4PO2A

Crystal structure of the stress-inducible human heat shock protein hsp70 substrate-binding domain in complex with peptide substrate
Total Genus 71
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
71
sequence length
228
structure length
228
Chain Sequence
ENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Heat shock 70 kDa protein 1A/1B
publication title Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with Peptide substrate.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Chaperone
total genus 71
structure length 228
sequence length 228
chains with identical sequence B
ec nomenclature
pdb deposition date 2014-02-24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1270.10 Mainly Alpha Up-down Bundle Substrate Binding Domain Of Dnak; Chain:A; Domain 2 Substrate Binding Domain Of Dnak; Chain:A; Domain 2 4po2A02
2.60.34.10 Mainly Beta Sandwich Substrate Binding Domain Of DNAk; Chain A, domain 1 Substrate Binding Domain Of DNAk; Chain A, domain 1 4po2A01
2OP6A 3QNJA 4JNFA 3DPQA 4EZYA 3OHXM 4WV5A 4EZWA 3D2FA 4PO2A 3DPPA 4JWCA 4R5LA 4R5KA 1DKYA 4F00A 1YUWA 4FL9A 5TKYA 4WV7A 3DOBA 2KHOA 2WINM 4JWDA 1U00A 4EZRA 1DG4A 1Q5LA 1CKRA 4R5IA 4JWEA 4F01A 4H6IA 3C7NA 3N8EA 4EZZA 2QFFA 5E84A 3T49A 4HYBA 4JN4A 1DKXA 4EZOA 7HSCA 4E81A 4EZVA 3DQGA 4EZUA 4HY9A 4EZPA 4R5GA 3H0XA 4EZXA 4EZTA 4EZQA 4R5JA 3T4AG 3L3OM 4B9QA 3DPOA 4H6HA 4JNEA 3T46A 1BPRA 2BPRA 4EZNA 1DKZA 4EZSA 2QXLA 4JWIA 3D2EA 3T47A 2V7YA 3T48A 3C7NB
chains in the Genus database with same CATH superfamily
1LQ7A 4ILIA 4FL9A 2Q13A 4EZRA 3DX2A 3SOGA 2RAJA 4EZPA 2YI9A 4NSWA 3EJPA 2D4CA 3EJSA 2V0OA 4IM0A 4IM3A 4EZYA 2JNSA 1YUWA 3O3MB 3CVRA 4EZZA 2D1LA 4JLCA 1DKXA 3DDGA 4EZQA 1W9MA 2LXYA 3VKHA 2GF4A 4ILHB 1E1DA 2Q12A 4UDXX 3SYVA 3T49A 4JN4A 4I1QA 2GAFD 4AZHA 1HXKA 3CZSA 2N3KA 2F7QA 2FICA 1GNLA 4JWDA 2OO2A 5E84A 2OBMA 2YLLA 5C5BA 4B9QA 1R33A 4BNEA 4EZWA 4R5KA 4R5LA 3BUDA 2ALWA 2WYIA 3EJRA 3SBSA 3KDRA 3UITA 3BUBA 3HAIA 3Q0KA 2YIVX 3LMFA 2X5CA 4UDYX 3CKDA 5KBPA 2Z8YA 4IWPA 3CV5A 4IWQA 1OAOA 3OWGA 2RT6A 4FZOA 1GNTA 7HSCA 3I2WA 4EZXA 1OA1A 