4Z21 | Genus

Total Genus 71

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	71
sequence length	196
structure length	196
Chain Sequence	ANEGSKTLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRNEPFKIPE

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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The Resolver thinks Pdb

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reading 196 atoms

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196 atoms created

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Signaling protein
source organism	Homo sapiens
publication title	Lack of evidence that CYTH2/ARNO functions as an intracellular EGFR activator rcsb
molecule keywords	Cytohesin-2
total genus	71
structure length	196
sequence length	196
ec nomenclature
pdb deposition date	2015-03-28

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF01369	Sec7	Sec7 domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.10.220.20	Mainly Alpha	Orthogonal Bundle	Annexin V; domain 1	Annexin V; domain 1	4z21A01
1.10.1000.11	Mainly Alpha	Orthogonal Bundle	Arf Nucleotide-binding Site Opener; domain 2	Arf Nucleotide-binding Site Opener,domain 2	4z21A02

1R8ME 3SWVA 4JMOA 1XSZA 4JWLA 1R8QE 1BC9A 4JXHA 4D7QA 4D7RA 4Z21A 1RE0B 4L5MA 4JMIA 3L8NA 4OIYA 1XT0B 2R0DA 1KU1A 4A4PA 4C0AA 4C7PA 2R09A 3LTLA 1S9DE 1PBVA 1R8SE
chains in the Genus database with same CATH superfamily

1BCZA 1BCYA 1I4AA 2IICA 1AXNA 3USYA 4JMOA 1AVRA 1YIIA 4EVFA 1BC9A 1RE0B 1YJ0A 4L5MA 2QEZA 1W45A 2Q4CA 1R4AE 2ZOCA 1HVFA 3L8NA 1YCNA 4C7PA 4FHRB 1G5NA 3HJLA 2OY9A 4KN4X 4MDVA 3ANYA 2HSNA 1R8ME 1DM5A 1BO9A 1HVGA 1ALAA 2XO2A 1ANNA 1SAVA 2ZHJA 4JWLA 3AJCA 4D7QA 2ZHIA 4KN7X 4JMIA 4HREA 1AOWA 4A4PA 1YGMA 2R09A 3LTLA 1S9DE 1PBVA 4KMUX 3TW5A 1BCWA 1ANWA 3SWVA 1N00A 1W3WA 1Q8DA 3ABSA 3USWA 2H0KA 2K6XA 4JK1X 2H0LA 3ABQA 4JXHA 1HVDA 1HM6A 1C1KA 1BC1A 1BC0A 3BRXA 1ANXA 4FQ0C 4OIYA 2R0DA 1QC7A 1BC3A 1DK5A 4X9PA 4EVHA 2RANA 2IE7A 1M9IA 1N42A 3SOHB 2HYUA 1W7BA 2II2A 1XJLA 1XSZA 2XO3A 1R8QE 1UPTB 1N41A 1MCXA 4D7RA 1AEIA 2HYVA 4Z21A 3AO0A 3ABOA 2HYWA 1AVCA 4Q2SA 2H0MA 1AIIA 3ABRA 1XT0B 1HVEA 1KU1A 4C0AA 2IE6A 1A8BA 1LKVX 2VXGA 1HAKA 4MDUA 1R8SE 1A8AA 1AVHA 1N44A
chains in the Genus database with same CATH topology

3SOHB 1R8ME 3SWVA 1Q8DA 3USYA 4JMOA 3USWA 2K6XA 1XSZA 4JK1X 4JWLA 1R8QE 1BC9A 3AJCA 4JXHA 4D7QA 4D7RA 4Z21A 1RE0B 4L5MA 4KN7X 4JMIA 3L8NA 4FQ0C 4OIYA 1XT0B 2R0DA 1KU1A 1QC7A 4A4PA 4C0AA 4C7PA 4FHRB 2R09A 3HJLA 3LTLA 1LKVX 1S9DE 1PBVA 1R8SE 4KMUX 4KN4X 3TW5A 2HSNA
chains in the Genus database with same CATH homology

#chains in the Genus database with same CATH superfamily
 1R8M E;  3SWV A;  4JMO A;  1XSZ A;  4JWL A;  1R8Q E;  1BC9 A;  4JXH A;  4D7Q A;  4D7R A;  4Z21 A;  1RE0 B;  4L5M A;  4JMI A;  3L8N A;  4OIY A;  1XT0 B;  2R0D A;  1KU1 A;  4A4P A;  4C0A A;  4C7P A;  2R09 A;  3LTL A;  1S9D E;  1PBV A;  1R8S E; 
#chains in the Genus database with same CATH topology
 1BCZ A;  1BCY A;  1I4A A;  2IIC A;  1AXN A;  3USY A;  4JMO A;  1AVR A;  1YII A;  4EVF A;  1BC9 A;  1RE0 B;  1YJ0 A;  4L5M A;  2QEZ A;  1W45 A;  2Q4C A;  1R4A E;  2ZOC A;  1HVF A;  3L8N A;  1YCN A;  4C7P A;  4FHR B;  1G5N A;  3HJL A;  2OY9 A;  4KN4 X;  4MDV A;  3ANY A;  2HSN A;  1R8M E;  1DM5 A;  1BO9 A;  1HVG A;  1ALA A;  2XO2 A;  1ANN A;  1SAV A;  2ZHJ A;  4JWL A;  3AJC A;  4D7Q A;  2ZHI A;  4KN7 X;  4JMI A;  4HRE A;  1AOW A;  4A4P A;  1YGM A;  2R09 A;  3LTL A;  1S9D E;  1PBV A;  4KMU X;  3TW5 A;  1BCW A;  1ANW A;  3SWV A;  1N00 A;  1W3W A;  1Q8D A;  3ABS A;  3USW A;  2H0K A;  2K6X A;  4JK1 X;  2H0L A;  3ABQ A;  4JXH A;  1HVD A;  1HM6 A;  1C1K A;  1BC1 A;  1BC0 A;  3BRX A;  1ANX A;  4FQ0 C;  4OIY A;  2R0D A;  1QC7 A;  1BC3 A;  1DK5 A;  4X9P A;  4EVH A;  2RAN A;  2IE7 A;  1M9I A;  1N42 A;  3SOH B;  2HYU A;  1W7B A;  2II2 A;  1XJL A;  1XSZ A;  2XO3 A;  1R8Q E;  1UPT B;  1N41 A;  1MCX A;  4D7R A;  1AEI A;  2HYV A;  4Z21 A;  3AO0 A;  3ABO A;  2HYW A;  1AVC A;  4Q2S A;  2H0M A;  1AII A;  3ABR A;  1XT0 B;  1HVE A;  1KU1 A;  4C0A A;  2IE6 A;  1A8B A;  1LKV X;  2VXG A;  1HAK A;  4MDU A;  1R8S E;  1A8A A;  1AVH A;  1N44 A; 
#chains in the Genus database with same CATH homology
 3SOH B;  1R8M E;  3SWV A;  1Q8D A;  3USY A;  4JMO A;  3USW A;  2K6X A;  1XSZ A;  4JK1 X;  4JWL A;  1R8Q E;  1BC9 A;  3AJC A;  4JXH A;  4D7Q A;  4D7R A;  4Z21 A;  1RE0 B;  4L5M A;  4KN7 X;  4JMI A;  3L8N A;  4FQ0 C;  4OIY A;  1XT0 B;  2R0D A;  1KU1 A;  1QC7 A;  4A4P A;  4C0A A;  4C7P A;  4FHR B;  2R09 A;  3HJL A;  3LTL A;  1LKV X;  1S9D E;  1PBV A;  1R8S E;  4KMU X;  4KN4 X;  3TW5 A;  2HSN A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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4Z21A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations