1I0EA

Crystal structure of creatine kinase from human muscle
Total Genus 99
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
374
structure length
365
Chain Sequence
NKFKLNYKPEEEYPDLSKHNNHMAKVLTLELYKKLRDKETPSGFTVDDVIQTGVDNPGHPFIMTVGCVAGDEESYEVFKELFDPIISDRHGGYKPTDKHKTDLNHENLKGGDDLDPNYVLSSRVRTGRSIKGYTLPPHCSRGERRAVEKLSVEALNSLTGEFKGKYYPLKSMTEKEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIWHNDNKSFLVWVNEEDHLRVISMEKGGNMKEVFRRFCVGLQKIEEIFKKAGHPFMWNQHLGYVLTCPSNLGTGLRGGVHVKLAHLSKHPKFEEILTRLRLQKRGTSVFDVSNADRLGSSEVEQVQLVVDGVKLMVEMEKKLEKGQSIDDMIPAQK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Structure of human muscle creatine kinase.
pubmed rcsb
molecule tags Transferase
molecule keywords CREATINE KINASE,M CHAIN
total genus 99
structure length 365
sequence length 374
chains with identical sequence B, C, D
ec nomenclature ec 2.7.3.2: Creatine kinase.
pdb deposition date 2001-01-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00217 ATP-gua_Ptrans ATP:guanido phosphotransferase, C-terminal catalytic domain
A PF02807 ATP-gua_PtransN ATP:guanido phosphotransferase, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.135.10 Mainly Alpha Orthogonal Bundle Transferase Creatine Kinase; Chain A, domain 1 ATP:guanido phosphotransferase, N-terminal domain 1i0eA01
3.30.590.10 Alpha Beta 2-Layer Sandwich Creatine Kinase; Chain A, domain 2 Glutamine synthetase/guanido kinase, catalytic domain 1i0eA02
1SD0A 1G0WA 4ACFA 1I0EA 3B6RA 1VRPA 4RF8A 4AM1A 2WHIA 3JU5A 3NG0A 4RF7A 2LGSA 2CRKA 5J9AA 1CRKA 1LGRA 1U6RA 3DRBA 1HTOA 4LNNA 3L2EB 4Q2RA 4HPPA 1M15A 1FPYA 1RL9A 3L2EA 4GVYA 4GW0A 2GLSA 2BVCA 4RF6A 4S17A 3M10A 3JPZA 4XYCA 1F52A 3DREA 1P50A 3ZXRA 2WGSA 4S0RA 3ZXVA 3JQ3A 3JU6A 4Z9MA 1QH4A 3L2DA 1HTQA 4RF9A 4LNKA 4LNOA 4BG4B 1P52A 4LNFA 1F1HA 4GW2A 1QK1A 4BG4A 5J99A 4LNIA 1BG0A 4GVZA 4BHLA 2J1QA
chains in the Genus database with same CATH superfamily
3LVVA 3NG0A 2LGSA 4BAXA 1M15A 2QC8A 3DREA 3LN6A 4S0RA 3JU6A 2GWCA 3NZTA 1P52A 1QK1A 4BG4A 2D32A 3LN7A 2WHIA 4AM1A 1R8GA 2D3CA 2CRKA 1CRKA 3L2EB 2OJWA 4GVYA 3FKYA 2GLSA 2BVCA 4S17A 3M10A 1F52A 2D3BA 1QH4A 1TT4A 1F1HA 1BG0A 4GVZA 3IG8A 1SD0A 1G0WA 1VA6A 3B6RA 2GWDA 3JU5A 4RF7A 1LGRA 3DRBA 1FPYA 1RL9A 3L2EA 4XYCA 3LVWA 2D3AA 3ZXRA 3ZXVA 3JQ3A 4Z9MA 1V4GA 1HTQA 4LNOA 4LNFA 5J99A 4LNIA 4BHLA 2J1QA 4ACFA 1I0EA 1VRPA 4RF8A 5J9AA 2D33A 1U6RA 1HTOA 4LNNA 4Q2RA 4HPPA 4GW0A 3IG5A 4RF6A 3JPZA 1P50A 2WGSA 3L2DA 2UU7A 4RF9A 4LNKA 4BG4B 4GW2A
chains in the Genus database with same CATH topology
1SD0A 1G0WA 4ACFA 1I0EA 3B6RA 1VRPA 4RF8A 4AM1A 2WHIA 3JU5A 3NG0A 4RF7A 2LGSA 2CRKA 5J9AA 1CRKA 1LGRA 1U6RA 3DRBA 1HTOA 4LNNA 3L2EB 4Q2RA 4HPPA 1M15A 1FPYA 1RL9A 3L2EA 4GVYA 4GW0A 2GLSA 2BVCA 4RF6A 4S17A 3M10A 3JPZA 4XYCA 1F52A 3DREA 1P50A 3ZXRA 2WGSA 4S0RA 3ZXVA 3JQ3A 3JU6A 4Z9MA 1QH4A 3L2DA 1HTQA 4RF9A 4LNKA 4LNOA 4BG4B 1P52A 4LNFA 1F1HA 4GW2A 1QK1A 4BG4A 5J99A 4LNIA 1BG0A 4GVZA 4BHLA 2J1QA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1SD0 A;  1G0W A;  4ACF A;  1I0E A;  3B6R A;  1VRP A;  4RF8 A;  4AM1 A;  2WHI A;  3JU5 A;  3NG0 A;  4RF7 A;  2LGS A;  2CRK A;  5J9A A;  1CRK A;  1LGR A;  1U6R A;  3DRB A;  1HTO A;  4LNN A;  3L2E B;  4Q2R A;  4HPP A;  1M15 A;  1FPY A;  1RL9 A;  3L2E A;  4GVY A;  4GW0 A;  2GLS A;  2BVC A;  4RF6 A;  4S17 A;  3M10 A;  3JPZ A;  4XYC A;  1F52 A;  3DRE A;  1P50 A;  3ZXR A;  2WGS A;  4S0R A;  3ZXV A;  3JQ3 A;  3JU6 A;  4Z9M A;  1QH4 A;  3L2D A;  1HTQ A;  4RF9 A;  4LNK A;  4LNO A;  4BG4 B;  1P52 A;  4LNF A;  1F1H A;  4GW2 A;  1QK1 A;  4BG4 A;  5J99 A;  4LNI A;  1BG0 A;  4GVZ A;  4BHL A;  2J1Q A; 
#chains in the Genus database with same CATH topology
 3LVV A;  3NG0 A;  2LGS A;  4BAX A;  1M15 A;  2QC8 A;  3DRE A;  3LN6 A;  4S0R A;  3JU6 A;  2GWC A;  3NZT A;  1P52 A;  1QK1 A;  4BG4 A;  2D32 A;  3LN7 A;  2WHI A;  4AM1 A;  1R8G A;  2D3C A;  2CRK A;  1CRK A;  3L2E B;  2OJW A;  4GVY A;  3FKY A;  2GLS A;  2BVC A;  4S17 A;  3M10 A;  1F52 A;  2D3B A;  1QH4 A;  1TT4 A;  1F1H A;  1BG0 A;  4GVZ A;  3IG8 A;  1SD0 A;  1G0W A;  1VA6 A;  3B6R A;  2GWD A;  3JU5 A;  4RF7 A;  1LGR A;  3DRB A;  1FPY A;  1RL9 A;  3L2E A;  4XYC A;  3LVW A;  2D3A A;  3ZXR A;  3ZXV A;  3JQ3 A;  4Z9M A;  1V4G A;  1HTQ A;  4LNO A;  4LNF A;  5J99 A;  4LNI A;  4BHL A;  2J1Q A;  4ACF A;  1I0E A;  1VRP A;  4RF8 A;  5J9A A;  2D33 A;  1U6R A;  1HTO A;  4LNN A;  4Q2R A;  4HPP A;  4GW0 A;  3IG5 A;  4RF6 A;  3JPZ A;  1P50 A;  2WGS A;  3L2D A;  2UU7 A;  4RF9 A;  4LNK A;  4BG4 B;  4GW2 A; 
#chains in the Genus database with same CATH homology
 1SD0 A;  1G0W A;  4ACF A;  1I0E A;  3B6R A;  1VRP A;  4RF8 A;  4AM1 A;  2WHI A;  3JU5 A;  3NG0 A;  4RF7 A;  2LGS A;  2CRK A;  5J9A A;  1CRK A;  1LGR A;  1U6R A;  3DRB A;  1HTO A;  4LNN A;  3L2E B;  4Q2R A;  4HPP A;  1M15 A;  1FPY A;  1RL9 A;  3L2E A;  4GVY A;  4GW0 A;  2GLS A;  2BVC A;  4RF6 A;  4S17 A;  3M10 A;  3JPZ A;  4XYC A;  1F52 A;  3DRE A;  1P50 A;  3ZXR A;  2WGS A;  4S0R A;  3ZXV A;  3JQ3 A;  3JU6 A;  4Z9M A;  1QH4 A;  3L2D A;  1HTQ A;  4RF9 A;  4LNK A;  4LNO A;  4BG4 B;  1P52 A;  4LNF A;  1F1H A;  4GW2 A;  1QK1 A;  4BG4 A;  5J99 A;  4LNI A;  1BG0 A;  4GVZ A;  4BHL A;  2J1Q A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...