1DM5A

Annexin xii e105k homohexamer crystal structure
Total Genus 128
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
128
sequence length
315
structure length
315
Chain Sequence
VVQGTVKPHASFNSREDAETLRKAMKGIGTDEKSITHILATRSNAQRQQIKTDYTTLFGKHLEDELKSELSGNYEAAALALLRKPDEFLAEQLHAAMKGLGTDKNALIDILCTQSNAQIHAIKAAFKLLYKEDLEKEIISETSGNFQRLLVSMLQGGRKEDEPVNAAHAAEDAAAIYQAGEGQIGTDESRFNAVLATRSYPQLHQIFHEYSKISNKTILQAIENEFSGDIKNGLLAIVKSVENRFAYFAERLHHAMKGLGTSDKTLIRILVSRSEIDLANIKETFQAMYGKSLYEFIADDCSGDYKDLLLQITGH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Annexin XII E105K crystal structure: identification of a pH-dependent switch for mutant hexamerization.
pubmed doi rcsb
molecule tags Unknown function
source organism Hydra vulgaris
molecule keywords ANNEXIN XII E105K MUTANT HOMOHEXAMER
total genus 128
structure length 315
sequence length 315
chains with identical sequence B, C, D, E, F
ec nomenclature
pdb deposition date 1999-12-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00191 Annexin Annexin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 1dm5A01
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 1dm5A04
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 1dm5A02
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 1dm5A03
1I4AA 1W7BA 1AOWA 1N00A 1SAVA 1MCXA 2XO2A 1AVRA 2HYVA 1BC3A 2RANA 2Q4CA 4HREA 1BCYA 1N44A 1AIIA 1G5NA 1BO9A 1XJLA 2H0MA 1AVHA 1N42A 2XO3A 2II2A 1DK5A 2ZHJA 1BC1A 2IE7A 1AEIA 1ANNA 1YJ0A 1HVGA 1DM5A 1AXNA 2HYWA 1HM6A 1HVDA 4EVFA 2HYUA 1M9IA 2H0LA 1HVEA 1N41A 1YCNA 1BC0A 1A8BA 1YIIA 1HVFA 1W3WA 1BCZA 1A8AA 1ANWA 1ANXA 1W45A 2H0KA 3BRXA 4X9PA 4MDVA 4EVHA 1ALAA 2ZOCA 4MDUA 1BCWA 2IE6A 2IICA 1AVCA 1HAKA 2ZHIA
chains in the Genus database with same CATH superfamily
4JK1X 1W7BA 4Q2SA 1SAVA 1AVRA 1BC3A 1XT0B 3ABOA 1G5NA 1BO9A 3AJCA 4D7QA 1YGMA 1ANNA 2HSNA 3ABQA 4EVFA 1R8QE 1M9IA 1PBVA 1N41A 1YCNA 1QC7A 1BC0A 1C1KA 1A8AA 3ABSA 4X9PA 1ANXA 4FQ0C 4MDVA 4JXHA 1BCWA 3USYA 1XSZA 4OIYA 1R4AE 2XO2A 2RANA 2Q4CA 4HREA 2K6XA 1AIIA 1XJLA 2ZHJA 1LKVX 2II2A 2R09A 1BC1A 1AEIA 1YJ0A 1S9DE 3HJLA 2HYWA 1HM6A 1HVDA 2QEZA 2HYUA 3ANYA 4L5MA 1YIIA 4C0AA 1W3WA 1W45A 2H0KA 1ALAA 2ZOCA 1R8SE 1R8ME 1I4AA 4JWLA 1AOWA 1N00A 2OY9A 4C7PA 3LTLA 1N44A 4KMUX 4D7RA 1Q8DA 1AVHA 3USWA 1DK5A 2IE7A 1AXNA 2H0LA 1HVEA 4Z21A 4JMIA 2VXGA 2IICA 1HAKA 3L8NA 3ABRA 1MCXA 1KU1A 2HYVA 1BC9A 1UPTB 3TW5A 1BCYA 2H0MA 2R0DA 1N42A 2XO3A 4JMOA 1RE0B 1HVGA 1DM5A 3SWVA 3AO0A 1A8BA 1HVFA 1BCZA 1ANWA 3BRXA 4EVHA 4KN7X 4A4PA 4MDUA 2IE6A 4KN4X 1AVCA 2ZHIA 3SOHB 4FHRB
chains in the Genus database with same CATH topology
