2HYVA

Human annexin a2 with heparin hexasaccharide bound
Total Genus 131
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
131
sequence length
308
structure length
308
Chain Sequence
NFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystallographic analysis of calcium-dependent heparin binding to annexin A2.
pubmed doi rcsb
molecule tags Metal binding protein
source organism Homo sapiens
molecule keywords Annexin A2
total genus 131
structure length 308
sequence length 308
ec nomenclature
pdb deposition date 2006-08-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00191 Annexin Annexin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 2hyvA04
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 2hyvA01
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 2hyvA02
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 2hyvA03
1I4AA 2XO2A 1HM6A 1YIIA 2IE6A 2H0KA 1G5NA 2RANA 2XO3A 1W45A 2HYWA 1W7BA 1A8BA 2H0LA 2HYVA 1ALAA 1W3WA 2HYUA 1AVHA 1HAKA 2ZHJA 1N42A 1ANXA 2Q4CA 1BC0A 1N44A 1BCYA 1A8AA 4HREA 1DM5A 2IE7A 1ANWA 1BCZA 4EVHA 1ANNA 1SAVA 1AIIA 1BC3A 4MDVA 1AVCA 1DK5A 2ZHIA 1AVRA 4MDUA 2ZOCA 1HVFA 1MCXA 1HVEA 2II2A 1N00A 1XJLA 2IICA 4X9PA 3BRXA 1HVGA 1AXNA 1AEIA 1M9IA 1BC1A 4EVFA 1AOWA 1BO9A 2H0MA 1N41A 1BCWA 1HVDA 1YCNA 1YJ0A
chains in the Genus database with same CATH superfamily
2IE6A 2XO3A 4FQ0C 2HYWA 1Q8DA 3L8NA 1A8BA 2H0LA 2OY9A 1ALAA 2R09A 1N42A 2Q4CA 3ABSA 3USWA 4Q2SA 1ANWA 3SOHB 1SAVA 1AIIA 1R8QE 4MDVA 1AVCA 1DK5A 1AVRA 1KU1A 4A4PA 1HVFA 1UPTB 4C7PA 2IICA 4X9PA 1M9IA 1R8ME 2XO2A 1S9DE 1HVDA 4KMUX 1LKVX 1YIIA 1XSZA 2H0KA 4KN4X 1W45A 2ZHJA 1C1KA 1ANXA 1BC0A 1DM5A 2IE7A 3SWVA 3TW5A 1BCZA 4EVHA 4OIYA 1BC3A 2R0DA 1YGMA 3AJCA 4MDUA 1N00A 4D7QA 1XT0B 1N41A 2K6XA 1BCWA 1YCNA 4JMOA 2HSNA 4D7RA 1G5NA 4KN7X 4C0AA 2QEZA 1W7BA 1W3WA 1N44A 1A8AA 3USYA 4JWLA 4HREA 4L5MA 3ABQA 1ANNA 3ABOA 2VXGA 1XJLA 1HVGA 3HJLA 1AXNA 3AO0A 1BO9A 1YJ0A 1I4AA 1HM6A 1RE0B 2RANA 4JMIA 3ANYA 2HYVA 2HYUA 1AVHA 1HAKA 1PBVA 1BCYA 4JXHA 3ABRA 4JK1X 3LTLA 1QC7A 1R8SE 2ZHIA 1BC9A 2ZOCA 4FHRB 1MCXA 1HVEA 2II2A 3BRXA 1R4AE 1AEIA 1BC1A 4EVFA 1AOWA 2H0MA 4Z21A
chains in the Genus database with same CATH topology
1I4AA 2XO2A 1HM6A 1YIIA 2IE6A 2H0KA 1G5NA 2RANA 2XO3A 1W45A 2HYWA 1W7BA 1A8BA 2H0LA 2HYVA 1ALAA 1W3WA 2HYUA 1AVHA 1HAKA 2ZHJA 1N42A 1ANXA 2Q4CA 1BC0A 1N44A 1BCYA 1A8AA 4HREA 1DM5A 2IE7A 1ANWA 1BCZA 4EVHA 1ANNA 1SAVA 1AIIA 1BC3A 4MDVA 1AVCA 1DK5A 2ZHIA 1AVRA 4MDUA 2ZOCA 1HVFA 1MCXA 1HVEA 2II2A 1N00A 1XJLA 2IICA 4X9PA 3BRXA 1HVGA 1AXNA 1AEIA 1M9IA 1BC1A 4EVFA 1AOWA 1BO9A 2H0MA 1N41A 1BCWA 1HVDA 1YCNA 1YJ0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1I4A A;  2XO2 A;  1HM6 A;  1YII A;  2IE6 A;  2H0K A;  1G5N A;  2RAN A;  2XO3 A;  1W45 A;  2HYW A;  1W7B A;  1A8B A;  2H0L A;  2HYV A;  1ALA A;  1W3W A;  2HYU A;  1AVH A;  1HAK A;  2ZHJ A;  1N42 A;  1ANX A;  2Q4C A;  1BC0 A;  1N44 A;  1BCY A;  1A8A A;  4HRE A;  1DM5 A;  2IE7 A;  1ANW A;  1BCZ A;  4EVH A;  1ANN A;  1SAV A;  1AII A;  1BC3 A;  4MDV A;  1AVC A;  1DK5 A;  2ZHI A;  1AVR A;  4MDU A;  2ZOC A;  1HVF A;  1MCX A;  1HVE A;  2II2 A;  1N00 A;  1XJL A;  2IIC A;  4X9P A;  3BRX A;  1HVG A;  1AXN A;  1AEI A;  1M9I A;  1BC1 A;  4EVF A;  1AOW A;  1BO9 A;  2H0M A;  1N41 A;  1BCW A;  1HVD A;  1YCN A;  1YJ0 A; 
#chains in the Genus database with same CATH topology
 2IE6 A;  2XO3 A;  4FQ0 C;  2HYW A;  1Q8D A;  3L8N A;  1A8B A;  2H0L A;  2OY9 A;  1ALA A;  2R09 A;  1N42 A;  2Q4C A;  3ABS A;  3USW A;  4Q2S A;  1ANW A;  3SOH B;  1SAV A;  1AII A;  1R8Q E;  4MDV A;  1AVC A;  1DK5 A;  1AVR A;  1KU1 A;  4A4P A;  1HVF A;  1UPT B;  4C7P A;  2IIC A;  4X9P A;  1M9I A;  1R8M E;  2XO2 A;  1S9D E;  1HVD A;  4KMU X;  1LKV X;  1YII A;  1XSZ A;  2H0K A;  4KN4 X;  1W45 A;  2ZHJ A;  1C1K A;  1ANX A;  1BC0 A;  1DM5 A;  2IE7 A;  3SWV A;  3TW5 A;  1BCZ A;  4EVH A;  4OIY A;  1BC3 A;  2R0D A;  1YGM A;  3AJC A;  4MDU A;  1N00 A;  4D7Q A;  1XT0 B;  1N41 A;  2K6X A;  1BCW A;  1YCN A;  4JMO A;  2HSN A;  4D7R A;  1G5N A;  4KN7 X;  4C0A A;  2QEZ A;  1W7B A;  1W3W A;  1N44 A;  1A8A A;  3USY A;  4JWL A;  4HRE A;  4L5M A;  3ABQ A;  1ANN A;  3ABO A;  2VXG A;  1XJL A;  1HVG A;  3HJL A;  1AXN A;  3AO0 A;  1BO9 A;  1YJ0 A;  1I4A A;  1HM6 A;  1RE0 B;  2RAN A;  4JMI A;  3ANY A;  2HYV A;  2HYU A;  1AVH A;  1HAK A;  1PBV A;  1BCY A;  4JXH A;  3ABR A;  4JK1 X;  3LTL A;  1QC7 A;  1R8S E;  2ZHI A;  1BC9 A;  2ZOC A;  4FHR B;  1MCX A;  1HVE A;  2II2 A;  3BRX A;  1R4A E;  1AEI A;  1BC1 A;  4EVF A;  1AOW A;  2H0M A;  4Z21 A; 
#chains in the Genus database with same CATH homology
 1I4A A;  2XO2 A;  1HM6 A;  1YII A;  2IE6 A;  2H0K A;  1G5N A;  2RAN A;  2XO3 A;  1W45 A;  2HYW A;  1W7B A;  1A8B A;  2H0L A;  2HYV A;  1ALA A;  1W3W A;  2HYU A;  1AVH A;  1HAK A;  2ZHJ A;  1N42 A;  1ANX A;  2Q4C A;  1BC0 A;  1N44 A;  1BCY A;  1A8A A;  4HRE A;  1DM5 A;  2IE7 A;  1ANW A;  1BCZ A;  4EVH A;  1ANN A;  1SAV A;  1AII A;  1BC3 A;  4MDV A;  1AVC A;  1DK5 A;  2ZHI A;  1AVR A;  4MDU A;  2ZOC A;  1HVF A;  1MCX A;  1HVE A;  2II2 A;  1N00 A;  1XJL A;  2IIC A;  4X9P A;  3BRX A;  1HVG A;  1AXN A;  1AEI A;  1M9I A;  1BC1 A;  4EVF A;  1AOW A;  1BO9 A;  2H0M A;  1N41 A;  1BCW A;  1HVD A;  1YCN A;  1YJ0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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