4JMI | Genus

Total Genus 74

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	74
sequence length	192
structure length	192
Chain Sequence	HMSKTLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRNEPFKI

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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The Resolver thinks Pdb

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reading 192 atoms

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192 atoms created

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Signaling protein
source organism	Homo sapiens
publication title	Fragment-based identification of a locus in the Sec7 domain of Arno for the design of protein-protein interaction inhibitors pubmed doi rcsb
molecule keywords	Cytohesin-2
total genus	74
structure length	192
sequence length	192
ec nomenclature
pdb deposition date	2013-03-14

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF01369	Sec7	Sec7 domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.10.220.20	Mainly Alpha	Orthogonal Bundle	Annexin V; domain 1	Annexin V; domain 1	4jmiA01
1.10.1000.11	Mainly Alpha	Orthogonal Bundle	Arf Nucleotide-binding Site Opener; domain 2	Arf Nucleotide-binding Site Opener,domain 2	4jmiA02

1XT0B 1XSZA 3SWVA 1BC9A 4A4PA 1PBVA 4JMIA 4Z21A 1KU1A 2R0DA 3LTLA 4JXHA 3L8NA 1R8QE 4OIYA 4D7QA 2R09A 4C7PA 4JWLA 4D7RA 1R8ME 1RE0B 4C0AA 4L5MA 4JMOA 1S9DE 1R8SE
chains in the Genus database with same CATH superfamily

1XSZA 2IICA 1ANNA 1BC9A 4KN4X 1XJLA 3ABSA 2RANA 1AIIA 1YCNA 2HSNA 2R0DA 1AVRA 4KN7X 4JXHA 4Q2SA 1AVHA 3ABQA 3HJLA 3SOHB 2H0KA 2XO3A 1RE0B 1G5NA 1W7BA 1LKVX 4EVHA 4L5MA 1S9DE 1XT0B 1SAVA 4FHRB 2Q4CA 4JK1X 1AVCA 3AJCA 1N44A 4JMIA 1BO9A 4MDVA 1DK5A 1AOWA 1AEIA 1ANWA 1MCXA 3L8NA 1HM6A 2H0LA 1N42A 1W45A 1R8QE 2XO2A 1A8BA 1HVGA 1W3WA 2HYWA 1YJ0A 1BCYA 1C1KA 2VXGA 2II2A 1Q8DA 4C0AA 1R4AE 2QEZA 4KMUX 1ANXA 4JMOA 1A8AA 3USWA 1ALAA 3USYA 4HREA 3AO0A 1M9IA 1PBVA 2ZHJA 4Z21A 3LTLA 1HVDA 3TW5A 2HYUA 1YIIA 4OIYA 4D7QA 2ZOCA 4C7PA 1UPTB 2H0MA 1BCWA 1YGMA 1R8SE 2K6XA 1AXNA 1HVEA 3SWVA 4A4PA 3BRXA 2OY9A 2HYVA 2ZHIA 1BC0A 2IE7A 1BC1A 1KU1A 1DM5A 1HAKA 1I4AA 3ANYA 1HVFA 4EVFA 4X9PA 1N41A 3ABOA 2R09A 1N00A 4MDUA 4FQ0C 1BC3A 4JWLA 3ABRA 4D7RA 1R8ME 1QC7A 2IE6A 1BCZA
chains in the Genus database with same CATH topology

1XT0B 2K6XA 1XSZA 3USYA 3SWVA 1BC9A 4KN4X 4A4PA 4FHRB 4JK1X 3AJCA 1PBVA 4JMIA 4Z21A 1KU1A 2HSNA 2R0DA 3LTLA 4KN7X 4JXHA 3TW5A 3L8NA 1R8QE 4OIYA 4D7QA 2R09A 3HJLA 3SOHB 4C7PA 4FQ0C 4JWLA 4D7RA 1R8ME 1Q8DA 1QC7A 1RE0B 1LKVX 4C0AA 4L5MA 4KMUX 4JMOA 1S9DE 3USWA 1R8SE
chains in the Genus database with same CATH homology

