1AVRA

Crystal and molecular structure of human annexin v after refinement. implications for structure, membrane binding and ion channel formation of the annexin family of proteins
Total Genus 126
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
126
sequence length
316
structure length
316
Chain Sequence
QVLRGTVTDFPGFDERADAETLRKAMKGLGTDEESILTLLTSRSNAQRQEISAAFKTLFGRDLLDDLKSELTGKFEKLIVALMKPSRLYDAYELKHALKGAGTNEKVLTEIIASRTPEELRAIKQVYEEEYGSSLEDDVVGDTSGYYQRMLVVLLQANRDPDAGIDEAQVEQDAQALFQAGELKWGTDEEKFITIFGTRSVSHLRKVFDKYMTISGFQIEETIDRETSGNLEQLLLAVVKSIRSIPAYLAETLYYAMKGAGTDDHTLIRVMVSRSEIDLFNIRKEFRKNFATSLYSMIKGDTSGDYKKALLLLCGE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal and molecular structure of human annexin V after refinement. Implications for structure, membrane binding and ion channel formation of the annexin family of proteins.
pubmed doi rcsb
molecule tags Calcium/phospholipid binding
source organism Homo sapiens
molecule keywords ANNEXIN V
total genus 126
structure length 316
sequence length 316
ec nomenclature
pdb deposition date 1991-10-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00191 Annexin Annexin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 1avrA02
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 1avrA04
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 1avrA01
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 1avrA03
1W45A 1DM5A 2HYVA 1DK5A 1G5NA 2HYWA 1ANXA 1N42A 1HVFA 4MDUA 1W7BA 1I4AA 1BCZA 1BC0A 2H0LA 1AVRA 2ZHIA 4HREA 1BC1A 1HVEA 2IE6A 2XO3A 1BC3A 4EVHA 1AOWA 1AXNA 1AEIA 1HVDA 1BCYA 1MCXA 2RANA 2H0KA 2II2A 2XO2A 1N44A 1HAKA 1N41A 1ANWA 2H0MA 2ZHJA 2ZOCA 1W3WA 1ALAA 2IE7A 1M9IA 2Q4CA 3BRXA 1BO9A 1YCNA 1AIIA 1HVGA 1YIIA 4MDVA 4EVFA 2HYUA 1A8AA 1HM6A 1A8BA 1YJ0A 1XJLA 4X9PA 1BCWA 1AVCA 1N00A 1AVHA 1ANNA 1SAVA 2IICA
chains in the Genus database with same CATH superfamily
3USWA 4JMIA 1S9DE 4MDUA 1BC0A 2H0LA 4EVHA 1AXNA 1C1KA 1MCXA 2QEZA 4D7QA 4JK1X 3SOHB 1N41A 2ZOCA 1KU1A 1W3WA 2HYUA 3ABSA 1PBVA 4C0AA 3AJCA 4KN7X 4C7PA 4FQ0C 2IICA 3ABOA 3TW5A 2HSNA 1R8ME 2OY9A 3L8NA 1RE0B 4JWLA 4HREA 1HVEA 1BC3A 1R8QE 1AEIA 1BCYA 2RANA 2H0KA 3USYA 2XO2A 1N44A 1ANWA 2H0MA 2K6XA 3BRXA 4FHRB 1YCNA 4KN4X 4OIYA 1A8AA 1A8BA 1YJ0A 1AVCA 1XT0B 1ANNA 4D7RA 1W45A 1QC7A 1DM5A 2HYVA 1UPTB 2HYWA 2R09A 1N42A 4A4PA 4L5MA 1R4AE 1BCZA 1AVRA 2IE6A 1AOWA 1HVDA 3HJLA 1YGMA 2II2A 1LKVX 2VXGA 1ALAA 2IE7A 2Q4CA 1XSZA 3ABQA 1BO9A 4MDVA 4X9PA 1XJLA 1AVHA 3SWVA 3AO0A 1SAVA 4Q2SA 4KMUX 4JXHA 1DK5A 1G5NA 1ANXA 1HVFA 1W7BA 3ANYA 1I4AA 2ZHIA 1BC1A 2XO3A 2R0DA 4JMOA 4Z21A 1HAKA 2ZHJA 3LTLA 1M9IA 1R8SE 3ABRA 1AIIA 1HVGA 1YIIA 4EVFA 1HM6A 1BCWA 1Q8DA 1N00A 1BC9A
chains in the Genus database with same CATH topology
1W45A 1DM5A 2HYVA 1DK5A 1G5NA 2HYWA 1ANXA 1N42A 1HVFA 4MDUA 1W7BA 1I4AA 1BCZA 1BC0A 2H0LA 1AVRA 2ZHIA 4HREA 1BC1A 1HVEA 2IE6A 2XO3A 1BC3A 4EVHA 1AOWA 1AXNA 1AEIA 1HVDA 1BCYA 1MCXA 2RANA 2H0KA 2II2A 2XO2A 1N44A 1HAKA 1N41A 1ANWA 2H0MA 2ZHJA 2ZOCA 1W3WA 1ALAA 2IE7A 1M9IA 2Q4CA 3BRXA 1BO9A 1YCNA 1AIIA 1HVGA 1YIIA 4MDVA 4EVFA 2HYUA 1A8AA 1HM6A 1A8BA 1YJ0A 1XJLA 4X9PA 1BCWA 1AVCA 1N00A 1AVHA 1ANNA 1SAVA 2IICA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1W45 A;  1DM5 A;  2HYV A;  1DK5 A;  1G5N A;  2HYW A;  1ANX A;  1N42 A;  1HVF A;  4MDU A;  1W7B A;  1I4A A;  1BCZ A;  1BC0 A;  2H0L A;  1AVR A;  2ZHI A;  4HRE A;  1BC1 A;  1HVE A;  2IE6 A;  2XO3 A;  1BC3 A;  4EVH A;  1AOW A;  1AXN A;  1AEI A;  1HVD A;  1BCY A;  1MCX A;  2RAN A;  2H0K A;  2II2 A;  2XO2 A;  1N44 A;  1HAK A;  1N41 A;  1ANW A;  2H0M A;  2ZHJ A;  2ZOC A;  1W3W A;  1ALA A;  2IE7 A;  1M9I A;  2Q4C A;  3BRX A;  1BO9 A;  1YCN A;  1AII A;  1HVG A;  1YII A;  4MDV A;  4EVF A;  2HYU A;  1A8A A;  1HM6 A;  1A8B A;  1YJ0 A;  1XJL A;  4X9P A;  1BCW A;  1AVC A;  1N00 A;  1AVH A;  1ANN A;  1SAV A;  2IIC A; 
#chains in the Genus database with same CATH topology
 3USW A;  4JMI A;  1S9D E;  4MDU A;  1BC0 A;  2H0L A;  4EVH A;  1AXN A;  1C1K A;  1MCX A;  2QEZ A;  4D7Q A;  4JK1 X;  3SOH B;  1N41 A;  2ZOC A;  1KU1 A;  1W3W A;  2HYU A;  3ABS A;  1PBV A;  4C0A A;  3AJC A;  4KN7 X;  4C7P A;  4FQ0 C;  2IIC A;  3ABO A;  3TW5 A;  2HSN A;  1R8M E;  2OY9 A;  3L8N A;  1RE0 B;  4JWL A;  4HRE A;  1HVE A;  1BC3 A;  1R8Q E;  1AEI A;  1BCY A;  2RAN A;  2H0K A;  3USY A;  2XO2 A;  1N44 A;  1ANW A;  2H0M A;  2K6X A;  3BRX A;  4FHR B;  1YCN A;  4KN4 X;  4OIY A;  1A8A A;  1A8B A;  1YJ0 A;  1AVC A;  1XT0 B;  1ANN A;  4D7R A;  1W45 A;  1QC7 A;  1DM5 A;  2HYV A;  1UPT B;  2HYW A;  2R09 A;  1N42 A;  4A4P A;  4L5M A;  1R4A E;  1BCZ A;  1AVR A;  2IE6 A;  1AOW A;  1HVD A;  3HJL A;  1YGM A;  2II2 A;  1LKV X;  2VXG A;  1ALA A;  2IE7 A;  2Q4C A;  1XSZ A;  3ABQ A;  1BO9 A;  4MDV A;  4X9P A;  1XJL A;  1AVH A;  3SWV A;  3AO0 A;  1SAV A;  4Q2S A;  4KMU X;  4JXH A;  1DK5 A;  1G5N A;  1ANX A;  1HVF A;  1W7B A;  3ANY A;  1I4A A;  2ZHI A;  1BC1 A;  2XO3 A;  2R0D A;  4JMO A;  4Z21 A;  1HAK A;  2ZHJ A;  3LTL A;  1M9I A;  1R8S E;  3ABR A;  1AII A;  1HVG A;  1YII A;  4EVF A;  1HM6 A;  1BCW A;  1Q8D A;  1N00 A;  1BC9 A; 
#chains in the Genus database with same CATH homology
 1W45 A;  1DM5 A;  2HYV A;  1DK5 A;  1G5N A;  2HYW A;  1ANX A;  1N42 A;  1HVF A;  4MDU A;  1W7B A;  1I4A A;  1BCZ A;  1BC0 A;  2H0L A;  1AVR A;  2ZHI A;  4HRE A;  1BC1 A;  1HVE A;  2IE6 A;  2XO3 A;  1BC3 A;  4EVH A;  1AOW A;  1AXN A;  1AEI A;  1HVD A;  1BCY A;  1MCX A;  2RAN A;  2H0K A;  2II2 A;  2XO2 A;  1N44 A;  1HAK A;  1N41 A;  1ANW A;  2H0M A;  2ZHJ A;  2ZOC A;  1W3W A;  1ALA A;  2IE7 A;  1M9I A;  2Q4C A;  3BRX A;  1BO9 A;  1YCN A;  1AII A;  1HVG A;  1YII A;  4MDV A;  4EVF A;  2HYU A;  1A8A A;  1HM6 A;  1A8B A;  1YJ0 A;  1XJL A;  4X9P A;  1BCW A;  1AVC A;  1N00 A;  1AVH A;  1ANN A;  1SAV A;  2IIC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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