1KU1A

Crystal structure of the sec7 domain of yeast gea2
Total Genus 74
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
74
sequence length
211
structure length
211
Chain Sequence
GLVPRGSHMDRKTEFIECTNAFNEKPKKGIPMLIEKGFIASDSDKDIAEFLFNNNNRMNKKTIGLLLCHPDKVSLLNEYIRLFDFSGLRVDEAIRILLTKFRLPGESQQIERIIEAFSSAYCENQDYDPSKISDNAEDDISTVQPDADSVFILSYSIIMLNTDLHNPQVKEHMSFEDYSGNLKGCCNHKDFPFWYLDRVYCSIRDKEIVMP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Mechanism of domain closure of Sec7 domains and role in BFA sensitivity.
pubmed doi rcsb
molecule tags Endocytosis/exocytosis
source organism Saccharomyces cerevisiae
molecule keywords ARF guanine-nucleotide exchange factor 2
total genus 74
structure length 211
sequence length 211
chains with identical sequence B
ec nomenclature
pdb deposition date 2002-01-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01369 Sec7 Sec7 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.220.20 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin V; domain 1 1ku1A01
1.10.1000.11 Mainly Alpha Orthogonal Bundle Arf Nucleotide-binding Site Opener; domain 2 Arf Nucleotide-binding Site Opener,domain 2 1ku1A02
3SWVA 4A4PA 4L5MA 4JMOA 1R8QE 4D7QA 4JMIA 1KU1A 3LTLA 4C0AA 2R09A 1R8ME 1S9DE 1BC9A 1RE0B 4D7RA 4OIYA 4JWLA 1XT0B 2R0DA 4Z21A 1PBVA 1XSZA 1R8SE 4JXHA 3L8NA 4C7PA
chains in the Genus database with same CATH superfamily
4L5MA 2IICA 2XO3A 1DM5A 4KMUX 1Q8DA 2VXGA 1QC7A 2II2A 4FQ0C 2H0LA 1ALAA 1ANNA 1N41A 3HJLA 3ABQA 4D7RA 1HAKA 2K6XA 3USWA 2RANA 3AO0A 4KN4X 2ZHIA 1C1KA 1XT0B 2ZOCA 2HYUA 4EVFA 1PBVA 4Q2SA 1G5NA 3ABRA 4JK1X 1A8BA 1BCYA 1N44A 2Q4CA 1A8AA 1XJLA 3TW5A 4JMIA 3LTLA 2IE6A 3BRXA 1S9DE 1W45A 4OIYA 1YCNA 3USYA 1AVHA 1AEIA 1AIIA 1BC3A 1HVDA 1DK5A 2R0DA 2H0KA 1AVCA 2H0MA 4Z21A 1R8SE 4MDUA 1SAVA 1R4AE 1AXNA 3SWVA 4MDVA 1AVRA 1M9IA 2QEZA 1YIIA 2R09A 1BC0A 2HYWA 3ABSA 1ANWA 1ANXA 1BC9A 1RE0B 1I4AA 3SOHB 4JWLA 2HYVA 4HREA 1N42A 1UPTB 1HVFA 1W7BA 4C7PA 1W3WA 1HVEA 3ANYA 2ZHJA 1BO9A 4A4PA 1BCZA 4JMOA 1LKVX 3ABOA 1R8QE 4D7QA 1KU1A 2OY9A 4C0AA 2HSNA 1HVGA 2XO2A 4KN7X 1HM6A 2IE7A 1MCXA 1R8ME 4EVHA 1N00A 4X9PA 1YGMA 1BCWA 3AJCA 1XSZA 4FHRB 1AOWA 4JXHA 3L8NA 1BC1A 1YJ0A
chains in the Genus database with same CATH topology
3SWVA 4A4PA 4L5MA 4JMOA 1LKVX 3TW5A 4KMUX 1Q8DA 1R8QE 4D7QA 4JMIA 1KU1A 3LTLA 4C0AA 1QC7A 2R09A 2HSNA 4FQ0C 4KN7X 3HJLA 1R8ME 1S9DE 1BC9A 1RE0B 4D7RA 4OIYA 2K6XA 3USWA 3USYA 4KN4X 3SOHB 4JWLA 1XT0B 2R0DA 3AJCA 4Z21A 1PBVA 1XSZA 1R8SE 4FHRB 4JXHA 3L8NA 4JK1X 4C7PA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3SWV A;  4A4P A;  4L5M A;  4JMO A;  1R8Q E;  4D7Q A;  4JMI A;  1KU1 A;  3LTL A;  4C0A A;  2R09 A;  1R8M E;  1S9D E;  1BC9 A;  1RE0 B;  4D7R A;  4OIY A;  4JWL A;  1XT0 B;  2R0D A;  4Z21 A;  1PBV A;  1XSZ A;  1R8S E;  4JXH A;  3L8N A;  4C7P A; 
#chains in the Genus database with same CATH topology
 4L5M A;  2IIC A;  2XO3 A;  1DM5 A;  4KMU X;  1Q8D A;  2VXG A;  1QC7 A;  2II2 A;  4FQ0 C;  2H0L A;  1ALA A;  1ANN A;  1N41 A;  3HJL A;  3ABQ A;  4D7R A;  1HAK A;  2K6X A;  3USW A;  2RAN A;  3AO0 A;  4KN4 X;  2ZHI A;  1C1K A;  1XT0 B;  2ZOC A;  2HYU A;  4EVF A;  1PBV A;  4Q2S A;  1G5N A;  3ABR A;  4JK1 X;  1A8B A;  1BCY A;  1N44 A;  2Q4C A;  1A8A A;  1XJL A;  3TW5 A;  4JMI A;  3LTL A;  2IE6 A;  3BRX A;  1S9D E;  1W45 A;  4OIY A;  1YCN A;  3USY A;  1AVH A;  1AEI A;  1AII A;  1BC3 A;  1HVD A;  1DK5 A;  2R0D A;  2H0K A;  1AVC A;  2H0M A;  4Z21 A;  1R8S E;  4MDU A;  1SAV A;  1R4A E;  1AXN A;  3SWV A;  4MDV A;  1AVR A;  1M9I A;  2QEZ A;  1YII A;  2R09 A;  1BC0 A;  2HYW A;  3ABS A;  1ANW A;  1ANX A;  1BC9 A;  1RE0 B;  1I4A A;  3SOH B;  4JWL A;  2HYV A;  4HRE A;  1N42 A;  1UPT B;  1HVF A;  1W7B A;  4C7P A;  1W3W A;  1HVE A;  3ANY A;  2ZHJ A;  1BO9 A;  4A4P A;  1BCZ A;  4JMO A;  1LKV X;  3ABO A;  1R8Q E;  4D7Q A;  1KU1 A;  2OY9 A;  4C0A A;  2HSN A;  1HVG A;  2XO2 A;  4KN7 X;  1HM6 A;  2IE7 A;  1MCX A;  1R8M E;  4EVH A;  1N00 A;  4X9P A;  1YGM A;  1BCW A;  3AJC A;  1XSZ A;  4FHR B;  1AOW A;  4JXH A;  3L8N A;  1BC1 A;  1YJ0 A; 
#chains in the Genus database with same CATH homology
 3SWV A;  4A4P A;  4L5M A;  4JMO A;  1LKV X;  3TW5 A;  4KMU X;  1Q8D A;  1R8Q E;  4D7Q A;  4JMI A;  1KU1 A;  3LTL A;  4C0A A;  1QC7 A;  2R09 A;  2HSN A;  4FQ0 C;  4KN7 X;  3HJL A;  1R8M E;  1S9D E;  1BC9 A;  1RE0 B;  4D7R A;  4OIY A;  2K6X A;  3USW A;  3USY A;  4KN4 X;  3SOH B;  4JWL A;  1XT0 B;  2R0D A;  3AJC A;  4Z21 A;  1PBV A;  1XSZ A;  1R8S E;  4FHR B;  4JXH A;  3L8N A;  4JK1 X;  4C7P A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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