1SAVA

Human annexin v with proline substitution by thioproline
Total Genus 119
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
119
sequence length
316
structure length
311
Chain Sequence
QVLRGTVTDFGFDERADAETLRKAMKGLGTDEESILTLLTSRSNAQRQEISAAFKTLFGRDLLDDLKSELTGKFEKLIVALMKSRLYDAYELKHALKGAGTNEKVLTEIIASRTEELRAIKQVYEEEYGSSLEDDVVGDTSGYYQRMLVVLLQANRDDAGIDEAQVEQDAQALFQAGELKWGTDEEKFITIFGTRSVSHLRKVFDKYMTISGFQIEETIDRETSGNLEQLLLAVVKSIRSIAYLAETLYYAMKGAGTDDHTLIRVMVSRSEIDLFNIRKEFRKNFATSLYSMIKGDTSGDYKKALLLLCGE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal and molecular structure of human annexin V after refinement. Implications for structure, membrane binding and ion channel formation of the annexin family of proteins.
pubmed doi rcsb
molecule tags Calcium/phospholipid binding
source organism Homo sapiens
molecule keywords ANNEXIN V
total genus 119
structure length 311
sequence length 316
ec nomenclature
pdb deposition date 1997-11-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00191 Annexin Annexin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 1savA02
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 1savA04
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 1savA01
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 1savA03
1N42A 1YJ0A 1N41A 1MCXA 4MDUA 1M9IA 2XO2A 2H0LA 1AEIA 1BC0A 2ZHJA 1BO9A 2H0MA 1I4AA 4EVHA 1BCWA 1BCZA 1W45A 1N44A 1BCYA 2HYWA 4X9PA 2II2A 1ANXA 1W7BA 1G5NA 2IE7A 4MDVA 1YIIA 1AOWA 1HAKA 1BC1A 2HYUA 4HREA 1W3WA 1A8AA 1ALAA 1AVHA 2IICA 2ZOCA 1AXNA 1HM6A 1DK5A 1AVRA 2ZHIA 2Q4CA 1HVGA 1AIIA 1DM5A 1SAVA 1A8BA 1YCNA 1N00A 1XJLA 2HYVA 2RANA 1HVEA 4EVFA 1ANNA 1HVFA 3BRXA 1ANWA 2H0KA 2XO3A 2IE6A 1BC3A 1AVCA 1HVDA
chains in the Genus database with same CATH superfamily
1YJ0A 1N41A 1R8QE 2XO2A 3L8NA 2II2A 1ANXA 2IE7A 1AOWA 2OY9A 1HAKA 1RE0B 1BC1A 1W3WA 1ALAA 3ABRA 1HM6A 1AIIA 1Q8DA 1A8BA 4D7RA 4JMOA 3LTLA 1R8SE 4KMUX 3BRXA 1AVCA 4L5MA 4JXHA 3TW5A 1N42A 4MDUA 2QEZA 4KN4X 1I4AA 1N44A 2HYWA 1XT0B 4OIYA 4MDVA 1R8ME 4C0AA 1YGMA 1BC9A 3ANYA 3USYA 1A8AA 2ZOCA 1AXNA 2Q4CA 1HVGA 1DM5A 1UPTB 2HYVA 3HJLA 1ANNA 2K6XA 4Q2SA 2IE6A 2RANA 1M9IA 4JMIA 1AEIA 2ZHJA 1BO9A 2H0MA 1BCWA 1W45A 4FQ0C 1W7BA 4JWLA 4D7QA 1DK5A 1S9DE 1AVRA 2ZHIA 3ABQA 1YCNA 1QC7A 4EVFA 1XJLA 1HVEA 1HVFA 2HSNA 1C1KA 3ABSA 4HREA 1R4AE 3AO0A 1MCXA 3USWA 2H0LA 1BC0A 4EVHA 1BCZA 1BCYA 1XSZA 4X9PA 2R0DA 1G5NA 4JK1X 1YIIA 3AJCA 4A4PA 4KN7X 2HYUA 4Z21A 1KU1A 3SOHB 2R09A 1AVHA 3SWVA 2IICA 2VXGA 3ABOA 4C7PA 1SAVA 1N00A 4FHRB 1PBVA 1ANWA 2H0KA 2XO3A 1BC3A 1HVDA 1LKVX
chains in the Genus database with same CATH topology
