4EVHA

Crystal structure of calcium-bound alpha-1 giardin
Total Genus 120
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
120
sequence length
294
structure length
294
Chain Sequence
PKVTDIANELKQAIDAKDEVQIAFIASEYSAESREKIAKAYVASYGKELPDDIKKALKGGSEESLLMDLFSDRHEVRAQHIRDALSGRNDHMAFFDTVILCTPEDWHETVAAYTRMFKKPLVEDFMKDVGRKEDWCLLMEKWMAHERVSRPGSPEDEAQRLDQAFDQKNTAYLIDFFGTVPSAEYRPIAEAFKAQNGKSIEQAIATIYTKTDYYTFYCAHFALLGMHRLAAYLINCACNDKGDEKRMRRITGMMVDKCLGAKHAYKIYGDMGTDIERCFDKRMAPILRTLWRVK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Alpha-1 giardin is an annexin with highly unusual calcium-regulated mechanisms
pubmed doi rcsb
molecule tags Metal binding protein
source organism Giardia intestinalis
molecule keywords Giardin subunit alpha-1
total genus 120
structure length 294
sequence length 294
ec nomenclature
pdb deposition date 2012-04-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00191 Annexin Annexin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 4evhA02
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 4evhA03
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 4evhA01
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 4evhA04
1BO9A 2ZHJA 4MDVA 1A8AA 1BCZA 2IICA 2XO3A 1DM5A 1XJLA 1W3WA 1AVRA 1M9IA 1YIIA 2IE6A 2II2A 1BC0A 1HVGA 2HYWA 3BRXA 2XO2A 1HM6A 2H0LA 2IE7A 1ALAA 1ANNA 1ANWA 1N41A 1ANXA 1MCXA 1W45A 4EVHA 1HAKA 1N00A 1YCNA 4X9PA 1AVHA 1AEIA 1N44A 1I4AA 2RANA 1AIIA 1BC3A 1HVDA 2HYVA 2ZHIA 1DK5A 1BCWA 4HREA 2ZOCA 2H0KA 1AVCA 2H0MA 1N42A 2HYUA 4EVFA 1HVFA 1AOWA 1W7BA 4MDUA 1G5NA 1SAVA 1A8BA 1BCYA 1BC1A 2Q4CA 1YJ0A 1HVEA 1AXNA
chains in the Genus database with same CATH superfamily
4L5MA 2IICA 2XO3A 1DM5A 4KMUX 1Q8DA 2VXGA 1QC7A 2II2A 4FQ0C 2H0LA 1ALAA 1ANNA 1N41A 3HJLA 3ABQA 4D7RA 1HAKA 2K6XA 3USWA 2RANA 3AO0A 4KN4X 2ZHIA 1C1KA 1XT0B 2ZOCA 2HYUA 4EVFA 1PBVA 4Q2SA 1G5NA 3ABRA 4JK1X 1A8BA 1BCYA 1N44A 2Q4CA 1A8AA 1XJLA 3TW5A 4JMIA 3LTLA 2IE6A 3BRXA 1S9DE 1W45A 4OIYA 1YCNA 3USYA 1AVHA 1AEIA 1AIIA 1BC3A 1HVDA 1DK5A 2R0DA 2H0KA 1AVCA 2H0MA 4Z21A 1R8SE 4MDUA 1SAVA 1R4AE 1AXNA 3SWVA 4MDVA 1AVRA 1M9IA 2QEZA 1YIIA 2R09A 1BC0A 2HYWA 3ABSA 1ANWA 1ANXA 1BC9A 1RE0B 1I4AA 3SOHB 4JWLA 2HYVA 4HREA 1N42A 1UPTB 1HVFA 1W7BA 4C7PA 1W3WA 1HVEA 3ANYA 2ZHJA 1BO9A 4A4PA 1BCZA 4JMOA 1LKVX 3ABOA 1R8QE 4D7QA 1KU1A 2OY9A 4C0AA 2HSNA 1HVGA 2XO2A 4KN7X 1HM6A 2IE7A 1MCXA 1R8ME 4EVHA 1N00A 4X9PA 1YGMA 1BCWA 3AJCA 1XSZA 4FHRB 1AOWA 4JXHA 3L8NA 1BC1A 1YJ0A
chains in the Genus database with same CATH topology
1BO9A 2ZHJA 4MDVA 1A8AA 1BCZA 2IICA 2XO3A 1DM5A 1XJLA 1W3WA 1AVRA 1M9IA 1YIIA 2IE6A 2II2A 1BC0A 1HVGA 2HYWA 3BRXA 2XO2A 1HM6A 2H0LA 2IE7A 1ALAA 1ANNA 1ANWA 1N41A 1ANXA 1MCXA 1W45A 4EVHA 1HAKA 1N00A 1YCNA 4X9PA 1AVHA 1AEIA 1N44A 1I4AA 2RANA 1AIIA 1BC3A 1HVDA 2HYVA 2ZHIA 1DK5A 1BCWA 4HREA 2ZOCA 2H0KA 1AVCA 2H0MA 1N42A 2HYUA 4EVFA 1HVFA 1AOWA 1W7BA 4MDUA 1G5NA 1SAVA 1A8BA 1BCYA 1BC1A 2Q4CA 1YJ0A 1HVEA 1AXNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1BO9 A;  2ZHJ A;  4MDV A;  1A8A A;  1BCZ A;  2IIC A;  2XO3 A;  1DM5 A;  1XJL A;  1W3W A;  1AVR A;  1M9I A;  1YII A;  2IE6 A;  2II2 A;  1BC0 A;  1HVG A;  2HYW A;  3BRX A;  2XO2 A;  1HM6 A;  2H0L A;  2IE7 A;  1ALA A;  1ANN A;  1ANW A;  1N41 A;  1ANX A;  1MCX A;  1W45 A;  4EVH A;  1HAK A;  1N00 A;  1YCN A;  4X9P A;  1AVH A;  1AEI A;  1N44 A;  1I4A A;  2RAN A;  1AII A;  1BC3 A;  1HVD A;  2HYV A;  2ZHI A;  1DK5 A;  1BCW A;  4HRE A;  2ZOC A;  2H0K A;  1AVC A;  2H0M A;  1N42 A;  2HYU A;  4EVF A;  1HVF A;  1AOW A;  1W7B A;  4MDU A;  1G5N A;  1SAV A;  1A8B A;  1BCY A;  1BC1 A;  2Q4C A;  1YJ0 A;  1HVE A;  1AXN A; 
#chains in the Genus database with same CATH topology
 4L5M A;  2IIC A;  2XO3 A;  1DM5 A;  4KMU X;  1Q8D A;  2VXG A;  1QC7 A;  2II2 A;  4FQ0 C;  2H0L A;  1ALA A;  1ANN A;  1N41 A;  3HJL A;  3ABQ A;  4D7R A;  1HAK A;  2K6X A;  3USW A;  2RAN A;  3AO0 A;  4KN4 X;  2ZHI A;  1C1K A;  1XT0 B;  2ZOC A;  2HYU A;  4EVF A;  1PBV A;  4Q2S A;  1G5N A;  3ABR A;  4JK1 X;  1A8B A;  1BCY A;  1N44 A;  2Q4C A;  1A8A A;  1XJL A;  3TW5 A;  4JMI A;  3LTL A;  2IE6 A;  3BRX A;  1S9D E;  1W45 A;  4OIY A;  1YCN A;  3USY A;  1AVH A;  1AEI A;  1AII A;  1BC3 A;  1HVD A;  1DK5 A;  2R0D A;  2H0K A;  1AVC A;  2H0M A;  4Z21 A;  1R8S E;  4MDU A;  1SAV A;  1R4A E;  1AXN A;  3SWV A;  4MDV A;  1AVR A;  1M9I A;  2QEZ A;  1YII A;  2R09 A;  1BC0 A;  2HYW A;  3ABS A;  1ANW A;  1ANX A;  1BC9 A;  1RE0 B;  1I4A A;  3SOH B;  4JWL A;  2HYV A;  4HRE A;  1N42 A;  1UPT B;  1HVF A;  1W7B A;  4C7P A;  1W3W A;  1HVE A;  3ANY A;  2ZHJ A;  1BO9 A;  4A4P A;  1BCZ A;  4JMO A;  1LKV X;  3ABO A;  1R8Q E;  4D7Q A;  1KU1 A;  2OY9 A;  4C0A A;  2HSN A;  1HVG A;  2XO2 A;  4KN7 X;  1HM6 A;  2IE7 A;  1MCX A;  1R8M E;  4EVH A;  1N00 A;  4X9P A;  1YGM A;  1BCW A;  3AJC A;  1XSZ A;  4FHR B;  1AOW A;  4JXH A;  3L8N A;  1BC1 A;  1YJ0 A; 
#chains in the Genus database with same CATH homology
 1BO9 A;  2ZHJ A;  4MDV A;  1A8A A;  1BCZ A;  2IIC A;  2XO3 A;  1DM5 A;  1XJL A;  1W3W A;  1AVR A;  1M9I A;  1YII A;  2IE6 A;  2II2 A;  1BC0 A;  1HVG A;  2HYW A;  3BRX A;  2XO2 A;  1HM6 A;  2H0L A;  2IE7 A;  1ALA A;  1ANN A;  1ANW A;  1N41 A;  1ANX A;  1MCX A;  1W45 A;  4EVH A;  1HAK A;  1N00 A;  1YCN A;  4X9P A;  1AVH A;  1AEI A;  1N44 A;  1I4A A;  2RAN A;  1AII A;  1BC3 A;  1HVD A;  2HYV A;  2ZHI A;  1DK5 A;  1BCW A;  4HRE A;  2ZOC A;  2H0K A;  1AVC A;  2H0M A;  1N42 A;  2HYU A;  4EVF A;  1HVF A;  1AOW A;  1W7B A;  4MDU A;  1G5N A;  1SAV A;  1A8B A;  1BCY A;  1BC1 A;  2Q4C A;  1YJ0 A;  1HVE A;  1AXN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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