3Q84A 4EZNA 1TQTA 3BVWA 2O0I1 2NCZA 5C5BB 4G6QA 3VEAA 1DKYA 2QKWA 4AVMA 4DYLA 2WINM 4R5IA 3C7NA 2YLAA 5FLEX 3D51A 2F1BA 2ZXQA 2EWFA 3ABHA 3FD9A 3ER9B 4ATMA 2YIAA 4AZIA 2YL9A 4AZ6A 3RV0A 4F00A 4WV7A 4KIKA 2KHOA 3F7WA 4HR1A 4E3CA 1PS3A 4AZCA 2F7RA 1I4TA 1R34A 4FZSA 2OZNB 4JNEA 2EFKA 3DPQA 2EFLA 3LVTA 3I04A 3SBTB 1SU8A 3D4YA 1U00A 1DG4A 4F01A 4AZ5A 2EX3B 2F1AA 3BVTA 1TQWA 4MQDA 3T4AG 2BPRA 3RV1A 3DX3A 3RPMA 4NQIA 4EZOA 2F18A 2Z0NA 3QNJA 3OHXM 1GN9A 2X3XA 3D2FA 3DX1A 3QWEA 4M0MA 4FZPA 4JWEA 3N8EA 1R5EA 3D4ZA 3BUQA 3BVVA 3QA8A 2OW7A 1JQKA 1DKZA 3QNIA 2ND1A 4AZCB 3I01A 4AZGA 3DDFA 3DX4A 3QE6A 3BVXA 3PLTA 1URUA 1ZYLA 4I43A 3B51X 2QFFA 3HAHA 2WYHA 1QX1A 2GA9D 3VEBA 1BPRA 3O3OB 2RAIA 1HWWA 1OA0A 2PMRA 1I49A 3D52A 4IW0A 4WV5A 1E2UA 3BLBA 3DPPA 3DYTA 3B52X 4AZBA 3ERCC 3LLLA 4ILGA 4NPHA 3DQGA 3OK8A 4R5GA 3I39X 2PY6A 3L3OM 1SU6A 4JL9A 4EZSA 2V7YA 3T48A 4JNFA 4DCNC 1I4DA 3ACOA 5TKYA 4WPCA 3ZEDA 3DOBA 3ZEFA 1X04A 4E81A 5FIGA 3H0XA 3EJTA 3D50A 2X3WA 4D8JA 2Z0OA 4H6HA 1Y2OA 3T46A 3BUIA 2JNKA 2QXLA 4JWIA 2RAKA 3L3PA 4FM3A 4JWCA 1SUFA 4IWOA 2Z0VA 1CKRA 1I4LA 4H6IA 4H8SA 4EZUA 4R5JA 1O7DC 3DPOA 2YI8A 1UPXA 3EJQA 2X3VA 3G9GA 1YWMA 3T47A 3C7NB 1X03A 3A98A 2FYVA 4IM2A 2F7PA 2YL8A 2YL5A 2YIBA 1HTYA 3BVUA 2YL6A 2LM0A 2MI7A 4AZ7A 4KIKB 3EJUA 2ND0A 2ELBA 4HR1B 2OP6A 3CZNA 4PO2A 2OBLA 1WDZA 2C08A 1QWNA 3KAWA 1TQSA 3ER8C 1SU7A 3B53X 2F7OA 4AKVA 1O7DB 1Q5LA 2YKTA 3M3WA 3HAJA 1TQUA 2OW6A 4HYBA 3KAVA 4EZVA 4WPEA 4HY9A 4EZTA 1MJGA 1QWUA 1TQVA 1E9VA 1ZWWA 3CAZA 3O3NB 3DX0A 3D2EA 3GI7A 3BUPA
chains in the Genus database with same CATH topology
4JNFA 3DPQA 4EZWA 4R5KA 4R5LA 4ILIA 3I04A 4FL9A 3SBTB 5TKYA 1SU8A 3ZEDA 3DOBA 1U00A 4EZRA 1DG4A 3SBSA 4F01A 3ZEFA 3KDRA 3UITA 2EX3B 4E81A 5FIGA 4EZPA 4MQDA 2YI9A 3H0XA 3T4AG 4D8JA 4H6HA 3T46A 2BPRA 3RV1A 2QXLA 4JWIA 2YIVX 4IM0A 3LMFA 4IM3A 2X5CA 4EZOA 4FM3A 4UDYX 3QNJA 4EZYA 2JNSA 2Z8YA 3OHXM 4IWPA 1GN9A 3D2FA 4JWCA 1YUWA 1SUFA 4IWQA 4IWOA 4M0MA 1OAOA 3O3MB 3OWGA 2RT6A 1CKRA 4JWEA 4H6IA 3N8EA 1GNTA 4EZZA 4JLCA 1DKXA 7HSCA 4EZUA 3QA8A 4EZXA 1OA1A 4EZQA 4R5JA 1W9MA 1JQKA 3DPOA 2YI8A 1UPXA 