1VA6A

Crystal structure of gamma-glutamylcysteine synthetase from escherichia coli b complexed with transition-state analogue
Total Genus 178
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
178
sequence length
515
structure length
507
Chain Sequence
b'MIPDVSQALAWLEKHPQALKGIQRGLERETLRVNADGTLATTGHPEALGSALTHKWITTDFAEALLEFITPVDGDIEHMLTFMRDLHRYTARNMGDERMWPLSMPSYIAEGQDIELAQYGTSNTGRFKTLYREGLKNRYGALMQTISGVHYNFSLPMAFWQAKSGDISGADAKEKISAGYFRVIRNYYRFGWVIPYLFGASPAISSSFLTSLPFEKTESGMYYLPYATSLRLSDLGYTNKSQSNLGITFNDLYEYVAGLKQAIKTPSEEYAKIGIEKDGKRLQINSNVLQIENELYAPIRPKRVTRSGESPSDALLRGGIEYIEVRSLDINPFSPIGVDEQQVRFLDLFMVWCALADAPEMSSSELACTRVNWNRVILEGRKPGLTLGIGCETAQFPLPQVGKDLFRDLKRVAQTLDSINGGEAYQKVCDELVACFDNPDLTFSARILRSMIDTTGKAFAEAYRNLLREEPLEILREEDFVAEREASERRQQEMEAADTEPFAVWLE'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Glutamate--cysteine ligase
publication title Crystal structure of gamma-glutamylcysteine synthetase: insights into the mechanism of catalysis by a key enzyme for glutathione homeostasis
pubmed doi rcsb
source organism Escherichia coli
molecule tags Ligase
total genus 178
structure length 507
sequence length 515
chains with identical sequence B
ec nomenclature ec 6.3.2.2: Glutamate--cysteine ligase.
pdb deposition date 2004-02-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF04262 Glu_cys_ligase Glutamate-cysteine ligase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.590.20 Alpha Beta 2-Layer Sandwich Creatine Kinase; Chain A, domain 2 Creatine Kinase; Chain A, domain 2 1va6A02
2D32A 2GWDA 3LN7A 1TT4A 3NZTA 1VA6A 1R8GA 2D33A 1V4GA 3LN6A 2GWCA
chains in the Genus database with same CATH superfamily
3DRBA 5J9AA 2OJWA 2D3BA 4ACFA 3IG5A 2D3CA 4BG4A 3LN6A 4XYCA 3LN7A 1TT4A 1F1HA 4GVZA 1FPYA 1SD0A 1I0EA 1P52A 2D3AA 3ZXRA 3JQ3A 4LNKA 4BAXA 1F52A 1QK1A 1P50A 4S17A 2WGSA 3DREA 4GW2A 3L2DA 3ZXVA 3L2EB 3NZTA 1VA6A 2J1QA 2QC8A 4RF8A 1HTQA 4Q2RA 4LNNA 1RL9A 4RF6A 2CRKA 3JU6A 4HPPA 1V4GA 4LNIA 3NG0A 2D33A 4Z9MA 5J99A 3JU5A 2GWCA 3FKYA 4BG4B 2UU7A 4RF7A 1CRKA 4GVYA 1LGRA 1QH4A 2LGSA 4GW0A 2GWDA 3LVVA 4LNOA 2GLSA 1BG0A 1M15A 4LNFA 1U6RA 4BHLA 3JPZA 1HTOA 4AM1A 4RF9A 4S0RA 2WHIA 3IG8A 3L2EA 2D32A 1G0WA 1R8GA 3B6RA 3M10A 3LVWA 1VRPA 2BVCA
chains in the Genus database with same CATH topology
2OJWA 2D3BA 2D33A 2GWCA 3FKYA 3IG5A 2D3CA 3IG8A 2UU7A 1VA6A 3NZTA 2QC8A 3LN6A 2D32A 2GWDA 3LN7A 1TT4A 1R8GA 3LVVA 2D3AA 3LVWA 4BAXA 1V4GA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2D32 A;  2GWD A;  3LN7 A;  1TT4 A;  3NZT A;  1VA6 A;  1R8G A;  2D33 A;  1V4G A;  3LN6 A;  2GWC A; 
#chains in the Genus database with same CATH topology
 3DRB A;  5J9A A;  2OJW A;  2D3B A;  4ACF A;  3IG5 A;  2D3C A;  4BG4 A;  3LN6 A;  4XYC A;  3LN7 A;  1TT4 A;  1F1H A;  4GVZ A;  1FPY A;  1SD0 A;  1I0E A;  1P52 A;  2D3A A;  3ZXR A;  3JQ3 A;  4LNK A;  4BAX A;  1F52 A;  1QK1 A;  1P50 A;  4S17 A;  2WGS A;  3DRE A;  4GW2 A;  3L2D A;  3ZXV A;  3L2E B;  3NZT A;  1VA6 A;  2J1Q A;  2QC8 A;  4RF8 A;  1HTQ A;  4Q2R A;  4LNN A;  1RL9 A;  4RF6 A;  2CRK A;  3JU6 A;  4HPP A;  1V4G A;  4LNI A;  3NG0 A;  2D33 A;  4Z9M A;  5J99 A;  3JU5 A;  2GWC A;  3FKY A;  4BG4 B;  2UU7 A;  4RF7 A;  1CRK A;  4GVY A;  1LGR A;  1QH4 A;  2LGS A;  4GW0 A;  2GWD A;  3LVV A;  4LNO A;  2GLS A;  1BG0 A;  1M15 A;  4LNF A;  1U6R A;  4BHL A;  3JPZ A;  1HTO A;  4AM1 A;  4RF9 A;  4S0R A;  2WHI A;  3IG8 A;  3L2E A;  2D32 A;  1G0W A;  1R8G A;  3B6R A;  3M10 A;  3LVW A;  1VRP A;  2BVC A; 
#chains in the Genus database with same CATH homology
 2OJW A;  2D3B A;  2D33 A;  2GWC A;  3FKY A;  3IG5 A;  2D3C A;  3IG8 A;  2UU7 A;  1VA6 A;  3NZT A;  2QC8 A;  3LN6 A;  2D32 A;  2GWD A;  3LN7 A;  1TT4 A;  1R8G A;  3LVV A;  2D3A A;  3LVW A;  4BAX A;  1V4G A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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