4JXH | Genus

Total Genus 71

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	71
sequence length	195
structure length	195
Chain Sequence	MSKTLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRNEPFKIPEDD

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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The Resolver thinks Pdb

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reading 195 atoms

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195 atoms created

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Signaling protein/inhibitor
source organism	Homo sapiens
publication title	Fragment-based identification of a locus in the Sec7 domain of Arno for the design of protein-protein interaction inhibitors pubmed doi rcsb
molecule keywords	Cytohesin-2
total genus	71
structure length	195
sequence length	195
ec nomenclature
pdb deposition date	2013-03-28

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF01369	Sec7	Sec7 domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.10.220.20	Mainly Alpha	Orthogonal Bundle	Annexin V; domain 1	Annexin V; domain 1	4jxhA01
1.10.1000.11	Mainly Alpha	Orthogonal Bundle	Arf Nucleotide-binding Site Opener; domain 2	Arf Nucleotide-binding Site Opener,domain 2	4jxhA02

1XT0B 1S9DE 4JWLA 1RE0B 4OIYA 3L8NA 4A4PA 4C7PA 1R8QE 2R09A 4JMIA 4JXHA 3SWVA 4D7QA 2R0DA 1KU1A 4C0AA 1PBVA 3LTLA 4Z21A 1R8SE 1R8ME 4JMOA 4D7RA 1BC9A 1XSZA 4L5MA
chains in the Genus database with same CATH superfamily

1XT0B 1ANXA 1YJ0A 1S9DE 1HVGA 1N44A 4JWLA 1W45A 1R4AE 1AOWA 2IE7A 1R8QE 4JXHA 2HYWA 3AJCA 1BCZA 4D7QA 4Q2SA 2K6XA 1G5NA 1PBVA 2H0MA 3LTLA 1N00A 1SAVA 4Z21A 2RANA 1HVDA 2OY9A 4X9PA 4JK1X 1ANWA 2HYVA 1AXNA 1XSZA 1Q8DA 1RE0B 1BCYA 1BCWA 1XJLA 3L8NA 3BRXA 4A4PA 3ABQA 4C7PA 4KN7X 1I4AA 4JMIA 4EVHA 1AIIA 4HREA 4KN4X 1M9IA 1YIIA 1HAKA 1BO9A 3ABOA 2XO3A 4MDUA 1AEIA 3SOHB 1W7BA 1R8ME 4JMOA 1A8AA 1YCNA 3AO0A 2II2A 2XO2A 2HSNA 1HVEA 1N41A 1DK5A 1HVFA 2H0KA 1YGMA 3ANYA 3SWVA 1W3WA 3ABSA 4EVFA 1KU1A 4C0AA 4KMUX 2ZHJA 3ABRA 2HYUA 1ALAA 2IE6A 1R8SE 4FQ0C 1C1KA 1A8BA 4D7RA 1BC9A 1AVCA 1HM6A 1LKVX 1BC0A 4L5MA 4OIYA 1DM5A 3USWA 2H0LA 1QC7A 2R09A 2QEZA 3HJLA 2ZHIA 4FHRB 1MCXA 1BC3A 2R0DA 3USYA 1N42A 2IICA 1AVHA 1AVRA 1BC1A 2Q4CA 2VXGA 4MDVA 1UPTB 1ANNA 3TW5A 2ZOCA
chains in the Genus database with same CATH topology

1XT0B 1S9DE 4JWLA 4OIYA 3L8NA 4A4PA 2HSNA 3USWA 4C7PA 1R8QE 1QC7A 2R09A 4KN7X 4JMIA 4JXHA 3SWVA 3HJLA 4KN4X 3AJCA 4FHRB 4D7QA 1Q8DA 2K6XA 4L5MA 2R0DA 1KU1A 4C0AA 3USYA 1PBVA 4KMUX 3LTLA 3SOHB 4Z21A 1R8SE 1R8ME 4FQ0C 4JMOA 4D7RA 1BC9A 4JK1X 1LKVX 3TW5A 1XSZA 1RE0B
chains in the Genus database with same CATH homology

