1K8WA

Crystal structure of the e. coli pseudouridine synthase trub bound to a t stem-loop rna
Total Genus 90
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
90
sequence length
304
structure length
304
Chain Sequence
MDINGVLLLDKPQGMSSNDALQKVKRIYNANRAGHTGALDPLATGMLPICLGEATKFSQYLLDSDKRYRVIARLGQRTDTSDADGQIVEERPVTFSAEQLAAALDTFRGDIEQIPSMYSALKYQGKKLYEYARQGIEVPREARPITVYELLFIRHEGNELELEIHCSKGTYIRTIIDDLGEKLGCGAHVIYLRRLAVSKYPVERMVTLEHLRELVEQAEQQDIPAAELLDPLLMPMDSPASDYPVVNLPLTSSVYFKNGNPVRTSGAPLEGLVRVTEGENGKFIGMGEIDDEGRVAPRRLVVEY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Cocrystal structure of a tRNA Psi55 pseudouridine synthase: nucleotide flipping by an RNA-modifying enzyme.
pubmed doi rcsb
molecule tags Lyase/rna
source organism Escherichia coli
molecule keywords 5'-R(*GP*GP*CP*AP*AP*CP*GP*GP*UP*(FHU)P*CP*GP*AP*UP*CP*CP*CP
total genus 90
structure length 304
sequence length 304
ec nomenclature ec 5.4.99.25: tRNA pseudouridine(55) synthase.
pdb deposition date 2001-10-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01509 TruB_N TruB family pseudouridylate synthase (N terminal domain)
A PF09157 TruB-C_2 Pseudouridine synthase II TruB, C-terminal
A PF16198 TruB_C_2 tRNA pseudouridylate synthase B C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.130.10 Mainly Beta Roll Archaeosine Trna-guanine Transglycosylase; Chain: A, domain 4 PUA domain 1k8wA02
3.30.2350.10 Alpha Beta 2-Layer Sandwich Pseudouridine synthase Pseudouridine synthase 1k8wA01
3HAXA 2I82A 4Q1TA 2AUSA 3HJWA 2APOA 1R3EA 4LGTA 2CX1A 2B78A 1V9KA 1Q7HA 1PRZA 1ZE1A 3LWOA 3DH3A 1IT7A 3LWVA 2J5TA 1KSKA 1IT8A 1ZS7A 1K8WA 3HJYA 2AB4A 2RFKA 1ZL3A 1R3FA 2HVYA 3LWRA 3MQKA 3UAIA 4LABA 1SQWA 1KSVA 2CWWA 1WXWA 2EY4A 3D79A 1XPIA 3C0KA 1KSLA 2P38A 1V9FA 1SGVA 1T5YA 3U28A 3LWPA 3VSEA 1ZE2A 1QYUA 3LDFA 1J2BA 2AS0A 2ISTA 2J5VA 1IQ8A 4DMGA 1WXXA 2Q07A 3LWQA 2CX0A
chains in the Genus database with same CATH superfamily
2I82A 3M6UA 2J5TA 1KSKA 1ZS7A 1ZL3A 4CI3B 3MQKA 4CI2B 2CWWA 2EY4A 4TZ4C 3LJCA 1QYUA 1J2BA 1R3FA 2CX0A 3LWQA 1KSLA 1S04A 3HJWA 1WK2A 2KKUA 1V9KA 1K8WA 3HJYA 2AB4A 2DP9A 1XNEA 1UOYA 2E5OA 3C0KA 2P38A 1SGVA 3VSEA 3M6XA 2ISTA 4DMGA 1KSVA 1WXXA 2Q07A 4CI1B 3HAXA 3M6VA 4Q1TA 2AUSA 2B78A 1Q7HA 3DH3A 3ZV0C 1SB7A 1XPIA 1T5YA 3LWPA 2Z0TA 1ZE2A 3LDFA 1Z2ZA 2J5VA 2ANEA 1ZBOA 2APOA 2FRXA 1R3EA 4LGTA 2CX1A 3LWOA 1PRZA 1ZE1A 1IT7A 3LWVA 1IT8A 3M4XA 2RFKA 3IUWA 2HVYA 3LWRA 3UAIA 4LABA 1SZWA 1SI7A 1SQWA 3M65A 1WXWA 3D79A 1V9FA 3U28A 1TE7A 2AS0A 1IQ8A 3M6WA
chains in the Genus database with same CATH topology
3HAXA 2I82A 4Q1TA 2AUSA 3HJWA 2APOA 1R3EA 4LGTA 2CX1A 2B78A 1V9KA 1Q7HA 1PRZA 1ZE1A 3LWOA 3DH3A 1IT7A 3LWVA 2J5TA 1KSKA 1IT8A 1ZS7A 1K8WA 3HJYA 2AB4A 2RFKA 1ZL3A 1R3FA 2HVYA 3LWRA 3MQKA 3UAIA 4LABA 1SZWA 1SI7A 1SQWA 1SB7A 1KSVA 2CWWA 1WXWA 2EY4A 3D79A 1XPIA 3C0KA 1KSLA 2P38A 1V9FA 1SGVA 1T5YA 3U28A 3LWPA 3VSEA 1ZE2A 1QYUA 3LDFA 1J2BA 2AS0A 1Z2ZA 2J5VA 2ISTA 1IQ8A 4DMGA 1WXXA 2Q07A 3LWQA 2CX0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3HAX A;  2I82 A;  4Q1T A;  2AUS A;  3HJW A;  2APO A;  1R3E A;  4LGT A;  2CX1 A;  2B78 A;  1V9K A;  1Q7H A;  1PRZ A;  1ZE1 A;  3LWO A;  3DH3 A;  1IT7 A;  3LWV A;  2J5T A;  1KSK A;  1IT8 A;  1ZS7 A;  1K8W A;  3HJY A;  2AB4 A;  2RFK A;  1ZL3 A;  1R3F A;  2HVY A;  3LWR A;  3MQK A;  3UAI A;  4LAB A;  1SQW A;  1KSV A;  2CWW A;  1WXW A;  2EY4 A;  3D79 A;  1XPI A;  3C0K A;  1KSL A;  2P38 A;  1V9F A;  1SGV A;  1T5Y A;  3U28 A;  3LWP A;  3VSE A;  1ZE2 A;  1QYU A;  3LDF A;  1J2B A;  2AS0 A;  2IST A;  2J5V A;  1IQ8 A;  4DMG A;  1WXX A;  2Q07 A;  3LWQ A;  2CX0 A; 
#chains in the Genus database with same CATH topology
 2I82 A;  3M6U A;  2J5T A;  1KSK A;  1ZS7 A;  1ZL3 A;  4CI3 B;  3MQK A;  4CI2 B;  2CWW A;  2EY4 A;  4TZ4 C;  3LJC A;  1QYU A;  1J2B A;  1R3F A;  2CX0 A;  3LWQ A;  1KSL A;  1S04 A;  3HJW A;  1WK2 A;  2KKU A;  1V9K A;  1K8W A;  3HJY A;  2AB4 A;  2DP9 A;  1XNE A;  1UOY A;  2E5O A;  3C0K A;  2P38 A;  1SGV A;  3VSE A;  3M6X A;  2IST A;  4DMG A;  1KSV A;  1WXX A;  2Q07 A;  4CI1 B;  3HAX A;  3M6V A;  4Q1T A;  2AUS A;  2B78 A;  1Q7H A;  3DH3 A;  3ZV0 C;  1SB7 A;  1XPI A;  1T5Y A;  3LWP A;  2Z0T A;  1ZE2 A;  3LDF A;  1Z2Z A;  2J5V A;  2ANE A;  1ZBO A;  2APO A;  2FRX A;  1R3E A;  4LGT A;  2CX1 A;  3LWO A;  1PRZ A;  1ZE1 A;  1IT7 A;  3LWV A;  1IT8 A;  3M4X A;  2RFK A;  3IUW A;  2HVY A;  3LWR A;  3UAI A;  4LAB A;  1SZW A;  1SI7 A;  1SQW A;  3M65 A;  1WXW A;  3D79 A;  1V9F A;  3U28 A;  1TE7 A;  2AS0 A;  1IQ8 A;  3M6W A; 
#chains in the Genus database with same CATH homology
 3HAX A;  2I82 A;  4Q1T A;  2AUS A;  3HJW A;  2APO A;  1R3E A;  4LGT A;  2CX1 A;  2B78 A;  1V9K A;  1Q7H A;  1PRZ A;  1ZE1 A;  3LWO A;  3DH3 A;  1IT7 A;  3LWV A;  2J5T A;  1KSK A;  1IT8 A;  1ZS7 A;  1K8W A;  3HJY A;  2AB4 A;  2RFK A;  1ZL3 A;  1R3F A;  2HVY A;  3LWR A;  3MQK A;  3UAI A;  4LAB A;  1SZW A;  1SI7 A;  1SQW A;  1SB7 A;  1KSV A;  2CWW A;  1WXW A;  2EY4 A;  3D79 A;  1XPI A;  3C0K A;  1KSL A;  2P38 A;  1V9F A;  1SGV A;  1T5Y A;  3U28 A;  3LWP A;  3VSE A;  1ZE2 A;  1QYU A;  3LDF A;  1J2B A;  2AS0 A;  1Z2Z A;  2J5V A;  2IST A;  1IQ8 A;  4DMG A;  1WXX A;  2Q07 A;  3LWQ A;  2CX0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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