1N42A 1YJ0A 1N41A 1MCXA 4MDUA 1M9IA 2XO2A 2H0LA 1AEIA 1BC0A 2ZHJA 1BO9A 2H0MA 1I4AA 4EVHA 1BCWA 1BCZA 1W45A 1N44A 1BCYA 2HYWA 4X9PA 2II2A 1ANXA 1W7BA 1G5NA 2IE7A 4MDVA 1YIIA 1AOWA 1HAKA 1BC1A 2HYUA 4HREA 1W3WA 1A8AA 1ALAA 1AVHA 2IICA 2ZOCA 1AXNA 1HM6A 1DK5A 1AVRA 2ZHIA 2Q4CA 1HVGA 1AIIA 1DM5A 1SAVA 1A8BA 1YCNA 1N00A 1XJLA 2HYVA 2RANA 1HVEA 4EVFA 1ANNA 1HVFA 3BRXA 1ANWA 2H0KA 2XO3A 2IE6A 1BC3A 1AVCA 1HVDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1N42 A;  1YJ0 A;  1N41 A;  1MCX A;  4MDU A;  1M9I A;  2XO2 A;  2H0L A;  1AEI A;  1BC0 A;  2ZHJ A;  1BO9 A;  2H0M A;  1I4A A;  4EVH A;  1BCW A;  1BCZ A;  1W45 A;  1N44 A;  1BCY A;  2HYW A;  4X9P A;  2II2 A;  1ANX A;  1W7B A;  1G5N A;  2IE7 A;  4MDV A;  1YII A;  1AOW A;  1HAK A;  1BC1 A;  2HYU A;  4HRE A;  1W3W A;  1A8A A;  1ALA A;  1AVH A;  2IIC A;  2ZOC A;  1AXN A;  1HM6 A;  1DK5 A;  1AVR A;  2ZHI A;  2Q4C A;  1HVG A;  1AII A;  1DM5 A;  1SAV A;  1A8B A;  1YCN A;  1N00 A;  1XJL A;  2HYV A;  2RAN A;  1HVE A;  4EVF A;  1ANN A;  1HVF A;  3BRX A;  1ANW A;  2H0K A;  2XO3 A;  2IE6 A;  1BC3 A;  1AVC A;  1HVD A; 
#chains in the Genus database with same CATH topology
 1YJ0 A;  1N41 A;  1R8Q E;  2XO2 A;  3L8N A;  2II2 A;  1ANX A;  2IE7 A;  1AOW A;  2OY9 A;  1HAK A;  1RE0 B;  1BC1 A;  1W3W A;  1ALA A;  3ABR A;  1HM6 A;  1AII A;  1Q8D A;  1A8B A;  4D7R A;  4JMO A;  3LTL A;  1R8S E;  4KMU X;  3BRX A;  1AVC A;  4L5M A;  4JXH A;  3TW5 A;  1N42 A;  4MDU A;  2QEZ A;  4KN4 X;  1I4A A;  1N44 A;  2HYW A;  1XT0 B;  4OIY A;  4MDV A;  1R8M E;  4C0A A;  1YGM A;  1BC9 A;  3ANY A;  3USY A;  1A8A A;  2ZOC A;  1AXN A;  2Q4C A;  1HVG A;  1DM5 A;  1UPT B;  2HYV A;  3HJL A;  1ANN A;  2K6X A;  4Q2S A;  2IE6 A;  2RAN A;  1M9I A;  4JMI A;  1AEI A;  2ZHJ A;  1BO9 A;  2H0M A;  1BCW A;  1W45 A;  4FQ0 C;  1W7B A;  4JWL A;  4D7Q A;  1DK5 A;  1S9D E;  1AVR A;  2ZHI A;  3ABQ A;  1YCN A;  1QC7 A;  4EVF A;  1XJL A;  1HVE A;  1HVF A;  2HSN A;  1C1K A;  3ABS A;  4HRE A;  1R4A E;  3AO0 A;  1MCX A;  3USW A;  2H0L A;  1BC0 A;  4EVH A;  1BCZ A;  1BCY A;  1XSZ A;  4X9P A;  2R0D A;  1G5N A;  4JK1 X;  1YII A;  3AJC A;  4A4P A;  4KN7 X;  2HYU A;  4Z21 A;  1KU1 A;  3SOH B;  2R09 A;  1AVH A;  3SWV A;  2IIC A;  2VXG A;  3ABO A;  4C7P A;  1SAV A;  1N00 A;  4FHR B;  1PBV A;  1ANW A;  2H0K A;  2XO3 A;  1BC3 A;  1HVD A;  1LKV X; 
#chains in the Genus database with same CATH homology
 1N42 A;  1YJ0 A;  1N41 A;  1MCX A;  4MDU A;  1M9I A;  2XO2 A;  2H0L A;  1AEI A;  1BC0 A;  2ZHJ A;  1BO9 A;  2H0M A;  1I4A A;  4EVH A;  1BCW A;  1BCZ A;  1W45 A;  1N44 A;  1BCY A;  2HYW A;  4X9P A;  2II2 A;  1ANX A;  1W7B A;  1G5N A;  2IE7 A;  4MDV A;  1YII A;  1AOW A;  1HAK A;  1BC1 A;  2HYU A;  4HRE A;  1W3W A;  1A8A A;  1ALA A;  1AVH A;  2IIC A;  2ZOC A;  1AXN A;  1HM6 A;  1DK5 A;  1AVR A;  2ZHI A;  2Q4C A;  1HVG A;  1AII A;  1DM5 A;  1SAV A;  1A8B A;  1YCN A;  1N00 A;  1XJL A;  2HYV A;  2RAN A;  1HVE A;  4EVF A;  1ANN A;  1HVF A;  3BRX A;  1ANW A;  2H0K A;  2XO3 A;  2IE6 A;  1BC3 A;  1AVC A;  1HVD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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