1V4GA

Crystal structure of gamma-glutamylcysteine synthetase from escherichia coli b
Total Genus 190
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
190
sequence length
517
structure length
508
Chain Sequence
IPDVSQALAWLEKHPQALKGIQRGLERETLRVNADGTLATTGHPEALGSALTHKWITTDFAEALLEFITPVDGDIEHMLTFMRDLHRYTARNMGDERMWPLSMPSYIAEGQDIELAQYGTSNTGRFKTLYREGLKNRYGALMQTISGVHYNFSLPMAFWQAKSGADAKEKISAGYFRVIRNYYRFGWVIPYLFGASPAISSSFLSLPFEKTESGMYYLPYATSLRLSDLGYTNKSQSNLGITFNDLYEYVAGLKQAIKTPSEEYAKIGIEKDGKRLQINSNVLQIENELYAPIRPKRVTRSGESPSDALLRGGIEYIEVRSLDINPFSPIGVDEQQVRFLDLFMVWCALADAPEMSSSELACTRVNWNRVILEGRKPGLTLGIGCETAQFPLPQVGKDLFRDLKRVAQTLDSINGGEAYQKVCDELVACFDNPDLTFSARILRSMIDTGIGGTGKAFAEAYRNLLREEPLEILREEDFVAEREASERRQQEMEAADTEPFAVWLEKHA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of gamma-glutamylcysteine synthetase: insights into the mechanism of catalysis by a key enzyme for glutathione homeostasis
pubmed doi rcsb
source organism Escherichia coli
molecule tags Ligase
molecule keywords Glutamate--cysteine ligase
total genus 190
structure length 508
sequence length 517
chains with identical sequence B, C, D
ec nomenclature ec 6.3.2.2: Glutamate--cysteine ligase.
pdb deposition date 2003-11-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF04262 Glu_cys_ligase Glutamate-cysteine ligase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.590.20 Alpha Beta 2-Layer Sandwich Creatine Kinase; Chain A, domain 2 Creatine Kinase; Chain A, domain 2 1v4gA02
3LN7A 3NZTA 1R8GA 1V4GA 1TT4A 1VA6A 3LN6A 2GWCA 2GWDA 2D33A 2D32A
chains in the Genus database with same CATH superfamily
1TT4A 1M15A 3L2DA 4S17A 4RF6A 4BHLA 1FPYA 4LNIA 2UU7A 4S0RA 3JU5A 4AM1A 3ZXVA 2LGSA 4XYCA 2BVCA 3JQ3A 3ZXRA 2D3AA 4LNNA 3NZTA 2GWCA 3JU6A 3LN6A 3B6RA 1F52A 2GWDA 3IG5A 3NG0A 4BG4A 1BG0A 5J9AA 1CRKA 4ACFA 2WHIA 2GLSA 1VRPA 2J1QA 3M10A 5J99A 2D32A 3FKYA 2QC8A 1QH4A 1V4GA 2OJWA 1P52A 4Q2RA 2D33A 1HTOA 1QK1A 2CRKA 3IG8A 3L2EB 4LNOA 1I0EA 3LVVA 2D3CA 1F1HA 1SD0A 4LNKA 4GW0A 1G0WA 4BAXA 3LVWA 4RF9A 4GW2A 4LNFA 2WGSA 3JPZA 1RL9A 1P50A 4BG4B 1HTQA 1VA6A 4HPPA 4GVYA 3L2EA 1LGRA 3DREA 3LN7A 4GVZA 2D3BA 1U6RA 4Z9MA 1R8GA 4RF7A 3DRBA 4RF8A
chains in the Genus database with same CATH topology
2QC8A 1V4GA 1TT4A 3LN6A 2OJWA 2GWDA 3IG5A 2D33A 2UU7A 1VA6A 3IG8A 3LN7A 2D3BA 2D3AA 3LVVA 2D3CA 2D32A 3NZTA 3FKYA 1R8GA 4BAXA 2GWCA 3LVWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3LN7 A;  3NZT A;  1R8G A;  1V4G A;  1TT4 A;  1VA6 A;  3LN6 A;  2GWC A;  2GWD A;  2D33 A;  2D32 A; 
#chains in the Genus database with same CATH topology
 1TT4 A;  1M15 A;  3L2D A;  4S17 A;  4RF6 A;  4BHL A;  1FPY A;  4LNI A;  2UU7 A;  4S0R A;  3JU5 A;  4AM1 A;  3ZXV A;  2LGS A;  4XYC A;  2BVC A;  3JQ3 A;  3ZXR A;  2D3A A;  4LNN A;  3NZT A;  2GWC A;  3JU6 A;  3LN6 A;  3B6R A;  1F52 A;  2GWD A;  3IG5 A;  3NG0 A;  4BG4 A;  1BG0 A;  5J9A A;  1CRK A;  4ACF A;  2WHI A;  2GLS A;  1VRP A;  2J1Q A;  3M10 A;  5J99 A;  2D32 A;  3FKY A;  2QC8 A;  1QH4 A;  1V4G A;  2OJW A;  1P52 A;  4Q2R A;  2D33 A;  1HTO A;  1QK1 A;  2CRK A;  3IG8 A;  3L2E B;  4LNO A;  1I0E A;  3LVV A;  2D3C A;  1F1H A;  1SD0 A;  4LNK A;  4GW0 A;  1G0W A;  4BAX A;  3LVW A;  4RF9 A;  4GW2 A;  4LNF A;  2WGS A;  3JPZ A;  1RL9 A;  1P50 A;  4BG4 B;  1HTQ A;  1VA6 A;  4HPP A;  4GVY A;  3L2E A;  1LGR A;  3DRE A;  3LN7 A;  4GVZ A;  2D3B A;  1U6R A;  4Z9M A;  1R8G A;  4RF7 A;  3DRB A;  4RF8 A; 
#chains in the Genus database with same CATH homology
 2QC8 A;  1V4G A;  1TT4 A;  3LN6 A;  2OJW A;  2GWD A;  3IG5 A;  2D33 A;  2UU7 A;  1VA6 A;  3IG8 A;  3LN7 A;  2D3B A;  2D3A A;  3LVV A;  2D3C A;  2D32 A;  3NZT A;  3FKY A;  1R8G A;  4BAX A;  2GWC A;  3LVW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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