1I0EA

Crystal structure of creatine kinase from human muscle
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
374
structure length
365
Chain Sequence
NKFKLNYKPEEEYPDLSKHNNHMAKVLTLELYKKLRDKETPSGFTVDDVIQTGVDNPGHPFIMTVGCVAGDEESYEVFKELFDPIISDRHGGYKPTDKHKTDLNHENLKGGDDLDPNYVLSSRVRTGRSIKGYTLPPHCSRGERRAVEKLSVEALNSLTGEFKGKYYPLKSMTEKEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIWHNDNKSFLVWVNEEDHLRVISMEKGGNMKEVFRRFCVGLQKIEEIFKKAGHPFMWNQHLGYVLTCPSNLGTGLRGGVHVKLAHLSKHPKFEEILTRLRLQKRGTSVFDVSNADRLGSSEVEQVQLVVDGVKLMVEMEKKLEKGQSIDDMIPAQK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of human muscle creatine kinase.
pubmed rcsb
molecule tags Transferase
molecule keywords CREATINE KINASE,M CHAIN
total genus 99
structure length 365
sequence length 374
chains with identical sequence B, C, D
ec nomenclature ec 2.7.3.2: Creatine kinase.
pdb deposition date 2001-01-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00217 ATP-gua_Ptrans ATP:guanido phosphotransferase, C-terminal catalytic domain
A PF02807 ATP-gua_PtransN ATP:guanido phosphotransferase, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.135.10 Mainly Alpha Orthogonal Bundle Transferase Creatine Kinase; Chain A, domain 1 ATP:guanido phosphotransferase, N-terminal domain 1i0eA01
3.30.590.10 Alpha Beta 2-Layer Sandwich Creatine Kinase; Chain A, domain 2 Glutamine synthetase/guanido kinase, catalytic domain 1i0eA02
2LGSA 1M15A 4LNKA 3ZXRA 3B6RA 3DREA 3DRBA 3M10A 1U6RA 4LNIA 3L2EA 4RF7A 3JPZA 1I0EA 2WHIA 1QH4A 4S17A 4GW0A 4BG4A 2BVCA 1P50A 3L2EB 1QK1A 1CRKA 1F1HA 1P52A 4RF8A 4AM1A 4S0RA 4GW2A 3JU5A 4BG4B 5J9AA 2CRKA 3JU6A 4RF9A 3L2DA 4LNFA 1HTQA 1FPYA 1RL9A 4GVYA 2WGSA 4LNNA 1VRPA 1F52A 3ZXVA 4RF6A 4GVZA 4ACFA 1LGRA 2GLSA 4BHLA 1BG0A 2J1QA 4HPPA 1HTOA 1G0WA 4XYCA 5J99A 4Q2RA 1SD0A 3NG0A 4LNOA 4Z9MA 3JQ3A
chains in the Genus database with same CATH superfamily
3ZXRA 3B6RA 3M10A 4BAXA 4RF7A 1QH4A 4GW0A 2BVCA 2GWCA 1QK1A 1P52A 4RF8A 4GW2A 4BG4B 3L2DA 1HTQA 1FPYA 4GVYA 2WGSA 2QC8A 4LNNA 3ZXVA 1LGRA 2GLSA 4HPPA 2D3CA 4Z9MA 3JQ3A 2LGSA 3LVVA 4LNKA 1VA6A 2D3BA 2WHIA 2UU7A 3FKYA 3LN7A 2D32A 2D33A 3L2EB 4AM1A 3JU5A 5J9AA 2CRKA 5J99A 4Q2RA 1SD0A 3LVWA 2OJWA 3DREA 1U6RA 3JPZA 1I0EA 4S17A 4BG4A 1P50A 4S0RA 2GWDA 4RF9A 4LNFA 1TT4A 3IG8A 1VRPA 1F52A 3NZTA 4GVZA 2J1QA 1HTOA 1G0WA 3NG0A 1M15A 3DRBA 4LNIA 3L2EA 3IG5A 1F1HA 1CRKA 3JU6A 2D3AA 1RL9A 4RF6A 4ACFA 3LN6A 4BHLA 1BG0A 1V4GA 1R8GA 4XYCA 4LNOA
chains in the Genus database with same CATH topology
