1SAV | Genus

Total Genus 119

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	119
sequence length	316
structure length	311
Chain Sequence	QVLRGTVTDFGFDERADAETLRKAMKGLGTDEESILTLLTSRSNAQRQEISAAFKTLFGRDLLDDLKSELTGKFEKLIVALMKSRLYDAYELKHALKGAGTNEKVLTEIIASRTEELRAIKQVYEEEYGSSLEDDVVGDTSGYYQRMLVVLLQANRDDAGIDEAQVEQDAQALFQAGELKWGTDEEKFITIFGTRSVSHLRKVFDKYMTISGFQIEETIDRETSGNLEQLLLAVVKSIRSIAYLAETLYYAMKGAGTDDHTLIRVMVSRSEIDLFNIRKEFRKNFATSLYSMIKGDTSGDYKKALLLLCGE

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Calcium/phospholipid binding
source organism	Homo sapiens
publication title	Crystal and molecular structure of human annexin V after refinement. Implications for structure, membrane binding and ion channel formation of the annexin family of proteins. pubmed doi rcsb
molecule keywords	ANNEXIN V
total genus	119
structure length	311
sequence length	316
ec nomenclature
pdb deposition date	1997-11-24

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00191	Annexin	Annexin

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.10.220.10	Mainly Alpha	Orthogonal Bundle	Annexin V; domain 1	Annexin	1savA02
1.10.220.10	Mainly Alpha	Orthogonal Bundle	Annexin V; domain 1	Annexin	1savA04
1.10.220.10	Mainly Alpha	Orthogonal Bundle	Annexin V; domain 1	Annexin	1savA01
1.10.220.10	Mainly Alpha	Orthogonal Bundle	Annexin V; domain 1	Annexin	1savA03

1AOWA 1MCXA 1HVFA 1BCZA 2XO2A 2H0LA 1ANXA 1A8BA 2HYVA 1HVGA 1HVEA 1ALAA 1A8AA 1AVHA 1G5NA 4HREA 1AIIA 2Q4CA 3BRXA 4X9PA 1BC0A 2HYWA 1BO9A 1BCWA 1YCNA 1BC3A 1AVCA 1AEIA 2IE6A 1M9IA 1N00A 1YJ0A 1XJLA 1BC1A 4MDUA 2RANA 2H0KA 1DK5A 1HM6A 1YIIA 1W3WA 2HYUA 1ANWA 2II2A 1AVRA 1DM5A 2IICA 4MDVA 4EVHA 1N44A 1I4AA 2ZHJA 2ZHIA 1W45A 2IE7A 4EVFA 2H0MA 2XO3A 1W7BA 1ANNA 1N42A 1HAKA 1N41A 1SAVA 1AXNA 2ZOCA 1BCYA 1HVDA
chains in the Genus database with same CATH superfamily