#chains in the Genus database with same CATH superfamily
 1XT0 B;  1S9D E;  4JWL A;  1RE0 B;  4OIY A;  3L8N A;  4A4P A;  4C7P A;  1R8Q E;  2R09 A;  4JMI A;  4JXH A;  3SWV A;  4D7Q A;  2R0D A;  1KU1 A;  4C0A A;  1PBV A;  3LTL A;  4Z21 A;  1R8S E;  1R8M E;  4JMO A;  4D7R A;  1BC9 A;  1XSZ A;  4L5M A; 
#chains in the Genus database with same CATH topology
 1XT0 B;  1ANX A;  1YJ0 A;  1S9D E;  1HVG A;  1N44 A;  4JWL A;  1W45 A;  1R4A E;  1AOW A;  2IE7 A;  1R8Q E;  4JXH A;  2HYW A;  3AJC A;  1BCZ A;  4D7Q A;  4Q2S A;  2K6X A;  1G5N A;  1PBV A;  2H0M A;  3LTL A;  1N00 A;  1SAV A;  4Z21 A;  2RAN A;  1HVD A;  2OY9 A;  4X9P A;  4JK1 X;  1ANW A;  2HYV A;  1AXN A;  1XSZ A;  1Q8D A;  1RE0 B;  1BCY A;  1BCW A;  1XJL A;  3L8N A;  3BRX A;  4A4P A;  3ABQ A;  4C7P A;  4KN7 X;  1I4A A;  4JMI A;  4EVH A;  1AII A;  4HRE A;  4KN4 X;  1M9I A;  1YII A;  1HAK A;  1BO9 A;  3ABO A;  2XO3 A;  4MDU A;  1AEI A;  3SOH B;  1W7B A;  1R8M E;  4JMO A;  1A8A A;  1YCN A;  3AO0 A;  2II2 A;  2XO2 A;  2HSN A;  1HVE A;  1N41 A;  1DK5 A;  1HVF A;  2H0K A;  1YGM A;  3ANY A;  3SWV A;  1W3W A;  3ABS A;  4EVF A;  1KU1 A;  4C0A A;  4KMU X;  2ZHJ A;  3ABR A;  2HYU A;  1ALA A;  2IE6 A;  1R8S E;  4FQ0 C;  1C1K A;  1A8B A;  4D7R A;  1BC9 A;  1AVC A;  1HM6 A;  1LKV X;  1BC0 A;  4L5M A;  4OIY A;  1DM5 A;  3USW A;  2H0L A;  1QC7 A;  2R09 A;  2QEZ A;  3HJL A;  2ZHI A;  4FHR B;  1MCX A;  1BC3 A;  2R0D A;  3USY A;  1N42 A;  2IIC A;  1AVH A;  1AVR A;  1BC1 A;  2Q4C A;  2VXG A;  4MDV A;  1UPT B;  1ANN A;  3TW5 A;  2ZOC A; 
#chains in the Genus database with same CATH homology
 1XT0 B;  1S9D E;  4JWL A;  4OIY A;  3L8N A;  4A4P A;  2HSN A;  3USW A;  4C7P A;  1R8Q E;  1QC7 A;  2R09 A;  4KN7 X;  4JMI A;  4JXH A;  3SWV A;  3HJL A;  4KN4 X;  3AJC A;  4FHR B;  4D7Q A;  1Q8D A;  2K6X A;  4L5M A;  2R0D A;  1KU1 A;  4C0A A;  3USY A;  1PBV A;  4KMU X;  3LTL A;  3SOH B;  4Z21 A;  1R8S E;  1R8M E;  4FQ0 C;  4JMO A;  4D7R A;  1BC9 A;  4JK1 X;  1LKV X;  3TW5 A;  1XSZ A;  1RE0 B;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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4JXHA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations