1R8M | Genus

Total Genus 71

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	71
sequence length	196
structure length	195
Chain Sequence	EANEGSKTLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLNPGVFQSTDTCYVLSYSVIMLNTDLHNPNVRDKMGLERFVAMNRGINEGGDLPEELLRNLYDSIRNEPFKIP

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Exchange factor
source organism	Homo sapiens
publication title	Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor pubmed doi rcsb
molecule keywords	Arno
total genus	71
structure length	195
sequence length	196
ec nomenclature
pdb deposition date	2003-10-27

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
E	PF01369	Sec7	Sec7 domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.10.220.20	Mainly Alpha	Orthogonal Bundle	Annexin V; domain 1	Annexin V; domain 1	1r8mE01
1.10.1000.11	Mainly Alpha	Orthogonal Bundle	Arf Nucleotide-binding Site Opener; domain 2	Arf Nucleotide-binding Site Opener,domain 2	1r8mE02

1S9DE 4JXHA 1XT0B 1RE0B 2R0DA 4OIYA 4L5MA 3L8NA 1PBVA 4C0AA 1BC9A 1R8ME 3LTLA 4D7QA 4A4PA 4C7PA 4JMIA 2R09A 1KU1A 4JMOA 4JWLA 4D7RA 3SWVA 1XSZA 4Z21A 1R8SE 1R8QE
chains in the Genus database with same CATH superfamily

1S9DE 1A8AA 1BC0A 1AVHA 1HVGA 1M9IA 2HYWA 2RANA 2IE7A 4MDUA 3SOHB 2OY9A 4FHRB 2HYVA 1ALAA 1QC7A 4MDVA 4C0AA 1MCXA 1R8ME 3LTLA 4A4PA 3ANYA 4KMUX 2K6XA 1YCNA 4EVFA 1KU1A 4JWLA 3SWVA 4EVHA 1XSZA 3HJLA 1YJ0A 1BO9A 1R8QE 4JXHA 1AVCA 1HVEA 2IE6A 1XJLA 2R0DA 1I4AA 1DK5A 4L5MA 2HSNA 2XO2A 4FQ0C 2H0MA 1N41A 1BC9A 4KN4X 3AO0A 1AEIA 4HREA 2QEZA 4C7PA 1HAKA 2IICA 3USWA 1AIIA 4JMIA 2R09A 1A8BA 4JMOA 2H0KA 1ANXA 1ANWA 4Z21A 1AOWA 3ABQA 2II2A 2ZOCA 1LKVX 1BCYA 3L8NA 2ZHJA 2HYUA 3ABOA 2XO3A 1BCWA 1G5NA 1DM5A 1HM6A 3AJCA 1BCZA 2Q4CA 1N00A 1UPTB 4D7QA 4X9PA 3BRXA 2VXGA 4Q2SA 1Q8DA 1AXNA 1ANNA 1YGMA 3ABSA 1BC3A 1R8SE 1BC1A 3ABRA 1W7BA 1XT0B 1W3WA 1RE0B 4OIYA 1YIIA 1HVDA 1HVFA 1PBVA 2H0LA 1W45A 3USYA 4KN7X 3TW5A 1AVRA 1C1KA 4JK1X 1N44A 1SAVA 4D7RA 2ZHIA 1N42A 1R4AE
chains in the Genus database with same CATH topology

1S9DE 4JXHA 1LKVX 1XT0B 1RE0B 2R0DA 4OIYA 4L5MA 3L8NA 1PBVA 2HSNA 4FQ0C 3SOHB 3USYA 4FHRB 4KN7X 3TW5A 1QC7A 4C0AA 3AJCA 1BC9A 1R8ME 3LTLA 4KN4X 4D7QA 4A4PA 4KMUX 2K6XA 4JK1X 4C7PA 3USWA 1Q8DA 4JMIA 2R09A 1KU1A 4JMOA 4JWLA 4D7RA 3SWVA 1XSZA 3HJLA 4Z21A 1R8SE 1R8QE
chains in the Genus database with same CATH homology

