1VA6A

Crystal structure of gamma-glutamylcysteine synthetase from escherichia coli b complexed with transition-state analogue
Total Genus 178
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
178
sequence length
515
structure length
507
Chain Sequence
MIPDVSQALAWLEKHPQALKGIQRGLERETLRVNADGTLATTGHPEALGSALTHKWITTDFAEALLEFITPVDGDIEHMLTFMRDLHRYTARNMGDERMWPLSMPSYIAEGQDIELAQYGTSNTGRFKTLYREGLKNRYGALMQTISGVHYNFSLPMAFWQAKSGDISGADAKEKISAGYFRVIRNYYRFGWVIPYLFGASPAISSSFLTSLPFEKTESGMYYLPYATSLRLSDLGYTNKSQSNLGITFNDLYEYVAGLKQAIKTPSEEYAKIGIEKDGKRLQINSNVLQIENELYAPIRPKRVTRSGESPSDALLRGGIEYIEVRSLDINPFSPIGVDEQQVRFLDLFMVWCALADAPEMSSSELACTRVNWNRVILEGRKPGLTLGIGCETAQFPLPQVGKDLFRDLKRVAQTLDSINGGEAYQKVCDELVACFDNPDLTFSARILRSMIDTTGKAFAEAYRNLLREEPLEILREEDFVAEREASERRQQEMEAADTEPFAVWLE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of gamma-glutamylcysteine synthetase: insights into the mechanism of catalysis by a key enzyme for glutathione homeostasis
pubmed doi rcsb
source organism Escherichia coli
molecule tags Ligase
molecule keywords Glutamate--cysteine ligase
total genus 178
structure length 507
sequence length 515
chains with identical sequence B
ec nomenclature ec 6.3.2.2: Glutamate--cysteine ligase.
pdb deposition date 2004-02-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF04262 Glu_cys_ligase Glutamate-cysteine ligase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.590.20 Alpha Beta 2-Layer Sandwich Creatine Kinase; Chain A, domain 2 Creatine Kinase; Chain A, domain 2 1va6A02
3LN6A 2D32A 2D33A 2GWCA 1VA6A 3LN7A 1V4GA 3NZTA 2GWDA 1TT4A 1R8GA
chains in the Genus database with same CATH superfamily
1VA6A 1V4GA 3NZTA 2BVCA 4BAXA 1R8GA 4BG4B 2D3AA 2QC8A 2D32A 1SD0A 2D33A 2LGSA 3L2EA 1RL9A 2GLSA 4GVZA 4BHLA 1LGRA 3JQ3A 3B6RA 4AM1A 1CRKA 1U6RA 3DREA 4S17A 4BG4A 4GW0A 4RF8A 1P50A 3LVWA 2GWDA 3M10A 2WGSA 3LN6A 4RF7A 2UU7A 1QH4A 4GVYA 3FKYA 2J1QA 4LNOA 3ZXVA 3DRBA 5J9AA 2D3CA 1F1HA 1QK1A 5J99A 3IG8A 1HTQA 3JU5A 4GW2A 3JPZA 2CRKA 1BG0A 2GWCA 2WHIA 1G0WA 1F52A 4Q2RA 2OJWA 3JU6A 1HTOA 1VRPA 3LVVA 3L2DA 3ZXRA 1FPYA 4LNNA 4RF9A 4S0RA 1M15A 3LN7A 3L2EB 4LNKA 1TT4A 2D3BA 3NG0A 4RF6A 1P52A 4HPPA 4LNFA 4Z9MA 4XYCA 1I0EA 3IG5A 4LNIA 4ACFA
chains in the Genus database with same CATH topology
3FKYA 1VA6A 1V4GA 3NZTA 2D3CA 3LVVA 3IG8A 4BAXA 1R8GA 2D3AA 2QC8A 2D32A 2D33A 2GWCA 3LN7A 3LVWA 2GWDA 1TT4A 2D3BA 3LN6A 3IG5A 2UU7A 2OJWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3LN6 A;  2D32 A;  2D33 A;  2GWC A;  1VA6 A;  3LN7 A;  1V4G A;  3NZT A;  2GWD A;  1TT4 A;  1R8G A; 
#chains in the Genus database with same CATH topology
 1VA6 A;  1V4G A;  3NZT A;  2BVC A;  4BAX A;  1R8G A;  4BG4 B;  2D3A A;  2QC8 A;  2D32 A;  1SD0 A;  2D33 A;  2LGS A;  3L2E A;  1RL9 A;  2GLS A;  4GVZ A;  4BHL A;  1LGR A;  3JQ3 A;  3B6R A;  4AM1 A;  1CRK A;  1U6R A;  3DRE A;  4S17 A;  4BG4 A;  4GW0 A;  4RF8 A;  1P50 A;  3LVW A;  2GWD A;  3M10 A;  2WGS A;  3LN6 A;  4RF7 A;  2UU7 A;  1QH4 A;  4GVY A;  3FKY A;  2J1Q A;  4LNO A;  3ZXV A;  3DRB A;  5J9A A;  2D3C A;  1F1H A;  1QK1 A;  5J99 A;  3IG8 A;  1HTQ A;  3JU5 A;  4GW2 A;  3JPZ A;  2CRK A;  1BG0 A;  2GWC A;  2WHI A;  1G0W A;  1F52 A;  4Q2R A;  2OJW A;  3JU6 A;  1HTO A;  1VRP A;  3LVV A;  3L2D A;  3ZXR A;  1FPY A;  4LNN A;  4RF9 A;  4S0R A;  1M15 A;  3LN7 A;  3L2E B;  4LNK A;  1TT4 A;  2D3B A;  3NG0 A;  4RF6 A;  1P52 A;  4HPP A;  4LNF A;  4Z9M A;  4XYC A;  1I0E A;  3IG5 A;  4LNI A;  4ACF A; 
#chains in the Genus database with same CATH homology
 3FKY A;  1VA6 A;  1V4G A;  3NZT A;  2D3C A;  3LVV A;  3IG8 A;  4BAX A;  1R8G A;  2D3A A;  2QC8 A;  2D32 A;  2D33 A;  2GWC A;  3LN7 A;  3LVW A;  2GWD A;  1TT4 A;  2D3B A;  3LN6 A;  3IG5 A;  2UU7 A;  2OJW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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