1K8WA

Crystal structure of the e. coli pseudouridine synthase trub bound to a t stem-loop rna
Total Genus 90
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
90
sequence length
304
structure length
304
Chain Sequence
MDINGVLLLDKPQGMSSNDALQKVKRIYNANRAGHTGALDPLATGMLPICLGEATKFSQYLLDSDKRYRVIARLGQRTDTSDADGQIVEERPVTFSAEQLAAALDTFRGDIEQIPSMYSALKYQGKKLYEYARQGIEVPREARPITVYELLFIRHEGNELELEIHCSKGTYIRTIIDDLGEKLGCGAHVIYLRRLAVSKYPVERMVTLEHLRELVEQAEQQDIPAAELLDPLLMPMDSPASDYPVVNLPLTSSVYFKNGNPVRTSGAPLEGLVRVTEGENGKFIGMGEIDDEGRVAPRRLVVEY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Cocrystal structure of a tRNA Psi55 pseudouridine synthase: nucleotide flipping by an RNA-modifying enzyme.
pubmed doi rcsb
molecule tags Lyase/rna
source organism Escherichia coli
molecule keywords 5'-R(*GP*GP*CP*AP*AP*CP*GP*GP*UP*(FHU)P*CP*GP*AP*UP*CP*CP*CP
total genus 90
structure length 304
sequence length 304
ec nomenclature ec 5.4.99.25: tRNA pseudouridine(55) synthase.
pdb deposition date 2001-10-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01509 TruB_N TruB family pseudouridylate synthase (N terminal domain)
A PF09157 TruB-C_2 Pseudouridine synthase II TruB, C-terminal
A PF16198 TruB_C_2 tRNA pseudouridylate synthase B C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.130.10 Mainly Beta Roll Archaeosine Trna-guanine Transglycosylase; Chain: A, domain 4 PUA domain 1k8wA02
3.30.2350.10 Alpha Beta 2-Layer Sandwich Pseudouridine synthase Pseudouridine synthase 1k8wA01
2AS0A 4Q1TA 2AUSA 1IQ8A 4LABA 3DH3A 3U28A 3D79A 1QYUA 3VSEA 1KSLA 2I82A 1V9KA 3MQKA 1V9FA 2EY4A 3HAXA 2ISTA 2P38A 3LWQA 1K8WA 3LWRA 2B78A 1KSKA 3HJYA 2Q07A 1XPIA 1SGVA 3HJWA 2J5VA 2CX1A 1ZE1A 3UAIA 1R3EA 1WXWA 1ZL3A 2APOA 2CX0A 2AB4A 4LGTA 3LWOA 1J2BA 1ZE2A 1R3FA 1PRZA 3LDFA 1T5YA 1WXXA 2RFKA 2HVYA 1KSVA 2CWWA 1IT8A 4DMGA 3C0KA 1SQWA 1IT7A 3LWVA 1Q7HA 1ZS7A 2J5TA 3LWPA
chains in the Genus database with same CATH superfamily
1IQ8A 2ANEA 1QYUA 2I82A 1V9KA 2FRXA 3LWRA 1K8WA 2Q07A 1XPIA 1ZL3A 3M6UA 1SZWA 1J2BA 1WXXA 2E5OA 3IUWA 2RFKA 2HVYA 1ZBOA 1KSVA 1IT8A 3M6XA 3C0KA 3LWVA 4CI2B 1Q7HA 3LJCA 3LWPA 1SB7A 3U28A 2KKUA 3HAXA 2P38A 2B78A 3HJWA 3M6VA 2CX0A 2AB4A 3LWOA 4LGTA 1ZE2A 1PRZA 1Z2ZA 1ZS7A 2J5TA 1TE7A 4Q1TA 3DH3A 4LABA 3VSEA 1KSLA 3MQKA 1V9FA 1UOYA 2EY4A 2ISTA 3HJYA 4CI3B 1SGVA 2CX1A 1R3EA 2APOA 1S04A 3ZV0C 1T5YA 3M4XA 4DMGA 1IT7A 4TZ4C 2AS0A 2AUSA 3D79A 4CI1B 1WK2A 3LWQA 1KSKA 1SI7A 2J5VA 1ZE1A 3UAIA 1WXWA 2DP9A 1XNEA 1R3FA 3LDFA 2Z0TA 2CWWA 1SQWA 3M65A 3M6WA
chains in the Genus database with same CATH topology
