1ZL3A

Coupling of active site motions and rna binding
Total Genus 80
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
80
sequence length
302
structure length
302
Chain Sequence
MDINGVLLLDKPQGMSSNDALQKVKRIYNANRAGHTGALNPLATGMLPICLGEATKFSQYLLDSDKRYRVIARLGQRTDTSDADGQIVEERPVTFSAEQLAAALDTFRGDIEQIPSMYSALKYQGKKLYEYARQGIEVPREARPITVYELLFIRHEGNELELEIHCSKGTYIRTIIDDLGEKLGCGAHVIYLRRLAVSKYPVERMVTLEHLRELVEQAEQQDIPAAELLDPLLMPMDSPASDYPVVNLPLTSSVYFKNGNPVRTSGAPLEGLVRVTEGENGKFIGMGEIDDEGRVAPRRLVV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Precursor complex structure of pseudouridine synthase TruB suggests coupling of active site perturbations to an RNA-sequestering peripheral protein domain
pubmed doi rcsb
molecule tags Lyase/rna
source organism Escherichia coli
molecule keywords 5'-R(*GP*GP*CP*AP*AP*CP*GP*GP*UP*(FLO) UP*CP*GP*AP*UP*CP*CP*
total genus 80
structure length 302
sequence length 302
ec nomenclature ec 5.4.99.25: tRNA pseudouridine(55) synthase.
pdb deposition date 2005-05-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01509 TruB_N TruB family pseudouridylate synthase (N terminal domain)
A PF09157 TruB-C_2 Pseudouridine synthase II TruB, C-terminal
A PF16198 TruB_C_2 tRNA pseudouridylate synthase B C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.130.10 Mainly Beta Roll Archaeosine Trna-guanine Transglycosylase; Chain: A, domain 4 PUA domain 1zl3A02
3.30.2350.10 Alpha Beta 2-Layer Sandwich Pseudouridine synthase Pseudouridine synthase 1zl3A01
1KSLA 3HJYA 3MQKA 3C0KA 1IT7A 1QYUA 3DH3A 1ZE2A 1KSVA 3LDFA 2CX1A 4LABA 2AS0A 2AB4A 1SGVA 1R3EA 1WXXA 1IT8A 2ISTA 2J5TA 3LWQA 3LWOA 3HAXA 2AUSA 1WXWA 1PRZA 3LWVA 2HVYA 3HJWA 2B78A 1V9FA 2RFKA 1SQWA 1IQ8A 4DMGA 1J2BA 1XPIA 2I82A 2J5VA 1R3FA 4LGTA 1V9KA 3VSEA 2EY4A 1ZL3A 3D79A 3U28A 1ZS7A 2P38A 3UAIA 2APOA 1K8WA 1T5YA 3LWRA 1ZE1A 4Q1TA 3LWPA 1KSKA 2CX0A 1Q7HA 2Q07A 2CWWA
chains in the Genus database with same CATH superfamily
1IT7A 1QYUA 2CX1A 2ISTA 3LWVA 1PRZA 1SQWA 1IQ8A 4TZ4C 3VSEA 4CI3B 1ZL3A 3D79A 3IUWA 1ZBOA 2AB4A 3HJYA 1S04A 2CWWA 3C0KA 1ZE2A 1Z2ZA 3M6WA 1SGVA 1IT8A 2J5TA 2DP9A 1SZWA 2FRXA 2I82A 1R3FA 4LGTA 1V9KA 3M6UA 1SI7A 3U28A 2ANEA 2P38A 1UOYA 3LWRA 1T5YA 2Z0TA 1KSKA 1Q7HA 4CI2B 2Q07A 1KSLA 3DH3A 3M65A 4LABA 2AS0A 3HAXA 1WXWA 3HJWA 1J2BA 2KKUA 1XPIA 2J5VA 3LJCA 3M4XA 3M6VA 1SB7A 2EY4A 3UAIA 3ZV0C 1WK2A 2APOA 1ZE1A 4Q1TA 4CI1B 3MQKA 1KSVA 3LDFA 1R3EA 1WXXA 3LWQA 3LWOA 2AUSA 2E5OA 2HVYA 2B78A 2RFKA 1V9FA 4DMGA 1ZS7A 1XNEA 1K8WA 3LWPA 2CX0A 3M6XA 1TE7A
chains in the Genus database with same CATH topology
