2HYVA

Human annexin a2 with heparin hexasaccharide bound
Total Genus 131
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
131
sequence length
308
structure length
308
Chain Sequence
NFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystallographic analysis of calcium-dependent heparin binding to annexin A2.
pubmed doi rcsb
molecule tags Metal binding protein
source organism Homo sapiens
molecule keywords Annexin A2
total genus 131
structure length 308
sequence length 308
ec nomenclature
pdb deposition date 2006-08-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00191 Annexin Annexin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 2hyvA04
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 2hyvA01
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 2hyvA02
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 2hyvA03
2Q4CA 2ZHJA 1XJLA 1SAVA 1HVFA 1ALAA 2HYWA 1ANWA 1HVEA 4EVFA 2H0LA 1A8BA 2RANA 1ANXA 1N41A 4MDVA 1BCWA 1YIIA 1YCNA 4X9PA 1N44A 2IICA 1BO9A 1W3WA 2II2A 1N00A 2IE7A 1M9IA 2HYUA 2ZOCA 1AEIA 2XO3A 1BCZA 1I4AA 1DM5A 1BCYA 4EVHA 1DK5A 2ZHIA 2XO2A 1HVGA 1HVDA 4MDUA 1BC1A 1AVRA 1AVCA 1A8AA 1AVHA 1AIIA 1G5NA 1HM6A 1W45A 1W7BA 1YJ0A 2H0MA 2IE6A 1AOWA 4HREA 1ANNA 1AXNA 3BRXA 1MCXA 1BC3A 2H0KA 1HAKA 2HYVA 1N42A 1BC0A
chains in the Genus database with same CATH superfamily
2R0DA 1SAVA 1BC0A 1KU1A 1A8BA 2H0LA 4KN4X 3ABRA 4X9PA 1YIIA 1YCNA 4Q2SA 4FQ0C 2QEZA 1W3WA 2IE7A 2ZOCA 3AO0A 4D7RA 1XSZA 1BCZA 1R4AE 1BC1A 1BC9A 1AIIA 1ANNA 3BRXA 2H0KA 1LKVX 2ZHJA 3TW5A 2HYWA 1ANWA 1BCWA 1QC7A 2II2A 3ABQA 3USYA 1M9IA 4KMUX 1AEIA 2XO3A 1DK5A 2ZHIA 1HVDA 1AVCA 1A8AA 1HM6A 1XT0B 1PBVA 1AOWA 1AXNA 1R8SE 1RE0B 1HAKA 4C7PA 4Z21A 1N42A 3SOHB 4C0AA 1XJLA 1HVFA 3AJCA 1ANXA 4MDVA 4FHRB 3HJLA 1N44A 2IICA 1N00A 2K6XA 3ABOA 2HYUA 1I4AA 1DM5A 2HSNA 1BCYA 4EVHA 2XO2A 1HVGA 3LTLA 1W7BA 1YJ0A 3ABSA 1YGMA 2R09A 4L5MA 1MCXA 1BC3A 2HYVA 4JMIA 4JMOA 1R8ME 2Q4CA 3USWA 4EVFA 1HVEA 3ANYA 2RANA 4JWLA 1N41A 4JXHA 4A4PA 1BO9A 1C1KA 3L8NA 2OY9A 4KN7X 4JK1X 1S9DE 4D7QA 1UPTB 4OIYA 4MDUA 2VXGA 1AVRA 1AVHA 1G5NA 1W45A 3SWVA 2H0MA 2IE6A 4HREA 1Q8DA 1R8QE 1ALAA
chains in the Genus database with same CATH topology
2Q4CA 2ZHJA 1XJLA 1SAVA 1HVFA 1ALAA 2HYWA 1ANWA 1HVEA 4EVFA 2H0LA 1A8BA 2RANA 1ANXA 1N41A 4MDVA 1BCWA 1YIIA 1YCNA 4X9PA 1N44A 2IICA 1BO9A 1W3WA 2II2A 1N00A 2IE7A 1M9IA 2HYUA 2ZOCA 1AEIA 2XO3A 1BCZA 1I4AA 1DM5A 1BCYA 4EVHA 1DK5A 2ZHIA 2XO2A 1HVGA 1HVDA 4MDUA 1BC1A 1AVRA 1AVCA 1A8AA 1AVHA 1AIIA 1G5NA 1HM6A 1W45A 1W7BA 1YJ0A 2H0MA 2IE6A 1AOWA 4HREA 1ANNA 1AXNA 3BRXA 1MCXA 1BC3A 2H0KA 1HAKA 2HYVA 1N42A 1BC0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2Q4C A;  2ZHJ A;  1XJL A;  1SAV A;  1HVF A;  1ALA A;  2HYW A;  1ANW A;  1HVE A;  4EVF A;  2H0L A;  1A8B A;  2RAN A;  1ANX A;  1N41 A;  4MDV A;  1BCW A;  1YII A;  1YCN A;  4X9P A;  1N44 A;  2IIC A;  1BO9 A;  1W3W A;  2II2 A;  1N00 A;  2IE7 A;  1M9I A;  2HYU A;  2ZOC A;  1AEI A;  2XO3 A;  1BCZ A;  1I4A A;  1DM5 A;  1BCY A;  4EVH A;  1DK5 A;  2ZHI A;  2XO2 A;  1HVG A;  1HVD A;  4MDU A;  1BC1 A;  1AVR A;  1AVC A;  1A8A A;  1AVH A;  1AII A;  1G5N A;  1HM6 A;  1W45 A;  1W7B A;  1YJ0 A;  2H0M A;  2IE6 A;  1AOW A;  4HRE A;  1ANN A;  1AXN A;  3BRX A;  1MCX A;  1BC3 A;  2H0K A;  1HAK A;  2HYV A;  1N42 A;  1BC0 A; 
#chains in the Genus database with same CATH topology
 2R0D A;  1SAV A;  1BC0 A;  1KU1 A;  1A8B A;  2H0L A;  4KN4 X;  3ABR A;  4X9P A;  1YII A;  1YCN A;  4Q2S A;  4FQ0 C;  2QEZ A;  1W3W A;  2IE7 A;  2ZOC A;  3AO0 A;  4D7R A;  1XSZ A;  1BCZ A;  1R4A E;  1BC1 A;  1BC9 A;  1AII A;  1ANN A;  3BRX A;  2H0K A;  1LKV X;  2ZHJ A;  3TW5 A;  2HYW A;  1ANW A;  1BCW A;  1QC7 A;  2II2 A;  3ABQ A;  3USY A;  1M9I A;  4KMU X;  1AEI A;  2XO3 A;  1DK5 A;  2ZHI A;  1HVD A;  1AVC A;  1A8A A;  1HM6 A;  1XT0 B;  1PBV A;  1AOW A;  1AXN A;  1R8S E;  1RE0 B;  1HAK A;  4C7P A;  4Z21 A;  1N42 A;  3SOH B;  4C0A A;  1XJL A;  1HVF A;  3AJC A;  1ANX A;  4MDV A;  4FHR B;  3HJL A;  1N44 A;  2IIC A;  1N00 A;  2K6X A;  3ABO A;  2HYU A;  1I4A A;  1DM5 A;  2HSN A;  1BCY A;  4EVH A;  2XO2 A;  1HVG A;  3LTL A;  1W7B A;  1YJ0 A;  3ABS A;  1YGM A;  2R09 A;  4L5M A;  1MCX A;  1BC3 A;  2HYV A;  4JMI A;  4JMO A;  1R8M E;  2Q4C A;  3USW A;  4EVF A;  1HVE A;  3ANY A;  2RAN A;  4JWL A;  1N41 A;  4JXH A;  4A4P A;  1BO9 A;  1C1K A;  3L8N A;  2OY9 A;  4KN7 X;  4JK1 X;  1S9D E;  4D7Q A;  1UPT B;  4OIY A;  4MDU A;  2VXG A;  1AVR A;  1AVH A;  1G5N A;  1W45 A;  3SWV A;  2H0M A;  2IE6 A;  4HRE A;  1Q8D A;  1R8Q E;  1ALA A; 
#chains in the Genus database with same CATH homology
 2Q4C A;  2ZHJ A;  1XJL A;  1SAV A;  1HVF A;  1ALA A;  2HYW A;  1ANW A;  1HVE A;  4EVF A;  2H0L A;  1A8B A;  2RAN A;  1ANX A;  1N41 A;  4MDV A;  1BCW A;  1YII A;  1YCN A;  4X9P A;  1N44 A;  2IIC A;  1BO9 A;  1W3W A;  2II2 A;  1N00 A;  2IE7 A;  1M9I A;  2HYU A;  2ZOC A;  1AEI A;  2XO3 A;  1BCZ A;  1I4A A;  1DM5 A;  1BCY A;  4EVH A;  1DK5 A;  2ZHI A;  2XO2 A;  1HVG A;  1HVD A;  4MDU A;  1BC1 A;  1AVR A;  1AVC A;  1A8A A;  1AVH A;  1AII A;  1G5N A;  1HM6 A;  1W45 A;  1W7B A;  1YJ0 A;  2H0M A;  2IE6 A;  1AOW A;  4HRE A;  1ANN A;  1AXN A;  3BRX A;  1MCX A;  1BC3 A;  2H0K A;  1HAK A;  2HYV A;  1N42 A;  1BC0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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