4EZNA 1DKZA 3T47A 3C7NB 2ND1A 2NCZA 3VKHA 3A98A 3I01A 4G6QA 3VEAA 4ILHB 1DKYA 4IM2A 1E1DA 2WINM 4R5IA 1ZYLA 2YIBA 3C7NA 4I43A 3B51X 4UDXX 2QFFA 3T49A 4JN4A 5FLEX 2LM0A 2GA9D 4KIKB 3VEBA 1BPRA 3O3OB 2GAFD 2ND0A 2EWFA 3FD9A 4HR1B 1OA0A 3ER9B 2OP6A 2YIAA 2N3KA 4IW0A 1E2UA 4PO2A 2OBLA 3DPPA 4WV5A 3RV0A 3KAWA 4F00A 3B52X 3ERCC 3ER8C 4WV7A 1SU7A 4KIKA 3B53X 1GNLA 2KHOA 4JWDA 3F7WA 1Q5LA 4HR1A 4ILGA 4NPHA 5E84A 4E3CA 4HYBA 3KAVA 4EZVA 3DQGA 4HY9A 2OBMA 3I39X 4R5GA 4EZTA 1MJGA 2PY6A 3L3OM 4B9QA 1E9VA 1SU6A 4JNEA 4JL9A 4EZSA 3O3NB 3D2EA 2V7YA 3T48A 3GI7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2OP6 A;  3QNJ A;  4JNF A;  3DPQ A;  4EZY A;  3OHX M;  4WV5 A;  4EZW A;  3D2F A;  4PO2 A;  3DPP A;  4JWC A;  4R5L A;  4R5K A;  1DKY A;  4F00 A;  1YUW A;  4FL9 A;  5TKY A;  4WV7 A;  3DOB A;  2KHO A;  2WIN M;  4JWD A;  1U00 A;  4EZR A;  1DG4 A;  1Q5L A;  1CKR A;  4R5I A;  4JWE A;  4F01 A;  4H6I A;  3C7N A;  3N8E A;  4EZZ A;  2QFF A;  5E84 A;  3T49 A;  4HYB A;  4JN4 A;  1DKX A;  4EZO A;  7HSC A;  4E81 A;  4EZV A;  3DQG A;  4EZU A;  4HY9 A;  4EZP A;  4R5G A;  3H0X A;  4EZX A;  4EZT A;  4EZQ A;  4R5J A;  3T4A G;  3L3O M;  4B9Q A;  3DPO A;  4H6H A;  4JNE A;  3T46 A;  1BPR A;  2BPR A;  4EZN A;  1DKZ A;  4EZS A;  2QXL A;  4JWI A;  3D2E A;  3T47 A;  2V7Y A;  3T48 A;  3C7N B; 
#chains in the Genus database with same CATH topology
 1LQ7 A;  4ILI A;  4FL9 A;  2Q13 A;  4EZR A;  3DX2 A;  3SOG A;  2RAJ A;  4EZP A;  2YI9 A;  4NSW A;  3EJP A;  2D4C A;  3EJS A;  2V0O A;  4IM0 A;  4IM3 A;  4EZY A;  2JNS A;  1YUW A;  3O3M B;  3CVR A;  4EZZ A;  2D1L A;  4JLC A;  1DKX A;  3DDG A;  4EZQ A;  1W9M A;  2LXY A;  3VKH A;  2GF4 A;  4ILH B;  1E1D A;  2Q12 A;  4UDX X;  3SYV A;  3T49 A;  4JN4 A;  4I1Q A;  2GAF D;  4AZH A;  1HXK A;  3CZS A;  2N3K A;  2F7Q A;  2FIC A;  1GNL A;  4JWD A;  2OO2 A;  5E84 A;  2OBM A;  2YLL A;  5C5B A;  4B9Q A;  1R33 A;  4BNE A;  4EZW A;  4R5K A;  4R5L A;  3BUD A;  2ALW A;  2WYI A;  3EJR A;  3SBS A;  3KDR A;  3UIT A;  3BUB A;  3HAI A;  3Q0K A;  2YIV X;  3LMF A;  2X5C A;  4UDY X;  3CKD A;  5KBP A;  2Z8Y A;  