4JWLA

Complexe of arno sec7 domain with the protein-protein interaction inhibitor n-(4-hydroxy-2,6-dimethylphenyl)benzenesulfonamide at ph7.5
Total Genus 75
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
75
sequence length
194
structure length
194
Chain Sequence
HMSKTLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRNEPFKIPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Signaling protein/inhibitor
source organism Homo sapiens
publication title Fragment-based identification of a locus in the Sec7 domain of Arno for the design of protein-protein interaction inhibitors
pubmed doi rcsb
molecule keywords Cytohesin-2
total genus 75
structure length 194
sequence length 194
ec nomenclature
pdb deposition date 2013-03-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01369 Sec7 Sec7 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.220.20 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin V; domain 1 4jwlA01
1.10.1000.11 Mainly Alpha Orthogonal Bundle Arf Nucleotide-binding Site Opener; domain 2 Arf Nucleotide-binding Site Opener,domain 2 4jwlA02
1S9DE 2R0DA 1R8SE 1KU1A 3LTLA 4OIYA 4D7RA 4JXHA 4C7PA 1BC9A 1RE0B 4Z21A 1XSZA 4JMIA 4C0AA 1PBVA 3L8NA 4L5MA 3SWVA 1R8ME 4D7QA 2R09A 1R8QE 4JMOA 4A4PA 1XT0B 4JWLA
chains in the Genus database with same CATH superfamily
1S9DE 4KMUX 4KN4X 1YGMA 3ABOA 1N41A 2R0DA 3LTLA 3ANYA 4JXHA 1HVFA 2Q4CA 1C1KA 1ANNA 1PBVA 3SOHB 1W45A 2HSNA 1HVGA 1ANWA 3BRXA 3ABQA 4EVHA 4D7QA 2ZOCA 2R09A 1R8QE 1AEIA 4JMOA 4X9PA 4MDUA 4A4PA 1W7BA 1N42A 2QEZA 1AVCA 1HVEA 4HREA 4JWLA 3TW5A 1KU1A 1BC9A 1DK5A 1RE0B 3AO0A 4Q2SA 3USWA 1SAVA 3ABRA 4Z21A 2H0MA 4C0AA 3L8NA 1BC1A 1DM5A 1YIIA 1A8BA 2ZHIA 2H0KA 1W3WA 1YCNA 1Q8DA 3ABSA 3SWVA 1R8ME 2OY9A 1BC0A 1LKVX 1BCYA 3AJCA 2H0LA 1AVRA 1AVHA 1BCZA 2IICA 1R8SE 2K6XA 4D7RA 2HYWA 1N00A 4C7PA 1QC7A 4JK1X 2XO2A 4FQ0C 2IE6A 4JMIA 1HVDA 1AOWA 1G5NA 1A8AA 2XO3A 3USYA 1BC3A 1XT0B 2HYVA 1ANXA 1MCXA 2IE7A 1BO9A 2ZHJA 1BCWA 1M9IA 4OIYA 2HYUA 3HJLA 1I4AA 1N44A 2II2A 1XSZA 1AIIA 1YJ0A 1HM6A 1XJLA 4KN7X 1AXNA 4MDVA 4L5MA 1R4AE 4EVFA 1HAKA 4FHRB 2RANA 1UPTB 2VXGA 1ALAA
chains in the Genus database with same CATH topology
1S9DE 3TW5A 4KMUX 4KN4X 2R0DA 1R8SE 1KU1A 3LTLA 2K6XA 4OIYA 4D7RA 4JXHA 3HJLA 4C7PA 1BC9A 1RE0B 1QC7A 4JK1X 4FQ0C 3USWA 4Z21A 1XSZA 4JMIA 4C0AA 1PBVA 3L8NA 3SOHB 2HSNA 4KN7X 4L5MA 1Q8DA 3SWVA 1R8ME 4D7QA 3USYA 2R09A 1R8QE 4JMOA 1LKVX 4A4PA 1XT0B 3AJCA 4FHRB 4JWLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1S9D E;  2R0D A;  1R8S E;  1KU1 A;  3LTL A;  4OIY A;  4D7R A;  4JXH A;  4C7P A;  1BC9 A;  1RE0 B;  4Z21 A;  1XSZ A;  4JMI A;  4C0A A;  1PBV A;  3L8N A;  4L5M A;  3SWV A;  1R8M E;  4D7Q A;  2R09 A;  1R8Q E;  4JMO A;  4A4P A;  1XT0 B;  4JWL A; 
#chains in the Genus database with same CATH topology
 1S9D E;  4KMU X;  4KN4 X;  1YGM A;  3ABO A;  1N41 A;  2R0D A;  3LTL A;  3ANY A;  4JXH A;  1HVF A;  2Q4C A;  1C1K A;  1ANN A;  1PBV A;  3SOH B;  1W45 A;  2HSN A;  1HVG A;  1ANW A;  3BRX A;  3ABQ A;  4EVH A;  4D7Q A;  2ZOC A;  2R09 A;  1R8Q E;  1AEI A;  4JMO A;  4X9P A;  4MDU A;  4A4P A;  1W7B A;  1N42 A;  2QEZ A;  1AVC A;  1HVE A;  4HRE A;  4JWL A;  3TW5 A;  1KU1 A;  1BC9 A;  1DK5 A;  1RE0 B;  3AO0 A;  4Q2S A;  3USW A;  1SAV A;  3ABR A;  4Z21 A;  2H0M A;  4C0A A;  3L8N A;  1BC1 A;  1DM5 A;  1YII A;  1A8B A;  2ZHI A;  2H0K A;  1W3W A;  1YCN A;  1Q8D A;  3ABS A;  3SWV A;  1R8M E;  2OY9 A;  1BC0 A;  1LKV X;  1BCY A;  3AJC A;  2H0L A;  1AVR A;  1AVH A;  1BCZ A;  2IIC A;  1R8S E;  2K6X A;  4D7R A;  2HYW A;  1N00 A;  4C7P A;  1QC7 A;  4JK1 X;  2XO2 A;  4FQ0 C;  2IE6 A;  4JMI A;  1HVD A;  1AOW A;  1G5N A;  1A8A A;  2XO3 A;  3USY A;  1BC3 A;  1XT0 B;  2HYV A;  1ANX A;  1MCX A;  2IE7 A;  1BO9 A;  2ZHJ A;  1BCW A;  1M9I A;  4OIY A;  2HYU A;  3HJL A;  1I4A A;  1N44 A;  2II2 A;  1XSZ A;  1AII A;  1YJ0 A;  1HM6 A;  1XJL A;  4KN7 X;  1AXN A;  4MDV A;  4L5M A;  1R4A E;  4EVF A;  1HAK A;  4FHR B;  2RAN A;  1UPT B;  2VXG A;  1ALA A; 
#chains in the Genus database with same CATH homology
 1S9D E;  3TW5 A;  4KMU X;  4KN4 X;  2R0D A;  1R8S E;  1KU1 A;  3LTL A;  2K6X A;  4OIY A;  4D7R A;  4JXH A;  3HJL A;  4C7P A;  1BC9 A;  1RE0 B;  1QC7 A;  4JK1 X;  4FQ0 C;  3USW A;  4Z21 A;  1XSZ A;  4JMI A;  4C0A A;  1PBV A;  3L8N A;  3SOH B;  2HSN A;  4KN7 X;  4L5M A;  1Q8D A;  3SWV A;  1R8M E;  4D7Q A;  3USY A;  2R09 A;  1R8Q E;  4JMO A;  1LKV X;  4A4P A;  1XT0 B;  3AJC A;  4FHR B;  4JWL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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