2HYUA

Human annexin a2 with heparin tetrasaccharide bound
Total Genus 126
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
126
sequence length
308
structure length
308
Chain Sequence
NFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystallographic Analysis of Calcium-dependent Heparin Binding to Annexin A2.
pubmed doi rcsb
molecule tags Metal binding protein
source organism Homo sapiens
molecule keywords Annexin A2
total genus 126
structure length 308
sequence length 308
ec nomenclature
pdb deposition date 2006-08-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00191 Annexin Annexin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 2hyuA04
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 2hyuA01
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 2hyuA02
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 2hyuA03
1N41A 1BCYA 1G5NA 2ZHIA 1AEIA 1XJLA 2HYUA 1AXNA 1SAVA 1ANNA 2HYWA 1AOWA 1HM6A 1M9IA 1HAKA 1N44A 1I4AA 1W3WA 2H0KA 3BRXA 1HVGA 1BC1A 1AVCA 1DK5A 2H0LA 2II2A 4X9PA 1AVHA 1YIIA 1BCZA 1N00A 1AVRA 1ANWA 1DM5A 2ZOCA 2HYVA 2XO2A 2H0MA 1A8BA 2ZHJA 4MDVA 1HVFA 4EVFA 1ANXA 4MDUA 2RANA 2IE6A 1HVDA 1A8AA 4EVHA 1BC3A 1W45A 1BCWA 2XO3A 1ALAA 1YJ0A 1BO9A 1W7BA 1AIIA 2IICA 1N42A 1HVEA 1YCNA 1BC0A 1MCXA 2IE7A 2Q4CA 4HREA
chains in the Genus database with same CATH superfamily
1N41A 1BCYA 4C0AA 1RE0B 1SAVA 2HYWA 1LKVX 1HM6A 1W3WA 1N44A 1I4AA 1AVCA 1YIIA 2QEZA 1AVRA 1ANWA 3LTLA 2HYVA 4Q2SA 4KN4X 4EVFA 4C7PA 4FQ0C 1YGMA 1HVDA 1W45A 4KN7X 3AO0A 1ALAA 3ABOA 1UPTB 1YCNA 1MCXA 4JMOA 3TW5A 3ABRA 1XJLA 4A4PA 1M9IA 1HAKA 2H0KA 1BC1A 2H0LA 2II2A 1AVHA 1N00A 4L5MA 2ZOCA 2K6XA 1Q8DA 4MDVA 4JXHA 4KMUX 2IE6A 1BC9A 1A8AA 4Z21A 2XO3A 1YJ0A 4FHRB 4OIYA 3USYA 1HVEA 1BC0A 1XSZA 2IE7A 1KU1A 4D7RA 2HYUA 1AXNA 1ANNA 2OY9A 3BRXA 3ABQA 1HVGA 4X9PA 1C1KA 1BCZA 2R09A 2H0MA 1A8BA 2ZHJA 1S9DE 1PBVA 1R8ME 1BC3A 3SOHB 1AIIA 1N42A 2HSNA 4HREA 1G5NA 2ZHIA 1AEIA 2R0DA 2VXGA 4JWLA 1AOWA 1R8SE 3AJCA 3ANYA 1DK5A 1XT0B 4JK1X 1DM5A 2XO2A 1HVFA 3HJLA 1ANXA 3USWA 4D7QA 4MDUA 1QC7A 2RANA 1R4AE 3L8NA 3ABSA 3SWVA 4EVHA 1BCWA 1R8QE 1BO9A 4JMIA 1W7BA 2IICA 2Q4CA
chains in the Genus database with same CATH topology
1N41A 1BCYA 1G5NA 2ZHIA 1AEIA 1XJLA 2HYUA 1AXNA 1SAVA 1ANNA 2HYWA 1AOWA 1HM6A 1M9IA 1HAKA 1N44A 1I4AA 1W3WA 2H0KA 3BRXA 1HVGA 1BC1A 1AVCA 1DK5A 2H0LA 2II2A 4X9PA 1AVHA 1YIIA 1BCZA 1N00A 1AVRA 1ANWA 1DM5A 2ZOCA 2HYVA 2XO2A 2H0MA 1A8BA 2ZHJA 4MDVA 1HVFA 4EVFA 1ANXA 4MDUA 2RANA 2IE6A 1HVDA 1A8AA 4EVHA 1BC3A 1W45A 1BCWA 2XO3A 1ALAA 1YJ0A 1BO9A 1W7BA 1AIIA 2IICA 1N42A 1HVEA 1YCNA 1BC0A 1MCXA 2IE7A 2Q4CA 4HREA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1N41 