1I4AA 1W7BA 1AOWA 1N00A 1SAVA 1MCXA 2XO2A 1AVRA 2HYVA 1BC3A 2RANA 2Q4CA 4HREA 1BCYA 1N44A 1AIIA 1G5NA 1BO9A 1XJLA 2H0MA 1AVHA 1N42A 2XO3A 2II2A 1DK5A 2ZHJA 1BC1A 2IE7A 1AEIA 1ANNA 1YJ0A 1HVGA 1DM5A 1AXNA 2HYWA 1HM6A 1HVDA 4EVFA 2HYUA 1M9IA 2H0LA 1HVEA 1N41A 1YCNA 1BC0A 1A8BA 1YIIA 1HVFA 1W3WA 1BCZA 1A8AA 1ANWA 1ANXA 1W45A 2H0KA 3BRXA 4X9PA 4MDVA 4EVHA 1ALAA 2ZOCA 4MDUA 1BCWA 2IE6A 2IICA 1AVCA 1HAKA 2ZHIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1I4A A;  1W7B A;  1AOW A;  1N00 A;  1SAV A;  1MCX A;  2XO2 A;  1AVR A;  2HYV A;  1BC3 A;  2RAN A;  2Q4C A;  4HRE A;  1BCY A;  1N44 A;  1AII A;  1G5N A;  1BO9 A;  1XJL A;  2H0M A;  1AVH A;  1N42 A;  2XO3 A;  2II2 A;  1DK5 A;  2ZHJ A;  1BC1 A;  2IE7 A;  1AEI A;  1ANN A;  1YJ0 A;  1HVG A;  1DM5 A;  1AXN A;  2HYW A;  1HM6 A;  1HVD A;  4EVF A;  2HYU A;  1M9I A;  2H0L A;  1HVE A;  1N41 A;  1YCN A;  1BC0 A;  1A8B A;  1YII A;  1HVF A;  1W3W A;  1BCZ A;  1A8A A;  1ANW A;  1ANX A;  1W45 A;  2H0K A;  3BRX A;  4X9P A;  4MDV A;  4EVH A;  1ALA A;  2ZOC A;  4MDU A;  1BCW A;  2IE6 A;  2IIC A;  1AVC A;  1HAK A;  2ZHI A; 
#chains in the Genus database with same CATH topology
 4JK1 X;  1W7B A;  4Q2S A;  1SAV A;  1AVR A;  1BC3 A;  1XT0 B;  3ABO A;  1G5N A;  1BO9 A;  3AJC A;  4D7Q A;  1YGM A;  1ANN A;  2HSN A;  3ABQ A;  4EVF A;  1R8Q E;  1M9I A;  1PBV A;  1N41 A;  1YCN A;  1QC7 A;  1BC0 A;  1C1K A;  1A8A A;  3ABS A;  4X9P A;  1ANX A;  4FQ0 C;  4MDV A;  4JXH A;  1BCW A;  3USY A;  1XSZ A;  4OIY A;  1R4A E;  2XO2 A;  2RAN A;  2Q4C A;  4HRE A;  2K6X A;  1AII A;  1XJL A;  2ZHJ A;  1LKV X;  2II2 A;  2R09 A;  1BC1 A;  1AEI A;  1YJ0 A;  1S9D E;  3HJL A;  2HYW A;  1HM6 A;  1HVD A;  2QEZ A;  2HYU A;  3ANY A;  4L5M A;  1YII A;  4C0A A;  1W3W A;  1W45 A;  2H0K A;  1ALA A;  2ZOC A;  1R8S E;  1R8M E;  1I4A A;  4JWL A;  1AOW A;  1N00 A;  2OY9 A;  4C7P A;  3LTL A;  1N44 A;  4KMU X;  4D7R A;  1Q8D A;  1AVH A;  3USW A;  1DK5 A;  2IE7 A;  1AXN A;  2H0L A;  1HVE A;  4Z21 A;  4JMI A;  2VXG A;  2IIC A;  1HAK A;  3L8N A;  3ABR A;  1MCX A;  1KU1 A;  2HYV A;  1BC9 A;  1UPT B;  3TW5 A;  1BCY A;  2H0M A;  2R0D A;  1N42 A;  2XO3 A;  4JMO A;  1RE0 B;  1HVG A;  1DM5 A;  3SWV A;  3AO0 A;  1A8B A;  1HVF A;  1BCZ A;  1ANW A;  3BRX A;  4EVH A;  4KN7 X;  4A4P A;  4MDU A;  2IE6 A;  4KN4 X;  1AVC A;  2ZHI A;  3SOH B;  4FHR B; 
#chains in the Genus database with same CATH homology
 1I4A A;  1W7B A;  1AOW A;  1N00 A;  1SAV A;  1MCX A;  2XO2 A;  1AVR A;  2HYV A;  1BC3 A;  2RAN A;  2Q4C A;  4HRE A;  1BCY A;  1N44 A;  1AII A;  1G5N A;  1BO9 A;  1XJL A;  2H0M A;  1AVH A;  1N42 A;  2XO3 A;  2II2 A;  1DK5 A;  2ZHJ A;  1BC1 A;  2IE7 A;  1AEI A;  1ANN A;  1YJ0 A;  1HVG A;  1DM5 A;  1AXN A;  2HYW A;  1HM6 A;  1HVD A;  4EVF A;  2HYU A;  1M9I A;  2H0L A;  1HVE A;  1N41 A;  1YCN A;  1BC0 A;  1A8B A;  1YII A;  1HVF A;  1W3W A;  1BCZ A;  1A8A A;  1ANW A;  1ANX A;  1W45 A;  2H0K A;  3BRX A;  4X9P A;  4MDV A;  4EVH A;  1ALA A;  2ZOC A;  4MDU A;  1BCW A;  2IE6 A;  2IIC A;  1AVC A;  1HAK A;  2ZHI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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