1W45A

The 2.5 angstroem structure of the k16a mutant of annexin a8, which has an intact n-terminus.
Total Genus 116
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
116
sequence length
320
structure length
320
Chain Sequence
IEQEGVTVASSSHFNPDPDAETLYKAMKGIGTNEQAIIDVLTKRSNTQRQQIAKSFKAQFGKDLTETLKSELSGKFERLIVALMYPPYRYEAKELHDAMKGLGTKEGVIIEILASRTKNQLREIMKAYEEDYGSSLEEDIQADTSGYLERILVCLLQGSRDDVSSFVDPALALQDAQDLYAAGEKIRGTDEMKFITILCTRSATHLLRVFEEYEKIANKSIEDSIKSETHGSLEEAMLTVVKCTQNLHSYFAERLYYAMKGAGTRDGTLIRNIVSRSEIDLNLIKCHFKKMYGKTLSSMIMEDTSGDYKNALLSLVGSDP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords ANNEXIN A8
publication title The Crystal Structure of Annexin A8 is Similar to that of Annexin A3
pubmed doi rcsb
source organism Homo sapiens
molecule tags Coagulation
total genus 116
structure length 320
sequence length 320
chains with identical sequence B
ec nomenclature
pdb deposition date 2004-07-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00191 Annexin Annexin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 1w45A02
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 1w45A04
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 1w45A01
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 1w45A03
1SAVA 1W7BA 1ANWA 1A8AA 1AEIA 1ANNA 2HYVA 2HYWA 2ZHIA 1YJ0A 1AVRA 1HVDA 1ALAA 2XO2A 1BO9A 1HVFA 2IICA 1A8BA 1W3WA 1HM6A 2HYUA 1BCWA 1YCNA 1W45A 2Q4CA 1ANXA 2H0KA 2IE7A 1AXNA 1BCYA 2H0LA 1N42A 1BC0A 2RANA 2ZHJA 4X9PA 1BCZA 1AOWA 4MDVA 1DK5A 1DM5A 4HREA 1AIIA 1XJLA 1HAKA 1HVGA 1N41A 1M9IA 3BRXA 1BC1A 2II2A 1BC3A 2IE6A 2ZOCA 1HVEA 1I4AA 4EVHA 2H0MA 2XO3A 1N44A 1AVHA 1G5NA 4EVFA 4MDUA 1AVCA 1YIIA 1MCXA 1N00A
chains in the Genus database with same CATH superfamily
1SAVA 1R8ME 1W7BA 3AJCA 1AEIA 4FQ0C 4A4PA 1YJ0A 1LKVX 4KN4X 2IICA 2HYUA 1ANXA 2IE7A 1C1KA 2ZHJA 4D7QA 2HSNA 1AIIA 1BC9A 1HVEA 4D7RA 1I4AA 3ABSA 3SOHB 4EVFA 1AVCA 1MCXA 4KMUX 1N00A 4KN7X 4C7PA 3L8NA 4JMIA 2QEZA 1HVFA 1W3WA 1HM6A 3LTLA 1BCWA 3AO0A 4L5MA 4JWLA 1AXNA 2RANA 4X9PA 1XT0B 1AOWA 1DK5A 3TW5A 1RE0B 1XJLA 1HVGA 2OY9A 1XSZA 2II2A 2H0MA 1N44A 3ABQA 3ABOA 4JK1X 4MDUA 1YIIA 1R8SE 4HREA 3SWVA 3USYA 1ANWA 1A8AA 1QC7A 2VXGA 2HYVA 2HYWA 4FHRB 2ZHIA 1AVRA 1HVDA 3USWA 1ALAA 2XO2A 1BO9A 4OIYA 1A8BA 4Q2SA 3ABRA 1YCNA 1W45A 2H0KA 1BCYA 1N42A 1PBVA 1BC0A 3HJLA 4C0AA 1BCZA 1DM5A 1HAKA 1S9DE 1R4AE 1BC3A 1KU1A 2XO3A 1UPTB 1AVHA 4MDVA 3BRXA 4JXHA 1ANNA 1YGMA 2Q4CA 2R09A 2H0LA 3ANYA 1Q8DA 1N41A 2R0DA 1M9IA 1BC1A 4Z21A 1R8QE 2IE6A 2ZOCA 4JMOA 4EVHA 2K6XA 1G5NA
chains in the Genus database with same CATH topology
1SAVA 1W7BA 1ANWA 1A8AA 1AEIA 1ANNA 2HYVA 2HYWA 2ZHIA 1YJ0A 1AVRA 1HVDA 1ALAA 2XO2A 1BO9A 1HVFA 2IICA 1A8BA 1W3WA 1HM6A 2HYUA 1BCWA 1YCNA 1W45A 2Q4CA 1ANXA 2H0KA 2IE7A 1AXNA 1BCYA 2H0LA 1N42A 1BC0A 2RANA 2ZHJA 4X9PA 1BCZA 1AOWA 4MDVA 1DK5A 1DM5A 4HREA 1AIIA 1XJLA 1HAKA 1HVGA 1N41A 1M9IA 3BRXA 1BC1A 2II2A 1BC3A 2IE6A 2ZOCA 1HVEA 1I4AA 4EVHA 2H0MA 2XO3A 1N44A 1AVHA 1G5NA 4EVFA 4MDUA 1AVCA 1YIIA 1MCXA 1N00A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1SAV A;  1W7B A;  1ANW A;  1A8A A;  1AEI A;  1ANN A;  2HYV A;  2HYW A;  2ZHI A;  1YJ0 A;  1AVR A;  1HVD A;  1ALA A;  2XO2 A;  1BO9 A;  1HVF A;  2IIC A;  1A8B A;  1W3W A;  1HM6 A;  2HYU A;  1BCW A;  1YCN A;  1W45 A;  2Q4C A;  1ANX A;  2H0K A;  2IE7 A;  1AXN A;  1BCY A;  2H0L A;  1N42 A;  1BC0 A;  2RAN A;  2ZHJ A;  4X9P A;  1BCZ A;  1AOW A;  4MDV A;  1DK5 A;  1DM5 A;  4HRE A;  1AII A;  1XJL A;  1HAK A;  1HVG A;  1N41 A;  1M9I A;  3BRX A;  1BC1 A;  2II2 A;  1BC3 A;  2IE6 A;  2ZOC A;  1HVE A;  1I4A A;  4EVH A;  2H0M A;  2XO3 A;  1N44 A;  1AVH A;  1G5N A;  4EVF A;  4MDU A;  1AVC A;  1YII A;  1MCX A;  1N00 A; 
#chains in the Genus database with same CATH topology
 1SAV A;  1R8M E;  1W7B A;  3AJC A;  1AEI A;  4FQ0 C;  4A4P A;  1YJ0 A;  1LKV X;  4KN4 X;  2IIC A;  2HYU A;  1ANX A;  2IE7 A;  1C1K A;  2ZHJ A;  4D7Q A;  2HSN A;  1AII A;  1BC9 A;  1HVE A;  4D7R A;  1I4A A;  3ABS A;  3SOH B;  4EVF A;  1AVC A;  1MCX A;  4KMU X;  1N00 A;  4KN7 X;  4C7P A;  3L8N A;  4JMI A;  2QEZ A;  1HVF A;  1W3W A;  1HM6 A;  3LTL A;  1BCW A;  3AO0 A;  4L5M A;  4JWL A;  1AXN A;  2RAN A;  4X9P A;  1XT0 B;  1AOW A;  1DK5 A;  3TW5 A;  1RE0 B;  1XJL A;  1HVG A;  2OY9 A;  1XSZ A;  2II2 A;  2H0M A;  1N44 A;  3ABQ A;  3ABO A;  4JK1 X;  4MDU A;  1YII A;  1R8S E;  4HRE A;  3SWV A;  3USY A;  1ANW A;  1A8A A;  1QC7 A;  2VXG A;  2HYV A;  2HYW A;  4FHR B;  2ZHI A;  1AVR A;  1HVD A;  3USW A;  1ALA A;  2XO2 A;  1BO9 A;  4OIY A;  1A8B A;  4Q2S A;  3ABR A;  1YCN A;  1W45 A;  2H0K A;  1BCY A;  1N42 A;  1PBV A;  1BC0 A;  3HJL A;  4C0A A;  1BCZ A;  1DM5 A;  1HAK A;  1S9D E;  1R4A E;  1BC3 A;  1KU1 A;  2XO3 A;  1UPT B;  1AVH A;  4MDV A;  3BRX A;  4JXH A;  1ANN A;  1YGM A;  2Q4C A;  2R09 A;  2H0L A;  3ANY A;  1Q8D A;  1N41 A;  2R0D A;  1M9I A;  1BC1 A;  4Z21 A;  1R8Q E;  2IE6 A;  2ZOC A;  4JMO A;  4EVH A;  2K6X A;  1G5N A; 
#chains in the Genus database with same CATH homology
 1SAV A;  1W7B A;  1ANW A;  1A8A A;  1AEI A;  1ANN A;  2HYV A;  2HYW A;  2ZHI A;  1YJ0 A;  1AVR A;  1HVD A;  1ALA A;  2XO2 A;  1BO9 A;  1HVF A;  2IIC A;  1A8B A;  1W3W A;  1HM6 A;  2HYU A;  1BCW A;  1YCN A;  1W45 A;  2Q4C A;  1ANX A;  2H0K A;  2IE7 A;  1AXN A;  1BCY A;  2H0L A;  1N42 A;  1BC0 A;  2RAN A;  2ZHJ A;  4X9P A;  1BCZ A;  1AOW A;  4MDV A;  1DK5 A;  1DM5 A;  4HRE A;  1AII A;  1XJL A;  1HAK A;  1HVG A;  1N41 A;  1M9I A;  3BRX A;  1BC1 A;  2II2 A;  1BC3 A;  2IE6 A;  2ZOC A;  1HVE A;  1I4A A;  4EVH A;  2H0M A;  2XO3 A;  1N44 A;  1AVH A;  1G5N A;  4EVF A;  4MDU A;  1AVC A;  1YII A;  1MCX A;  1N00 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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