#chains in the Genus database with same CATH superfamily
 1S9D E;  4JXH A;  1XT0 B;  1RE0 B;  2R0D A;  4OIY A;  4L5M A;  3L8N A;  1PBV A;  4C0A A;  1BC9 A;  1R8M E;  3LTL A;  4D7Q A;  4A4P A;  4C7P A;  4JMI A;  2R09 A;  1KU1 A;  4JMO A;  4JWL A;  4D7R A;  3SWV A;  1XSZ A;  4Z21 A;  1R8S E;  1R8Q E; 
#chains in the Genus database with same CATH topology
 1S9D E;  1A8A A;  1BC0 A;  1AVH A;  1HVG A;  1M9I A;  2HYW A;  2RAN A;  2IE7 A;  4MDU A;  3SOH B;  2OY9 A;  4FHR B;  2HYV A;  1ALA A;  1QC7 A;  4MDV A;  4C0A A;  1MCX A;  1R8M E;  3LTL A;  4A4P A;  3ANY A;  4KMU X;  2K6X A;  1YCN A;  4EVF A;  1KU1 A;  4JWL A;  3SWV A;  4EVH A;  1XSZ A;  3HJL A;  1YJ0 A;  1BO9 A;  1R8Q E;  4JXH A;  1AVC A;  1HVE A;  2IE6 A;  1XJL A;  2R0D A;  1I4A A;  1DK5 A;  4L5M A;  2HSN A;  2XO2 A;  4FQ0 C;  2H0M A;  1N41 A;  1BC9 A;  4KN4 X;  3AO0 A;  1AEI A;  4HRE A;  2QEZ A;  4C7P A;  1HAK A;  2IIC A;  3USW A;  1AII A;  4JMI A;  2R09 A;  1A8B A;  4JMO A;  2H0K A;  1ANX A;  1ANW A;  4Z21 A;  1AOW A;  3ABQ A;  2II2 A;  2ZOC A;  1LKV X;  1BCY A;  3L8N A;  2ZHJ A;  2HYU A;  3ABO A;  2XO3 A;  1BCW A;  1G5N A;  1DM5 A;  1HM6 A;  3AJC A;  1BCZ A;  2Q4C A;  1N00 A;  1UPT B;  4D7Q A;  4X9P A;  3BRX A;  2VXG A;  4Q2S A;  1Q8D A;  1AXN A;  1ANN A;  1YGM A;  3ABS A;  1BC3 A;  1R8S E;  1BC1 A;  3ABR A;  1W7B A;  1XT0 B;  1W3W A;  1RE0 B;  4OIY A;  1YII A;  1HVD A;  1HVF A;  1PBV A;  2H0L A;  1W45 A;  3USY A;  4KN7 X;  3TW5 A;  1AVR A;  1C1K A;  4JK1 X;  1N44 A;  1SAV A;  4D7R A;  2ZHI A;  1N42 A;  1R4A E; 
#chains in the Genus database with same CATH homology
 1S9D E;  4JXH A;  1LKV X;  1XT0 B;  1RE0 B;  2R0D A;  4OIY A;  4L5M A;  3L8N A;  1PBV A;  2HSN A;  4FQ0 C;  3SOH B;  3USY A;  4FHR B;  4KN7 X;  3TW5 A;  1QC7 A;  4C0A A;  3AJC A;  1BC9 A;  1R8M E;  3LTL A;  4KN4 X;  4D7Q A;  4A4P A;  4KMU X;  2K6X A;  4JK1 X;  4C7P A;  3USW A;  1Q8D A;  4JMI A;  2R09 A;  1KU1 A;  4JMO A;  4JWL A;  4D7R A;  3SWV A;  1XSZ A;  3HJL A;  4Z21 A;  1R8S E;  1R8Q E;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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1R8ME

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations