2EY4A

Crystal structure of a cbf5-nop10-gar1 complex
Total Genus 91
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
91
sequence length
329
structure length
329
Chain Sequence
EVRRILPADIKREVLIKDENAETNPDWGFPPEKRPIEMHIQFGVINLDKPPGPTSHEVVAWIKKILNLEKAGHGGTLDPKVSGVLPVALEKATRVVQALLPAGKEYVALMHLHGDVPEDKIIQVMKEFEGEIIQRPPLRSAVKRRLRTRKVYYIEVLEIEGRDVLFRVGVEAGTYIRSLIHHIGLALGVGAHMSELRRTRSGPFKEDETLITLHDLVDYYYFWKEDGIEEYFRKAIQPMEKAVEHLPKVWIKDSAVAAVTHGADLAVPGIAKLHAGIKRGDLVAIMTLKDELVALGKAMMTSQEMLEKTKGIAVDVEKVFMPRDWYPKL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of a Cbf5-Nop10-Gar1 complex and implications in RNA-guided pseudouridylation and dyskeratosis congenita.
pubmed doi rcsb
molecule tags Isomerase/biosynthetic protein
source organism Pyrococcus furiosus
molecule keywords Probable tRNA pseudouridine synthase B
total genus 91
structure length 329
sequence length 329
chains with identical sequence B
ec nomenclature ec 5.4.99.25: tRNA pseudouridine(55) synthase.
pdb deposition date 2005-11-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01472 PUA PUA domain
A PF01509 TruB_N TruB family pseudouridylate synthase (N terminal domain)
A PF08068 DKCLD DKCLD (NUC011) domain
A PF16198 TruB_C_2 tRNA pseudouridylate synthase B C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.130.70 Mainly Beta Roll Archaeosine Trna-guanine Transglycosylase; Chain: A, domain 4 Archaeosine Trna-guanine Transglycosylase; Chain: A, domain 4 2ey4A01
3.30.2350.10 Alpha Beta 2-Layer Sandwich Pseudouridine synthase Pseudouridine synthase 2ey4A02
1KSVA 3UAIA 1PRZA 1V9KA 3LWOA 3HJWA 3LWRA 3LWQA 1SGVA 4LGTA 2HVYA 2I82A 2ISTA 4LABA 2AB4A 2EY4A 3DH3A 2APOA 2RFKA 1XPIA 1ZE2A 1ZL3A 1KSKA 3LWPA 1R3EA 1V9FA 3LWVA 3MQKA 3HAXA 1KSLA 1QYUA 1R3FA 2AUSA 3ZV0C 3HJYA 1ZE1A 1K8WA 3U28A
chains in the Genus database with same CATH superfamily
3LWOA 1WXWA 2Z0TA 3M6VA 2EY4A 1ZL3A 2APOA 3M6WA 3LWPA 1XNEA 1Q7HA 1Z2ZA 1QYUA 1IT7A 2CX0A 4Q1TA 1SQWA 1K8WA 1SZWA 1KSVA 1SB7A 1IT8A 3HJWA 1SGVA 4LGTA 2HVYA 4DMGA 2ANEA 2AB4A 1IQ8A 1WXXA 1ZS7A 3LJCA 1TE7A 3LWVA 1KSLA 2AS0A 1R3FA 3ZV0C 2CWWA 1T5YA 2DP9A 3D79A 2KKUA 3M6XA 1V9KA 3LWRA 3LWQA 1ZBOA 2I82A 2ISTA 4CI3B 4CI1B 4LABA 1ZE2A 3DH3A 2RFKA 3C0KA 3M65A 1KSKA 2J5VA 2P38A 4TZ4C 1R3EA 1J2BA 3M6UA 1V9FA 3MQKA 3HAXA 1WK2A 2AUSA 1ZE1A 4CI2B 2J5TA 2CX1A 3UAIA 3IUWA 1PRZA 1UOYA 2E5OA 1SI7A 3M4XA 1XPIA 2Q07A 2B78A 3LDFA 3VSEA 2FRXA 3HJYA 1S04A 3U28A
