3ORGA

Crystal structure of a eukaryotic clc transporter
Total Genus 170
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
170
sequence length
623
structure length
534
Chain Sequence
SLMYLLRLVCFLTLLGVTAALFIFAVDLAVHGLEELRMKISRLAGRFAGYILYVVSGVALCLLSTFWCAVLSTEAEGSGLPQMKSILSGFYDKMRSALELRVLFAKALGLICAIGGGLPVGWEGPNVHIACIIAHQFYRLGVFKELCTDRALRLQTLAAACAVGLASSFGAPLGGVLYSIETIASFYLVQAFWKGVLSALSGAIVYELDVSRTQTLLYAILGALMGVLGALFIRCVRSIYELRMRHYPGTNRYFLVGVVALFASALQYPFPRATINDLFKAVTELILMPIIKFILVALSIGLPLPAGVFVPSFLIGAGFGRLYGELMRVVFGNAIVPGSYAVVGAAAFTAGVTRALSCAVIIFEVTGQIRHLVPVLISVLLAVIVGNAFNRSLYETLVLMKHLPYMPILRRDRSPEMTAREIMHPIEGEPHLFPDSEPQHIKGILEKFPNRLVFPVIDANGYLLGAISRKEIVDRLQHVVVPCDVSPIVVTSYSLVRQLHFLFVMLMPSMIYVTERGKLVGIVEREDVAYGYSN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of a eukaryotic CLC transporter defines an intermediate state in the transport cycle.
pubmed doi rcsb
molecule tags Transport protein
source organism Cyanidioschyzon merolae
molecule keywords CmCLC
total genus 170
structure length 534
sequence length 623
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2010-09-07
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3080.10 Mainly Alpha Orthogonal Bundle Clc chloride channel Clc chloride channel 3orgA01
3.10.580.10 Alpha Beta Roll CBS-domain CBS-domain 3orgA02
4FG6A 4KJPA 2PFIA 4L27A 4KJQA 4P1OA 2QREE 3ND0A 3KXRA 4NOCA 2YVYA 3EJYA 2ZY9A 3K6EA 4ESYB 4IY3A 2OUXA 3GBYA 4COOA 3I8NA 4LOUA 2YZQA 2HTKA 5K24C 3LFZA 1PVMA 2HLFA 4FTPA 4KK5A 3ORGA 2D4ZA 1KPKA 2P9MA 3TE5C 4GQVA 3NMOA 5HD8A 3OCMA 5K23C 5K22B 4GQYA 3FV6A 2HT2A 1PBJA 2RC3A 5LXQA 4HG0A 4O9KA 2EXWA 3KPBA 2NYCA 4KK6A 2EF7A 2QLVC 2QRDE 3PC3A 4KKCA 2H2SA 1Y5HA 4KKLA 2OOXE 2YVXA 4GQWA 5KS7A 3SL7A 2UV5A 1O50A 3OI8A 4KJWA 3FWRA 4PCUA 1OTTA 4L3VA 2HTLA 2HT3A 3DETA 3FHMA 3FNAA 2FEEA 3PC4A 2H2PA 2FECA 3EJZA 2NYEA 1OTSA 2UV6A 4MQXA 2R9HA 2UV7A 2YZIA 2RIFA 3LV9A 4FRYA 3K2VA 1XKFA 2QRCE 3DDJA 2EXYA 4FXSA 2O16A 4KK8A 2UV4A 2EZ0A 3HF7A 3L31A 1YAVA 5K25C 4KKAA 4L0DA 4P1GA 2EMQA 2QR1E 3FWSA 3KPCA 3Q17A 2RIHA 3T4NC 1KPLA 2YVZA 3KH5A 4UUUA 4ESYA 4ENEA 4IY4A 4IY0A 3L2BA 2QH1A 3TDHC 3PC2A 3KPDA 2FEDA 2HT4A 1OTUA 3LQNA 5MMZA 3OCOA 5IIPA 4KK9A 4IYSA 4L28A 4KKBA 4DQWA 4IY2A 3LHHA 2OOYE
chains in the Genus database with same CATH superfamily
4FG6A 4KJPA 2PFIA 4L27A 4KJQA 4P1OA 2QREE 3ND0A 3KXRA 4NOCA 2YVYA 3EJYA 2ZY9A 3K6EA 4ESYB 4IY3A 2OUXA 3GBYA 4COOA 3I8NA 2J9LA 4LOUA 2YZQA 2HTKA 5K24C 3LFZA 1PVMA 2HLFA 4FTPA 4KK5A 3ORGA 2D4ZA 1KPKA 2P9MA 3TE5C 4GQVA 3NMOA 5HD8A 3OCMA 5K23C 5K22B 4GQYA 3FV6A 2HT2A 1PBJA 2RC3A 5LXQA 4HG0A 4O9KA 2EXWA 2JA3A 3KPBA 2NYCA 4KK6A 2EF7A 2QLVC 2QRDE 3PC3A 4KKCA 2H2SA 1Y5HA 4KKLA 2OOXE 2YVXA 4GQWA 5KS7A 3SL7A 2UV5A 1O50A 3OI8A 4KJWA 3FWRA 4PCUA 1OTTA 4L3VA 2HTLA 2HT3A 3DETA 3FHMA 3FNAA 2FEEA 3PC4A 2H2PA 2FECA 3EJZA 2NYEA 1OTSA 2UV6A 4MQXA 2R9HA 2UV7A 2YZIA 2RIFA 3LV9A 4FRYA 3K2VA 1XKFA 2QRCE 3DDJA 2EXYA 4FXSA 2O16A 4KK8A 2UV4A 2EZ0A 3HF7A 3L31A 1YAVA 5K25C 4KKAA 4L0DA 4P1GA 2EMQA 2QR1E 3FWSA 3KPCA 3Q17A 2RIHA 3T4NC 1KPLA 2YVZA 3KH5A 4UUUA 4ESYA 4ENEA 4IY4A 4IY0A 3L2BA 2QH1A 3TDHC 3PC2A 3KPDA 2FEDA 2HT4A 1OTUA 3LQNA 5MMZA 3OCOA 5IIPA 4KK9A 4IYSA 4L28A 4KKBA 4DQWA 4IY2A 3LHHA 2OOYE
chains in the Genus database with same CATH topology
4FG6A 4KJPA 2PFIA 4L27A 4KJQA 4P1OA 2QREE 3ND0A 3KXRA 4NOCA 2YVYA 3EJYA 2ZY9A 3K6EA 4ESYB 4IY3A 2OUXA 3GBYA 4COOA 3I8NA 2J9LA 4LOUA 2YZQA 2HTKA 5K24C 3LFZA 1PVMA 2HLFA 4FTPA 4KK5A 3ORGA 2D4ZA 1KPKA 2P9MA 3TE5C 4GQVA 3NMOA 5HD8A 3OCMA 5K23C 5K22B 4GQYA 3FV6A 2HT2A 1PBJA 2RC3A 5LXQA 4HG0A 4O9KA 2EXWA 2JA3A 3KPBA 2NYCA 4KK6A 2EF7A 2QLVC 2QRDE 3PC3A 4KKCA 2H2SA 1Y5HA 4KKLA 2OOXE 2YVXA 4GQWA 5KS7A 3SL7A 2UV5A 1O50A 3OI8A 4KJWA 3FWRA 4PCUA 1OTTA 4L3VA 2HTLA 2HT3A 3DETA 3FHMA 3FNAA 2FEEA 3PC4A 2H2PA 2FECA 3EJZA 2NYEA 1OTSA 2UV6A 4MQXA 2R9HA 2UV7A 2YZIA 2RIFA 3LV9A 4FRYA 3K2VA 1XKFA 2QRCE 3DDJA 2EXYA 4FXSA 2O16A 4KK8A 2UV4A 2EZ0A 3HF7A 3L31A 1YAVA 5K25C 4KKAA 4L0DA 4P1GA 2EMQA 2QR1E 3FWSA 3KPCA 3Q17A 2RIHA 3T4NC 1KPLA 2YVZA 3KH5A 4UUUA 4ESYA 4ENEA 4IY4A 4IY0A 3L2BA 2QH1A 3TDHC 3PC2A 3KPDA 2FEDA 2HT4A 1OTUA 3LQNA 5MMZA 3OCOA 5IIPA 4KK9A 4IYSA 4L28A 4KKBA 4DQWA 4IY2A 3LHHA 2OOYE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4FG6 A;  4KJP A;  2PFI A;  4L27 A;  4KJQ A;  4P1O A;  2QRE E;  3ND0 A;  3KXR A;  4NOC A;  2YVY A;  3EJY A;  2ZY9 A;  3K6E A;  4ESY B;  4IY3 A;  2OUX A;  3GBY A;  4COO A;  3I8N A;  4LOU A;  2YZQ A;  2HTK A;  5K24 C;  3LFZ A;  1PVM A;  2HLF A;  4FTP A;  4KK5 A;  3ORG A;  2D4Z A;  1KPK A;  2P9M A;  3TE5 C;  4GQV A;  3NMO A;  5HD8 A;  3OCM A;  5K23 C;  5K22 B;  4GQY A;  3FV6 A;  2HT2 A;  1PBJ A;  2RC3 A;  5LXQ A;  4HG0 A;  4O9K A;  2EXW A;  3KPB A;  2NYC A;  4KK6 A;  2EF7 A;  2QLV C;  2QRD E;  3PC3 A;  4KKC A;  2H2S A;  1Y5H A;  4KKL A;  2OOX E;  2YVX A;  4GQW A;  5KS7 A;  3SL7 A;  2UV5 A;  1O50 A;  3OI8 A;  4KJW A;  3FWR A;  4PCU A;  1OTT A;  4L3V A;  2HTL A;  2HT3 A;  3DET A;  3FHM A;  3FNA A;  2FEE A;  3PC4 A;  2H2P A;  2FEC A;  3EJZ A;  2NYE A;  1OTS A;  2UV6 A;  4MQX A;  2R9H A;  2UV7 A;  2YZI A;  2RIF A;  3LV9 A;  4FRY A;  3K2V A;  1XKF A;  2QRC E;  3DDJ A;  2EXY A;  4FXS A;  2O16 A;  4KK8 A;  2UV4 A;  2EZ0 A;  3HF7 A;  3L31 A;  1YAV A;  5K25 C;  4KKA A;  4L0D A;  4P1G A;  2EMQ A;  2QR1 E;  3FWS A;  3KPC A;  3Q17 A;  2RIH A;  3T4N C;  1KPL A;  2YVZ A;  3KH5 A;  4UUU A;  4ESY A;  4ENE A;  4IY4 A;  4IY0 A;  3L2B A;  2QH1 A;  3TDH C;  3PC2 A;  3KPD A;  2FED A;  2HT4 A;  1OTU A;  3LQN A;  5MMZ A;  3OCO A;  5IIP A;  4KK9 A;  4IYS A;  4L28 A;  4KKB A;  4DQW A;  4IY2 A;  3LHH A;  2OOY E; 
#chains in the Genus database with same CATH topology
 4FG6 A;  4KJP A;  2PFI A;  4L27 A;  4KJQ A;  4P1O A;  2QRE E;  3ND0 A;  3KXR A;  4NOC A;  2YVY A;  3EJY A;  2ZY9 A;  3K6E A;  4ESY B;  4IY3 A;  2OUX A;  3GBY A;  4COO A;  3I8N A;  2J9L A;  4LOU A;  2YZQ A;  2HTK A;  5K24 C;  3LFZ A;  1PVM A;  2HLF A;  4FTP A;  4KK5 A;  3ORG A;  2D4Z A;  1KPK A;  2P9M A;  3TE5 C;  4GQV A;  3NMO A;  5HD8 A;  3OCM A;  5K23 C;  5K22 B;  4GQY A;  3FV6 A;  2HT2 A;  1PBJ A;  2RC3 A;  5LXQ A;  4HG0 A;  4O9K A;  2EXW A;  2JA3 A;  3KPB A;  2NYC A;  4KK6 A;  2EF7 A;  2QLV C;  2QRD E;  3PC3 A;  4KKC A;  2H2S A;  1Y5H A;  4KKL A;  2OOX E;  2YVX A;  4GQW A;  5KS7 A;  3SL7 A;  2UV5 A;  1O50 A;  3OI8 A;  4KJW A;  3FWR A;  4PCU A;  1OTT A;  4L3V A;  2HTL A;  2HT3 A;  3DET A;  3FHM A;  3FNA A;  2FEE A;  3PC4 A;  2H2P