2AB4 | Genus

Total Genus 81

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	81
sequence length	308
structure length	300
Chain Sequence	MKHGILVAYKPKGPTSHDVVDEVRKKLKTRKVGHGGTLDPFACGVLIIGVNQGTRILEFYKDLKKVFWVKMRLGLITETFDITGEVVEERECNVTEEEIREAIFSFVGEYDQVPPAYSAKKYKGERLYKLAREGKIINLPPKRVKIFKIWDVNIEGRDVSFRVEVSPGTYIRSLCMDIGYKLGCGATAVELVRESVGPHTIEESLNVFEAAPEEIENRIIPLEKCLEWLPRVVVHQESTKMILNGSQIHLEMLKEWDGFKKGEVVRVFNEEGRLLALAEAERNSSFRQERVLTLRKVFQT

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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The Resolver thinks Pdb

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reading 300 atoms

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Isomerase/rna
source organism	Thermotoga maritima
publication title	Dissecting the roles of a strictly conserved tyrosine in substrate recognition and catalysis by pseudouridine 55 synthase. pubmed doi rcsb
molecule keywords	5'-R(CPCPAPCPGPGPUP(FHU)PCPGPAPAPUPCPCPGP*UP
total genus	81
structure length	300
sequence length	308
ec nomenclature	ec 5.4.99.25: tRNA pseudouridine(55) synthase.
pdb deposition date	2005-07-14

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF01472	PUA	PUA domain
A	PF01509	TruB_N	TruB family pseudouridylate synthase (N terminal domain)
A	PF16198	TruB_C_2	tRNA pseudouridylate synthase B C-terminal domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
2.30.130.10	Mainly Beta	Roll	Archaeosine Trna-guanine Transglycosylase; Chain: A, domain 4	PUA domain	2ab4A02
3.30.2350.10	Alpha Beta	2-Layer Sandwich	Pseudouridine synthase	Pseudouridine synthase	2ab4A01

1T5YA 3UAIA 1V9FA 1ZE1A 1QYUA 1WXXA 3C0KA 3LWQA 2CX0A 2J5TA 1XPIA 2AS0A 1Q7HA 1ZE2A 2AUSA 1IT8A 1K8WA 2P38A 2CWWA 2AB4A 3HJYA 2ISTA 4Q1TA 3MQKA 1IT7A 3HAXA 3LWPA 1J2BA 3LDFA 1ZS7A 3D79A 3U28A 1KSVA 2HVYA 1ZL3A 1WXWA 3LWVA 2APOA 3LWRA 1SGVA 2B78A 3VSEA 3LWOA 1R3FA 1SQWA 1V9KA 2I82A 1KSLA 1PRZA 4LGTA 2CX1A 2RFKA 2J5VA 2Q07A 2EY4A 4LABA 3DH3A 1R3EA 1IQ8A 3HJWA 4DMGA 1KSKA
chains in the Genus database with same CATH superfamily

1UOYA 1QYUA 3M6UA 2AS0A 1Q7HA 1SB7A 1ZE2A 3ZV0C 3HJYA 2ISTA 1J2BA 2HVYA 1KSVA 1WXWA 3LWRA 1SGVA 1SQWA 1PRZA 4LGTA 2RFKA 2Q07A 1R3EA 4DMGA 1WXXA 3M6WA 1XPIA 1Z2ZA 1IT8A 1K8WA 2AB4A 3MQKA 3HAXA 3M6VA 3M6XA 1SZWA 3IUWA 1V9KA 1S04A 2E5OA 2J5VA 1IQ8A 1SI7A 3UAIA 1ZE1A 3LWQA 2CX0A 2KKUA 1TE7A 2AUSA 1WK2A 1IT7A 3LWPA 3LDFA 3D79A 4CI1B 1ZL3A 3LWVA 2ANEA 3M65A 3M4XA 3VSEA 2I82A 1ZBOA 2EY4A 4LABA 3DH3A 1T5YA 1V9FA 3LJCA 3C0KA 2DP9A 2J5TA 2P38A 2CWWA 4CI3B 4Q1TA 1ZS7A 3U28A 2Z0TA 2APOA 2B78A 2FRXA 3LWOA 1R3FA 4TZ4C 4CI2B 1KSLA 2CX1A 1XNEA 3HJWA 1KSKA
chains in the Genus database with same CATH topology

1T5YA 3UAIA 1V9FA 1ZE1A 1QYUA 1WXXA 3C0KA 3LWQA 2CX0A 2J5TA 1XPIA 2AS0A 1Q7HA 1SB7A 1Z2ZA 1ZE2A 2AUSA 1IT8A 1K8WA 2P38A 2CWWA 2AB4A 3HJYA 2ISTA 4Q1TA 3MQKA 1IT7A 3HAXA 1SI7A 3LWPA 1J2BA 3LDFA 1ZS7A 3D79A 3U28A 1KSVA 2HVYA 1ZL3A 1WXWA 3LWVA 2APOA 3LWRA 1SGVA 2B78A 3VSEA 1SZWA 3LWOA 1R3FA 1SQWA 1V9KA 2I82A 1KSLA 1PRZA 4LGTA 2CX1A 2RFKA 2J5VA 2Q07A 2EY4A 4LABA 3DH3A 1R3EA 1IQ8A 3HJWA 4DMGA 1KSKA
chains in the Genus database with same CATH homology

#chains in the Genus database with same CATH superfamily
 1T5Y A;  3UAI A;  1V9F A;  1ZE1 A;  1QYU A;  1WXX A;  3C0K A;  3LWQ A;  2CX0 A;  2J5T A;  1XPI A;  2AS0 A;  1Q7H A;  1ZE2 A;  2AUS A;  1IT8 A;  1K8W A;  2P38 A;  2CWW A;  2AB4 A;  3HJY A;  2IST A;  4Q1T A;  3MQK A;  1IT7 A;  3HAX A;  3LWP A;  1J2B A;  3LDF A;  1ZS7 A;  3D79 A;  3U28 A;  1KSV A;  2HVY A;  1ZL3 A;  1WXW A;  3LWV A;  2APO A;  3LWR A;  1SGV A;  2B78 A;  3VSE A;  3LWO A;  1R3F A;  1SQW A;  1V9K A;  2I82 A;  1KSL A;  1PRZ A;  4LGT A;  2CX1 A;  2RFK A;  2J5V A;  2Q07 A;  2EY4 A;  4LAB A;  3DH3 A;  1R3E A;  1IQ8 A;  3HJW A;  4DMG A;  1KSK A; 
#chains in the Genus database with same CATH topology
 1UOY A;  1QYU A;  3M6U A;  2AS0 A;  1Q7H A;  1SB7 A;  1ZE2 A;  3ZV0 C;  3HJY A;  2IST A;  1J2B A;  2HVY A;  1KSV A;  1WXW A;  3LWR A;  1SGV A;  1SQW A;  1PRZ A;  4LGT A;  2RFK A;  2Q07 A;  1R3E A;  4DMG A;  1WXX A;  3M6W A;  1XPI A;  1Z2Z A;  1IT8 A;  1K8W A;  2AB4 A;  3MQK A;  3HAX A;  3M6V A;  3M6X A;  1SZW A;  3IUW A;  1V9K A;  1S04 A;  2E5O A;  2J5V A;  1IQ8 A;  1SI7 A;  3UAI A;  1ZE1 A;  3LWQ A;  2CX0 A;  2KKU A;  1TE7 A;  2AUS A;  1WK2 A;  1IT7 A;  3LWP A;  3LDF A;  3D79 A;  4CI1 B;  1ZL3 A;  3LWV A;  2ANE A;  3M65 A;  3M4X A;  3VSE A;  2I82 A;  1ZBO A;  2EY4 A;  4LAB A;  3DH3 A;  1T5Y A;  1V9F A;  3LJC A;  3C0K A;  2DP9 A;  2J5T A;  2P38 A;  2CWW A;  4CI3 B;  4Q1T A;  1ZS7 A;  3U28 A;  2Z0T A;  2APO A;  2B78 A;  2FRX A;  3LWO A;  1R3F A;  4TZ4 C;  4CI2 B;  1KSL A;  2CX1 A;  1XNE A;  3HJW A;  1KSK A; 
#chains in the Genus database with same CATH homology
 1T5Y A;  3UAI A;  1V9F A;  1ZE1 A;  1QYU A;  1WXX A;  3C0K A;  3LWQ A;  2CX0 A;  2J5T A;  1XPI A;  2AS0 A;  1Q7H A;  1SB7 A;  1Z2Z A;  1ZE2 A;  2AUS A;  1IT8 A;  1K8W A;  2P38 A;  2CWW A;  2AB4 A;  3HJY A;  2IST A;  4Q1T A;  3MQK A;  1IT7 A;  3HAX A;  1SI7 A;  3LWP A;  1J2B A;  3LDF A;  1ZS7 A;  3D79 A;  3U28 A;  1KSV A;  2HVY A;  1ZL3 A;  1WXW A;  3LWV A;  2APO A;  3LWR A;  1SGV A;  2B78 A;  3VSE A;  1SZW A;  3LWO A;  1R3F A;  1SQW A;  1V9K A;  2I82 A;  1KSL A;  1PRZ A;  4LGT A;  2CX1 A;  2RFK A;  2J5V A;  2Q07 A;  2EY4 A;  4LAB A;  3DH3 A;  1R3E A;  1IQ8 A;  3HJW A;  4DMG A;  1KSK A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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2AB4A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations