2AB4A

Dissecting the roles of a strictly conserved tyrosine in substrate recognition and catalysis by pseudouridine 55 synthase
Total Genus 81
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
81
sequence length
308
structure length
300
Chain Sequence
MKHGILVAYKPKGPTSHDVVDEVRKKLKTRKVGHGGTLDPFACGVLIIGVNQGTRILEFYKDLKKVFWVKMRLGLITETFDITGEVVEERECNVTEEEIREAIFSFVGEYDQVPPAYSAKKYKGERLYKLAREGKIINLPPKRVKIFKIWDVNIEGRDVSFRVEVSPGTYIRSLCMDIGYKLGCGATAVELVRESVGPHTIEESLNVFEAAPEEIENRIIPLEKCLEWLPRVVVHQESTKMILNGSQIHLEMLKEWDGFKKGEVVRVFNEEGRLLALAEAERNSSFRQERVLTLRKVFQT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Dissecting the roles of a strictly conserved tyrosine in substrate recognition and catalysis by pseudouridine 55 synthase.
pubmed doi rcsb
molecule tags Isomerase/rna
source organism Thermotoga maritima
molecule keywords 5'-R(*CP*CP*AP*CP*GP*GP*UP*(FHU)P*CP*GP*AP*AP*UP*CP*CP*GP*UP
total genus 81
structure length 300
sequence length 308
ec nomenclature ec 5.4.99.25: tRNA pseudouridine(55) synthase.
pdb deposition date 2005-07-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01472 PUA PUA domain
A PF01509 TruB_N TruB family pseudouridylate synthase (N terminal domain)
A PF16198 TruB_C_2 tRNA pseudouridylate synthase B C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.130.10 Mainly Beta Roll Archaeosine Trna-guanine Transglycosylase; Chain: A, domain 4 PUA domain 2ab4A02
3.30.2350.10 Alpha Beta 2-Layer Sandwich Pseudouridine synthase Pseudouridine synthase 2ab4A01
2I82A 1IQ8A 2CX0A 1WXXA 2J5VA 4DMGA 2RFKA 1KSLA 4LGTA 3MQKA 1V9FA 2APOA 3LWQA 1R3FA 2B78A 2P38A 3C0KA 1Q7HA 1SGVA 3LWRA 3DH3A 2ISTA 1ZE1A 4LABA 2HVYA 1ZS7A 2CX1A 3LWVA 1ZL3A 4Q1TA 1IT8A 1T5YA 3LDFA 3HJWA 2J5TA 2AS0A 3VSEA 1IT7A 3HAXA 1KSVA 2Q07A 1V9KA 3LWOA 1SQWA 1K8WA 2AUSA 2AB4A 2EY4A 1XPIA 3LWPA 1PRZA 1R3EA 3UAIA 1ZE2A 3U28A 1WXWA 3D79A 1QYUA 3HJYA 1KSKA 2CWWA 1J2BA
chains in the Genus database with same CATH superfamily
2I82A 1IQ8A 1WXXA 2APOA 2ISTA 1ZE1A 4TZ4C 1ZL3A 1T5YA 2AS0A 3VSEA 3HAXA 3M6XA 1XPIA 1XNEA 3D79A 1SI7A 2CWWA 2CX0A 1J2BA 3ZV0C 1SZWA 1TE7A 3M6WA 1R3FA 2B78A 2P38A 3C0KA 3IUWA 2HVYA 1IT7A 3LWOA 1UOYA 2AUSA 2EY4A 1R3EA 1WXWA 3HJYA 1KSKA 3M6UA 2DP9A 4CI2B 4DMGA 2RFKA 1V9FA 1Q7HA 3DH3A 2Z0TA 1SB7A 4LABA 1ZS7A 3LWVA 1ZBOA 4Q1TA 1IT8A 1Z2ZA 3HJWA 4CI1B 2Q07A 2AB4A 2ANEA 3UAIA 3U28A 1ZE2A 3M4XA 1QYUA 3M6VA 1S04A 2FRXA 2J5VA 2E5OA 1KSLA 4LGTA 3MQKA 3LWQA 1SGVA 3LWRA 3M65A 2CX1A 1WK2A 4CI3B 3LJCA 3LDFA 2J5TA 1KSVA 1V9KA 1SQWA 1K8WA 2KKUA 3LWPA 1PRZA
chains in the Genus database with same CATH topology