A;  2FEC A;  3EJZ A;  2NYE A;  1OTS A;  2UV6 A;  4MQX A;  2R9H A;  2UV7 A;  2YZI A;  2RIF A;  3LV9 A;  4FRY A;  3K2V A;  1XKF A;  2QRC E;  3DDJ A;  2EXY A;  4FXS A;  2O16 A;  4KK8 A;  2UV4 A;  2EZ0 A;  3HF7 A;  3L31 A;  1YAV A;  5K25 C;  4KKA A;  4L0D A;  4P1G A;  2EMQ A;  2QR1 E;  3FWS A;  3KPC A;  3Q17 A;  2RIH A;  3T4N C;  1KPL A;  2YVZ A;  3KH5 A;  4UUU A;  4ESY A;  4ENE A;  4IY4 A;  4IY0 A;  3L2B A;  2QH1 A;  3TDH C;  3PC2 A;  3KPD A;  2FED A;  2HT4 A;  1OTU A;  3LQN A;  5MMZ A;  3OCO A;  5IIP A;  4KK9 A;  4IYS A;  4L28 A;  4KKB A;  4DQW A;  4IY2 A;  3LHH A;  2OOY E; 
#chains in the Genus database with same CATH homology
 4FG6 A;  4KJP A;  2PFI A;  4L27 A;  4KJQ A;  4P1O A;  2QRE E;  3ND0 A;  3KXR A;  4NOC A;  2YVY A;  3EJY A;  2ZY9 A;  3K6E A;  4ESY B;  4IY3 A;  2OUX A;  3GBY A;  4COO A;  3I8N A;  2J9L A;  4LOU A;  2YZQ A;  2HTK A;  5K24 C;  3LFZ A;  1PVM A;  2HLF A;  4FTP A;  4KK5 A;  3ORG A;  2D4Z A;  1KPK A;  2P9M A;  3TE5 C;  4GQV A;  3NMO A;  5HD8 A;  3OCM A;  5K23 C;  5K22 B;  4GQY A;  3FV6 A;  2HT2 A;  1PBJ A;  2RC3 A;  5LXQ A;  4HG0 A;  4O9K A;  2EXW A;  2JA3 A;  3KPB A;  2NYC A;  4KK6 A;  2EF7 A;  2QLV C;  2QRD E;  3PC3 A;  4KKC A;  2H2S A;  1Y5H A;  4KKL A;  2OOX E;  2YVX A;  4GQW A;  5KS7 A;  3SL7 A;  2UV5 A;  1O50 A;  3OI8 A;  4KJW A;  3FWR A;  4PCU A;  1OTT A;  4L3V A;  2HTL A;  2HT3 A;  3DET A;  3FHM A;  3FNA A;  2FEE A;  3PC4 A;  2H2P A;  2FEC A;  3EJZ A;  2NYE A;  1OTS A;  2UV6 A;  4MQX A;  2R9H A;  2UV7 A;  2YZI A;  2RIF A;  3LV9 A;  4FRY A;  3K2V A;  1XKF A;  2QRC E;  3DDJ A;  2EXY A;  4FXS A;  2O16 A;  4KK8 A;  2UV4 A;  2EZ0 A;  3HF7 A;  3L31 A;  1YAV A;  5K25 C;  4KKA A;  4L0D A;  4P1G A;  2EMQ A;  2QR1 E;  3FWS A;  3KPC A;  3Q17 A;  2RIH A;  3T4N C;  1KPL A;  2YVZ A;  3KH5 A;  4UUU A;  4ESY A;  4ENE A;  4IY4 A;  4IY0 A;  3L2B A;  2QH1 A;  3TDH C;  3PC2 A;  3KPD A;  2FED A;  2HT4 A;  1OTU A;  3LQN A;  5MMZ A;  3OCO A;  5IIP A;  4KK9 A;  4IYS A;  4L28 A;  4KKB A;  4DQW A;  4IY2 A;  3LHH A;  2OOY E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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