1W7BA

Annexin a2: does it induce membrane aggregation by a new multimeric state of the protein.
Total Genus 135
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
135
sequence length
319
structure length
319
Chain Sequence
PSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Annexin A2: Does It Induce Membrane Aggregation by a New Multimeric State of the Protein
rcsb
molecule tags Calcium-binding protein
source organism Homo sapiens
molecule keywords ANNEXIN A2
total genus 135
structure length 319
sequence length 319
ec nomenclature
pdb deposition date 2004-09-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00191 Annexin Annexin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 1w7bA04
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 1w7bA01
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 1w7bA02
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 1w7bA03
2HYWA 1AVCA 1AVRA 1XJLA 2XO3A 1BCWA 1ANNA 1BCZA 2IE7A 1W7BA 1BCYA 4EVFA 1BO9A 1YJ0A 1N00A 1AVHA 1BC3A 1ANWA 1HAKA 1N42A 2IICA 1DM5A 2H0KA 1A8BA 1ANXA 1HVDA 1N41A 1YIIA 1BC0A 2ZOCA 4EVHA 2IE6A 1ALAA 2HYUA 1W45A 3BRXA 1YCNA 1AIIA 1M9IA 2H0MA 2RANA 2ZHJA 2Q4CA 1DK5A 2H0LA 4MDUA 2XO2A 1HM6A 4HREA 1MCXA 1HVGA 4MDVA 2HYVA 1BC1A 1I4AA 1HVFA 1W3WA 1AOWA 1AEIA 1SAVA 1G5NA 1HVEA 1A8AA 2ZHIA 1N44A 1AXNA 4X9PA 2II2A
chains in the Genus database with same CATH superfamily
1AVCA 3HJLA 4A4PA 3AJCA 4EVFA 1BO9A 1N00A 1AVHA 2K6XA 1ANWA 1N42A 1A8BA 3TW5A 1ANXA 2ZOCA 4C0AA 1ALAA 1W45A 4Q2SA 3ABRA 1AIIA 3L8NA 2ZHJA 1S9DE 1DK5A 4MDUA 4MDVA 4FHRB 1AEIA 1G5NA 1HVEA 2ZHIA 1AXNA 1R4AE 1UPTB 1XJLA 1BCWA 1PBVA 1BCZA 1BCYA 1YJ0A 3ABOA 1HAKA 2IE6A 3SOHB 2H0MA 1QC7A 2R09A 1XSZA 3AO0A 1W3WA 4OIYA 1SAVA 1LKVX 1A8AA 2R0DA 1N44A 1R8QE 4Z21A 2II2A 2HSNA 2HYWA 2XO3A 4KMUX 4JMOA 2IE7A 1W7BA 1R8ME 1DM5A 2H0KA 4FQ0C 4KN7X 1KU1A 2OY9A 2VXGA 3ABSA 4KN4X 1YCNA 3ANYA 1RE0B 3LTLA 2H0LA 1YGMA 2XO2A 3USYA 4HREA 1MCXA 1HVGA 2HYVA 1I4AA 4D7QA 1R8SE 4X9PA 4EVHA 1AVRA 1ANNA 4JMIA 1BC3A 4C7PA 2IICA 4JK1X 1HVDA 1N41A 1YIIA 1BC0A 4JXHA 1BC9A 4JWLA 4D7RA 3BRXA 1M9IA 1C1KA 2QEZA 2RANA 2Q4CA 3USWA 1Q8DA 1XT0B 1HM6A 1BC1A 1HVFA 3ABQA 1AOWA 4L5MA 3SWVA 2HYUA
chains in the Genus database with same CATH topology
2HYWA 1AVCA 1AVRA 1XJLA 2XO3A 1BCWA 1ANNA 1BCZA 2IE7A 1W7BA 1BCYA 4EVFA 1BO9A 1YJ0A 1N00A 1AVHA 1BC3A 1ANWA 1HAKA 1N42A 2IICA 1DM5A 2H0KA 1A8BA 1ANXA 1HVDA 1N41A 1YIIA 1BC0A 2ZOCA 4EVHA 2IE6A 1ALAA 2HYUA 1W45A 3BRXA 1YCNA 1AIIA 1M9IA 2H0MA 2RANA 2ZHJA 2Q4CA 1DK5A 2H0LA 4MDUA 2XO2A 1HM6A 4HREA 1MCXA 1HVGA 4MDVA 2HYVA 1BC1A 1I4AA 1HVFA 1W3WA 1AOWA 1AEIA 1SAVA 1G5NA 1HVEA 1A8AA 2ZHIA 1N44A 1AXNA 4X9PA 2II2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2HYW A;  1AVC A;  1AVR A;  1XJL A;  2XO3 A;  1BCW A;  1ANN A;  1BCZ A;  2IE7 A;  1W7B A;  1BCY A;  4EVF A;  1BO9 A;  1YJ0 A;  1N00 A;  1AVH A;  1BC3 A;  1ANW A;  1HAK A;  1N42 A;  2IIC A;  1DM5 A;  2H0K A;  1A8B A;  1ANX A;  1HVD A;  1N41 A;  1YII A;  1BC0 A;  2ZOC A;  4EVH A;  2IE6 A;  1ALA A;  2HYU A;  1W45 A;  3BRX A;  1YCN A;  1AII A;  1M9I A;  2H0M A;  2RAN A;  2ZHJ A;  2Q4C A;  1DK5 A;  2H0L A;  4MDU A;  2XO2 A;  1HM6 A;  4HRE A;  1MCX A;  1HVG A;  4MDV A;  2HYV A;  1BC1 A;  1I4A A;  1HVF A;  1W3W A;  1AOW A;  1AEI A;  1SAV A;  1G5N A;  1HVE A;  1A8A A;  2ZHI A;  1N44 A;  1AXN A;  4X9P A;  2II2 A; 
#chains in the Genus database with same CATH topology
 1AVC A;  3HJL A;  4A4P A;  3AJC A;  4EVF A;  1BO9 A;  1N00 A;  1AVH A;  2K6X A;  1ANW A;  1N42 A;  1A8B A;  3TW5 A;  1ANX A;  2ZOC A;  4C0A A;  1ALA A;  1W45 A;  4Q2S A;  3ABR A;  1AII A;  3L8N A;  2ZHJ A;  1S9D E;  1DK5 A;  4MDU A;  4MDV A;  4FHR B;  1AEI A;  1G5N A;  1HVE A;  2ZHI A;  1AXN A;  1R4A E;  1UPT B;  1XJL A;  1BCW A;  1PBV A;  1BCZ A;  1BCY A;  1YJ0 A;  3ABO A;  1HAK A;  2IE6 A;  3SOH B;  2H0M A;  1QC7 A;  2R09 A;  1XSZ A;  3AO0 A;  1W3W A;  4OIY A;  1SAV A;  1LKV X;  1A8A A;  2R0D A;  1N44 A;  1R8Q E;  4Z21 A;  2II2 A;  2HSN A;  2HYW A;  2XO3 A;  4KMU X;  4JMO A;  2IE7 A;  1W7B A;  1R8M E;  1DM5 A;  2H0K A;  4FQ0 C;  4KN7 X;  1KU1 A;  2OY9 A;  2VXG A;  3ABS A;  4KN4 X;  1YCN A;  3ANY A;  1RE0 B;  3LTL A;  2H0L A;  1YGM A;  2XO2 A;  3USY A;  4HRE A;  1MCX A;  1HVG A;  2HYV A;  1I4A A;  4D7Q A;  1R8S E;  4X9P A;  4EVH A;  1AVR A;  1ANN A;  4JMI A;  1BC3 A;  4C7P A;  2IIC A;  4JK1 X;  1HVD A;  1N41 A;  1YII A;  1BC0 A;  4JXH A;  1BC9 A;  4JWL A;  4D7R A;  3BRX A;  1M9I A;  1C1K A;  2QEZ A;  2RAN A;  2Q4C A;  3USW A;  1Q8D A;  1XT0 B;  1HM6 A;  1BC1 A;  1HVF A;  3ABQ A;  1AOW A;  4L5M A;  3SWV A;  2HYU A; 
#chains in the Genus database with same CATH homology
 2HYW A;  1AVC A;  1AVR A;  1XJL A;  2XO3 A;  1BCW A;  1ANN A;  1BCZ A;  2IE7 A;  1W7B A;  1BCY A;  4EVF A;  1BO9 A;  1YJ0 A;  1N00 A;  1AVH A;  1BC3 A;  1ANW A;  1HAK A;  1N42 A;  2IIC A;  1DM5 A;  2H0K A;  1A8B A;  1ANX A;  1HVD A;  1N41 A;  1YII A;  1BC0 A;  2ZOC A;  4EVH A;  2IE6 A;  1ALA A;  2HYU A;  1W45 A;  3BRX A;  1YCN A;  1AII A;  1M9I A;  2H0M A;  2RAN A;  2ZHJ A;  2Q4C A;  1DK5 A;  2H0L A;  4MDU A;  2XO2 A;  1HM6 A;  4HRE A;  1MCX A;  1HVG A;  4MDV A;  2HYV A;  1BC1 A;  1I4A A;  1HVF A;  1W3W A;  1AOW A;  1AEI A;  1SAV A;  1G5N A;  1HVE A;  1A8A A;  2ZHI A;  1N44 A;  1AXN A;  4X9P A;  2II2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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