1Q4KA

The polo-box domain of plk1 in complex with a phospho-peptide
Total Genus 72
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
72
sequence length
222
structure length
222
Chain Sequence
CHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
molecule keywords Serine/threonine-protein kinase PLK
publication title The crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complex.
pubmed doi rcsb
source organism Homo sapiens
total genus 72
structure length 222
sequence length 222
chains with identical sequence B, C
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2003-08-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 1q4kA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 1q4kA01
3HIKA 1Q4KA 4HCOA 3P2ZA 4H5XA 4E9CA 4YYPA 4X9RA 4LKLA 4O6WA 3FVHA 4O9WA 5LHZA 3P34A 1UMWA 4RS6A 4HABA 4J7BB 4LKMA 5DNJA 2OJXA 4WHKA 4E67A 3Q1IA 4XB0A 4DFWA 5J19A 4HY2A 4H71A 5DMSA 3P36A 3P2WA 3P35A 3P37A 3HIHA 4RCPA 4X9VA 4E9DA 3C5LA 2OGQA 5DMVC 4WHLA 4O56A 1Q4OA 3BZIA 2N19A 4WHHA 4X9WA 3RQ7A
chains in the Genus database with same CATH superfamily
3HIKA 3P2ZA 1P49A 4E9CA 3FVHA 1E1ZP 5DAYA 4HABA 1N2KA 4E67A 2UV8G 4CYRA 3P36A 3P2WA 3P35A 4RCPA 4N9JA 4HCOA 4YYPA 4X9RA 1E2SP 4RS6A 2E50A 4J7BB 4LKMA 4WHKA 3Q1IA 4HY2A 3P37A 3GYWA 3C5LA 2OGQA 1HDHA 2N19A 3RQ7A 4NK7A 3LXQA 1Q4KA 4H5XA 1E3CP 5AJ9A 4LKLA 1F32A 4O9WA 1F34B 3P34A 2VKZG 1FSUA 5DNJA 2I9ZA 4CXSA 3HFDA 4DFWA 1E2TA 3ED4A 4G7NA 5J19A 5DMSA 4NKBA 1E33P 3HMJG 4X9VA 4E9DA 1AUKA 5DMVC 4WHLA 1Q4OA 4N7VA 3GYVA 3BZIA 4CXKA 4CYSA 1A87A 4O6WA 3LM3A 4FDIA 2I9XA 2IA9A 3FS3A 5LHZA 1UMWA 4FDJA 1N2LA 2OJXA 2QZUA 4XB0A 4H71A 3HIHA 4N7ZA 4CXUA 3KDRA 4O56A 4WHHA 4X9WA
chains in the Genus database with same CATH topology
3HIKA 1Q4KA 4HCOA 3P2ZA 4H5XA 4E9CA 4YYPA 4X9RA 4LKLA 4O6WA 3FVHA 4O9WA 5LHZA 3P34A 1UMWA 4RS6A 4HABA 4J7BB 4LKMA 5DNJA 2OJXA 4WHKA 4E67A 3Q1IA 4XB0A 4DFWA 5J19A 4HY2A 4H71A 5DMSA 3P36A 3P2WA 3P35A 3P37A 3HIHA 4RCPA 4X9VA 4E9DA 3C5LA 2OGQA 5DMVC 4WHLA 4O56A 1Q4OA 3BZIA 2N19A 4WHHA 4X9WA 3RQ7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3HIK A;  1Q4K A;  4HCO A;  3P2Z A;  4H5X A;  4E9C A;  4YYP A;  4X9R A;  4LKL A;  4O6W A;  3FVH A;  4O9W A;  5LHZ A;  3P34 A;  1UMW A;  4RS6 A;  4HAB A;  4J7B B;  4LKM A;  5DNJ A;  2OJX A;  4WHK A;  4E67 A;  3Q1I A;  4XB0 A;  4DFW A;  5J19 A;  4HY2 A;  4H71 A;  5DMS A;  3P36 A;  3P2W A;  3P35 A;  3P37 A;  3HIH A;  4RCP A;  4X9V A;  4E9D A;  3C5L A;  2OGQ A;  5DMV C;  4WHL A;  4O56 A;  1Q4O A;  3BZI A;  2N19 A;  4WHH A;  4X9W A;  3RQ7 A; 
#chains in the Genus database with same CATH topology
 3HIK A;  3P2Z A;  1P49 A;  4E9C A;  3FVH A;  1E1Z P;  5DAY A;  4HAB A;  1N2K A;  4E67 A;  2UV8 G;  4CYR A;  3P36 A;  3P2W A;  3P35 A;  4RCP A;  4N9J A;  4HCO A;  4YYP A;  4X9R A;  1E2S P;  4RS6 A;  2E50 A;  4J7B B;  4LKM A;  4WHK A;  3Q1I A;  4HY2 A;  3P37 A;  3GYW A;  3C5L A;  2OGQ A;  1HDH A;  2N19 A;  3RQ7 A;  4NK7 A;  3LXQ A;  1Q4K A;  4H5X A;  1E3C P;  5AJ9 A;  4LKL A;  1F32 A;  4O9W A;  1F34 B;  3P34 A;  2VKZ G;  1FSU A;  5DNJ A;  2I9Z A;  4CXS A;  3HFD A;  4DFW A;  1E2T A;  3ED4 A;  4G7N A;  5J19 A;  5DMS A;  4NKB A;  1E33 P;  3HMJ G;  4X9V A;  4E9D A;  1AUK A;  5DMV C;  4WHL A;  1Q4O A;  4N7V A;  3GYV A;  3BZI A;  4CXK A;  4CYS A;  1A87 A;  4O6W A;  3LM3 A;  4FDI A;  2I9X A;  2IA9 A;  3FS3 A;  5LHZ A;  1UMW A;  4FDJ A;  1N2L A;  2OJX A;  2QZU A;  4XB0 A;  4H71 A;  3HIH A;  4N7Z A;  4CXU A;  3KDR A;  4O56 A;  4WHH A;  4X9W A; 
#chains in the Genus database with same CATH homology
 3HIK A;  1Q4K A;  4HCO A;  3P2Z A;  4H5X A;  4E9C A;  4YYP A;  4X9R A;  4LKL A;  4O6W A;  3FVH A;  4O9W A;  5LHZ A;  3P34 A;  1UMW A;  4RS6 A;  4HAB A;  4J7B B;  4LKM A;  5DNJ A;  2OJX A;  4WHK A;  4E67 A;  3Q1I A;  4XB0 A;  4DFW A;  5J19 A;  4HY2 A;  4H71 A;  5DMS A;  3P36 A;  3P2W A;  3P35 A;  3P37 A;  3HIH A;  4RCP A;  4X9V A;  4E9D A;  3C5L A;  2OGQ A;  5DMV C;  4WHL A;  4O56 A;  1Q4O A;  3BZI A;  2N19 A;  4WHH A;  4X9W A;  3RQ7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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