1SAVA

Human annexin v with proline substitution by thioproline
Total Genus 119
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
119
sequence length
316
structure length
311
Chain Sequence
QVLRGTVTDFGFDERADAETLRKAMKGLGTDEESILTLLTSRSNAQRQEISAAFKTLFGRDLLDDLKSELTGKFEKLIVALMKSRLYDAYELKHALKGAGTNEKVLTEIIASRTEELRAIKQVYEEEYGSSLEDDVVGDTSGYYQRMLVVLLQANRDDAGIDEAQVEQDAQALFQAGELKWGTDEEKFITIFGTRSVSHLRKVFDKYMTISGFQIEETIDRETSGNLEQLLLAVVKSIRSIAYLAETLYYAMKGAGTDDHTLIRVMVSRSEIDLFNIRKEFRKNFATSLYSMIKGDTSGDYKKALLLLCGE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal and molecular structure of human annexin V after refinement. Implications for structure, membrane binding and ion channel formation of the annexin family of proteins.
pubmed doi rcsb
molecule tags Calcium/phospholipid binding
source organism Homo sapiens
molecule keywords ANNEXIN V
total genus 119
structure length 311
sequence length 316
ec nomenclature
pdb deposition date 1997-11-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00191 Annexin Annexin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 1savA02
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 1savA04
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 1savA01
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 1savA03
1DK5A 1BCWA 1BC0A 1N41A 2HYWA 4X9PA 1HM6A 2HYVA 4EVHA 2RANA 1YIIA 1MCXA 2IE6A 1AVCA 1HVFA 1ALAA 2ZHIA 1ANNA 2ZOCA 1AEIA 1XJLA 4MDVA 4EVFA 1SAVA 1AOWA 1I4AA 1N00A 1M9IA 1N44A 4HREA 1ANWA 1DM5A 1G5NA 1A8AA 2IICA 2ZHJA 3BRXA 1BCZA 1AXNA 1HAKA 4MDUA 1BO9A 1AVHA 1W45A 1YJ0A 1HVGA 2II2A 2XO3A 1W7BA 1BC3A 1HVDA 1YCNA 2XO2A 1W3WA 1AVRA 2Q4CA 1A8BA 1AIIA 1BC1A 1N42A 1BCYA 1ANXA 2H0LA 2H0MA 1HVEA 2HYUA 2H0KA 2IE7A
chains in the Genus database with same CATH superfamily
2VXGA 1N41A 2HYWA 2HYVA 3ABOA 1XSZA 1BC9A 1ALAA 2ZOCA 4JXHA 4EVFA 1SAVA 4D7QA 1Q8DA 2ZHJA 1BCZA 1AXNA 2K6XA 3SWVA 1YJ0A 3SOHB 4L5MA 2R09A 1W7BA 4Z21A 1BC3A 1HVDA 1AVRA 3USYA 2QEZA 4FHRB 3HJLA 3ABQA 1AIIA 1N42A 3AO0A 1AVCA 1BCYA 1ANXA 4C7PA 1HVEA 2R0DA 1BCWA 4KN7X 1HM6A 1YIIA 1PBVA 3TW5A 4MDVA 1AEIA 1N00A 4JWLA 1M9IA 4HREA 4Q2SA 1ANWA 1A8AA 2IICA 1AVHA 1W45A 2II2A 1S9DE 1YGMA 2Q4CA 3ANYA 2HYUA 4KMUX 1W3WA 4C0AA 4JMIA 1QC7A 1KU1A 4EVHA 1R8ME 2RANA 2IE6A 1LKVX 1XJLA 2OY9A 1I4AA 4KN4X 1N44A 1R4AE 3BRXA 1C1KA 1HAKA 3ABSA 1HVGA 2XO3A 1YCNA 2XO2A 3ABRA 1BC1A 2H0MA 1DK5A 1R8SE 1BC0A 4X9PA 3LTLA 1MCXA 3L8NA 1HVFA 2ZHIA 1ANNA 1AOWA 3USWA 1RE0B 1DM5A 1G5NA 1XT0B 4D7RA 4A4PA 4MDUA 4JMOA 1BO9A 3AJCA 1R8QE 4FQ0C 4JK1X 2HSNA 4OIYA 1UPTB 1A8BA 2IE7A 2H0LA 2H0KA
chains in the Genus database with same CATH topology
1DK5A 1BCWA 1BC0A 1N41A 2HYWA 4X9PA 1HM6A 2HYVA 4EVHA 2RANA 1YIIA 1MCXA 2IE6A 1AVCA 1HVFA 1ALAA 2ZHIA 1ANNA 2ZOCA 1AEIA 1XJLA 4MDVA 4EVFA 1SAVA 1AOWA 1I4AA 1N00A 1M9IA 1N44A 4HREA 1ANWA 1DM5A 1G5NA 1A8AA 2IICA 2ZHJA 3BRXA 1BCZA 1AXNA 1HAKA 4MDUA 1BO9A 1AVHA 1W45A 1YJ0A 1HVGA 2II2A 2XO3A 1W7BA 1BC3A 1HVDA 1YCNA 2XO2A 1W3WA 1AVRA 2Q4CA 1A8BA 1AIIA 1BC1A 1N42A 1BCYA 1ANXA 2H0LA 2H0MA 1HVEA 2HYUA 2H0KA 2IE7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1DK5 A;  1BCW A;  1BC0 A;  1N41 A;  2HYW A;  4X9P A;  1HM6 A;  2HYV A;  4EVH A;  2RAN A;  1YII A;  1MCX A;  2IE6 A;  1AVC A;  1HVF A;  1ALA A;  2ZHI A;  1ANN A;  2ZOC A;  1AEI A;  1XJL A;  4MDV A;  4EVF A;  1SAV A;  1AOW A;  1I4A A;  1N00 A;  1M9I A;  1N44 A;  4HRE A;  1ANW A;  1DM5 A;  1G5N A;  1A8A A;  2IIC A;  2ZHJ A;  3BRX A;  1BCZ A;  1AXN A;  1HAK A;  4MDU A;  1BO9 A;  1AVH A;  1W45 A;  1YJ0 A;  1HVG A;  2II2 A;  2XO3 A;  1W7B A;  1BC3 A;  1HVD A;  1YCN A;  2XO2 A;  1W3W A;  1AVR A;  2Q4C A;  1A8B A;  1AII A;  1BC1 A;  1N42 A;  1BCY A;  1ANX A;  2H0L A;  2H0M A;  1HVE A;  2HYU A;  2H0K A;  2IE7 A; 
#chains in the Genus database with same CATH topology
 2VXG A;  1N41 A;  2HYW A;  2HYV A;  3ABO A;  1XSZ A;  1BC9 A;  1ALA A;  2ZOC A;  4JXH A;  4EVF A;  1SAV A;  4D7Q A;  1Q8D A;  2ZHJ A;  1BCZ A;  1AXN A;  2K6X A;  3SWV A;  1YJ0 A;  3SOH B;  4L5M A;  2R09 A;  1W7B A;  4Z21 A;  1BC3 A;  1HVD A;  1AVR A;  3USY A;  2QEZ A;  4FHR B;  3HJL A;  3ABQ A;  1AII A;  1N42 A;  3AO0 A;  1AVC A;  1BCY A;  1ANX A;  4C7P A;  1HVE A;  2R0D A;  1BCW A;  4KN7 X;  1HM6 A;  1YII A;  1PBV A;  3TW5 A;  4MDV A;  1AEI A;  1N00 A;  4JWL A;  1M9I A;  4HRE A;  4Q2S A;  1ANW A;  1A8A A;  2IIC A;  1AVH A;  1W45 A;  2II2 A;  1S9D E;  1YGM A;  2Q4C A;  3ANY A;  2HYU A;  4KMU X;  1W3W A;  4C0A A;  4JMI A;  1QC7 A;  1KU1 A;  4EVH A;  1R8M E;  2RAN A;  2IE6 A;  1LKV X;  1XJL A;  2OY9 A;  1I4A A;  4KN4 X;  1N44 A;  1R4A E;  3BRX A;  1C1K A;  1HAK A;  3ABS A;  1HVG A;  2XO3 A;  1YCN A;  2XO2 A;  3ABR A;  1BC1 A;  2H0M A;  1DK5 A;  1R8S E;  1BC0 A;  4X9P A;  3LTL A;  1MCX A;  3L8N A;  1HVF A;  2ZHI A;  1ANN A;  1AOW A;  3USW A;  1RE0 B;  1DM5 A;  1G5N A;  1XT0 B;  4D7R A;  4A4P A;  4MDU A;  4JMO A;  1BO9 A;  3AJC A;  1R8Q E;  4FQ0 C;  4JK1 X;  2HSN A;  4OIY A;  1UPT B;  1A8B A;  2IE7 A;  2H0L A;  2H0K A; 
#chains in the Genus database with same CATH homology
 1DK5 A;  1BCW A;  1BC0 A;  1N41 A;  2HYW A;  4X9P A;  1HM6 A;  2HYV A;  4EVH A;  2RAN A;  1YII A;  1MCX A;  2IE6 A;  1AVC A;  1HVF A;  1ALA A;  2ZHI A;  1ANN A;  2ZOC A;  1AEI A;  1XJL A;  4MDV A;  4EVF A;  1SAV A;  1AOW A;  1I4A A;  1N00 A;  1M9I A;  1N44 A;  4HRE A;  1ANW A;  1DM5 A;  1G5N A;  1A8A A;  2IIC A;  2ZHJ A;  3BRX A;  1BCZ A;  1AXN A;  1HAK A;  4MDU A;  1BO9 A;  1AVH A;  1W45 A;  1YJ0 A;  1HVG A;  2II2 A;  2XO3 A;  1W7B A;  1BC3 A;  1HVD A;  1YCN A;  2XO2 A;  1W3W A;  1AVR A;  2Q4C A;  1A8B A;  1AII A;  1BC1 A;  1N42 A;  1BCY A;  1ANX A;  2H0L A;  2H0M A;  1HVE A;  2HYU A;  2H0K A;  2IE7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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