  3BVT A;  3BUB A;  2F1A A;  1DKZ A;  1O7D B;  4FZS A;  4AZC B;  2OO2 A;  4FZP A;  2GA9 D;  2WYI A;  2YL8 A;  3D50 A;  3PLT A;  4EZT A;  2EWF A;  2V7Y A;  2YI8 A;  7HSC A;  4AZI A;  2Z0O A;  1WDZ A;  2Z0V A;  3FD9 A;  3G9G A;  3LMF A;  4AZB A;  2F7Q A;  3O3O B;  4HR1 B;  3EJT A;  3BVX A;  4E3C A;  1SU6 A;  3C7N A;  3I04 A;  3DOB A;  3T4A G;  3UIT A;  1OA1 A;  1I4T A;  4EZY A;  3QWE A;  2EFL A;  3D52 A;  1OA0 A;  3DPQ A;  1GNT A;  1JQK A;  2QFF A;  2RAJ A;  2ZXQ A;  4JL9 A;  4EZV A;  2X3V A;  3LLL A;  1URU A;  4AZG A;  3GI7 A;  2OW6 A;  2LXY A;  1QWN A;  5FLE X;  2YL5 A;  3A98 A; 
#chains in the Genus database with same CATH homology
 3F7W A;  4HR1 A;  2OBM A;  2PY6 A;  4E81 A;  1ZYL A;  4R5L A;  4I43 A;  4ILH B;  4F00 A;  4JN4 A;  2GAF D;  3QA8 A;  4EZW A;  3O3N B;  3KDR A;  3ER8 C;  4EZX A;  2NCZ A;  4HY9 A;  3T46 A;  4JWE A;  2ND0 A;  4IWP A;  3ERC C;  1Q5L A;  4EZZ A;  1OAO A;  3O3M B;  4IM3 A;  2RT6 A;  2ND1 A;  4HYB A;  4FL9 A;  2Z8Y A;  3DPP A;  4WV5 A;  4B9Q A;  1U00 A;  4NPH A;  5E84 A;  3DPO A;  3RV1 A;  4EZS A;  3ZED A;  3ER9 B;  1YUW A;  1SU8 A;  4KIK B;  3T48 A;  3I01 A;  4IWQ A;  1GN9 A;  4EZP A;  2QXL A;  4JWD A;  3B53 X;  3B51 X;  4H6I A;  3I39 X;  4IM0 A;  1GNL A;  1DKZ A;  3VEA A;  3VKH A;  1SU7 A;  3C7N B;  4FM3 A;  4M0M A;  1DKY A;  1SUF A;  3D2F A;  3L3O M;  4JNE A;  4R5G A;  1CKR A;  2YIB A;  4UDX X;  1BPR A;  3D2E A;  3KAW A;  4IW0 A;  4EZO A;  2GA9 D;  2BPR A;  4JLC A;  4G6Q A;  2OBL A;  4JWC A;  4EZN A;  1UPX A;  4EZT A;  1E9V A;  2EWF A;  2V7Y A;  4JNF A;  2YI8 A;  2YIV X;  7HSC A;  2JNS A;  2N3K A;  4EZR A;  4R5I A;  5TKY A;  2LM0 A;  4R5K A;  1DG4 A;  5FIG A;  3B52 X;  3FD9 A;  3OWG A;  2YIA A;  4IWO A;  3LMF A;  3T47 A;  4KIK A;  1W9M A;  3DQG A;  4WV7 A;  3O3O B;  4HR1 B;  4D8J A;  4PO2 A;  4EZU A;  4E3C A;  1SU6 A;  3C7N A;  3I04 A;  1MJG A;  3DOB A;  3T4A G;  3UIT A;  1OA1 A;  3KAV A;  4R5J A;  2WIN M;  4EZY A;  4F01 A;  1OA0 A;  4UDY X;  3VEB A;  3DPQ A;  4JWI A;  1E1D A;  3T49 A;  3N8E A;  3SBT B;  4ILI A;  1GNT A;  1JQK A;  2X5C A;  2OP6 A;  2YI9 A;  2QFF A;  3QNJ A;  1E2U A;  4JL9 A;  3H0X A;  4IM2 A;  1DKX A;  4EZV A;  3SBS A;  3GI7 A;  4H6H A;  4ILG A;  3ZEF A;  3OHX M;  2EX3 B;  2KHO A;  4EZQ A;  4MQD A;  3RV0 A;  5FLE X;  3A98 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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