3ORGA

Crystal structure of a eukaryotic clc transporter
Total Genus 170
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
170
sequence length
623
structure length
534
Chain Sequence
SLMYLLRLVCFLTLLGVTAALFIFAVDLAVHGLEELRMKISRLAGRFAGYILYVVSGVALCLLSTFWCAVLSTEAEGSGLPQMKSILSGFYDKMRSALELRVLFAKALGLICAIGGGLPVGWEGPNVHIACIIAHQFYRLGVFKELCTDRALRLQTLAAACAVGLASSFGAPLGGVLYSIETIASFYLVQAFWKGVLSALSGAIVYELDVSRTQTLLYAILGALMGVLGALFIRCVRSIYELRMRHYPGTNRYFLVGVVALFASALQYPFPRATINDLFKAVTELILMPIIKFILVALSIGLPLPAGVFVPSFLIGAGFGRLYGELMRVVFGNAIVPGSYAVVGAAAFTAGVTRALSCAVIIFEVTGQIRHLVPVLISVLLAVIVGNAFNRSLYETLVLMKHLPYMPILRRDRSPEMTAREIMHPIEGEPHLFPDSEPQHIKGILEKFPNRLVFPVIDANGYLLGAISRKEIVDRLQHVVVPCDVSPIVVTSYSLVRQLHFLFVMLMPSMIYVTERGKLVGIVEREDVAYGYSN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of a eukaryotic CLC transporter defines an intermediate state in the transport cycle.
pubmed doi rcsb
molecule tags Transport protein
source organism Cyanidioschyzon merolae
molecule keywords CmCLC
total genus 170
structure length 534
sequence length 623
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2010-09-07
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3080.10 Mainly Alpha Orthogonal Bundle Clc chloride channel Clc chloride channel 3orgA01
3.10.580.10 Alpha Beta Roll CBS-domain CBS-domain 3orgA02
3K2VA 2HLFA 3KH5A 4KJQA 4KJPA 3FHMA 4KKCA 2HTKA 3L2BA 4HG0A 1KPKA 3PC3A 2YZIA 3PC4A 4L0DA 4COOA 4KK9A 2EF7A 2EXWA 4KKLA 2OOYE 3L31A 4O9KA 3DDJA 2EMQA 2QRDE 2RC3A 2RIFA 2QH1A 1PBJA 2D4ZA 5K25C 3FWSA 4FXSA 3ND0A 4KKAA 1OTTA 1Y5HA 5MMZA 2UV6A 3KPBA 3K6EA 3NMOA 5K24C 2HTLA 3T4NC 4MQXA 4IYSA 4P1OA 2YVZA 5LXQA 3I8NA 2PFIA 5KS7A 4ENEA 4KK6A 2RIHA 1YAVA 3HF7A 3ORGA 2YVYA 3GBYA 3LHHA 4GQYA 5IIPA 2H2PA 2ZY9A 1OTSA 4ESYA 3Q17A 5HD8A 1KPLA 4IY2A 2HT2A 4P1GA 2UV7A 2QRCE 1XKFA 2QREE 2EZ0A 2HT4A 3PC2A 4L3VA 2NYCA 3OCOA 2OOXE 2FEDA 4DQWA 2FEEA 4KJWA 1O50A 3TE5C 3KPDA 2H2SA 3OI8A 3TDHC 3DETA 3LFZA 4L27A 2P9MA 3KXRA 4KK5A 4UUUA 4FG6A 2YVXA 2HT3A 4GQVA 2YZQA 4PCUA 3FV6A 3KPCA 2EXYA 2O16A 4NOCA 2FECA 4IY0A 3FNAA 3EJZA 3OCMA 2OUXA 4LOUA 4FRYA 2QLVC 3FWRA 1PVMA 2QR1E 4IY4A 3LV9A 5K23C 3SL7A 4FTPA 2NYEA 4ESYB 5K22B 2UV5A 4KK8A 2R9HA 4IY3A 4GQWA 3EJYA 1OTUA 2UV4A 3LQNA 4KKBA 4L28A
chains in the Genus database with same CATH superfamily
3K2VA 2HLFA 3KH5A 4KJQA 4KJPA 3FHMA 4KKCA 2HTKA 3L2BA 4HG0A 1KPKA 3PC3A 2YZIA 3PC4A 4L0DA 4COOA 4KK9A 2EF7A 2EXWA 4KKLA 2OOYE 3L31A 4O9KA 3DDJA 2EMQA 2QRDE 2RC3A 2RIFA 2QH1A 1PBJA 2D4ZA 5K25C 3FWSA 4FXSA 3ND0A 4KKAA 1OTTA 1Y5HA 5MMZA 2UV6A 3KPBA 3K6EA 3NMOA 2JA3A 5K24C 2HTLA 3T4NC 4MQXA 4IYSA 4P1OA 2YVZA 5LXQA 3I8NA 2PFIA 5KS7A 4ENEA 4KK6A 2RIHA 1YAVA 3HF7A 3ORGA 2YVYA 3GBYA 3LHHA 4GQYA 5IIPA 2H2PA 2ZY9A 1OTSA 4ESYA 3Q17A 5HD8A 1KPLA 4IY2A 2HT2A 4P1GA 2UV7A 2QRCE 1XKFA 2QREE 2EZ0A 2HT4A 3PC2A 4L3VA 2NYCA 3OCOA 2OOXE 2FEDA 4DQWA 2FEEA 4KJWA 1O50A 3TE5C 2J9LA 3KPDA 2H2SA 3OI8A 3TDHC 3DETA 3LFZA 4L27A 2P9MA 3KXRA 4KK5A 4UUUA 4FG6A 2YVXA 2HT3A 4GQVA 2YZQA 4PCUA 3FV6A 3KPCA 2EXYA 2O16A 4NOCA 2FECA 4IY0A 3FNAA 3EJZA 3OCMA 2OUXA 4LOUA 4FRYA 2QLVC 3FWRA 1PVMA 2QR1E 4IY4A 3LV9A 5K23C 3SL7A 4FTPA 2NYEA 4ESYB 5K22B 2UV5A 4KK8A 2R9HA 4IY3A 4GQWA 3EJYA 1OTUA 2UV4A 3LQNA 4KKBA 4L28A
chains in the Genus database with same CATH topology
3K2VA 2HLFA 3KH5A 4KJQA 4KJPA 3FHMA 4KKCA 2HTKA 3L2BA 4HG0A 1KPKA 3PC3A 2YZIA 3PC4A 4L0DA 4COOA 4KK9A 2EF7A 2EXWA 4KKLA 2OOYE 3L31A 4O9KA 3DDJA 2EMQA 2QRDE 2RC3A 2RIFA 2QH1A 1PBJA 2D4ZA 5K25C 3FWSA 4FXSA 3ND0A 4KKAA 1OTTA 1Y5HA 5MMZA 2UV6A 3KPBA 3K6EA 3NMOA 2JA3A 5K24C 2HTLA 3T4NC 4MQXA 4IYSA 4P1OA 2YVZA 5LXQA 3I8NA 2PFIA 5KS7A 4ENEA 4KK6A 2RIHA 1YAVA 3HF7A 3ORGA 2YVYA 3GBYA 3LHHA 4GQYA 5IIPA 2H2PA 2ZY9A 1OTSA 4ESYA 3Q17A 5HD8A 1KPLA 4IY2A 2HT2A 4P1GA 2UV7A 2QRCE 1XKFA 2QREE 2EZ0A 2HT4A 3PC2A 4L3VA 2NYCA 3OCOA 2OOXE 2FEDA 4DQWA 2FEEA 4KJWA 1O50A 3TE5C 2J9LA 3KPDA 2H2SA 3OI8A 3TDHC 3DETA 3LFZA 4L27A 2P9MA 3KXRA 4KK5A 4UUUA 4FG6A 2YVXA 2HT3A 4GQVA 2YZQA 4PCUA 3FV6A 3KPCA 2EXYA 2O16A 4NOCA 2FECA 4IY0A 3FNAA 3EJZA 3OCMA 2OUXA 4LOUA 4FRYA 2QLVC 3FWRA 1PVMA 2QR1E 4IY4A 3LV9A 5K23C 3SL7A 4FTPA 2NYEA 4ESYB 5K22B 2UV5A 4KK8A 2R9HA 4IY3A 4GQWA 3EJYA 1OTUA 2UV4A 3LQNA 4KKBA 4L28A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3K2V A;  2HLF A;  3KH5 A;  4KJQ A;  4KJP A;  3FHM A;  4KKC A;  2HTK A;  3L2B A;  4HG0 A;  1KPK A;  3PC3 A;  2YZI A;  3PC4 A;  4L0D A;  4COO A;  4KK9 A;  2EF7 A;  2EXW A;  4KKL A;  2OOY E;  3L31 A;  4O9K A;  3DDJ A;  2EMQ A;  2QRD E;  2RC3 A;  2RIF A;  2QH1 A;  1PBJ A;  2D4Z A;  5K25 C;  3FWS A;  4FXS A;  3ND0 A;  4KKA A;  1OTT A;  1Y5H A;  5MMZ A;  2UV6 A;  3KPB A;  3K6E A;  3NMO A;  5K24 C;  2HTL A;  3T4N C;  4MQX A;  4IYS A;  4P1O A;  2YVZ A;  5LXQ A;  3I8N A;  2PFI A;  5KS7 A;  4ENE A;  4KK6 A;  2RIH A;  1YAV A;  3HF7 A;  3ORG A;  2YVY A;  3GBY A;  3LHH A;  4GQY A;  5IIP A;  2H2P A;  2ZY9 A;  1OTS A;  4ESY A;  3Q17 A;  5HD8 A;  1KPL A;  4IY2 A;  2HT2 A;  4P1G A;  2UV7 A;  2QRC E;  1XKF A;  2QRE E;  2EZ0 A;  2HT4 A;  3PC2 A;  4L3V A;  2NYC A;  3OCO A;  2OOX E;  2FED A;  4DQW A;  2FEE A;  4KJW A;  1O50 A;  3TE5 C;  3KPD A;  2H2S A;  3OI8 A;  3TDH C;  3DET A;  3LFZ A;  4L27 A;  2P9M A;  3KXR A;  4KK5 A;  4UUU A;  4FG6 A;  2YVX A;  2HT3 A;  4GQV A;  2YZQ A;  4PCU A;  3FV6 A;  3KPC A;  2EXY A;  2O16 A;  4NOC A;  2FEC A;  4IY0 A;  3FNA A;  3EJZ A;  3OCM A;  2OUX A;  4LOU A;  4FRY A;  2QLV C;  3FWR A;  1PVM A;  2QR1 E;  4IY4 A;  3LV9 A;  5K23 C;  3SL7 A;  4FTP A;  2NYE A;  4ESY B;  5K22 B;  2UV5 A;  4KK8 A;  2R9H A;  4IY3 A;  4GQW A;  3EJY A;  1OTU A;  2UV4 A;  3LQN A;  4KKB A;  4L28 A; 
#chains in the Genus database with same CATH topology
 3K2V A;  2HLF A;  3KH5 A;  4KJQ A;  4KJP A;  3FHM A;  4KKC A;  2HTK A;  3L2B A;  4HG0 A;  1KPK A;  3PC3 A;  2YZI A;  3PC4 A;  4L0D A;  4COO A;  4KK9 A;  2EF7 A;  2EXW A;  4KKL A;  2OOY E;  3L31 A;  4O9K A;  3DDJ A;  2EMQ A;  2QRD E;  2RC3 A;  2RIF A;  2QH1 A;  1PBJ A;  2D4Z A;  5K25 C;  3FWS A;  4FXS A;  3ND0 A;  4KKA A;  1OTT A;  1Y5H A;  5MMZ A;  2UV6 A;  3KPB A;  3K6E A;  3NMO A;  2JA3 A;  5K24 C;  2HTL A;  3T4N C;  4MQX A;  4IYS A;  4P1O A;  2YVZ A;  5LXQ A;  3I8N A;  2PFI A;  5KS7 A;  4ENE A;  4KK6 A;  2RIH A;  1YAV A;  3HF7 A;  3ORG A;  2YVY A;  3GBY A;  3LHH A;  4GQY A;  5IIP A;  2H2P A;  2ZY9 A;  1OTS A;  4ESY A;  3Q17 A;  5HD8 A;  1KPL A;  4IY2 A;  2HT2 A;  4P1G A;  2UV7 A;  2QRC E;  1XKF A;  2QRE E;  2EZ0 A;  2HT4 A;  3PC2 A;  4L3V A;  2NYC A;  3OCO A;  2OOX E;  2FED A;  4DQW A;  2FEE A;  4KJW A;  1O50 A;  3TE5 C;  2J9L A;  3KPD A;  2H2S A;  3OI8 A;  3TDH C;  3DET A;  3LFZ A;  4L27 A;  2P9M A;  3KXR A;  4KK5 A;  4UUU A;  4FG6 A;  2YVX A;  2HT3 A;  4GQV A;  2YZQ A;  4PCU A;  3FV6 A;  3KPC A;  2EXY A;  2O16 A;  4NOC A;  2FEC A;  4IY0 A;  3FNA A;  3EJZ A;  3OCM A;  2OUX A;  4LOU A;  4FRY A;  2QLV C;  3FWR A;  1PVM A;  2QR1 E;  4IY4 A;  3LV9 A;  5K23 C;  3SL7 A;  4FTP A;  2NYE A;  4ESY B;  5K22 B;  2UV5 A;  4KK8 A;  2R9H A;  4IY3 A;  4GQW A;  3EJY A;  1OTU A;  2UV4 A;  3LQN A;  4KKB A;  4L28 A; 
#chains in the Genus database with same CATH homology
 3K2V A;  2HLF A;  3KH5 A;  4KJQ A;  4KJP A;  3FHM A;  4KKC A;  2HTK A;  3L2B A;  4HG0 A;  1KPK A;  3PC3 A;  2YZI A;  3PC4 A;  4L0D A;  4COO A;  4KK9 A;  2EF7 A;  2EXW A;  4KKL A;  2OOY E;  3L31 A;  4O9K A;  3DDJ A;  2EMQ A;  2QRD E;  2RC3 A;  2RIF A;  2QH1 A;  1PBJ A;  2D4Z A;  5K25 C;  3FWS A;  4FXS A;  3ND0 A;  4KKA A;  1OTT A;  1Y5H A;  5MMZ A;  2UV6 A;  3KPB A;  3K6E A;  3NMO A;  2JA3 A;  5K24 C;  2HTL A;  3T4N C;  4MQX A;  4IYS A;  4P1O A;  2YVZ A;  5LXQ A;  3I8N A;  2PFI A;  5KS7 A;  4ENE A;  4KK6 A;  2RIH A;  1YAV A;  3HF7 A;  3ORG A;  2YVY A;  3GBY A;  3LHH A;  4GQY A;  5IIP A;  2H2P A;  2ZY9 A;  1OTS A;  4ESY A;  3Q17 A;  5HD8 A;  1KPL A;  4IY2 A;  2HT2 A;  4P1G A;  2UV7 A;  2QRC E;  1XKF A;  2QRE E;  2EZ0 A;  2HT4 A;  3PC2 A;  4L3V A;  2NYC A;  3OCO A;  2OOX E;  2FED A;  4DQW A;  2FEE A;  4KJW A;  1O50 A;  3TE5 C;  2J9L A;  3KPD A;  2H2S A;  3OI8 A;  3TDH C;  3DET A;  3LFZ A;  4L27 A;  2P9M A;  3KXR A;  4KK5 A;  4UUU A;  4FG6 A;  2YVX A;  2HT3 A;  4GQV A;  2YZQ A;  4PCU A;  3FV6 A;  3KPC A;  2EXY A;  2O16 A;  4NOC A;  2FEC A;  4IY0 A;  3FNA A;  3EJZ A;  3OCM A;  2OUX A;  4LOU A;  4FRY A;  2QLV C;  3FWR A;  1PVM A;  2QR1 E;  4IY4 A;  3LV9 A;  5K23 C;  3SL7 A;  4FTP A;  2NYE A;  4ESY B;  5K22 B;  2UV5 A;  4KK8 A;  2R9H A;  4IY3 A;  4GQW A;  3EJY A;  1OTU A;  2UV4 A;  3LQN A;  4KKB A;  4L28 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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