3LTLA

Crystal structure of human big1 sec7 domain
Total Genus 73
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
73
sequence length
191
structure length
191
Chain Sequence
LKQQKEIIEQGIDLFNKKPKRGIQYLQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGKKISMK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title The Sec7 domain structures of human BIG1 and Cytohesin1 Arf nucleotide exchange factors
rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords Brefeldin A-inhibited guanine nucleotide-exchange protein 1
total genus 73
structure length 191
sequence length 191
chains with identical sequence B
ec nomenclature
pdb deposition date 2010-02-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01369 Sec7 Sec7 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.220.20 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin V; domain 1 3ltlA01
1.10.1000.11 Mainly Alpha Orthogonal Bundle Arf Nucleotide-binding Site Opener; domain 2 Arf Nucleotide-binding Site Opener,domain 2 3ltlA02
1KU1A 3L8NA 1R8ME 4JMIA 1PBVA 4Z21A 2R09A 4OIYA 2R0DA 3SWVA 1XSZA 4D7RA 4A4PA 1R8SE 4L5MA 4JMOA 3LTLA 4C7PA 4JXHA 1RE0B 4D7QA 1R8QE 1BC9A 4C0AA 1S9DE 1XT0B 4JWLA
chains in the Genus database with same CATH superfamily
1W45A 1AIIA 1M9IA 4JMIA 4EVHA 2R09A 2ZHJA 1UPTB 4OIYA 2R0DA 2IE6A 4FHRB 1A8AA 1HM6A 1HVGA 1HAKA 1R8SE 2HSNA 1N42A 3USYA 1BC9A 1XJLA 1YJ0A 1N44A 1AVHA 1AXNA 3AO0A 1R8ME 1ANXA 1PBVA 2ZHIA 4X9PA 3USWA 1BCWA 1YIIA 1ANNA 2OY9A 1BCZA 4KN7X 3ABSA 1W3WA 1C1KA 1BCYA 1ANWA 1AVCA 1AEIA 4MDUA 4JK1X 1RE0B 3TW5A 4HREA 1N00A 2XO2A 4C0AA 1S9DE 4JWLA 2IE7A 1BC1A 1KU1A 1BC3A 1HVFA 1BC0A 2IICA 4FQ0C 3SWVA 2HYWA 1YGMA 1DM5A 1MCXA 4D7RA 2K6XA 1I4AA 1SAVA 2RANA 4A4PA 1A8BA 4MDVA 4L5MA 1G5NA 3LTLA 1DK5A 1LKVX 1Q8DA 4C7PA 2HYUA 4JXHA 4D7QA 2H0MA 2II2A 1N41A 4KMUX 1XT0B 1ALAA 2H0LA 1R4AE 2H0KA 1HVDA 2XO3A 3L8NA 3SOHB 1W7BA 1YCNA 4Z21A 1XSZA 2HYVA 2QEZA 3ANYA 2ZOCA 3HJLA 1QC7A 1AVRA 2VXGA 1HVEA 1BO9A 4JMOA 3ABOA 3ABQA 1AOWA 2Q4CA 4EVFA 3AJCA 3BRXA 3ABRA 1R8QE 4KN4X 4Q2SA
chains in the Genus database with same CATH topology
1KU1A 3L8NA 1R8ME 3SOHB 4JMIA 1PBVA 4Z21A 2R09A 4FQ0C 4OIYA 3USWA 2R0DA 3SWVA 1XSZA 4D7RA 4FHRB 4KN7X 2K6XA 3HJLA 1QC7A 4A4PA 1R8SE 4L5MA 4JMOA 3LTLA 2HSNA 1LKVX 1Q8DA 4C7PA 4JK1X 3AJCA 4JXHA 3USYA 1RE0B 3TW5A 4D7QA 1R8QE 1BC9A 4KN4X 4C0AA 1S9DE 4KMUX 1XT0B 4JWLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1KU1 A;  3L8N A;  1R8M E;  4JMI A;  1PBV A;  4Z21 A;  2R09 A;  4OIY A;  2R0D A;  3SWV A;  1XSZ A;  4D7R A;  4A4P A;  1R8S E;  4L5M A;  4JMO A;  3LTL A;  4C7P A;  4JXH A;  1RE0 B;  4D7Q A;  1R8Q E;  1BC9 A;  4C0A A;  1S9D E;  1XT0 B;  4JWL A; 
#chains in the Genus database with same CATH topology
 1W45 A;  1AII A;  1M9I A;  4JMI A;  4EVH A;  2R09 A;  2ZHJ A;  1UPT B;  4OIY A;  2R0D A;  2IE6 A;  4FHR B;  1A8A A;  1HM6 A;  1HVG A;  1HAK A;  1R8S E;  2HSN A;  1N42 A;  3USY A;  1BC9 A;  1XJL A;  1YJ0 A;  1N44 A;  1AVH A;  1AXN A;  3AO0 A;  1R8M E;  1ANX A;  1PBV A;  2ZHI A;  4X9P A;  3USW A;  1BCW A;  1YII A;  1ANN A;  2OY9 A;  1BCZ A;  4KN7 X;  3ABS A;  1W3W A;  1C1K A;  1BCY A;  1ANW A;  1AVC A;  1AEI A;  4MDU A;  4JK1 X;  1RE0 B;  3TW5 A;  4HRE A;  1N00 A;  2XO2 A;  4C0A A;  1S9D E;  4JWL A;  2IE7 A;  1BC1 A;  1KU1 A;  1BC3 A;  1HVF A;  1BC0 A;  2IIC A;  4FQ0 C;  3SWV A;  2HYW A;  1YGM A;  1DM5 A;  1MCX A;  4D7R A;  2K6X A;  1I4A A;  1SAV A;  2RAN A;  4A4P A;  1A8B A;  4MDV A;  4L5M A;  1G5N A;  3LTL A;  1DK5 A;  1LKV X;  1Q8D A;  4C7P A;  2HYU A;  4JXH A;  4D7Q A;  2H0M A;  2II2 A;  1N41 A;  4KMU X;  1XT0 B;  1ALA A;  2H0L A;  1R4A E;  2H0K A;  1HVD A;  2XO3 A;  3L8N A;  3SOH B;  1W7B A;  1YCN A;  4Z21 A;  1XSZ A;  2HYV A;  2QEZ A;  3ANY A;  2ZOC A;  3HJL A;  1QC7 A;  1AVR A;  2VXG A;  1HVE A;  1BO9 A;  4JMO A;  3ABO A;  3ABQ A;  1AOW A;  2Q4C A;  4EVF A;  3AJC A;  3BRX A;  3ABR A;  1R8Q E;  4KN4 X;  4Q2S A; 
#chains in the Genus database with same CATH homology
 1KU1 A;  3L8N A;  1R8M E;  3SOH B;  4JMI A;  1PBV A;  4Z21 A;  2R09 A;  4FQ0 C;  4OIY A;  3USW A;  2R0D A;  3SWV A;  1XSZ A;  4D7R A;  4FHR B;  4KN7 X;  2K6X A;  3HJL A;  1QC7 A;  4A4P A;  1R8S E;  4L5M A;  4JMO A;  3LTL A;  2HSN A;  1LKV X;  1Q8D A;  4C7P A;  4JK1 X;  3AJC A;  4JXH A;  3USY A;  1RE0 B;  3TW5 A;  4D7Q A;  1R8Q E;  1BC9 A;  4KN4 X;  4C0A A;  1S9D E;  4KMU X;  1XT0 B;  4JWL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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