1ZL3A

Coupling of active site motions and rna binding
Total Genus 80
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
80
sequence length
302
structure length
302
Chain Sequence
MDINGVLLLDKPQGMSSNDALQKVKRIYNANRAGHTGALNPLATGMLPICLGEATKFSQYLLDSDKRYRVIARLGQRTDTSDADGQIVEERPVTFSAEQLAAALDTFRGDIEQIPSMYSALKYQGKKLYEYARQGIEVPREARPITVYELLFIRHEGNELELEIHCSKGTYIRTIIDDLGEKLGCGAHVIYLRRLAVSKYPVERMVTLEHLRELVEQAEQQDIPAAELLDPLLMPMDSPASDYPVVNLPLTSSVYFKNGNPVRTSGAPLEGLVRVTEGENGKFIGMGEIDDEGRVAPRRLVV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Precursor complex structure of pseudouridine synthase TruB suggests coupling of active site perturbations to an RNA-sequestering peripheral protein domain
pubmed doi rcsb
molecule tags Lyase/rna
source organism Escherichia coli
molecule keywords 5'-R(*GP*GP*CP*AP*AP*CP*GP*GP*UP*(FLO) UP*CP*GP*AP*UP*CP*CP*
total genus 80
structure length 302
sequence length 302
ec nomenclature ec 5.4.99.25: tRNA pseudouridine(55) synthase.
pdb deposition date 2005-05-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01509 TruB_N TruB family pseudouridylate synthase (N terminal domain)
A PF09157 TruB-C_2 Pseudouridine synthase II TruB, C-terminal
A PF16198 TruB_C_2 tRNA pseudouridylate synthase B C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.130.10 Mainly Beta Roll Archaeosine Trna-guanine Transglycosylase; Chain: A, domain 4 PUA domain 1zl3A02
3.30.2350.10 Alpha Beta 2-Layer Sandwich Pseudouridine synthase Pseudouridine synthase 1zl3A01
2AB4A 3VSEA 1V9KA 3C0KA 1QYUA 1Q7HA 1KSLA 1IT8A 2P38A 1KSVA 2APOA 3HJWA 2EY4A 1ZE1A 4DMGA 1J2BA 1IQ8A 2CWWA 1T5YA 1KSKA 3U28A 1R3EA 1ZE2A 1K8WA 3MQKA 3HAXA 1R3FA 2CX0A 1IT7A 4LGTA 1V9FA 1SQWA 2CX1A 3LWQA 2ISTA 1WXWA 1ZS7A 2I82A 3LDFA 2HVYA 3UAIA 3LWPA 1WXXA 3D79A 3LWVA 4Q1TA 2AS0A 1PRZA 4LABA 1SGVA 2J5TA 3LWRA 2J5VA 2RFKA 3HJYA 2Q07A 2B78A 1ZL3A 3LWOA 1XPIA 2AUSA 3DH3A
chains in the Genus database with same CATH superfamily
1UOYA 3LJCA 3HJWA 4CI2B 1J2BA 1IQ8A 3U28A 1R3EA 1K8WA 2ANEA 1R3FA 2CX0A 2KKUA 3LWQA 2ISTA 1SZWA 1SI7A 3LWVA 3ZV0C 4LABA 3LWOA 2P38A 1KSVA 3M4XA 2FRXA 2EY4A 2Z0TA 1ZE1A 1ZBOA 4DMGA 2CWWA 3MQKA 3HAXA 1V9FA 1WXWA 4TZ4C 1WXXA 4Q1TA 1SB7A 2AS0A 3LWRA 1SGVA 3HJYA 1WK2A 2Q07A 1Z2ZA 2DP9A 1XPIA 2AB4A 3VSEA 1QYUA 1KSLA 1IT8A 2APOA 2E5OA 3M65A 1IT7A 4LGTA 1SQWA 2CX1A 1TE7A 3M6WA 2HVYA 3UAIA 3D79A 3M6UA 2RFKA 3M6VA 2B78A 1ZL3A 3M6XA 1V9KA 3C0KA 1Q7HA 4CI1B 1KSKA 1T5YA 3IUWA 1XNEA 1ZE2A 1ZS7A 2I82A 3LDFA 3LWPA 1PRZA 1S04A 2J5TA 4CI3B 2J5VA 2AUSA 3DH3A
chains in the Genus database with same CATH topology
