4HREA

Crystal structure of p11/annexin a2 heterotetramer in complex with smarca3 peptide
Total Genus 131
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
131
sequence length
338
structure length
338
Chain Sequence
STVHEILCKLSLEGDHSTPPSAYGSVKPYTNFDAERDALNIETAVKTKGVDEVTIVNILTNRSNVQRQDIAFAYQRRTKKELPSALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARELYDAGVKRKGTDVPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title SMARCA3, a Chromatin-Remodeling Factor, Is Required for p11-Dependent Antidepressant Action.
pubmed doi rcsb
molecule tags Calcium-binding protein
source organism Mus musculus
molecule keywords Annexin A2
total genus 131
structure length 338
sequence length 338
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2012-10-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00191 Annexin Annexin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 4hreA04
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 4hreA01
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 4hreA02
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 4hreA03
1AVCA 2ZOCA 1AIIA 2HYUA 2IE7A 2II2A 2H0MA 2ZHJA 2RANA 4MDVA 1W45A 1BC3A 1DM5A 1XJLA 1BCZA 1BO9A 1MCXA 4EVHA 2ZHIA 1N00A 1YJ0A 1ANXA 2XO3A 2XO2A 1N44A 3BRXA 1DK5A 2IE6A 4MDUA 4EVFA 1YIIA 1YCNA 1ANWA 1W3WA 1AOWA 1BC0A 1AVHA 1AEIA 1HVGA 1AXNA 2H0LA 1A8BA 1HVDA 1ALAA 2HYVA 1N42A 4X9PA 1N41A 1W7BA 2HYWA 1BCYA 1BC1A 1A8AA 1HVFA 1BCWA 1I4AA 1M9IA 1G5NA 2Q4CA 1HM6A 1ANNA 1HAKA 2H0KA 4HREA 1AVRA 2IICA 1SAVA 1HVEA
chains in the Genus database with same CATH superfamily
4JXHA 2ZOCA 2HYUA 2ZHJA 1W45A 1BC3A 2R09A 2ZHIA 3USYA 3HJLA 1ANXA 3ANYA 3BRXA 1ANWA 1W3WA 1AOWA 1AVHA 1HVGA 1A8BA 1ALAA 3ABQA 2HSNA 1N42A 1C1KA 1W7BA 1I4AA 4D7QA 1AVRA 4JK1X 1SAVA 2H0LA 1AVCA 1XT0B 2K6XA 1XJLA 4KN7X 1LKVX 2XO2A 2IE6A 4D7RA 4Z21A 3L8NA 2OY9A 2HYVA 1N41A 1G5NA 1ANNA 4A4PA 1HAKA 1KU1A 4HREA 2IICA 3AJCA 1BC9A 2QEZA 1AIIA 2IE7A 1UPTB 2H0MA 2RANA 4MDVA 3USWA 1DM5A 2VXGA 3TW5A 1N00A 1R8QE 1YJ0A 2XO3A 1N44A 3ABSA 1DK5A 4JWLA 4EVFA 1YCNA 1BC0A 1AXNA 4X9PA 1BC1A 1HVFA 1A8AA 3ABOA 1BCWA 4C0AA 4JMOA 1HM6A 1RE0B 3LTLA 2H0KA 3AO0A 2II2A 4JMIA 4L5MA 4FQ0C 1QC7A 4OIYA 4KN4X 1R4AE 1BCZA 4KMUX 1BO9A 4EVHA 1Q8DA 1YGMA 1HVEA 1R8ME 2R0DA 4MDUA 4Q2SA 1YIIA 4FHRB 3SWVA 1AEIA 1HVDA 3ABRA 4C7PA 2HYWA 1BCYA 2Q4CA 1M9IA 1XSZA 1S9DE 3SOHB 1PBVA 1MCXA 1R8SE
chains in the Genus database with same CATH topology
1AVCA 2ZOCA 1AIIA 2HYUA 2IE7A 2II2A 2H0MA 2ZHJA 2RANA 4MDVA 1W45A 1BC3A 1DM5A 1XJLA 1BCZA 1BO9A 1MCXA 4EVHA 2ZHIA 1N00A 1YJ0A 1ANXA 2XO3A 2XO2A 1N44A 3BRXA 1DK5A 2IE6A 4MDUA 4EVFA 1YIIA 1YCNA 1ANWA 1W3WA 1AOWA 1BC0A 1AVHA 1AEIA 1HVGA 1AXNA 2H0LA 1A8BA 1HVDA 1ALAA 2HYVA 1N42A 4X9PA 1N41A 1W7BA 2HYWA 1BCYA 1BC1A 1A8AA 1HVFA 1BCWA 1I4AA 1M9IA 1G5NA 2Q4CA 1HM6A 1ANNA 1HAKA 2H0KA 4HREA 1AVRA 2IICA 1SAVA 1HVEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1AVC A;  2ZOC A;  1AII A;  2HYU A;  2IE7 A;  2II2 A;  2H0M A;  2ZHJ A;  2RAN A;  4MDV A;  1W45 A;  1BC3 A;  1DM5 A;  1XJL A;  1BCZ A;  1BO9 A;  1MCX A;  4EVH A;  2ZHI A;  1N00 A;  1YJ0 A;  1ANX A;  2XO3 A;  2XO2 A;  1N44 A;  3BRX A;  1DK5 A;  2IE6 A;  4MDU A;  4EVF A;  1YII A;  1YCN A;  1ANW A;  1W3W A;  1AOW A;  1BC0 A;  1AVH A;  1AEI A;  1HVG A;  1AXN A;  2H0L A;  1A8B A;  1HVD A;  1ALA A;  2HYV A;  1N42 A;  4X9P A;  1N41 A;  1W7B A;  2HYW A;  1BCY A;  1BC1 A;  1A8A A;  1HVF A;  1BCW A;  1I4A A;  1M9I A;  1G5N A;  2Q4C A;  1HM6 A;  1ANN A;  1HAK A;  2H0K A;  4HRE A;  1AVR A;  2IIC A;  1SAV A;  1HVE A; 
#chains in the Genus database with same CATH topology
 4JXH A;  2ZOC A;  2HYU A;  2ZHJ A;  1W45 A;  1BC3 A;  2R09 A;  2ZHI A;  3USY A;  3HJL A;  1ANX A;  3ANY A;  3BRX A;  1ANW A;  1W3W A;  1AOW A;  1AVH A;  1HVG A;  1A8B A;  1ALA A;  3ABQ A;  2HSN A;  1N42 A;  1C1K A;  1W7B A;  1I4A A;  4D7Q A;  1AVR A;  4JK1 X;  1SAV A;  2H0L A;  1AVC A;  1XT0 B;  2K6X A;  1XJL A;  4KN7 X;  1LKV X;  2XO2 A;  2IE6 A;  4D7R A;  4Z21 A;  3L8N A;  2OY9 A;  2HYV A;  1N41 A;  1G5N A;  1ANN A;  4A4P A;  1HAK A;  1KU1 A;  4HRE A;  2IIC A;  3AJC A;  1BC9 A;  2QEZ A;  1AII A;  2IE7 A;  1UPT B;  2H0M A;  2RAN A;  4MDV A;  3USW A;  1DM5 A;  2VXG A;  3TW5 A;  1N00 A;  1R8Q E;  1YJ0 A;  2XO3 A;  1N44 A;  3ABS A;  1DK5 A;  4JWL A;  4EVF A;  1YCN A;  1BC0 A;  1AXN A;  4X9P A;  1BC1 A;  1HVF A;  1A8A A;  3ABO A;  1BCW A;  4C0A A;  4JMO A;  1HM6 A;  1RE0 B;  3LTL A;  2H0K A;  3AO0 A;  2II2 A;  4JMI A;  4L5M A;  4FQ0 C;  1QC7 A;  4OIY A;  4KN4 X;  1R4A E;  1BCZ A;  4KMU X;  1BO9 A;  4EVH A;  1Q8D A;  1YGM A;  1HVE A;  1R8M E;  2R0D A;  4MDU A;  4Q2S A;  1YII A;  4FHR B;  3SWV A;  1AEI A;  1HVD A;  3ABR A;  4C7P A;  2HYW A;  1BCY A;  2Q4C A;  1M9I A;  1XSZ A;  1S9D E;  3SOH B;  1PBV A;  1MCX A;  1R8S E; 
#chains in the Genus database with same CATH homology
 1AVC A;  2ZOC A;  1AII A;  2HYU A;  2IE7 A;  2II2 A;  2H0M A;  2ZHJ A;  2RAN A;  4MDV A;  1W45 A;  1BC3 A;  1DM5 A;  1XJL A;  1BCZ A;  1BO9 A;  1MCX A;  4EVH A;  2ZHI A;  1N00 A;  1YJ0 A;  1ANX A;  2XO3 A;  2XO2 A;  1N44 A;  3BRX A;  1DK5 A;  2IE6 A;  4MDU A;  4EVF A;  1YII A;  1YCN A;  1ANW A;  1W3W A;  1AOW A;  1BC0 A;  1AVH A;  1AEI A;  1HVG A;  1AXN A;  2H0L A;  1A8B A;  1HVD A;  1ALA A;  2HYV A;  1N42 A;  4X9P A;  1N41 A;  1W7B A;  2HYW A;  1BCY A;  1BC1 A;  1A8A A;  1HVF A;  1BCW A;  1I4A A;  1M9I A;  1G5N A;  2Q4C A;  1HM6 A;  1ANN A;  1HAK A;  2H0K A;  4HRE A;  1AVR A;  2IIC A;  1SAV A;  1HVE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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