1KSLA 3HJYA 3MQKA 3C0KA 1IT7A 1QYUA 3DH3A 1ZE2A 1Z2ZA 1KSVA 3LDFA 2CX1A 4LABA 2AS0A 2AB4A 1SGVA 1R3EA 1WXXA 1IT8A 2ISTA 2J5TA 3LWQA 3LWOA 3HAXA 2AUSA 1WXWA 1PRZA 3LWVA 2HVYA 3HJWA 2B78A 1SZWA 1V9FA 2RFKA 1SQWA 1IQ8A 4DMGA 1J2BA 1XPIA 2I82A 2J5VA 1R3FA 4LGTA 1V9KA 3VSEA 1SB7A 1SI7A 2EY4A 1ZL3A 3D79A 3U28A 1ZS7A 2P38A 3UAIA 2APOA 1K8WA 1T5YA 3LWRA 1ZE1A 4Q1TA 3LWPA 1KSKA 2CX0A 1Q7HA 2Q07A 2CWWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1KSL A;  3HJY A;  3MQK A;  3C0K A;  1IT7 A;  1QYU A;  3DH3 A;  1ZE2 A;  1KSV A;  3LDF A;  2CX1 A;  4LAB A;  2AS0 A;  2AB4 A;  1SGV A;  1R3E A;  1WXX A;  1IT8 A;  2IST A;  2J5T A;  3LWQ A;  3LWO A;  3HAX A;  2AUS A;  1WXW A;  1PRZ A;  3LWV A;  2HVY A;  3HJW A;  2B78 A;  1V9F A;  2RFK A;  1SQW A;  1IQ8 A;  4DMG A;  1J2B A;  1XPI A;  2I82 A;  2J5V A;  1R3F A;  4LGT A;  1V9K A;  3VSE A;  2EY4 A;  1ZL3 A;  3D79 A;  3U28 A;  1ZS7 A;  2P38 A;  3UAI A;  2APO A;  1K8W A;  1T5Y A;  3LWR A;  1ZE1 A;  4Q1T A;  3LWP A;  1KSK A;  2CX0 A;  1Q7H A;  2Q07 A;  2CWW A; 
#chains in the Genus database with same CATH topology
 1IT7 A;  1QYU A;  2CX1 A;  2IST A;  3LWV A;  1PRZ A;  1SQW A;  1IQ8 A;  4TZ4 C;  3VSE A;  4CI3 B;  1ZL3 A;  3D79 A;  3IUW A;  1ZBO A;  2AB4 A;  3HJY A;  1S04 A;  2CWW A;  3C0K A;  1ZE2 A;  1Z2Z A;  3M6W A;  1SGV A;  1IT8 A;  2J5T A;  2DP9 A;  1SZW A;  2FRX A;  2I82 A;  1R3F A;  4LGT A;  1V9K A;  3M6U A;  1SI7 A;  3U28 A;  2ANE A;  2P38 A;  1UOY A;  3LWR A;  1T5Y A;  2Z0T A;  1KSK A;  1Q7H A;  4CI2 B;  2Q07 A;  1KSL A;  3DH3 A;  3M65 A;  4LAB A;  2AS0 A;  3HAX A;  1WXW A;  3HJW A;  1J2B A;  2KKU A;  1XPI A;  2J5V A;  3LJC A;  3M4X A;  3M6V A;  1SB7 A;  2EY4 A;  3UAI A;  3ZV0 C;  1WK2 A;  2APO A;  1ZE1 A;  4Q1T A;  4CI1 B;  3MQK A;  1KSV A;  3LDF A;  1R3E A;  1WXX A;  3LWQ A;  3LWO A;  2AUS A;  2E5O A;  2HVY A;  2B78 A;  2RFK A;  1V9F A;  4DMG A;  1ZS7 A;  1XNE A;  1K8W A;  3LWP A;  2CX0 A;  3M6X A;  1TE7 A; 
#chains in the Genus database with same CATH homology
 1KSL A;  3HJY A;  3MQK A;  3C0K A;  1IT7 A;  1QYU A;  3DH3 A;  1ZE2 A;  1Z2Z A;  1KSV A;  3LDF A;  2CX1 A;  4LAB A;  2AS0 A;  2AB4 A;  1SGV A;  1R3E A;  1WXX A;  1IT8 A;  2IST A;  2J5T A;  3LWQ A;  3LWO A;  3HAX A;  2AUS A;  1WXW A;  1PRZ A;  3LWV A;  2HVY A;  3HJW A;  2B78 A;  1SZW A;  1V9F A;  2RFK A;  1SQW A;  1IQ8 A;  4DMG A;  1J2B A;  1XPI A;  2I82 A;  2J5V A;  1R3F A;  4LGT A;  1V9K A;  3VSE A;  1SB7 A;  1SI7 A;  2EY4 A;  1ZL3 A;  3D79 A;  3U28 A;  1ZS7 A;  2P38 A;  3UAI A;  2APO A;  1K8W A;  1T5Y A;  3LWR A;  1ZE1 A;  4Q1T A;  3LWP A;  1KSK A;  2CX0 A;  1Q7H A;  2Q07 A;  2CWW A; 
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