1MCXA 1QC7A 2H0LA 1ANXA 1HVEA 3ABQA 1ALAA 1G5NA 3BRXA 1R8SE 4X9PA 1BO9A 1YJ0A 4L5MA 4OIYA 1XJLA 4MDUA 4C0AA 2H0KA 1DK5A 4Z21A 1W3WA 3USYA 1W45A 2XO3A 1N41A 3SOHB 3AJCA 1BCYA 1HVDA 4JK1X 1HVFA 1A8BA 1AVHA 4HREA 1AIIA 1BC0A 4JMOA 4JWLA 1AVCA 2QEZA 1M9IA 2RANA 1HM6A 4FQ0C 4Q2SA 1ANWA 2IICA 1DM5A 4MDVA 4EVHA 2ZHJA 2IE7A 4EVFA 1ANNA 1R8QE 4JXHA 1XSZA 4KN7X 2ZOCA 4FHRB 1PBVA 4C7PA 4D7RA 1R4AE 2XO2A 2HYVA 1BC9A 1HVGA 1XT0B 1UPTB 2HYWA 1YCNA 2IE6A 4KMUX 1N00A 4A4PA 1BC1A 2HYUA 1N44A 3L8NA 1I4AA 1YGMA 4D7QA 2H0MA 1N42A 1Q8DA 1AXNA 2OY9A 4KN4X 2R0DA 1AOWA 1BCZA 4JMIA 3ABOA 1S9DE 3AO0A 1A8AA 1C1KA 2Q4CA 1BCWA 1BC3A 2VXGA 1AEIA 3TW5A 3LTLA 1LKVX 1YIIA 2II2A 1AVRA 2R09A 1KU1A 2ZHIA 3ABRA 1R8ME 1W7BA 3ANYA 2K6XA 3SWVA 1HAKA 1SAVA 3ABSA 3HJLA 1RE0B 3USWA 2HSNA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 1AOW A;  1MCX A;  1HVF A;  1BCZ A;  2XO2 A;  2H0L A;  1ANX A;  1A8B A;  2HYV A;  1HVG A;  1HVE A;  1ALA A;  1A8A A;  1AVH A;  1G5N A;  4HRE A;  1AII A;  2Q4C A;  3BRX A;  4X9P A;  1BC0 A;  2HYW A;  1BO9 A;  1BCW A;  1YCN A;  1BC3 A;  1AVC A;  1AEI A;  2IE6 A;  1M9I A;  1N00 A;  1YJ0 A;  1XJL A;  1BC1 A;  4MDU A;  2RAN A;  2H0K A;  1DK5 A;  1HM6 A;  1YII A;  1W3W A;  2HYU A;  1ANW A;  2II2 A;  1AVR A;  1DM5 A;  2IIC A;  4MDV A;  4EVH A;  1N44 A;  1I4A A;  2ZHJ A;  2ZHI A;  1W45 A;  2IE7 A;  4EVF A;  2H0M A;  2XO3 A;  1W7B A;  1ANN A;  1N42 A;  1HAK A;  1N41 A;  1SAV A;  1AXN A;  2ZOC A;  1BCY A;  1HVD A; 
#chains in the Genus database with same CATH topology
 1MCX A;  1QC7 A;  2H0L A;  1ANX A;  1HVE A;  3ABQ A;  1ALA A;  1G5N A;  3BRX A;  1R8S E;  4X9P A;  1BO9 A;  1YJ0 A;  4L5M A;  4OIY A;  1XJL A;  4MDU A;  4C0A A;  2H0K A;  1DK5 A;  4Z21 A;  1W3W A;  3USY A;  1W45 A;  2XO3 A;  1N41 A;  3SOH B;  3AJC A;  1BCY A;  1HVD A;  4JK1 X;  1HVF A;  1A8B A;  1AVH A;  4HRE A;  1AII A;  1BC0 A;  4JMO A;  4JWL A;  1AVC A;  2QEZ A;  1M9I A;  2RAN A;  1HM6 A;  4FQ0 C;  4Q2S A;  1ANW A;  2IIC A;  1DM5 A;  4MDV A;  4EVH A;  2ZHJ A;  2IE7 A;  4EVF A;  1ANN A;  1R8Q E;  4JXH A;  1XSZ A;  4KN7 X;  2ZOC A;  4FHR B;  1PBV A;  4C7P A;  4D7R A;  1R4A E;  2XO2 A;  2HYV A;  1BC9 A;  1HVG A;  1XT0 B;  1UPT B;  2HYW A;  1YCN A;  2IE6 A;  4KMU X;  1N00 A;  4A4P A;  1BC1 A;  2HYU A;  1N44 A;  3L8N A;  1I4A A;  1YGM A;  4D7Q A;  2H0M A;  1N42 A;  1Q8D A;  1AXN A;  2OY9 A;  4KN4 X;  2R0D A;  1AOW A;  1BCZ A;  4JMI A;  3ABO A;  1S9D E;  3AO0 A;  1A8A A;  1C1K A;  2Q4C A;  1BCW A;  1BC3 A;  2VXG A;  1AEI A;  3TW5 A;  3LTL A;  1LKV X;  1YII A;  2II2 A;  1AVR A;  2R09 A;  1KU1 A;  2ZHI A;  3ABR A;  1R8M E;  1W7B A;  3ANY A;  2K6X A;  3SWV A;  1HAK A;  1SAV A;  3ABS A;  3HJL A;  1RE0 B;  3USW A;  2HSN A; 
#chains in the Genus database with same CATH homology
 1AOW A;  1MCX A;  1HVF A;  1BCZ A;  2XO2 A;  2H0L A;  1ANX A;  1A8B A;  2HYV A;  1HVG A;  1HVE A;  1ALA A;  1A8A A;  1AVH A;  1G5N A;  4HRE A;  1AII A;  2Q4C A;  3BRX A;  4X9P A;  1BC0 A;  2HYW A;  1BO9 A;  1BCW A;  1YCN A;  1BC3 A;  1AVC A;  1AEI A;  2IE6 A;  1M9I A;  1N00 A;  1YJ0 A;  1XJL A;  1BC1 A;  4MDU A;  2RAN A;  2H0K A;  1DK5 A;  1HM6 A;  1YII A;  1W3W A;  2HYU A;  1ANW A;  2II2 A;  1AVR A;  1DM5 A;  2IIC A;  4MDV A;  4EVH A;  1N44 A;  1I4A A;  2ZHJ A;  2ZHI A;  1W45 A;  2IE7 A;  4EVF A;  2H0M A;  2XO3 A;  1W7B A;  1ANN A;  1N42 A;  1HAK A;  1N41 A;  1SAV A;  1AXN A;  2ZOC A;  1BCY A;  1HVD A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

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#similar chains, but unknotted
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1SAVA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations