1V4GA

Crystal structure of gamma-glutamylcysteine synthetase from escherichia coli b
Total Genus 190
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
190
sequence length
517
structure length
508
Chain Sequence
IPDVSQALAWLEKHPQALKGIQRGLERETLRVNADGTLATTGHPEALGSALTHKWITTDFAEALLEFITPVDGDIEHMLTFMRDLHRYTARNMGDERMWPLSMPSYIAEGQDIELAQYGTSNTGRFKTLYREGLKNRYGALMQTISGVHYNFSLPMAFWQAKSGADAKEKISAGYFRVIRNYYRFGWVIPYLFGASPAISSSFLSLPFEKTESGMYYLPYATSLRLSDLGYTNKSQSNLGITFNDLYEYVAGLKQAIKTPSEEYAKIGIEKDGKRLQINSNVLQIENELYAPIRPKRVTRSGESPSDALLRGGIEYIEVRSLDINPFSPIGVDEQQVRFLDLFMVWCALADAPEMSSSELACTRVNWNRVILEGRKPGLTLGIGCETAQFPLPQVGKDLFRDLKRVAQTLDSINGGEAYQKVCDELVACFDNPDLTFSARILRSMIDTGIGGTGKAFAEAYRNLLREEPLEILREEDFVAEREASERRQQEMEAADTEPFAVWLEKHA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Glutamate--cysteine ligase
publication title Crystal structure of gamma-glutamylcysteine synthetase: insights into the mechanism of catalysis by a key enzyme for glutathione homeostasis
pubmed doi rcsb
source organism Escherichia coli
molecule tags Ligase
total genus 190
structure length 508
sequence length 517
chains with identical sequence B, C, D
ec nomenclature ec 6.3.2.2: Glutamate--cysteine ligase.
pdb deposition date 2003-11-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF04262 Glu_cys_ligase Glutamate-cysteine ligase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.590.20 Alpha Beta 2-Layer Sandwich Creatine Kinase; Chain A, domain 2 Creatine Kinase; Chain A, domain 2 1v4gA02
2GWCA 2D33A 3LN7A 1TT4A 1R8GA 2D32A 3NZTA 2GWDA 3LN6A 1V4GA 1VA6A
chains in the Genus database with same CATH superfamily
3B6RA 1FPYA 1U6RA 3LN7A 4GVZA 4ACFA 1RL9A 2OJWA 3DRBA 1VA6A 5J9AA 2LGSA 1V4GA 2GWCA 2D33A 2D32A 3L2EA 4LNNA 2BVCA 4LNIA 2CRKA 1HTOA 1TT4A 3JU6A 4LNFA 4Q2RA 2D3AA 2D3BA 1F52A 1F1HA 3ZXVA 4GW0A 3ZXRA 4Z9MA 1M15A 1QK1A 2GLSA 4RF9A 3L2EB 1VRPA 3JU5A 4GW2A 4XYCA 4S17A 1SD0A 1CRKA 2WHIA 1I0EA 3JPZA 4BG4A 2WGSA 4BAXA 2D3CA 3NG0A 4S0RA 1HTQA 4AM1A 2J1QA 3L2DA 3NZTA 1P50A 3LN6A 4LNKA 4RF8A 4HPPA 5J99A 4GVYA 3M10A 2UU7A 1QH4A 4RF7A 4LNOA 2QC8A 3JQ3A 1BG0A 1G0WA 3LVVA 2GWDA 3FKYA 3IG8A 1R8GA 4BG4B 1P52A 1LGRA 3DREA 4RF6A 3IG5A 4BHLA 3LVWA
chains in the Genus database with same CATH topology
4BAXA 3LN7A 1TT4A 2D3AA 2QC8A 2D3CA 2D3BA 3LVVA 2OJWA 3NZTA 2GWDA 3FKYA 3LN6A 1VA6A 3IG8A 1R8GA 1V4GA 2GWCA 2D33A 2UU7A 2D32A 3IG5A 3LVWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2GWC A;  2D33 A;  3LN7 A;  1TT4 A;  1R8G A;  2D32 A;  3NZT A;  2GWD A;  3LN6 A;  1V4G A;  1VA6 A; 
#chains in the Genus database with same CATH topology
 3B6R A;  1FPY A;  1U6R A;  3LN7 A;  4GVZ A;  4ACF A;  1RL9 A;  2OJW A;  3DRB A;  1VA6 A;  5J9A A;  2LGS A;  1V4G A;  2GWC A;  2D33 A;  2D32 A;  3L2E A;  4LNN A;  2BVC A;  4LNI A;  2CRK A;  1HTO A;  1TT4 A;  3JU6 A;  4LNF A;  4Q2R A;  2D3A A;  2D3B A;  1F52 A;  1F1H A;  3ZXV A;  4GW0 A;  3ZXR A;  4Z9M A;  1M15 A;  1QK1 A;  2GLS A;  4RF9 A;  3L2E B;  1VRP A;  3JU5 A;  4GW2 A;  4XYC A;  4S17 A;  1SD0 A;  1CRK A;  2WHI A;  1I0E A;  3JPZ A;  4BG4 A;  2WGS A;  4BAX A;  2D3C A;  3NG0 A;  4S0R A;  1HTQ A;  4AM1 A;  2J1Q A;  3L2D A;  3NZT A;  1P50 A;  3LN6 A;  4LNK A;  4RF8 A;  4HPP A;  5J99 A;  4GVY A;  3M10 A;  2UU7 A;  1QH4 A;  4RF7 A;  4LNO A;  2QC8 A;  3JQ3 A;  1BG0 A;  1G0W A;  3LVV A;  2GWD A;  3FKY A;  3IG8 A;  1R8G A;  4BG4 B;  1P52 A;  1LGR A;  3DRE A;  4RF6 A;  3IG5 A;  4BHL A;  3LVW A; 
#chains in the Genus database with same CATH homology
 4BAX A;  3LN7 A;  1TT4 A;  2D3A A;  2QC8 A;  2D3C A;  2D3B A;  3LVV A;  2OJW A;  3NZT A;  2GWD A;  3FKY A;  3LN6 A;  1VA6 A;  3IG8 A;  1R8G A;  1V4G A;  2GWC A;  2D33 A;  2UU7 A;  2D32 A;  3IG5 A;  3LVW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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