4JXHA

Complexe of arno sec7 domain with the protein-protein interaction inhibitor n-(4-hydroxy-2,6-dimethylphenyl)benzenesulfonamide at ph 8.5
Total Genus 71
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
71
sequence length
195
structure length
195
Chain Sequence
MSKTLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRNEPFKIPEDD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Signaling protein/inhibitor
molecule keywords Cytohesin-2
publication title Fragment-based identification of a locus in the Sec7 domain of Arno for the design of protein-protein interaction inhibitors
pubmed doi rcsb
source organism Homo sapiens
total genus 71
structure length 195
sequence length 195
ec nomenclature
pdb deposition date 2013-03-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01369 Sec7 Sec7 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.220.20 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin V; domain 1 4jxhA01
1.10.1000.11 Mainly Alpha Orthogonal Bundle Arf Nucleotide-binding Site Opener; domain 2 Arf Nucleotide-binding Site Opener,domain 2 4jxhA02
1PBVA 4C0AA 1XSZA 1KU1A 4A4PA 4Z21A 1R8SE 4JMIA 2R09A 1S9DE 1BC9A 4JMOA 1R8ME 4L5MA 3SWVA 1XT0B 3L8NA 4JXHA 4D7QA 1R8QE 4D7RA 4JWLA 3LTLA 4OIYA 2R0DA 1RE0B 4C7PA
chains in the Genus database with same CATH superfamily
2ZHJA 1HVEA 1PBVA 1XSZA 1YJ0A 1W7BA 4JK1X 1KU1A 1HVGA 1YGMA 2H0KA 1SAVA 4Z21A 1W3WA 4JMOA 2IICA 2QEZA 1N41A 3ABSA 1C1KA 4MDVA 1XT0B 4JXHA 4D7RA 1XJLA 1HAKA 3USWA 4MDUA 1I4AA 4C7PA 3ABOA 1ANNA 4EVHA 4Q2SA 2IE6A 4KN7X 1ANWA 2OY9A 1N42A 2K6XA 1R4AE 1BO9A 1R8SE 4JMIA 2II2A 1S9DE 1N44A 1AIIA 1BC9A 2R09A 4HREA 4EVFA 1AXNA 2HSNA 1A8BA 1YCNA 3LTLA 3SOHB 1M9IA 2XO2A 1LKVX 3USYA 1AVCA 1QC7A 2HYVA 1BC0A 1BCWA 1HVDA 4A4PA 4X9PA 4KMUX 1BC1A 2VXGA 1AVHA 3BRXA 1HM6A 1AEIA 1Q8DA 2Q4CA 2HYUA 3L8NA 1HVFA 1MCXA 1AOWA 2H0LA 2R0DA 1BCYA 2ZOCA 1RE0B 1A8AA 1W45A 2HYWA 1DK5A 1YIIA 4C0AA 4KN4X 1BCZA 1BC3A 3AO0A 3ANYA 1DM5A 2H0MA 4FQ0C 1R8ME 1ANXA 4L5MA 2IE7A 3SWVA 1UPTB 4D7QA 1G5NA 3HJLA 1R8QE 2ZHIA 2RANA 4JWLA 2XO3A 3TW5A 3ABQA 1N00A 4OIYA 1ALAA 3AJCA 3ABRA 4FHRB 1AVRA
chains in the Genus database with same CATH topology
1PBVA 4C0AA 4KN4X 1XSZA 4JK1X 1KU1A 4KN7X 4A4PA 2K6XA 4Z21A 4KMUX 1R8SE 4JMIA 2R09A 1S9DE 4FQ0C 1BC9A 4JMOA 2HSNA 1R8ME 4L5MA 1Q8DA 3SWVA 1XT0B 3L8NA 4JXHA 3HJLA 1R8QE 4D7QA 4D7RA 4JWLA 3USWA 3SOHB 3LTLA 3TW5A 4OIYA 2R0DA 3AJCA 1LKVX 3USYA 4FHRB 1RE0B 4C7PA 1QC7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1PBV A;  4C0A A;  1XSZ A;  1KU1 A;  4A4P A;  4Z21 A;  1R8S E;  4JMI A;  2R09 A;  1S9D E;  1BC9 A;  4JMO A;  1R8M E;  4L5M A;  3SWV A;  1XT0 B;  3L8N A;  4JXH A;  4D7Q A;  1R8Q E;  4D7R A;  4JWL A;  3LTL A;  4OIY A;  2R0D A;  1RE0 B;  4C7P A; 
#chains in the Genus database with same CATH topology
 2ZHJ A;  1HVE A;  1PBV A;  1XSZ A;  1YJ0 A;  1W7B A;  4JK1 X;  1KU1 A;  1HVG A;  1YGM A;  2H0K A;  1SAV A;  4Z21 A;  1W3W A;  4JMO A;  2IIC A;  2QEZ A;  1N41 A;  3ABS A;  1C1K A;  4MDV A;  1XT0 B;  4JXH A;  4D7R A;  1XJL A;  1HAK A;  3USW A;  4MDU A;  1I4A A;  4C7P A;  3ABO A;  1ANN A;  4EVH A;  4Q2S A;  2IE6 A;  4KN7 X;  1ANW A;  2OY9 A;  1N42 A;  2K6X A;  1R4A E;  1BO9 A;  1R8S E;  4JMI A;  2II2 A;  1S9D E;  1N44 A;  1AII A;  1BC9 A;  2R09 A;  4HRE A;  4EVF A;  1AXN A;  2HSN A;  1A8B A;  1YCN A;  3LTL A;  3SOH B;  1M9I A;  2XO2 A;  1LKV X;  3USY A;  1AVC A;  1QC7 A;  2HYV A;  1BC0 A;  1BCW A;  1HVD A;  4A4P A;  4X9P A;  4KMU X;  1BC1 A;  2VXG A;  1AVH A;  3BRX A;  1HM6 A;  1AEI A;  1Q8D A;  2Q4C A;  2HYU A;  3L8N A;  1HVF A;  1MCX A;  1AOW A;  2H0L A;  2R0D A;  1BCY A;  2ZOC A;  1RE0 B;  1A8A A;  1W45 A;  2HYW A;  1DK5 A;  1YII A;  4C0A A;  4KN4 X;  1BCZ A;  1BC3 A;  3AO0 A;  3ANY A;  1DM5 A;  2H0M A;  4FQ0 C;  1R8M E;  1ANX A;  4L5M A;  2IE7 A;  3SWV A;  1UPT B;  4D7Q A;  1G5N A;  3HJL A;  1R8Q E;  2ZHI A;  2RAN A;  4JWL A;  2XO3 A;  3TW5 A;  3ABQ A;  1N00 A;  4OIY A;  1ALA A;  3AJC A;  3ABR A;  4FHR B;  1AVR A; 
#chains in the Genus database with same CATH homology
 1PBV A;  4C0A A;  4KN4 X;  1XSZ A;  4JK1 X;  1KU1 A;  4KN7 X;  4A4P A;  2K6X A;  4Z21 A;  4KMU X;  1R8S E;  4JMI A;  2R09 A;  1S9D E;  4FQ0 C;  1BC9 A;  4JMO A;  2HSN A;  1R8M E;  4L5M A;  1Q8D A;  3SWV A;  1XT0 B;  3L8N A;  4JXH A;  3HJL A;  1R8Q E;  4D7Q A;  4D7R A;  4JWL A;  3USW A;  3SOH B;  3LTL A;  3TW5 A;  4OIY A;  2R0D A;  3AJC A;  1LKV X;  3USY A;  4FHR B;  1RE0 B;  4C7P A;  1QC7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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