1V4GA

Crystal structure of gamma-glutamylcysteine synthetase from escherichia coli b
Total Genus 190
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
190
sequence length
517
structure length
508
Chain Sequence
b'IPDVSQALAWLEKHPQALKGIQRGLERETLRVNADGTLATTGHPEALGSALTHKWITTDFAEALLEFITPVDGDIEHMLTFMRDLHRYTARNMGDERMWPLSMPSYIAEGQDIELAQYGTSNTGRFKTLYREGLKNRYGALMQTISGVHYNFSLPMAFWQAKSGADAKEKISAGYFRVIRNYYRFGWVIPYLFGASPAISSSFLSLPFEKTESGMYYLPYATSLRLSDLGYTNKSQSNLGITFNDLYEYVAGLKQAIKTPSEEYAKIGIEKDGKRLQINSNVLQIENELYAPIRPKRVTRSGESPSDALLRGGIEYIEVRSLDINPFSPIGVDEQQVRFLDLFMVWCALADAPEMSSSELACTRVNWNRVILEGRKPGLTLGIGCETAQFPLPQVGKDLFRDLKRVAQTLDSINGGEAYQKVCDELVACFDNPDLTFSARILRSMIDTGIGGTGKAFAEAYRNLLREEPLEILREEDFVAEREASERRQQEMEAADTEPFAVWLEKHA'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Glutamate--cysteine ligase
publication title Crystal structure of gamma-glutamylcysteine synthetase: insights into the mechanism of catalysis by a key enzyme for glutathione homeostasis
pubmed doi rcsb
source organism Escherichia coli
molecule tags Ligase
total genus 190
structure length 508
sequence length 517
chains with identical sequence B, C, D
ec nomenclature ec 6.3.2.2: Glutamate--cysteine ligase.
pdb deposition date 2003-11-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF04262 Glu_cys_ligase Glutamate-cysteine ligase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.590.20 Alpha Beta 2-Layer Sandwich Creatine Kinase; Chain A, domain 2 Creatine Kinase; Chain A, domain 2 1v4gA02
2D33A 1R8GA 1TT4A 2GWDA 2GWCA 1V4GA 3LN7A 3LN6A 3NZTA 1VA6A 2D32A
chains in the Genus database with same CATH superfamily
3M10A 1QK1A 4RF7A 2J1QA 4S0RA 2D3AA 2GWCA 1BG0A 1U6RA 3FKYA 3NZTA 1I0EA 4LNIA 2LGSA 4S17A 4RF9A 2BVCA 2D3CA 4BG4B 4AM1A 3NG0A 2D32A 3L2EA 1F1HA 3L2DA 3ZXRA 4LNFA 3JU5A 1M15A 1F52A 1V4GA 1FPYA 4Q2RA 2CRKA 3B6RA 4BG4A 3DREA 2WHIA 2GLSA 4HPPA 1HTQA 5J99A 3IG5A 4BHLA 4RF6A 1G0WA 3LN7A 3LVVA 3JQ3A 2WGSA 3LN6A 2OJWA 1R8GA 4GVZA 4GVYA 2D3BA 4LNNA 1QH4A 3JPZA 4ACFA 4GW0A 1CRKA 4LNOA 3DRBA 3ZXVA 2D33A 4GW2A 2QC8A 1LGRA 1TT4A 5J9AA 3LVWA 4BAXA 3IG8A 4XYCA 4Z9MA 4RF8A 1RL9A 2UU7A 1P50A 4LNKA 3JU6A 1VRPA 1P52A 1SD0A 1HTOA 2GWDA 3L2EB 1VA6A
chains in the Genus database with same CATH topology
1TT4A 2D3AA 2GWCA 1V4GA 3LN6A 2OJWA 3LVWA 4BAXA 3IG8A 1R8GA 2UU7A 3FKYA 3NZTA 2D3BA 2D3CA 2D32A 3IG5A 2D33A 2GWDA 3LN7A 1VA6A 3LVVA 2QC8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2D33 A;  1R8G A;  1TT4 A;  2GWD A;  2GWC A;  1V4G A;  3LN7 A;  3LN6 A;  3NZT A;  1VA6 A;  2D32 A; 
#chains in the Genus database with same CATH topology
 3M10 A;  1QK1 A;  4RF7 A;  2J1Q A;  4S0R A;  2D3A A;  2GWC A;  1BG0 A;  1U6R A;  3FKY A;  3NZT A;  1I0E A;  4LNI A;  2LGS A;  4S17 A;  4RF9 A;  2BVC A;  2D3C A;  4BG4 B;  4AM1 A;  3NG0 A;  2D32 A;  3L2E A;  1F1H A;  3L2D A;  3ZXR A;  4LNF A;  3JU5 A;  1M15 A;  1F52 A;  1V4G A;  1FPY A;  4Q2R A;  2CRK A;  3B6R A;  4BG4 A;  3DRE A;  2WHI A;  2GLS A;  4HPP A;  1HTQ A;  5J99 A;  3IG5 A;  4BHL A;  4RF6 A;  1G0W A;  3LN7 A;  3LVV A;  3JQ3 A;  2WGS A;  3LN6 A;  2OJW A;  1R8G A;  4GVZ A;  4GVY A;  2D3B A;  4LNN A;  1QH4 A;  3JPZ A;  4ACF A;  4GW0 A;  1CRK A;  4LNO A;  3DRB A;  3ZXV A;  2D33 A;  4GW2 A;  2QC8 A;  1LGR A;  1TT4 A;  5J9A A;  3LVW A;  4BAX A;  3IG8 A;  4XYC A;  4Z9M A;  4RF8 A;  1RL9 A;  2UU7 A;  1P50 A;  4LNK A;  3JU6 A;  1VRP A;  1P52 A;  1SD0 A;  1HTO A;  2GWD A;  3L2E B;  1VA6 A; 
#chains in the Genus database with same CATH homology
 1TT4 A;  2D3A A;  2GWC A;  1V4G A;  3LN6 A;  2OJW A;  3LVW A;  4BAX A;  3IG8 A;  1R8G A;  2UU7 A;  3FKY A;  3NZT A;  2D3B A;  2D3C A;  2D32 A;  3IG5 A;  2D33 A;  2GWD A;  3LN7 A;  1VA6 A;  3LVV A;  2QC8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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