4Z21A

Crystal structure of arno sec7
Total Genus 71
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
71
sequence length
196
structure length
196
Chain Sequence
ANEGSKTLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRNEPFKIPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Lack of evidence that CYTH2/ARNO functions as an intracellular EGFR activator
rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords Cytohesin-2
total genus 71
structure length 196
sequence length 196
ec nomenclature
pdb deposition date 2015-03-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01369 Sec7 Sec7 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.220.20 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin V; domain 1 4z21A01
1.10.1000.11 Mainly Alpha Orthogonal Bundle Arf Nucleotide-binding Site Opener; domain 2 Arf Nucleotide-binding Site Opener,domain 2 4z21A02
3LTLA 4C0AA 4A4PA 4JMOA 4D7RA 3L8NA 4L5MA 1XSZA 4JMIA 1R8ME 1R8SE 2R0DA 4Z21A 4JWLA 4C7PA 4OIYA 4JXHA 2R09A 1R8QE 3SWVA 1PBVA 1RE0B 1S9DE 4D7QA 1BC9A 1XT0B 1KU1A
chains in the Genus database with same CATH superfamily
3LTLA 1ANXA 1HVGA 4A4PA 1LKVX 4KMUX 3L8NA 4L5MA 4HREA 1BCZA 1HM6A 2XO3A 3ABQA 4MDUA 4C7PA 2Q4CA 1N44A 1BC0A 1QC7A 2QEZA 2HYVA 3SOHB 3AO0A 3ANYA 3USWA 1BO9A 1XJLA 2ZHIA 1ANNA 4D7QA 1BC3A 1XT0B 2K6XA 1BCWA 1BC1A 2IE6A 1AXNA 4JMIA 2VXGA 1N00A 1R8SE 2R0DA 1KU1A 1G5NA 1DK5A 4OIYA 1AEIA 2ZOCA 1A8BA 2HSNA 1R8QE 1YIIA 1DM5A 1RE0B 4Q2SA 1W45A 1HVFA 1Q8DA 2IE7A 4C0AA 1AVHA 4JMOA 1HVEA 4D7RA 3ABSA 3AJCA 2H0MA 2RANA 1AVRA 4MDVA 4JK1X 4Z21A 1M9IA 1I4AA 2ZHJA 4KN7X 1W3WA 1BCYA 1YCNA 1R4AE 3ABRA 1UPTB 2R09A 3SWVA 1N41A 2HYUA 1AOWA 1S9DE 3ABOA 1N42A 2OY9A 2HYWA 4X9PA 3HJLA 4FQ0C 1ANWA 1AVCA 1HVDA 2II2A 1YGMA 2IICA 2XO2A 1A8AA 1SAVA 1ALAA 1XSZA 4EVFA 1R8ME 4FHRB 1C1KA 1HAKA 4JWLA 1MCXA 4EVHA 1YJ0A 4JXHA 3TW5A 1AIIA 3USYA 2H0KA 1W7BA 4KN4X 1PBVA 1BC9A 3BRXA 2H0LA
chains in the Genus database with same CATH topology
2K6XA 3HJLA 3LTLA 4FQ0C 4C0AA 4A4PA 1LKVX 4JMOA 4KMUX 4D7RA 3L8NA 3AJCA 4L5MA 1XSZA 4JMIA 1R8ME 1R8SE 2R0DA 4FHRB 4JK1X 4Z21A 4JWLA 4C7PA 4KN7X 4OIYA 4JXHA 1QC7A 3TW5A 3SOHB 2R09A 3USYA 2HSNA 1R8QE 3SWVA 4KN4X 3USWA 1PBVA 1RE0B 1S9DE 4D7QA 1BC9A 1Q8DA 1XT0B 1KU1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3LTL A;  4C0A A;  4A4P A;  4JMO A;  4D7R A;  3L8N A;  4L5M A;  1XSZ A;  4JMI A;  1R8M E;  1R8S E;  2R0D A;  4Z21 A;  4JWL A;  4C7P A;  4OIY A;  4JXH A;  2R09 A;  1R8Q E;  3SWV A;  1PBV A;  1RE0 B;  1S9D E;  4D7Q A;  1BC9 A;  1XT0 B;  1KU1 A; 
#chains in the Genus database with same CATH topology
 3LTL A;  1ANX A;  1HVG A;  4A4P A;  1LKV X;  4KMU X;  3L8N A;  4L5M A;  4HRE A;  1BCZ A;  1HM6 A;  2XO3 A;  3ABQ A;  4MDU A;  4C7P A;  2Q4C A;  1N44 A;  1BC0 A;  1QC7 A;  2QEZ A;  2HYV A;  3SOH B;  3AO0 A;  3ANY A;  3USW A;  1BO9 A;  1XJL A;  2ZHI A;  1ANN A;  4D7Q A;  1BC3 A;  1XT0 B;  2K6X A;  1BCW A;  1BC1 A;  2IE6 A;  1AXN A;  4JMI A;  2VXG A;  1N00 A;  1R8S E;  2R0D A;  1KU1 A;  1G5N A;  1DK5 A;  4OIY A;  1AEI A;  2ZOC A;  1A8B A;  2HSN A;  1R8Q E;  1YII A;  1DM5 A;  1RE0 B;  4Q2S A;  1W45 A;  1HVF A;  1Q8D A;  2IE7 A;  4C0A A;  1AVH A;  4JMO A;  1HVE A;  4D7R A;  3ABS A;  3AJC A;  2H0M A;  2RAN A;  1AVR A;  4MDV A;  4JK1 X;  4Z21 A;  1M9I A;  1I4A A;  2ZHJ A;  4KN7 X;  1W3W A;  1BCY A;  1YCN A;  1R4A E;  3ABR A;  1UPT B;  2R09 A;  3SWV A;  1N41 A;  2HYU A;  1AOW A;  1S9D E;  3ABO A;  1N42 A;  2OY9 A;  2HYW A;  4X9P A;  3HJL A;  4FQ0 C;  1ANW A;  1AVC A;  1HVD A;  2II2 A;  1YGM A;  2IIC A;  2XO2 A;  1A8A A;  1SAV A;  1ALA A;  1XSZ A;  4EVF A;  1R8M E;  4FHR B;  1C1K A;  1HAK A;  4JWL A;  1MCX A;  4EVH A;  1YJ0 A;  4JXH A;  3TW5 A;  1AII A;  3USY A;  2H0K A;  1W7B A;  4KN4 X;  1PBV A;  1BC9 A;  3BRX A;  2H0L A; 
#chains in the Genus database with same CATH homology
 2K6X A;  3HJL A;  3LTL A;  4FQ0 C;  4C0A A;  4A4P A;  1LKV X;  4JMO A;  4KMU X;  4D7R A;  3L8N A;  3AJC A;  4L5M A;  1XSZ A;  4JMI A;  1R8M E;  1R8S E;  2R0D A;  4FHR B;  4JK1 X;  4Z21 A;  4JWL A;  4C7P A;  4KN7 X;  4OIY A;  4JXH A;  1QC7 A;  3TW5 A;  3SOH B;  2R09 A;  3USY A;  2HSN A;  1R8Q E;  3SWV A;  4KN4 X;  3USW A;  1PBV A;  1RE0 B;  1S9D E;  4D7Q A;  1BC9 A;  1Q8D A;  1XT0 B;  1KU1 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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