2AS0A 4Q1TA 1SB7A 1IQ8A 2AUSA 4LABA 3DH3A 3U28A 3D79A 1QYUA 3VSEA 1KSLA 2I82A 1V9KA 3MQKA 1V9FA 2EY4A 3HAXA 2ISTA 2P38A 3LWQA 1K8WA 3LWRA 2B78A 1KSKA 3HJYA 2Q07A 1XPIA 1SI7A 1SGVA 3HJWA 2J5VA 2CX1A 1ZE1A 3UAIA 1R3EA 1WXWA 1ZL3A 2APOA 2CX0A 2AB4A 4LGTA 3LWOA 1SZWA 1J2BA 1ZE2A 1R3FA 1PRZA 3LDFA 1T5YA 1WXXA 2RFKA 2HVYA 1KSVA 2CWWA 1IT8A 4DMGA 3C0KA 1SQWA 1IT7A 3LWVA 1Z2ZA 1Q7HA 1ZS7A 2J5TA 3LWPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2AS0 A;  4Q1T A;  2AUS A;  1IQ8 A;  4LAB A;  3DH3 A;  3U28 A;  3D79 A;  1QYU A;  3VSE A;  1KSL A;  2I82 A;  1V9K A;  3MQK A;  1V9F A;  2EY4 A;  3HAX A;  2IST A;  2P38 A;  3LWQ A;  1K8W A;  3LWR A;  2B78 A;  1KSK A;  3HJY A;  2Q07 A;  1XPI A;  1SGV A;  3HJW A;  2J5V A;  2CX1 A;  1ZE1 A;  3UAI A;  1R3E A;  1WXW A;  1ZL3 A;  2APO A;  2CX0 A;  2AB4 A;  4LGT A;  3LWO A;  1J2B A;  1ZE2 A;  1R3F A;  1PRZ A;  3LDF A;  1T5Y A;  1WXX A;  2RFK A;  2HVY A;  1KSV A;  2CWW A;  1IT8 A;  4DMG A;  3C0K A;  1SQW A;  1IT7 A;  3LWV A;  1Q7H A;  1ZS7 A;  2J5T A;  3LWP A; 
#chains in the Genus database with same CATH topology
 1IQ8 A;  2ANE A;  1QYU A;  2I82 A;  1V9K A;  2FRX A;  3LWR A;  1K8W A;  2Q07 A;  1XPI A;  1ZL3 A;  3M6U A;  1SZW A;  1J2B A;  1WXX A;  2E5O A;  3IUW A;  2RFK A;  2HVY A;  1ZBO A;  1KSV A;  1IT8 A;  3M6X A;  3C0K A;  3LWV A;  4CI2 B;  1Q7H A;  3LJC A;  3LWP A;  1SB7 A;  3U28 A;  2KKU A;  3HAX A;  2P38 A;  2B78 A;  3HJW A;  3M6V A;  2CX0 A;  2AB4 A;  3LWO A;  4LGT A;  1ZE2 A;  1PRZ A;  1Z2Z A;  1ZS7 A;  2J5T A;  1TE7 A;  4Q1T A;  3DH3 A;  4LAB A;  3VSE A;  1KSL A;  3MQK A;  1V9F A;  1UOY A;  2EY4 A;  2IST A;  3HJY A;  4CI3 B;  1SGV A;  2CX1 A;  1R3E A;  2APO A;  1S04 A;  3ZV0 C;  1T5Y A;  3M4X A;  4DMG A;  1IT7 A;  4TZ4 C;  2AS0 A;  2AUS A;  3D79 A;  4CI1 B;  1WK2 A;  3LWQ A;  1KSK A;  1SI7 A;  2J5V A;  1ZE1 A;  3UAI A;  1WXW A;  2DP9 A;  1XNE A;  1R3F A;  3LDF A;  2Z0T A;  2CWW A;  1SQW A;  3M65 A;  3M6W A; 
#chains in the Genus database with same CATH homology
 2AS0 A;  4Q1T A;  1SB7 A;  1IQ8 A;  2AUS A;  4LAB A;  3DH3 A;  3U28 A;  3D79 A;  1QYU A;  3VSE A;  1KSL A;  2I82 A;  1V9K A;  3MQK A;  1V9F A;  2EY4 A;  3HAX A;  2IST A;  2P38 A;  3LWQ A;  1K8W A;  3LWR A;  2B78 A;  1KSK A;  3HJY A;  2Q07 A;  1XPI A;  1SI7 A;  1SGV A;  3HJW A;  2J5V A;  2CX1 A;  1ZE1 A;  3UAI A;  1R3E A;  1WXW A;  1ZL3 A;  2APO A;  2CX0 A;  2AB4 A;  4LGT A;  3LWO A;  1SZW A;  1J2B A;  1ZE2 A;  1R3F A;  1PRZ A;  3LDF A;  1T5Y A;  1WXX A;  2RFK A;  2HVY A;  1KSV A;  2CWW A;  1IT8 A;  4DMG A;  3C0K A;  1SQW A;  1IT7 A;  3LWV A;  1Z2Z A;  1Q7H A;  1ZS7 A;  2J5T A;  3LWP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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