2AB4A 3VSEA 1V9KA 3C0KA 1QYUA 1Q7HA 1KSLA 1IT8A 2P38A 1KSVA 2APOA 3HJWA 2EY4A 1ZE1A 4DMGA 1J2BA 1IQ8A 2CWWA 1T5YA 1KSKA 3U28A 1R3EA 1ZE2A 1K8WA 3MQKA 3HAXA 1R3FA 2CX0A 1IT7A 4LGTA 1V9FA 1SQWA 2CX1A 3LWQA 2ISTA 1WXWA 1ZS7A 2I82A 3LDFA 2HVYA 3UAIA 1SZWA 3LWPA 1WXXA 1SI7A 3D79A 3LWVA 4Q1TA 1SB7A 2AS0A 1PRZA 4LABA 1SGVA 2J5TA 3LWRA 2J5VA 2RFKA 3HJYA 2Q07A 2B78A 1ZL3A 3LWOA 1Z2ZA 1XPIA 2AUSA 3DH3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2AB4 A;  3VSE A;  1V9K A;  3C0K A;  1QYU A;  1Q7H A;  1KSL A;  1IT8 A;  2P38 A;  1KSV A;  2APO A;  3HJW A;  2EY4 A;  1ZE1 A;  4DMG A;  1J2B A;  1IQ8 A;  2CWW A;  1T5Y A;  1KSK A;  3U28 A;  1R3E A;  1ZE2 A;  1K8W A;  3MQK A;  3HAX A;  1R3F A;  2CX0 A;  1IT7 A;  4LGT A;  1V9F A;  1SQW A;  2CX1 A;  3LWQ A;  2IST A;  1WXW A;  1ZS7 A;  2I82 A;  3LDF A;  2HVY A;  3UAI A;  3LWP A;  1WXX A;  3D79 A;  3LWV A;  4Q1T A;  2AS0 A;  1PRZ A;  4LAB A;  1SGV A;  2J5T A;  3LWR A;  2J5V A;  2RFK A;  3HJY A;  2Q07 A;  2B78 A;  1ZL3 A;  3LWO A;  1XPI A;  2AUS A;  3DH3 A; 
#chains in the Genus database with same CATH topology
 1UOY A;  3LJC A;  3HJW A;  4CI2 B;  1J2B A;  1IQ8 A;  3U28 A;  1R3E A;  1K8W A;  2ANE A;  1R3F A;  2CX0 A;  2KKU A;  3LWQ A;  2IST A;  1SZW A;  1SI7 A;  3LWV A;  3ZV0 C;  4LAB A;  3LWO A;  2P38 A;  1KSV A;  3M4X A;  2FRX A;  2EY4 A;  2Z0T A;  1ZE1 A;  1ZBO A;  4DMG A;  2CWW A;  3MQK A;  3HAX A;  1V9F A;  1WXW A;  4TZ4 C;  1WXX A;  4Q1T A;  1SB7 A;  2AS0 A;  3LWR A;  1SGV A;  3HJY A;  1WK2 A;  2Q07 A;  1Z2Z A;  2DP9 A;  1XPI A;  2AB4 A;  3VSE A;  1QYU A;  1KSL A;  1IT8 A;  2APO A;  2E5O A;  3M65 A;  1IT7 A;  4LGT A;  1SQW A;  2CX1 A;  1TE7 A;  3M6W A;  2HVY A;  3UAI A;  3D79 A;  3M6U A;  2RFK A;  3M6V A;  2B78 A;  1ZL3 A;  3M6X A;  1V9K A;  3C0K A;  1Q7H A;  4CI1 B;  1KSK A;  1T5Y A;  3IUW A;  1XNE A;  1ZE2 A;  1ZS7 A;  2I82 A;  3LDF A;  3LWP A;  1PRZ A;  1S04 A;  2J5T A;  4CI3 B;  2J5V A;  2AUS A;  3DH3 A; 
#chains in the Genus database with same CATH homology
 2AB4 A;  3VSE A;  1V9K A;  3C0K A;  1QYU A;  1Q7H A;  1KSL A;  1IT8 A;  2P38 A;  1KSV A;  2APO A;  3HJW A;  2EY4 A;  1ZE1 A;  4DMG A;  1J2B A;  1IQ8 A;  2CWW A;  1T5Y A;  1KSK A;  3U28 A;  1R3E A;  1ZE2 A;  1K8W A;  3MQK A;  3HAX A;  1R3F A;  2CX0 A;  1IT7 A;  4LGT A;  1V9F A;  1SQW A;  2CX1 A;  3LWQ A;  2IST A;  1WXW A;  1ZS7 A;  2I82 A;  3LDF A;  2HVY A;  3UAI A;  1SZW A;  3LWP A;  1WXX A;  1SI7 A;  3D79 A;  3LWV A;  4Q1T A;  1SB7 A;  2AS0 A;  1PRZ A;  4LAB A;  1SGV A;  2J5T A;  3LWR A;  2J5V A;  2RFK A;  3HJY A;  2Q07 A;  2B78 A;  1ZL3 A;  3LWO A;  1Z2Z A;  1XPI A;  2AUS A;  3DH3 A; 
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