4JMO | Genus

Total Genus 68

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	68
sequence length	193
structure length	193
Chain Sequence	HMSKTLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRNEPFKIP

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Signaling protein/inhibitor
source organism	Homo sapiens
publication title	Fragment-based identification of a locus in the Sec7 domain of Arno for the design of protein-protein interaction inhibitors pubmed doi rcsb
molecule keywords	Cytohesin-2
total genus	68
structure length	193
sequence length	193
ec nomenclature
pdb deposition date	2013-03-14

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF01369	Sec7	Sec7 domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.10.220.20	Mainly Alpha	Orthogonal Bundle	Annexin V; domain 1	Annexin V; domain 1	4jmoA01
1.10.1000.11	Mainly Alpha	Orthogonal Bundle	Arf Nucleotide-binding Site Opener; domain 2	Arf Nucleotide-binding Site Opener,domain 2	4jmoA02

1R8QE 4C0AA 3L8NA 1KU1A 4JMIA 1R8ME 1PBVA 4D7RA 3LTLA 1RE0B 1XT0B 4D7QA 4C7PA 4L5MA 1S9DE 1BC9A 4OIYA 4A4PA 2R0DA 4JMOA 4JXHA 3SWVA 2R09A 4Z21A 1R8SE 4JWLA 1XSZA
chains in the Genus database with same CATH superfamily

1BCYA 2XO2A 1R8QE 1XJLA 1HVEA 3TW5A 4JMIA 1YIIA 1YCNA 2H0KA 1YGMA 2IE6A 2II2A 4EVHA 4FHRB 1BC1A 3HJLA 1ANNA 1ANXA 1AVRA 3AO0A 2K6XA 4JK1X 1N42A 1W45A 1W7BA 3ABRA 3ABQA 4KMUX 1YJ0A 2RANA 2H0MA 4C0AA 1AEIA 1ANWA 2XO3A 1DK5A 1N44A 2ZHJA 1R8ME 3USYA 2ZHIA 1AIIA 1HVDA 2HSNA 4L5MA 1A8AA 1S9DE 1QC7A 1BCWA 1BC3A 1N41A 3ABSA 1C1KA 4Z21A 1UPTB 2IE7A 1AOWA 1G5NA 1HAKA 3BRXA 1BCZA 3AJCA 4MDUA 1HVGA 3ABOA 1BO9A 1KU1A 2IICA 1ALAA 1AVHA 4D7RA 1W3WA 4EVFA 4MDVA 2HYVA 1A8BA 4KN7X 1XT0B 1I4AA 4C7PA 1HVFA 1M9IA 4OIYA 4A4PA 4HREA 3SOHB 2VXGA 3SWVA 2R09A 1MCXA 2HYUA 1N00A 1R8SE 1AVCA 4JWLA 1LKVX 1XSZA 1BC0A 4Q2SA 4KN4X 3ANYA 3L8NA 2OY9A 2ZOCA 1PBVA 3USWA 3LTLA 1RE0B 1Q8DA 1R4AE 4D7QA 1SAVA 4X9PA 1BC9A 1AXNA 1DM5A 4FQ0C 2R0DA 2QEZA 4JMOA 4JXHA 2H0LA 2HYWA 1HM6A 2Q4CA
chains in the Genus database with same CATH topology

4KMUX 1R8QE 4C0AA 3AJCA 3L8NA 3TW5A 1KU1A 4JMIA 1R8ME 3USYA 1PBVA 4D7RA 3USWA 4FHRB 3LTLA 1RE0B 4KN7X 1XT0B 3HJLA 1Q8DA 4D7QA 4C7PA 2HSNA 4L5MA 1S9DE 1BC9A 4OIYA 1QC7A 2K6XA 4FQ0C 2R0DA 4JMOA 4JK1X 4JXHA 3SOHB 4A4PA 3SWVA 2R09A 4Z21A 1R8SE 4KN4X 4JWLA 1LKVX 1XSZA
chains in the Genus database with same CATH homology