2I82A 1IQ8A 2CX0A 1WXXA 2J5VA 4DMGA 2RFKA 1KSLA 4LGTA 1SZWA 1V9FA 2APOA 3LWQA 1R3FA 2B78A 2P38A 3C0KA 3MQKA 1Q7HA 1SGVA 3LWRA 3DH3A 1SB7A 1ZE1A 2ISTA 4LABA 1ZS7A 2HVYA 2CX1A 3LWVA 1ZL3A 4Q1TA 1IT8A 1T5YA 1Z2ZA 3LDFA 3HJWA 2J5TA 2AS0A 3VSEA 1IT7A 3HAXA 1KSVA 2Q07A 1V9KA 3LWOA 1SQWA 1K8WA 2AUSA 2AB4A 2EY4A 1XPIA 3LWPA 1PRZA 1R3EA 3UAIA 1ZE2A 3U28A 1WXWA 3D79A 1QYUA 3HJYA 1SI7A 1KSKA 2CWWA 1J2BA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2I82 A;  1IQ8 A;  2CX0 A;  1WXX A;  2J5V A;  4DMG A;  2RFK A;  1KSL A;  4LGT A;  3MQK A;  1V9F A;  2APO A;  3LWQ A;  1R3F A;  2B78 A;  2P38 A;  3C0K A;  1Q7H A;  1SGV A;  3LWR A;  3DH3 A;  2IST A;  1ZE1 A;  4LAB A;  2HVY A;  1ZS7 A;  2CX1 A;  3LWV A;  1ZL3 A;  4Q1T A;  1IT8 A;  1T5Y A;  3LDF A;  3HJW A;  2J5T A;  2AS0 A;  3VSE A;  1IT7 A;  3HAX A;  1KSV A;  2Q07 A;  1V9K A;  3LWO A;  1SQW A;  1K8W A;  2AUS A;  2AB4 A;  2EY4 A;  1XPI A;  3LWP A;  1PRZ A;  1R3E A;  3UAI A;  1ZE2 A;  3U28 A;  1WXW A;  3D79 A;  1QYU A;  3HJY A;  1KSK A;  2CWW A;  1J2B A; 
#chains in the Genus database with same CATH topology
 2I82 A;  1IQ8 A;  1WXX A;  2APO A;  2IST A;  1ZE1 A;  4TZ4 C;  1ZL3 A;  1T5Y A;  2AS0 A;  3VSE A;  3HAX A;  3M6X A;  1XPI A;  1XNE A;  3D79 A;  1SI7 A;  2CWW A;  2CX0 A;  1J2B A;  3ZV0 C;  1SZW A;  1TE7 A;  3M6W A;  1R3F A;  2B78 A;  2P38 A;  3C0K A;  3IUW A;  2HVY A;  1IT7 A;  3LWO A;  1UOY A;  2AUS A;  2EY4 A;  1R3E A;  1WXW A;  3HJY A;  1KSK A;  3M6U A;  2DP9 A;  4CI2 B;  4DMG A;  2RFK A;  1V9F A;  1Q7H A;  3DH3 A;  2Z0T A;  1SB7 A;  4LAB A;  1ZS7 A;  3LWV A;  1ZBO A;  4Q1T A;  1IT8 A;  1Z2Z A;  3HJW A;  4CI1 B;  2Q07 A;  2AB4 A;  2ANE A;  3UAI A;  3U28 A;  1ZE2 A;  3M4X A;  1QYU A;  3M6V A;  1S04 A;  2FRX A;  2J5V A;  2E5O A;  1KSL A;  4LGT A;  3MQK A;  3LWQ A;  1SGV A;  3LWR A;  3M65 A;  2CX1 A;  1WK2 A;  4CI3 B;  3LJC A;  3LDF A;  2J5T A;  1KSV A;  1V9K A;  1SQW A;  1K8W A;  2KKU A;  3LWP A;  1PRZ A; 
#chains in the Genus database with same CATH homology
 2I82 A;  1IQ8 A;  2CX0 A;  1WXX A;  2J5V A;  4DMG A;  2RFK A;  1KSL A;  4LGT A;  1SZW A;  1V9F A;  2APO A;  3LWQ A;  1R3F A;  2B78 A;  2P38 A;  3C0K A;  3MQK A;  1Q7H A;  1SGV A;  3LWR A;  3DH3 A;  1SB7 A;  1ZE1 A;  2IST A;  4LAB A;  1ZS7 A;  2HVY A;  2CX1 A;  3LWV A;  1ZL3 A;  4Q1T A;  1IT8 A;  1T5Y A;  1Z2Z A;  3LDF A;  3HJW A;  2J5T A;  2AS0 A;  3VSE A;  1IT7 A;  3HAX A;  1KSV A;  2Q07 A;  1V9K A;  3LWO A;  1SQW A;  1K8W A;  2AUS A;  2AB4 A;  2EY4 A;  1XPI A;  3LWP A;  1PRZ A;  1R3E A;  3UAI A;  1ZE2 A;  3U28 A;  1WXW A;  3D79 A;  1QYU A;  3HJY A;  1SI7 A;  1KSK A;  2CWW A;  1J2B A; 
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similar chains in the Genus database (?% sequence similarity)
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