4JWL | Genus

Total Genus 75

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	75
sequence length	194
structure length	194
Chain Sequence	HMSKTLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRNEPFKIPE

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Signaling protein/inhibitor
source organism	Homo sapiens
publication title	Fragment-based identification of a locus in the Sec7 domain of Arno for the design of protein-protein interaction inhibitors pubmed doi rcsb
molecule keywords	Cytohesin-2
total genus	75
structure length	194
sequence length	194
ec nomenclature
pdb deposition date	2013-03-27

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF01369	Sec7	Sec7 domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.10.220.20	Mainly Alpha	Orthogonal Bundle	Annexin V; domain 1	Annexin V; domain 1	4jwlA01
1.10.1000.11	Mainly Alpha	Orthogonal Bundle	Arf Nucleotide-binding Site Opener; domain 2	Arf Nucleotide-binding Site Opener,domain 2	4jwlA02

1R8ME 4C0AA 2R0DA 1R8SE 4D7QA 4JXHA 4JMIA 4C7PA 4JWLA 3SWVA 1R8QE 4A4PA 2R09A 1XT0B 3L8NA 1KU1A 1BC9A 1XSZA 1PBVA 1RE0B 4Z21A 4OIYA 3LTLA 4JMOA 4L5MA 4D7RA 1S9DE
chains in the Genus database with same CATH superfamily

2RANA 1BC3A 4C0AA 4MDVA 4KMUX 4JK1X 4JMIA 3ABOA 4EVHA 3ABQA 2Q4CA 4JWLA 1BCWA 3SWVA 1W3WA 4A4PA 2R09A 1XJLA 3SOHB 2HYUA 1BC1A 1I4AA 2ZOCA 2ZHIA 4KN4X 1AOWA 1HVGA 1R4AE 1ANXA 1QC7A 2IE6A 4FHRB 2HSNA 2IICA 1M9IA 1BCZA 1DK5A 1HVFA 1UPTB 4EVFA 1AXNA 1YCNA 1G5NA 1HVDA 3USWA 3TW5A 2II2A 3HJLA 1YIIA 1ANNA 1A8BA 1W7BA 1XSZA 1MCXA 4FQ0C 2K6XA 1C1KA 1N00A 1AEIA 3LTLA 1HVEA 1ALAA 4Q2SA 1R8ME 1ANWA 3ABRA 1AVRA 4D7QA 2H0MA 2IE7A 3AJCA 1AIIA 1HM6A 1BO9A 1Q8DA 3ANYA 1HAKA 1N42A 1W45A 1XT0B 2XO3A 3USYA 4X9PA 1BC9A 1PBVA 1N44A 1RE0B 1BCYA 4L5MA 3AO0A 2R0DA 1R8SE 1LKVX 4JXHA 2QEZA 1AVHA 4C7PA 1YGMA 2H0LA 1DM5A 2H0KA 2XO2A 2OY9A 1YJ0A 2HYWA 1R8QE 1AVCA 4HREA 3L8NA 1KU1A 4KN7X 1BC0A 1A8AA 3BRXA 4MDUA 2ZHJA 1SAVA 4Z21A 4OIYA 2HYVA 4JMOA 2VXGA 3ABSA 4D7RA 1S9DE 1N41A
chains in the Genus database with same CATH topology

1QC7A 1R8ME 4C0AA 2R0DA 4FHRB 1R8SE 1LKVX 4KMUX 2HSNA 4D7QA 4JXHA 4JK1X 4JMIA 4C7PA 3AJCA 4JWLA 1Q8DA 3SWVA 1R8QE 3TW5A 3USWA 2R09A 4A4PA 1XT0B 3L8NA 3SOHB 1KU1A 3HJLA 3USYA 4KN7X 1BC9A 1XSZA 1PBVA 4FQ0C 2K6XA 1RE0B 4Z21A 4KN4X 4OIYA 3LTLA 4JMOA 4L5MA 4D7RA 1S9DE
chains in the Genus database with same CATH homology

#chains in the Genus database with same CATH superfamily
 1R8M E;  4C0A A;  2R0D A;  1R8S E;  4D7Q A;  4JXH A;  4JMI A;  4C7P A;  4JWL A;  3SWV A;  1R8Q E;  4A4P A;  2R09 A;  1XT0 B;  3L8N A;  1KU1 A;  1BC9 A;  1XSZ A;  1PBV A;  1RE0 B;  4Z21 A;  4OIY A;  3LTL A;  4JMO A;  4L5M A;  4D7R A;  1S9D E; 
#chains in the Genus database with same CATH topology
 2RAN A;  1BC3 A;  4C0A A;  4MDV A;  4KMU X;  4JK1 X;  4JMI A;  3ABO A;  4EVH A;  3ABQ A;  2Q4C A;  4JWL A;  1BCW A;  3SWV A;  1W3W A;  4A4P A;  2R09 A;  1XJL A;  3SOH B;  2HYU A;  1BC1 A;  1I4A A;  2ZOC A;  2ZHI A;  4KN4 X;  1AOW A;  1HVG A;  1R4A E;  1ANX A;  1QC7 A;  2IE6 A;  4FHR B;  2HSN A;  2IIC A;  1M9I A;  1BCZ A;  1DK5 A;  1HVF A;  1UPT B;  4EVF A;  1AXN A;  1YCN A;  1G5N A;  1HVD A;  3USW A;  3TW5 A;  2II2 A;  3HJL A;  1YII A;  1ANN A;  1A8B A;  1W7B A;  1XSZ A;  1MCX A;  4FQ0 C;  2K6X A;  1C1K A;  1N00 A;  1AEI A;  3LTL A;  1HVE A;  1ALA A;  4Q2S A;  1R8M E;  1ANW A;  3ABR A;  1AVR A;  4D7Q A;  2H0M A;  2IE7 A;  3AJC A;  1AII A;  1HM6 A;  1BO9 A;  1Q8D A;  3ANY A;  1HAK A;  1N42 A;  1W45 A;  1XT0 B;  2XO3 A;  3USY A;  4X9P A;  1BC9 A;  1PBV A;  1N44 A;  1RE0 B;  1BCY A;  4L5M A;  3AO0 A;  2R0D A;  1R8S E;  1LKV X;  4JXH A;  2QEZ A;  1AVH A;  4C7P A;  1YGM A;  2H0L A;  1DM5 A;  2H0K A;  2XO2 A;  2OY9 A;  1YJ0 A;  2HYW A;  1R8Q E;  1AVC A;  4HRE A;  3L8N A;  1KU1 A;  4KN7 X;  1BC0 A;  1A8A A;  3BRX A;  4MDU A;  2ZHJ A;  1SAV A;  4Z21 A;  4OIY A;  2HYV A;  4JMO A;  2VXG A;  3ABS A;  4D7R A;  1S9D E;  1N41 A; 
#chains in the Genus database with same CATH homology
 1QC7 A;  1R8M E;  4C0A A;  2R0D A;  4FHR B;  1R8S E;  1LKV X;  4KMU X;  2HSN A;  4D7Q A;  4JXH A;  4JK1 X;  4JMI A;  4C7P A;  3AJC A;  4JWL A;  1Q8D A;  3SWV A;  1R8Q E;  3TW5 A;  3USW A;  2R09 A;  4A4P A;  1XT0 B;  3L8N A;  3SOH B;  1KU1 A;  3HJL A;  3USY A;  4KN7 X;  1BC9 A;  1XSZ A;  1PBV A;  4FQ0 C;  2K6X A;  1RE0 B;  4Z21 A;  4KN4 X;  4OIY A;  3LTL A;  4JMO A;  4L5M A;  4D7R A;  1S9D E;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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4JWLA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations