2HYUA

Human annexin a2 with heparin tetrasaccharide bound
Total Genus 126
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
126
sequence length
308
structure length
308
Chain Sequence
NFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystallographic Analysis of Calcium-dependent Heparin Binding to Annexin A2.
pubmed doi rcsb
molecule tags Metal binding protein
source organism Homo sapiens
molecule keywords Annexin A2
total genus 126
structure length 308
sequence length 308
ec nomenclature
pdb deposition date 2006-08-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00191 Annexin Annexin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 2hyuA04
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 2hyuA01
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 2hyuA02
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 2hyuA03
1YCNA 1M9IA 1YJ0A 1BO9A 1BCYA 1YIIA 2II2A 1HVEA 1ANWA 1AVHA 2IICA 2RANA 1AOWA 1ALAA 2Q4CA 4MDVA 1BC0A 2H0KA 1HVDA 2XO3A 2IE6A 1BCWA 1BCZA 1G5NA 1AVCA 2H0MA 2XO2A 4X9PA 1ANXA 1HVFA 1AVRA 1W45A 4EVHA 2HYUA 3BRXA 1SAVA 1W3WA 1HM6A 1AEIA 1W7BA 1BC3A 1AIIA 2ZOCA 1HAKA 2HYWA 1XJLA 1N42A 1N00A 1A8BA 1ANNA 1N44A 2HYVA 1AXNA 4EVFA 1DK5A 1DM5A 2ZHJA 2IE7A 1I4AA 4MDUA 2ZHIA 1MCXA 1A8AA 1HVGA 2H0LA 1N41A 1BC1A 4HREA
chains in the Genus database with same CATH superfamily
1BC9A 1BO9A 1YIIA 1ANWA 2Q4CA 4D7RA 1C1KA 1G5NA 1HVFA 4C7PA 1W45A 3ANYA 1W3WA 1AEIA 1BC3A 3ABQA 3L8NA 3USWA 1N42A 1N00A 4D7QA 1N44A 1YGMA 1R8QE 4MDUA 2HSNA 4OIYA 4JWLA 1A8AA 1R8ME 4JXHA 1R8SE 1KU1A 1N41A 2VXGA 4L5MA 2II2A 1AVHA 1PBVA 1QC7A 4MDVA 1BC0A 1HVDA 2IE6A 1AVCA 2H0MA 3LTLA 1AVRA 4JMIA 1SAVA 4KN4X 1AIIA 4Z21A 1HAKA 2R09A 2HYWA 4FHRB 1XJLA 1R4AE 4JK1X 4EVFA 2K6XA 2IE7A 1I4AA 3AJCA 4KN7X 1HVGA 2H0LA 3AO0A 2R0DA 4HREA 4JMOA 1YCNA 1M9IA 1YJ0A 3TW5A 1HVEA 4Q2SA 3SOHB 2H0KA 2XO2A 1BCWA 1BCZA 1ANXA 2OY9A 4EVHA 1XT0B 2HYUA 2QEZA 3HJLA 3ABOA 1HM6A 3SWVA 3ABSA 4KMUX 2HYVA 1AXNA 1DM5A 4C0AA 1MCXA 1Q8DA 3ABRA 1BC1A 1BCYA 3USYA 2RANA 2IICA 1AOWA 1ALAA 2XO3A 4X9PA 1S9DE 1RE0B 1UPTB 3BRXA 1W7BA 2ZOCA 4FQ0C 1A8BA 1ANNA 1DK5A 2ZHJA 2ZHIA 1XSZA 4A4PA 1LKVX
chains in the Genus database with same CATH topology
1YCNA 1M9IA 1YJ0A 1BO9A 1BCYA 1YIIA 2II2A 1HVEA 1ANWA 1AVHA 2IICA 2RANA 1AOWA 1ALAA 2Q4CA 4MDVA 1BC0A 2H0KA 1HVDA 2XO3A 2IE6A 1BCWA 1BCZA 1G5NA 1AVCA 2H0MA 2XO2A 4X9PA 1ANXA 1HVFA 1AVRA 1W45A 4EVHA 2HYUA 3BRXA 1SAVA 1W3WA 1HM6A 1AEIA 1W7BA 1BC3A 1AIIA 2ZOCA 1HAKA 2HYWA 1XJLA 1N42A 1N00A 1A8BA 1ANNA 1N44A 2HYVA 1AXNA 4EVFA 1DK5A 1DM5A 2ZHJA 2IE7A 1I4AA 4MDUA 2ZHIA 1MCXA 1A8AA 1HVGA 2H0LA 1N41A 1BC1A 4HREA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1YCN A;  1M9I A;  1YJ0 A;  1BO9 A;  1BCY A;  1YII A;  2II2 A;  1HVE A;  1ANW A;  1AVH A;  2IIC A;  2RAN A;  1AOW A;  1ALA A;  2Q4C A;  4MDV A;  1BC0 A;  2H0K A;  1HVD A;  2XO3 A;  2IE6 A;  1BCW A;  1BCZ A;  1G5N A;  1AVC A;  2H0M A;  2XO2 A;  4X9P A;  1ANX A;  1HVF A;  1AVR A;  1W45 A;  4EVH A;  2HYU A;  3BRX A;  1SAV A;  1W3W A;  1HM6 A;  1AEI A;  1W7B A;  1BC3 A;  1AII A;  2ZOC A;  1HAK A;  2HYW A;  1XJL A;  1N42 A;  1N00 A;  1A8B A;  1ANN A;  1N44 A;  2HYV A;  1AXN A;  4EVF A;  1DK5 A;  1DM5 A;  2ZHJ A;  2IE7 A;  1I4A A;  4MDU A;  2ZHI A;  1MCX A;  1A8A A;  1HVG A;  2H0L A;  1N41 A;  1BC1 A;  4HRE A; 
#chains in the Genus database with same CATH topology
 1BC9 A;  1BO9 A;  1YII A;  1ANW A;  2Q4C A;  4D7R A;  1C1K A;  1G5N A;  1HVF A;  4C7P A;  1W45 A;  3ANY A;  1W3W A;  1AEI A;  1BC3 A;  3ABQ A;  3L8N A;  3USW A;  1N42 A;  1N00 A;  4D7Q A;  1N44 A;  1YGM A;  1R8Q E;  4MDU A;  2HSN A;  4OIY A;  4JWL A;  1A8A A;  1R8M E;  4JXH A;  1R8S E;  1KU1 A;  1N41 A;  2VXG A;  4L5M A;  2II2 A;  1AVH A;  1PBV A;  1QC7 A;  4MDV A;  1BC0 A;  1HVD A;  2IE6 A;  1AVC A;  2H0M A;  3LTL A;  1AVR A;  4JMI A;  1SAV A;  4KN4 X;  1AII A;  4Z21 A;  1HAK A;  2R09 A;  2HYW A;  4FHR B;  1XJL A;  1R4A E;  4JK1 X;  4EVF A;  2K6X A;  2IE7 A;  1I4A A;  3AJC A;  4KN7 X;  1HVG A;  2H0L A;  3AO0 A;  2R0D A;  4HRE A;  4JMO A;  1YCN A;  1M9I A;  1YJ0 A;  3TW5 A;  1HVE A;  4Q2S A;  3SOH B;  2H0K A;  2XO2 A;  1BCW A;  1BCZ A;  1ANX A;  2OY9 A;  4EVH A;  1XT0 B;  2HYU A;  2QEZ A;  3HJL A;  3ABO A;  1HM6 A;  3SWV A;  3ABS A;  4KMU X;  2HYV A;  1AXN A;  1DM5 A;  4C0A A;  1MCX A;  1Q8D A;  3ABR A;  1BC1 A;  1BCY A;  3USY A;  2RAN A;  2IIC A;  1AOW A;  1ALA A;  2XO3 A;  4X9P A;  1S9D E;  1RE0 B;  1UPT B;  3BRX A;  1W7B A;  2ZOC A;  4FQ0 C;  1A8B A;  1ANN A;  1DK5 A;  2ZHJ A;  2ZHI A;  1XSZ A;  4A4P A;  1LKV X; 
#chains in the Genus database with same CATH homology
 1YCN A;  1M9I A;  1YJ0 A;  1BO9 A;  1BCY A;  1YII A;  2II2 A;  1HVE A;  1ANW A;  1AVH A;  2IIC A;  2RAN A;  1AOW A;  1ALA A;  2Q4C A;  4MDV A;  1BC0 A;  2H0K A;  1HVD A;  2XO3 A;  2IE6 A;  1BCW A;  1BCZ A;  1G5N A;  1AVC A;  2H0M A;  2XO2 A;  4X9P A;  1ANX A;  1HVF A;  1AVR A;  1W45 A;  4EVH A;  2HYU A;  3BRX A;  1SAV A;  1W3W A;  1HM6 A;  1AEI A;  1W7B A;  1BC3 A;  1AII A;  2ZOC A;  1HAK A;  2HYW A;  1XJL A;  1N42 A;  1N00 A;  1A8B A;  1ANN A;  1N44 A;  2HYV A;  1AXN A;  4EVF A;  1DK5 A;  1DM5 A;  2ZHJ A;  2IE7 A;  1I4A A;  4MDU A;  2ZHI A;  1MCX A;  1A8A A;  1HVG A;  2H0L A;  1N41 A;  1BC1 A;  4HRE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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