A;  1BCY A;  1G5N A;  2ZHI A;  1AEI A;  1XJL A;  2HYU A;  1AXN A;  1SAV A;  1ANN A;  2HYW A;  1AOW A;  1HM6 A;  1M9I A;  1HAK A;  1N44 A;  1I4A A;  1W3W A;  2H0K A;  3BRX A;  1HVG A;  1BC1 A;  1AVC A;  1DK5 A;  2H0L A;  2II2 A;  4X9P A;  1AVH A;  1YII A;  1BCZ A;  1N00 A;  1AVR A;  1ANW A;  1DM5 A;  2ZOC A;  2HYV A;  2XO2 A;  2H0M A;  1A8B A;  2ZHJ A;  4MDV A;  1HVF A;  4EVF A;  1ANX A;  4MDU A;  2RAN A;  2IE6 A;  1HVD A;  1A8A A;  4EVH A;  1BC3 A;  1W45 A;  1BCW A;  2XO3 A;  1ALA A;  1YJ0 A;  1BO9 A;  1W7B A;  1AII A;  2IIC A;  1N42 A;  1HVE A;  1YCN A;  1BC0 A;  1MCX A;  2IE7 A;  2Q4C A;  4HRE A; 
#chains in the Genus database with same CATH topology
 1N41 A;  1BCY A;  4C0A A;  1RE0 B;  1SAV A;  2HYW A;  1LKV X;  1HM6 A;  1W3W A;  1N44 A;  1I4A A;  1AVC A;  1YII A;  2QEZ A;  1AVR A;  1ANW A;  3LTL A;  2HYV A;  4Q2S A;  4KN4 X;  4EVF A;  4C7P A;  4FQ0 C;  1YGM A;  1HVD A;  1W45 A;  4KN7 X;  3AO0 A;  1ALA A;  3ABO A;  1UPT B;  1YCN A;  1MCX A;  4JMO A;  3TW5 A;  3ABR A;  1XJL A;  4A4P A;  1M9I A;  1HAK A;  2H0K A;  1BC1 A;  2H0L A;  2II2 A;  1AVH A;  1N00 A;  4L5M A;  2ZOC A;  2K6X A;  1Q8D A;  4MDV A;  4JXH A;  4KMU X;  2IE6 A;  1BC9 A;  1A8A A;  4Z21 A;  2XO3 A;  1YJ0 A;  4FHR B;  4OIY A;  3USY A;  1HVE A;  1BC0 A;  1XSZ A;  2IE7 A;  1KU1 A;  4D7R A;  2HYU A;  1AXN A;  1ANN A;  2OY9 A;  3BRX A;  3ABQ A;  1HVG A;  4X9P A;  1C1K A;  1BCZ A;  2R09 A;  2H0M A;  1A8B A;  2ZHJ A;  1S9D E;  1PBV A;  1R8M E;  1BC3 A;  3SOH B;  1AII A;  1N42 A;  2HSN A;  4HRE A;  1G5N A;  2ZHI A;  1AEI A;  2R0D A;  2VXG A;  4JWL A;  1AOW A;  1R8S E;  3AJC A;  3ANY A;  1DK5 A;  1XT0 B;  4JK1 X;  1DM5 A;  2XO2 A;  1HVF A;  3HJL A;  1ANX A;  3USW A;  4D7Q A;  4MDU A;  1QC7 A;  2RAN A;  1R4A E;  3L8N A;  3ABS A;  3SWV A;  4EVH A;  1BCW A;  1R8Q E;  1BO9 A;  4JMI A;  1W7B A;  2IIC A;  2Q4C A; 
#chains in the Genus database with same CATH homology
 1N41 A;  1BCY A;  1G5N A;  2ZHI A;  1AEI A;  1XJL A;  2HYU A;  1AXN A;  1SAV A;  1ANN A;  2HYW A;  1AOW A;  1HM6 A;  1M9I A;  1HAK A;  1N44 A;  1I4A A;  1W3W A;  2H0K A;  3BRX A;  1HVG A;  1BC1 A;  1AVC A;  1DK5 A;  2H0L A;  2II2 A;  4X9P A;  1AVH A;  1YII A;  1BCZ A;  1N00 A;  1AVR A;  1ANW A;  1DM5 A;  2ZOC A;  2HYV A;  2XO2 A;  2H0M A;  1A8B A;  2ZHJ A;  4MDV A;  1HVF A;  4EVF A;  1ANX A;  4MDU A;  2RAN A;  2IE6 A;  1HVD A;  1A8A A;  4EVH A;  1BC3 A;  1W45 A;  1BCW A;  2XO3 A;  1ALA A;  1YJ0 A;  1BO9 A;  1W7B A;  1AII A;  2IIC A;  1N42 A;  1HVE A;  1YCN A;  1BC0 A;  1MCX A;  2IE7 A;  2Q4C A;  4HRE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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