#chains in the Genus database with same CATH superfamily
 1XT0 B;  1XSZ A;  3SWV A;  1BC9 A;  4A4P A;  1PBV A;  4JMI A;  4Z21 A;  1KU1 A;  2R0D A;  3LTL A;  4JXH A;  3L8N A;  1R8Q E;  4OIY A;  4D7Q A;  2R09 A;  4C7P A;  4JWL A;  4D7R A;  1R8M E;  1RE0 B;  4C0A A;  4L5M A;  4JMO A;  1S9D E;  1R8S E; 
#chains in the Genus database with same CATH topology
 1XSZ A;  2IIC A;  1ANN A;  1BC9 A;  4KN4 X;  1XJL A;  3ABS A;  2RAN A;  1AII A;  1YCN A;  2HSN A;  2R0D A;  1AVR A;  4KN7 X;  4JXH A;  4Q2S A;  1AVH A;  3ABQ A;  3HJL A;  3SOH B;  2H0K A;  2XO3 A;  1RE0 B;  1G5N A;  1W7B A;  1LKV X;  4EVH A;  4L5M A;  1S9D E;  1XT0 B;  1SAV A;  4FHR B;  2Q4C A;  4JK1 X;  1AVC A;  3AJC A;  1N44 A;  4JMI A;  1BO9 A;  4MDV A;  1DK5 A;  1AOW A;  1AEI A;  1ANW A;  1MCX A;  3L8N A;  1HM6 A;  2H0L A;  1N42 A;  1W45 A;  1R8Q E;  2XO2 A;  1A8B A;  1HVG A;  1W3W A;  2HYW A;  1YJ0 A;  1BCY A;  1C1K A;  2VXG A;  2II2 A;  1Q8D A;  4C0A A;  1R4A E;  2QEZ A;  4KMU X;  1ANX A;  4JMO A;  1A8A A;  3USW A;  1ALA A;  3USY A;  4HRE A;  3AO0 A;  1M9I A;  1PBV A;  2ZHJ A;  4Z21 A;  3LTL A;  1HVD A;  3TW5 A;  2HYU A;  1YII A;  4OIY A;  4D7Q A;  2ZOC A;  4C7P A;  1UPT B;  2H0M A;  1BCW A;  1YGM A;  1R8S E;  2K6X A;  1AXN A;  1HVE A;  3SWV A;  4A4P A;  3BRX A;  2OY9 A;  2HYV A;  2ZHI A;  1BC0 A;  2IE7 A;  1BC1 A;  1KU1 A;  1DM5 A;  1HAK A;  1I4A A;  3ANY A;  1HVF A;  4EVF A;  4X9P A;  1N41 A;  3ABO A;  2R09 A;  1N00 A;  4MDU A;  4FQ0 C;  1BC3 A;  4JWL A;  3ABR A;  4D7R A;  1R8M E;  1QC7 A;  2IE6 A;  1BCZ A; 
#chains in the Genus database with same CATH homology
 1XT0 B;  2K6X A;  1XSZ A;  3USY A;  3SWV A;  1BC9 A;  4KN4 X;  4A4P A;  4FHR B;  4JK1 X;  3AJC A;  1PBV A;  4JMI A;  4Z21 A;  1KU1 A;  2HSN A;  2R0D A;  3LTL A;  4KN7 X;  4JXH A;  3TW5 A;  3L8N A;  1R8Q E;  4OIY A;  4D7Q A;  2R09 A;  3HJL A;  3SOH B;  4C7P A;  4FQ0 C;  4JWL A;  4D7R A;  1R8M E;  1Q8D A;  1QC7 A;  1RE0 B;  1LKV X;  4C0A A;  4L5M A;  4KMU X;  4JMO A;  1S9D E;  3USW A;  1R8S E;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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4JMIA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations