2D32A

Crystal structure of michaelis complex of gamma-glutamylcysteine synthetase
Total Genus 188
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
188
sequence length
518
structure length
510
Chain Sequence
MIPDVSQALAWLEKHPQALKGIQRGLERETLRVNADGTLATTGHPEALGSALTHKWITTDFAEALLEFITPVDGDIEHMLTFMRDLHRYTARNMGDERMWPLSMPSYIAEGQDIELAQYGTSNTGRFKTLYREGLKNRYGALMQTISGVHYNFSLPMAFWQAKSGADAKEKISAGYFRVIRNYYRFGWVIPYLFGASPAISSSFLTSLPFEKTESGMYYLPYATSLRLSDLGYTNKSQSNLGITFNDLYEYVAGLKQAIKTPSEEYAKIGIEKDGKRLQINSNVLQIENELYAPIRPKRVTRSGESPSDALLRGGIEYIEVRSLDINPFSPIGVDEQQVRFLDLFMVWCALADAPEMSSSELACTRVNWNRVILEGRKPGLTLGIGCETAQFPLPQVGKDLFRDLKRVAQTLDSINGGEAYQKVCDELVACFDNPDLTFSARILRSMIDTGIGGTGKAFAEAYRNLLREEPLEILREEDFVAEREASERRQQEMEAADTEPFAVWLEKHA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Glutamate--cysteine ligase
publication title Structural basis of efficient coupling peptide ligation and ATP hydrolysis by gamma-gluatamylcysteine synthetase
rcsb
source organism Escherichia coli
molecule tags Ligase
total genus 188
structure length 510
sequence length 518
chains with identical sequence B, C, D
ec nomenclature ec 6.3.2.2: Glutamate--cysteine ligase.
pdb deposition date 2005-09-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF04262 Glu_cys_ligase Glutamate-cysteine ligase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.590.20 Alpha Beta 2-Layer Sandwich Creatine Kinase; Chain A, domain 2 Creatine Kinase; Chain A, domain 2 2d32A02
1TT4A 1V4GA 2D32A 3LN7A 1R8GA 1VA6A 2GWCA 2D33A 3NZTA 3LN6A 2GWDA
chains in the Genus database with same CATH superfamily
4RF9A 3FKYA 4BG4A 1VRPA 1QH4A 2D3CA 3NG0A 4Q2RA 1TT4A 3IG8A 2D32A 1QK1A 2GWCA 1I0EA 3ZXVA 2BVCA 1M15A 2LGSA 4LNKA 1P52A 2D33A 4LNNA 2QC8A 4HPPA 4AM1A 4S0RA 1V4GA 1HTOA 4RF6A 4BG4B 2D3AA 2GWDA 4BAXA 4LNIA 1F1HA 2WGSA 3ZXRA 4BHLA 2D3BA 3DREA 3JU5A 3IG5A 2WHIA 1P50A 2CRKA 4GVYA 5J9AA 3LVWA 1RL9A 3L2EA 1G0WA 1F52A 1HTQA 3JPZA 5J99A 1CRKA 4RF8A 3B6RA 3LN6A 3NZTA 4GW2A 1FPYA 3LN7A 2UU7A 3JU6A 3JQ3A 4XYCA 3LVVA 4LNFA 4S17A 1BG0A 1U6RA 2J1QA 1SD0A 3DRBA 3L2EB 4GW0A 2GLSA 4RF7A 1R8GA 4GVZA 4LNOA 4Z9MA 1VA6A 1LGRA 2OJWA 4ACFA 3L2DA 3M10A
chains in the Genus database with same CATH topology
3LVWA 2QC8A 3FKYA 3LN6A 3NZTA 1V4GA 3LN7A 2UU7A 1R8GA 2D3AA 2D3CA 2GWDA 1TT4A 4BAXA 3IG8A 2D32A 2D3BA 1VA6A 2GWCA 3IG5A 2OJWA 3LVVA 2D33A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1TT4 A;  1V4G A;  2D32 A;  3LN7 A;  1R8G A;  1VA6 A;  2GWC A;  2D33 A;  3NZT A;  3LN6 A;  2GWD A; 
#chains in the Genus database with same CATH topology
 4RF9 A;  3FKY A;  4BG4 A;  1VRP A;  1QH4 A;  2D3C A;  3NG0 A;  4Q2R A;  1TT4 A;  3IG8 A;  2D32 A;  1QK1 A;  2GWC A;  1I0E A;  3ZXV A;  2BVC A;  1M15 A;  2LGS A;  4LNK A;  1P52 A;  2D33 A;  4LNN A;  2QC8 A;  4HPP A;  4AM1 A;  4S0R A;  1V4G A;  1HTO A;  4RF6 A;  4BG4 B;  2D3A A;  2GWD A;  4BAX A;  4LNI A;  1F1H A;  2WGS A;  3ZXR A;  4BHL A;  2D3B A;  3DRE A;  3JU5 A;  3IG5 A;  2WHI A;  1P50 A;  2CRK A;  4GVY A;  5J9A A;  3LVW A;  1RL9 A;  3L2E A;  1G0W A;  1F52 A;  1HTQ A;  3JPZ A;  5J99 A;  1CRK A;  4RF8 A;  3B6R A;  3LN6 A;  3NZT A;  4GW2 A;  1FPY A;  3LN7 A;  2UU7 A;  3JU6 A;  3JQ3 A;  4XYC A;  3LVV A;  4LNF A;  4S17 A;  1BG0 A;  1U6R A;  2J1Q A;  1SD0 A;  3DRB A;  3L2E B;  4GW0 A;  2GLS A;  4RF7 A;  1R8G A;  4GVZ A;  4LNO A;  4Z9M A;  1VA6 A;  1LGR A;  2OJW A;  4ACF A;  3L2D A;  3M10 A; 
#chains in the Genus database with same CATH homology
 3LVW A;  2QC8 A;  3FKY A;  3LN6 A;  3NZT A;  1V4G A;  3LN7 A;  2UU7 A;  1R8G A;  2D3A A;  2D3C A;  2GWD A;  1TT4 A;  4BAX A;  3IG8 A;  2D32 A;  2D3B A;  1VA6 A;  2GWC A;  3IG5 A;  2OJW A;  3LVV A;  2D33 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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