1Q4KA

The polo-box domain of plk1 in complex with a phospho-peptide
Total Genus 72
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
72
sequence length
222
structure length
222
Chain Sequence
CHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Serine/threonine-protein kinase PLK
publication title The crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complex.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
total genus 72
structure length 222
sequence length 222
chains with identical sequence B, C
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2003-08-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 1q4kA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 1q4kA01
4DFWA 3RQ7A 5DMVC 4HABA 4WHLA 3P37A 5DNJA 3Q1IA 5LHZA 2OJXA 4X9VA 3P2WA 4LKMA 5J19A 3FVHA 3P2ZA 4H71A 4X9RA 4J7BB 2OGQA 2N19A 4E9DA 4E67A 4RS6A 1Q4OA 3P36A 4X9WA 4O56A 4O6WA 4XB0A 3P35A 4YYPA 4HY2A 3HIKA 1Q4KA 4HCOA 3HIHA 4E9CA 1UMWA 4WHHA 4H5XA 4O9WA 4LKLA 4RCPA 3BZIA 4WHKA 5DMSA 3P34A 3C5LA
chains in the Genus database with same CATH superfamily
2QZUA 2I9ZA 2OJXA 4X9VA 4LKMA 5J19A 3FVHA 3P2ZA 4H71A 2OGQA 3P36A 4O56A 4FDIA 4O6WA 4YYPA 3HIKA 4HCOA 5DAYA 2VKZG 4N7ZA 3HIHA 4H5XA 4O9WA 4WHKA 5DMSA 2I9XA 5AJ9A 5DMVC 4WHLA 3P37A 5DNJA 1N2LA 3P2WA 4CXUA 3LM3A 4J7BB 4E9DA 4E67A 4RS6A 4X9WA 1Q4KA 1N2KA 3ED4A 4E9CA 1F32A 1FSUA 1A87A 3P34A 4HABA 1HDHA 3Q1IA 1E2SP 1F34B 4X9RA 4N9JA 1AUKA 4CYSA 1Q4OA 1P49A 3P35A 4HY2A 4CXSA 3HMJG 4N7VA 1UMWA 4WHHA 3FS3A 2UV8G 3BZIA 1E1ZP 4CXKA 4G7NA 3KDRA 4DFWA 3RQ7A 4CYRA 5LHZA 4NK7A 3LXQA 4FDJA 2N19A 4XB0A 1E33P 3GYVA 3GYWA 3HFDA 1E3CP 4NKBA 1E2TA 4LKLA 4RCPA 2E50A 2IA9A 3C5LA
chains in the Genus database with same CATH topology
4DFWA 3RQ7A 5DMVC 4HABA 4WHLA 3P37A 5DNJA 3Q1IA 5LHZA 2OJXA 4X9VA 3P2WA 4LKMA 5J19A 3FVHA 3P2ZA 4H71A 4X9RA 4J7BB 2OGQA 2N19A 4E9DA 4E67A 4RS6A 1Q4OA 3P36A 4X9WA 4O56A 4O6WA 4XB0A 3P35A 4YYPA 4HY2A 3HIKA 1Q4KA 4HCOA 3HIHA 4E9CA 1UMWA 4WHHA 4H5XA 4O9WA 4LKLA 4RCPA 3BZIA 4WHKA 5DMSA 3P34A 3C5LA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4DFW A;  3RQ7 A;  5DMV C;  4HAB A;  4WHL A;  3P37 A;  5DNJ A;  3Q1I A;  5LHZ A;  2OJX A;  4X9V A;  3P2W A;  4LKM A;  5J19 A;  3FVH A;  3P2Z A;  4H71 A;  4X9R A;  4J7B B;  2OGQ A;  2N19 A;  4E9D A;  4E67 A;  4RS6 A;  1Q4O A;  3P36 A;  4X9W A;  4O56 A;  4O6W A;  4XB0 A;  3P35 A;  4YYP A;  4HY2 A;  3HIK A;  1Q4K A;  4HCO A;  3HIH A;  4E9C A;  1UMW A;  4WHH A;  4H5X A;  4O9W A;  4LKL A;  4RCP A;  3BZI A;  4WHK A;  5DMS A;  3P34 A;  3C5L A; 
#chains in the Genus database with same CATH topology
 2QZU A;  2I9Z A;  2OJX A;  4X9V A;  4LKM A;  5J19 A;  3FVH A;  3P2Z A;  4H71 A;  2OGQ A;  3P36 A;  4O56 A;  4FDI A;  4O6W A;  4YYP A;  3HIK A;  4HCO A;  5DAY A;  2VKZ G;  4N7Z A;  3HIH A;  4H5X A;  4O9W A;  4WHK A;  5DMS A;  2I9X A;  5AJ9 A;  5DMV C;  4WHL A;  3P37 A;  5DNJ A;  1N2L A;  3P2W A;  4CXU A;  3LM3 A;  4J7B B;  4E9D A;  4E67 A;  4RS6 A;  4X9W A;  1Q4K A;  1N2K A;  3ED4 A;  4E9C A;  1F32 A;  1FSU A;  1A87 A;  3P34 A;  4HAB A;  1HDH A;  3Q1I A;  1E2S P;  1F34 B;  4X9R A;  4N9J A;  1AUK A;  4CYS A;  1Q4O A;  1P49 A;  3P35 A;  4HY2 A;  4CXS A;  3HMJ G;  4N7V A;  1UMW A;  4WHH A;  3FS3 A;  2UV8 G;  3BZI A;  1E1Z P;  4CXK A;  4G7N A;  3KDR A;  4DFW A;  3RQ7 A;  4CYR A;  5LHZ A;  4NK7 A;  3LXQ A;  4FDJ A;  2N19 A;  4XB0 A;  1E33 P;  3GYV A;  3GYW A;  3HFD A;  1E3C P;  4NKB A;  1E2T A;  4LKL A;  4RCP A;  2E50 A;  2IA9 A;  3C5L A; 
#chains in the Genus database with same CATH homology
 4DFW A;  3RQ7 A;  5DMV C;  4HAB A;  4WHL A;  3P37 A;  5DNJ A;  3Q1I A;  5LHZ A;  2OJX A;  4X9V A;  3P2W A;  4LKM A;  5J19 A;  3FVH A;  3P2Z A;  4H71 A;  4X9R A;  4J7B B;  2OGQ A;  2N19 A;  4E9D A;  4E67 A;  4RS6 A;  1Q4O A;  3P36 A;  4X9W A;  4O56 A;  4O6W A;  4XB0 A;  3P35 A;  4YYP A;  4HY2 A;  3HIK A;  1Q4K A;  4HCO A;  3HIH A;  4E9C A;  1UMW A;  4WHH A;  4H5X A;  4O9W A;  4LKL A;  4RCP A;  3BZI A;  4WHK A;  5DMS A;  3P34 A;  3C5L A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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