#chains in the Genus database with same CATH superfamily
 1R8Q E;  4C0A A;  3L8N A;  1KU1 A;  4JMI A;  1R8M E;  1PBV A;  4D7R A;  3LTL A;  1RE0 B;  1XT0 B;  4D7Q A;  4C7P A;  4L5M A;  1S9D E;  1BC9 A;  4OIY A;  4A4P A;  2R0D A;  4JMO A;  4JXH A;  3SWV A;  2R09 A;  4Z21 A;  1R8S E;  4JWL A;  1XSZ A; 
#chains in the Genus database with same CATH topology
 1BCY A;  2XO2 A;  1R8Q E;  1XJL A;  1HVE A;  3TW5 A;  4JMI A;  1YII A;  1YCN A;  2H0K A;  1YGM A;  2IE6 A;  2II2 A;  4EVH A;  4FHR B;  1BC1 A;  3HJL A;  1ANN A;  1ANX A;  1AVR A;  3AO0 A;  2K6X A;  4JK1 X;  1N42 A;  1W45 A;  1W7B A;  3ABR A;  3ABQ A;  4KMU X;  1YJ0 A;  2RAN A;  2H0M A;  4C0A A;  1AEI A;  1ANW A;  2XO3 A;  1DK5 A;  1N44 A;  2ZHJ A;  1R8M E;  3USY A;  2ZHI A;  1AII A;  1HVD A;  2HSN A;  4L5M A;  1A8A A;  1S9D E;  1QC7 A;  1BCW A;  1BC3 A;  1N41 A;  3ABS A;  1C1K A;  4Z21 A;  1UPT B;  2IE7 A;  1AOW A;  1G5N A;  1HAK A;  3BRX A;  1BCZ A;  3AJC A;  4MDU A;  1HVG A;  3ABO A;  1BO9 A;  1KU1 A;  2IIC A;  1ALA A;  1AVH A;  4D7R A;  1W3W A;  4EVF A;  4MDV A;  2HYV A;  1A8B A;  4KN7 X;  1XT0 B;  1I4A A;  4C7P A;  1HVF A;  1M9I A;  4OIY A;  4A4P A;  4HRE A;  3SOH B;  2VXG A;  3SWV A;  2R09 A;  1MCX A;  2HYU A;  1N00 A;  1R8S E;  1AVC A;  4JWL A;  1LKV X;  1XSZ A;  1BC0 A;  4Q2S A;  4KN4 X;  3ANY A;  3L8N A;  2OY9 A;  2ZOC A;  1PBV A;  3USW A;  3LTL A;  1RE0 B;  1Q8D A;  1R4A E;  4D7Q A;  1SAV A;  4X9P A;  1BC9 A;  1AXN A;  1DM5 A;  4FQ0 C;  2R0D A;  2QEZ A;  4JMO A;  4JXH A;  2H0L A;  2HYW A;  1HM6 A;  2Q4C A; 
#chains in the Genus database with same CATH homology
 4KMU X;  1R8Q E;  4C0A A;  3AJC A;  3L8N A;  3TW5 A;  1KU1 A;  4JMI A;  1R8M E;  3USY A;  1PBV A;  4D7R A;  3USW A;  4FHR B;  3LTL A;  1RE0 B;  4KN7 X;  1XT0 B;  3HJL A;  1Q8D A;  4D7Q A;  4C7P A;  2HSN A;  4L5M A;  1S9D E;  1BC9 A;  4OIY A;  1QC7 A;  2K6X A;  4FQ0 C;  2R0D A;  4JMO A;  4JK1 X;  4JXH A;  3SOH B;  4A4P A;  3SWV A;  2R09 A;  4Z21 A;  1R8S E;  4KN4 X;  4JWL A;  1LKV X;  1XSZ A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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4JMOA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations