1W45A

The 2.5 angstroem structure of the k16a mutant of annexin a8, which has an intact n-terminus.
Total Genus 116
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
116
sequence length
320
structure length
320
Chain Sequence
IEQEGVTVASSSHFNPDPDAETLYKAMKGIGTNEQAIIDVLTKRSNTQRQQIAKSFKAQFGKDLTETLKSELSGKFERLIVALMYPPYRYEAKELHDAMKGLGTKEGVIIEILASRTKNQLREIMKAYEEDYGSSLEEDIQADTSGYLERILVCLLQGSRDDVSSFVDPALALQDAQDLYAAGEKIRGTDEMKFITILCTRSATHLLRVFEEYEKIANKSIEDSIKSETHGSLEEAMLTVVKCTQNLHSYFAERLYYAMKGAGTRDGTLIRNIVSRSEIDLNLIKCHFKKMYGKTLSSMIMEDTSGDYKNALLSLVGSDP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The Crystal Structure of Annexin A8 is Similar to that of Annexin A3
pubmed doi rcsb
molecule tags Coagulation
source organism Homo sapiens
molecule keywords ANNEXIN A8
total genus 116
structure length 320
sequence length 320
chains with identical sequence B
ec nomenclature
pdb deposition date 2004-07-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00191 Annexin Annexin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 1w45A02
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 1w45A04
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 1w45A01
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 1w45A03
1ANNA 1I4AA 4MDVA 4EVHA 2RANA 1AIIA 1YIIA 2ZHJA 4MDUA 1AVHA 2HYVA 1ANWA 2Q4CA 2ZHIA 1AEIA 1BC3A 1HVGA 1M9IA 4EVFA 1A8BA 1HVFA 1AVCA 1DK5A 1AVRA 2HYUA 2XO2A 1N41A 2II2A 2IE6A 1BCZA 2IICA 1BCYA 1HAKA 4X9PA 1DM5A 1W3WA 1N44A 1N00A 1G5NA 1YCNA 1ALAA 1AXNA 1HVDA 1HM6A 1SAVA 1ANXA 1AOWA 3BRXA 4HREA 1YJ0A 2H0LA 1MCXA 2HYWA 1A8AA 1XJLA 2IE7A 1BCWA 1W7BA 2XO3A 2ZOCA 1BC1A 2H0MA 1W45A 1N42A 1BC0A 1HVEA 2H0KA 1BO9A
chains in the Genus database with same CATH superfamily
3ABOA 1S9DE 1YIIA 3LTLA 4OIYA 3ABRA 1AVHA 2ZHIA 1AEIA 1BC3A 4EVFA 1R4AE 3HJLA 4JMOA 1AVRA 2R09A 1BCZA 4JK1X 2VXGA 4KN7X 1HVDA 4JXHA 3USWA 1R8SE 1AOWA 1YJ0A 2XO3A 3L8NA 1RE0B 1BC1A 1I4AA 4L5MA 4MDVA 3USYA 4EVHA 1UPTB 2ZHJA 3AJCA 1ANWA 4FHRB 1HVGA 1HVFA 3AO0A 2XO2A 4JMIA 4A4PA 1W3WA 4JWLA 1QC7A 1HM6A 1KU1A 2OY9A 3BRXA 1XJLA 2IE7A 1BCWA 2ZOCA 1N42A 1BC0A 2HYVA 2H0KA 4KN4X 4D7QA 1AIIA 3ANYA 4MDUA 2Q4CA 1XT0B 1M9IA 3SWVA 3ABQA 1BC9A 2HYUA 1R8QE 1N41A 2II2A 2IICA 1BCYA 1HAKA 4X9PA 1YGMA 3SOHB 4C0AA 4Q2SA 1N44A 1AXNA 1SAVA 2HYWA 4Z21A 1W7BA 1R8ME 2H0MA 2QEZA 4C7PA 1BO9A 1XSZA 1ANNA 2K6XA 4FQ0C 2RANA 1A8BA 4D7RA 1AVCA 1DK5A 2HSNA 2IE6A 1DM5A 1Q8DA 1PBVA 1N00A 1G5NA 1YCNA 1ALAA 3TW5A 1ANXA 4HREA 2R0DA 2H0LA 1MCXA 3ABSA 1A8AA 1C1KA 1LKVX 1W45A 4KMUX 1HVEA
chains in the Genus database with same CATH topology
1ANNA 1I4AA 4MDVA 4EVHA 2RANA 1AIIA 1YIIA 2ZHJA 4MDUA 1AVHA 2HYVA 1ANWA 2Q4CA 2ZHIA 1AEIA 1BC3A 1HVGA 1M9IA 4EVFA 1A8BA 1HVFA 1AVCA 1DK5A 1AVRA 2HYUA 2XO2A 1N41A 2II2A 2IE6A 1BCZA 2IICA 1BCYA 1HAKA 4X9PA 1DM5A 1W3WA 1N44A 1N00A 1G5NA 1YCNA 1ALAA 1AXNA 1HVDA 1HM6A 1SAVA 1ANXA 1AOWA 3BRXA 4HREA 1YJ0A 2H0LA 1MCXA 2HYWA 1A8AA 1XJLA 2IE7A 1BCWA 1W7BA 2XO3A 2ZOCA 1BC1A 2H0MA 1W45A 1N42A 1BC0A 1HVEA 2H0KA 1BO9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ANN A;  1I4A A;  4MDV A;  4EVH A;  2RAN A;  1AII A;  1YII A;  2ZHJ A;  4MDU A;  1AVH A;  2HYV A;  1ANW A;  2Q4C A;  2ZHI A;  1AEI A;  1BC3 A;  1HVG A;  1M9I A;  4EVF A;  1A8B A;  1HVF A;  1AVC A;  1DK5 A;  1AVR A;  2HYU A;  2XO2 A;  1N41 A;  2II2 A;  2IE6 A;  1BCZ A;  2IIC A;  1BCY A;  1HAK A;  4X9P A;  1DM5 A;  1W3W A;  1N44 A;  1N00 A;  1G5N A;  1YCN A;  1ALA A;  1AXN A;  1HVD A;  1HM6 A;  1SAV A;  1ANX A;  1AOW A;  3BRX A;  4HRE A;  1YJ0 A;  2H0L A;  1MCX A;  2HYW A;  1A8A A;  1XJL A;  2IE7 A;  1BCW A;  1W7B A;  2XO3 A;  2ZOC A;  1BC1 A;  2H0M A;  1W45 A;  1N42 A;  1BC0 A;  1HVE A;  2H0K A;  1BO9 A; 
#chains in the Genus database with same CATH topology
 3ABO A;  1S9D E;  1YII A;  3LTL A;  4OIY A;  3ABR A;  1AVH A;  2ZHI A;  1AEI A;  1BC3 A;  4EVF A;  1R4A E;  3HJL A;  4JMO A;  1AVR A;  2R09 A;  1BCZ A;  4JK1 X;  2VXG A;  4KN7 X;  1HVD A;  4JXH A;  3USW A;  1R8S E;  1AOW A;  1YJ0 A;  2XO3 A;  3L8N A;  1RE0 B;  1BC1 A;  1I4A A;  4L5M A;  4MDV A;  3USY A;  4EVH A;  1UPT B;  2ZHJ A;  3AJC A;  1ANW A;  4FHR B;  1HVG A;  1HVF A;  3AO0 A;  2XO2 A;  4JMI A;  4A4P A;  1W3W A;  4JWL A;  1QC7 A;  1HM6 A;  1KU1 A;  2OY9 A;  3BRX A;  1XJL A;  2IE7 A;  1BCW A;  2ZOC A;  1N42 A;  1BC0 A;  2HYV A;  2H0K A;  4KN4 X;  4D7Q A;  1AII A;  3ANY A;  4MDU A;  2Q4C A;  1XT0 B;  1M9I A;  3SWV A;  3ABQ A;  1BC9 A;  2HYU A;  1R8Q E;  1N41 A;  2II2 A;  2IIC A;  1BCY A;  1HAK A;  4X9P A;  1YGM A;  3SOH B;  4C0A A;  4Q2S A;  1N44 A;  1AXN A;  1SAV A;  2HYW A;  4Z21 A;  1W7B A;  1R8M E;  2H0M A;  2QEZ A;  4C7P A;  1BO9 A;  1XSZ A;  1ANN A;  2K6X A;  4FQ0 C;  2RAN A;  1A8B A;  4D7R A;  1AVC A;  1DK5 A;  2HSN A;  2IE6 A;  1DM5 A;  1Q8D A;  1PBV A;  1N00 A;  1G5N A;  1YCN A;  1ALA A;  3TW5 A;  1ANX A;  4HRE A;  2R0D A;  2H0L A;  1MCX A;  3ABS A;  1A8A A;  1C1K A;  1LKV X;  1W45 A;  4KMU X;  1HVE A; 
#chains in the Genus database with same CATH homology
 1ANN A;  1I4A A;  4MDV A;  4EVH A;  2RAN A;  1AII A;  1YII A;  2ZHJ A;  4MDU A;  1AVH A;  2HYV A;  1ANW A;  2Q4C A;  2ZHI A;  1AEI A;  1BC3 A;  1HVG A;  1M9I A;  4EVF A;  1A8B A;  1HVF A;  1AVC A;  1DK5 A;  1AVR A;  2HYU A;  2XO2 A;  1N41 A;  2II2 A;  2IE6 A;  1BCZ A;  2IIC A;  1BCY A;  1HAK A;  4X9P A;  1DM5 A;  1W3W A;  1N44 A;  1N00 A;  1G5N A;  1YCN A;  1ALA A;  1AXN A;  1HVD A;  1HM6 A;  1SAV A;  1ANX A;  1AOW A;  3BRX A;  4HRE A;  1YJ0 A;  2H0L A;  1MCX A;  2HYW A;  1A8A A;  1XJL A;  2IE7 A;  1BCW A;  1W7B A;  2XO3 A;  2ZOC A;  1BC1 A;  2H0M A;  1W45 A;  1N42 A;  1BC0 A;  1HVE A;  2H0K A;  1BO9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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