4IWP A;  3CV5 A;  4IWQ A;  1OAO A;  3OWG A;  2RT6 A;  4FZO A;  1GNT A;  7HSC A;  3I2W A;  4EZX A;  1OA1 A;  3Q84 A;  4EZN A;  1TQT A;  3BVW A;  2O0I 1;  2NCZ A;  5C5B B;  4G6Q A;  3VEA A;  1DKY A;  2QKW A;  4AVM A;  4DYL A;  2WIN M;  4R5I A;  3C7N A;  2YLA A;  5FLE X;  3D51 A;  2F1B A;  2ZXQ A;  2EWF A;  3ABH A;  3FD9 A;  3ER9 B;  4ATM A;  2YIA A;  4AZI A;  2YL9 A;  4AZ6 A;  3RV0 A;  4F00 A;  4WV7 A;  4KIK A;  2KHO A;  3F7W A;  4HR1 A;  4E3C A;  1PS3 A;  4AZC A;  2F7R A;  1I4T A;  1R34 A;  4FZS A;  2OZN B;  4JNE A;  2EFK A;  3DPQ A;  2EFL A;  3LVT A;  3I04 A;  3SBT B;  1SU8 A;  3D4Y A;  1U00 A;  1DG4 A;  4F01 A;  4AZ5 A;  2EX3 B;  2F1A A;  3BVT A;  1TQW A;  4MQD A;  3T4A G;  2BPR A;  3RV1 A;  3DX3 A;  3RPM A;  4NQI A;  4EZO A;  2F18 A;  2Z0N A;  3QNJ A;  3OHX M;  1GN9 A;  2X3X A;  3D2F A;  3DX1 A;  3QWE A;  4M0M A;  4FZP A;  4JWE A;  3N8E A;  1R5E A;  3D4Z A;  3BUQ A;  3BVV A;  3QA8 A;  2OW7 A;  1JQK A;  1DKZ A;  3QNI A;  2ND1 A;  4AZC B;  3I01 A;  4AZG A;  3DDF A;  3DX4 A;  3QE6 A;  3BVX A;  3PLT A;  1URU A;  1ZYL A;  4I43 A;  3B51 X;  2QFF A;  3HAH A;  2WYH A;  1QX1 A;  2GA9 D;  3VEB A;  1BPR A;  3O3O B;  2RAI A;  1HWW A;  1OA0 A;  2PMR A;  1I49 A;  3D52 A;  4IW0 A;  4WV5 A;  1E2U A;  3BLB A;  3DPP A;  3DYT A;  3B52 X;  4AZB A;  3ERC C;  3LLL A;  4ILG A;  4NPH A;  3DQG A;  3OK8 A;  4R5G A;  3I39 X;  2PY6 A;  3L3O M;  1SU6 A;  4JL9 A;  4EZS A;  2V7Y A;  3T48 A;  4JNF A;  4DCN C;  1I4D A;  3ACO A;  5TKY A;  4WPC A;  3ZED A;  3DOB A;  3ZEF A;  1X04 A;  4E81 A;  5FIG A;  3H0X A;  3EJT A;  3D50 A;  2X3W A;  4D8J A;  2Z0O A;  4H6H A;  1Y2O A;  3T46 A;  3BUI A;  2JNK A;  2QXL A;  4JWI A;  2RAK A;  3L3P A;  4FM3 A;  4JWC A;  1SUF A;  4IWO A;  2Z0V A;  1CKR A;  1I4L A;  4H6I A;  4H8S A;  4EZU A;  4R5J A;  1O7D C;  3DPO A;  2YI8 A;  1UPX A;  3EJQ A;  2X3V A;  3G9G A;  1YWM A;  3T47 A;  3C7N B;  1X03 A;  3A98 A;  2FYV A;  4IM2 A;  2F7P A;  2YL8 A;  2YL5 A;  2YIB A;  1HTY A;  3BVU A;  2YL6 A;  2LM0 A;  2MI7 A;  4AZ7 A;  4KIK B;  3EJU A;  2ND0 A;  2ELB A;  4HR1 B;  2OP6 A;  3CZN A;  4PO2 A;  2OBL A;  1WDZ A;  2C08 A;  1QWN A;  3KAW A;  1TQS A;  3ER8 C;  1SU7 A;  3B53 X;  2F7O A;  4AKV A;  1O7D B;  1Q5L A;  2YKT A;  3M3W A;  3HAJ A;  1TQU A;  2OW6 A;  4HYB A;  3KAV A;  4EZV A;  4WPE A;  4HY9 A;  4EZT A;  1MJG A;  1QWU A;  1TQV A;  1E9V A;  1ZWW A;  3CAZ A;  3O3N B;  3DX0 A;  3D2E A;  3GI7 A;  3BUP A; 
#chains in the Genus database with same CATH homology
 4JNF A;  3DPQ A;  4EZW A;  4R5K A;  4R5L A;  4ILI A;  3I04 A;  4FL9 A;  3SBT B;  5TKY A;  1SU8 A;  3ZED A;  3DOB A;  1U00 A;  4EZR A;  1DG4 A;  3SBS A;  4F01 A;  3ZEF A;  3KDR A;  3UIT A;  2EX3 B;  4E81 A;  5FIG A;  4EZP A;  4MQD A;  2YI9 A;  3H0X A;  3T4A G;  4D8J A;  4H6H A;  3T46 A;  2BPR A;  3RV1 A;  2QXL A;  4JWI A;  2YIV X;  4IM0 A;  3LMF A;  4IM3 A;  2X5C A;  4EZO A;  4FM3 A;  4UDY X;  3QNJ A;  4EZY A;  2JNS A;  2Z8Y A;  3OHX M;  4IWP A;  1GN9 A;  3D2F A;  4JWC A;  1YUW A;  1SUF A;  4IWQ A;  4IWO A;  4M0M A;  1OAO A;  3O3M B;  3OWG A;  2RT6 A;  1CKR A;  4JWE A;  4H6I A;  3N8E A;  1GNT A;  4EZZ A;  4JLC A;  1DKX A;  7HSC A;  4EZU A;  3QA8 A;  4EZX A;  1OA1 A;  4EZQ A;  4R5J A;  1W9M A;  1JQK A;  3DPO A;  2YI8 A;  1UPX A;  4EZN A;  1DKZ A;  3T47 A;  3C7N B;  2ND1 A;  2NCZ A;  3VKH A;  3A98 A;  3I01 A;  4G6Q A;  3VEA A;  4ILH B;  1DKY A;  4IM2 A;  1E1D A;  2WIN M;  4R5I A;  1ZYL A;  2YIB A;  3C7N A;  4I43 A;  3B51 X;  4UDX X;  2QFF A;  3T49 A;  4JN4 A;  5FLE X;  2LM0 A;  2GA9 D;  4KIK B;  3VEB A;  1BPR A;  3O3O B;  2GAF D;  2ND0 A;  2EWF A;  3FD9 A;  4HR1 B;  1OA0 A;  3ER9 B;  2OP6 A;  2YIA A;  2N3K A;  4IW0 A;  1E2U A;  4PO2 A;  2OBL A;  3DPP A;  4WV5 A;  3RV0 A;  3KAW A;  4F00 A;  3B52 X;  3ERC C;  3ER8 C;  4WV7 A;  1SU7 A;  4KIK A;  3B53 X;  1GNL A;  2KHO A;  4JWD A;  3F7W A;  1Q5L A;  4HR1 A;  4ILG A;  4NPH A;  5E84 A;  4E3C A;  4HYB A;  3KAV A;  4EZV A;  3DQG A;  4HY9 A;  2OBM A;  3I39 X;  4R5G A;  4EZT A;  1MJG A;  2PY6 A;  3L3O M;  4B9Q A;  1E9V A;  1SU6 A;  4JNE A;  4JL9 A;  4EZS A;  3O3N B;  3D2E A;  2V7Y A;  3T48 A;  3GI7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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