chains in the Genus database with same CATH topology
1KSVA 1SB7A 3UAIA 1SZWA 3M6XA 1PRZA 1V9KA 3LWOA 3HJWA 3LWRA 1UOYA 3LWQA 1SGVA 4LGTA 2HVYA 2I82A 2ISTA 3M6VA 4LABA 1SI7A 2AB4A 3M4XA 2EY4A 3DH3A 2APOA 2RFKA 1XPIA 3M6WA 1ZE2A 1ZL3A 1KSKA 3LWPA 1R3EA 3M6UA 1V9FA 3LWVA 3MQKA 3HAXA 1Z2ZA 1KSLA 1QYUA 1R3FA 2AUSA 2FRXA 3ZV0C 3HJYA 1ZE1A 1K8WA 3U28A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1KSV A;  3UAI A;  1PRZ A;  1V9K A;  3LWO A;  3HJW A;  3LWR A;  3LWQ A;  1SGV A;  4LGT A;  2HVY A;  2I82 A;  2IST A;  4LAB A;  2AB4 A;  2EY4 A;  3DH3 A;  2APO A;  2RFK A;  1XPI A;  1ZE2 A;  1ZL3 A;  1KSK A;  3LWP A;  1R3E A;  1V9F A;  3LWV A;  3MQK A;  3HAX A;  1KSL A;  1QYU A;  1R3F A;  2AUS A;  3ZV0 C;  3HJY A;  1ZE1 A;  1K8W A;  3U28 A; 
#chains in the Genus database with same CATH topology
 3LWO A;  1WXW A;  2Z0T A;  3M6V A;  2EY4 A;  1ZL3 A;  2APO A;  3M6W A;  3LWP A;  1XNE A;  1Q7H A;  1Z2Z A;  1QYU A;  1IT7 A;  2CX0 A;  4Q1T A;  1SQW A;  1K8W A;  1SZW A;  1KSV A;  1SB7 A;  1IT8 A;  3HJW A;  1SGV A;  4LGT A;  2HVY A;  4DMG A;  2ANE A;  2AB4 A;  1IQ8 A;  1WXX A;  1ZS7 A;  3LJC A;  1TE7 A;  3LWV A;  1KSL A;  2AS0 A;  1R3F A;  3ZV0 C;  2CWW A;  1T5Y A;  2DP9 A;  3D79 A;  2KKU A;  3M6X A;  1V9K A;  3LWR A;  3LWQ A;  1ZBO A;  2I82 A;  2IST A;  4CI3 B;  4CI1 B;  4LAB A;  1ZE2 A;  3DH3 A;  2RFK A;  3C0K A;  3M65 A;  1KSK A;  2J5V A;  2P38 A;  4TZ4 C;  1R3E A;  1J2B A;  3M6U A;  1V9F A;  3MQK A;  3HAX A;  1WK2 A;  2AUS A;  1ZE1 A;  4CI2 B;  2J5T A;  2CX1 A;  3UAI A;  3IUW A;  1PRZ A;  1UOY A;  2E5O A;  1SI7 A;  3M4X A;  1XPI A;  2Q07 A;  2B78 A;  3LDF A;  3VSE A;  2FRX A;  3HJY A;  1S04 A;  3U28 A; 
#chains in the Genus database with same CATH homology
 1KSV A;  1SB7 A;  3UAI A;  1SZW A;  3M6X A;  1PRZ A;  1V9K A;  3LWO A;  3HJW A;  3LWR A;  1UOY A;  3LWQ A;  1SGV A;  4LGT A;  2HVY A;  2I82 A;  2IST A;  3M6V A;  4LAB A;  1SI7 A;  2AB4 A;  3M4X A;  2EY4 A;  3DH3 A;  2APO A;  2RFK A;  1XPI A;  3M6W A;  1ZE2 A;  1ZL3 A;  1KSK A;  3LWP A;  1R3E A;  3M6U A;  1V9F A;  3LWV A;  3MQK A;  3HAX A;  1Z2Z A;  1KSL A;  1QYU A;  1R3F A;  2AUS A;  2FRX A;  3ZV0 C;  3HJY A;  1ZE1 A;  1K8W A;  3U28 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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