2LGSA 1M15A 4LNKA 3ZXRA 3B6RA 3DREA 3DRBA 3M10A 1U6RA 4LNIA 3L2EA 4RF7A 3JPZA 1I0EA 2WHIA 1QH4A 4S17A 4GW0A 4BG4A 2BVCA 1P50A 3L2EB 1QK1A 1CRKA 1F1HA 1P52A 4RF8A 4AM1A 4S0RA 4GW2A 3JU5A 4BG4B 5J9AA 2CRKA 3JU6A 4RF9A 3L2DA 4LNFA 1HTQA 1FPYA 1RL9A 4GVYA 2WGSA 4LNNA 1VRPA 1F52A 3ZXVA 4RF6A 4GVZA 4ACFA 1LGRA 2GLSA 4BHLA 1BG0A 2J1QA 4HPPA 1HTOA 1G0WA 4XYCA 5J99A 4Q2RA 1SD0A 3NG0A 4LNOA 4Z9MA 3JQ3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2LGS A;  1M15 A;  4LNK A;  3ZXR A;  3B6R A;  3DRE A;  3DRB A;  3M10 A;  1U6R A;  4LNI A;  3L2E A;  4RF7 A;  3JPZ A;  1I0E A;  2WHI A;  1QH4 A;  4S17 A;  4GW0 A;  4BG4 A;  2BVC A;  1P50 A;  3L2E B;  1QK1 A;  1CRK A;  1F1H A;  1P52 A;  4RF8 A;  4AM1 A;  4S0R A;  4GW2 A;  3JU5 A;  4BG4 B;  5J9A A;  2CRK A;  3JU6 A;  4RF9 A;  3L2D A;  4LNF A;  1HTQ A;  1FPY A;  1RL9 A;  4GVY A;  2WGS A;  4LNN A;  1VRP A;  1F52 A;  3ZXV A;  4RF6 A;  4GVZ A;  4ACF A;  1LGR A;  2GLS A;  4BHL A;  1BG0 A;  2J1Q A;  4HPP A;  1HTO A;  1G0W A;  4XYC A;  5J99 A;  4Q2R A;  1SD0 A;  3NG0 A;  4LNO A;  4Z9M A;  3JQ3 A; 
#chains in the Genus database with same CATH topology
 3ZXR A;  3B6R A;  3M10 A;  4BAX A;  4RF7 A;  1QH4 A;  4GW0 A;  2BVC A;  2GWC A;  1QK1 A;  1P52 A;  4RF8 A;  4GW2 A;  4BG4 B;  3L2D A;  1HTQ A;  1FPY A;  4GVY A;  2WGS A;  2QC8 A;  4LNN A;  3ZXV A;  1LGR A;  2GLS A;  4HPP A;  2D3C A;  4Z9M A;  3JQ3 A;  2LGS A;  3LVV A;  4LNK A;  1VA6 A;  2D3B A;  2WHI A;  2UU7 A;  3FKY A;  3LN7 A;  2D32 A;  2D33 A;  3L2E B;  4AM1 A;  3JU5 A;  5J9A A;  2CRK A;  5J99 A;  4Q2R A;  1SD0 A;  3LVW A;  2OJW A;  3DRE A;  1U6R A;  3JPZ A;  1I0E A;  4S17 A;  4BG4 A;  1P50 A;  4S0R A;  2GWD A;  4RF9 A;  4LNF A;  1TT4 A;  3IG8 A;  1VRP A;  1F52 A;  3NZT A;  4GVZ A;  2J1Q A;  1HTO A;  1G0W A;  3NG0 A;  1M15 A;  3DRB A;  4LNI A;  3L2E A;  3IG5 A;  1F1H A;  1CRK A;  3JU6 A;  2D3A A;  1RL9 A;  4RF6 A;  4ACF A;  3LN6 A;  4BHL A;  1BG0 A;  1V4G A;  1R8G A;  4XYC A;  4LNO A; 
#chains in the Genus database with same CATH homology
 2LGS A;  1M15 A;  4LNK A;  3ZXR A;  3B6R A;  3DRE A;  3DRB A;  3M10 A;  1U6R A;  4LNI A;  3L2E A;  4RF7 A;  3JPZ A;  1I0E A;  2WHI A;  1QH4 A;  4S17 A;  4GW0 A;  4BG4 A;  2BVC A;  1P50 A;  3L2E B;  1QK1 A;  1CRK A;  1F1H A;  1P52 A;  4RF8 A;  4AM1 A;  4S0R A;  4GW2 A;  3JU5 A;  4BG4 B;  5J9A A;  2CRK A;  3JU6 A;  4RF9 A;  3L2D A;  4LNF A;  1HTQ A;  1FPY A;  1RL9 A;  4GVY A;  2WGS A;  4LNN A;  1VRP A;  1F52 A;  3ZXV A;  4RF6 A;  4GVZ A;  4ACF A;  1LGR A;  2GLS A;  4BHL A;  1BG0 A;  2J1Q A;  4HPP A;  1HTO A;  1G0W A;  4XYC A;  5J99 A;  4Q2R A;  1SD0 A;  3NG0 A;  4LNO A;  4Z9M A;  3JQ3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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