4HABA

Crystal structure of plk1 polo-box domain in complex with pl-49
Total Genus 73
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
73
sequence length
223
structure length
223
Chain Sequence
DCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase/transferase inhibitor
molecule keywords Serine/threonine-protein kinase PLK1
publication title Development of cyclic peptomer inhibitors targeting the polo-box domain of polo-like kinase 1.
pubmed doi rcsb
source organism Homo sapiens
total genus 73
structure length 223
sequence length 223
chains with identical sequence B, C
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2012-09-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4habA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4habA01
4X9RA 4J7BB 3P36A 4H71A 4HCOA 3Q1IA 4WHHA 3HIHA 4RS6A 1UMWA 4WHKA 4HABA 4E9CA 3P34A 4X9VA 4O9WA 3P37A 1Q4KA 4H5XA 2OJXA 4YYPA 3RQ7A 3P2WA 5LHZA 5J19A 5DNJA 4O6WA 4X9WA 4HY2A 4RCPA 4E9DA 3P35A 5DMVC 3P2ZA 1Q4OA 3FVHA 4DFWA 2N19A 2OGQA 4O56A 3BZIA 4XB0A 5DMSA 4E67A 4LKMA 3HIKA 3C5LA 4WHLA 4LKLA
chains in the Genus database with same CATH superfamily
1AUKA 4FDIA 4CYRA 1A87A 4RS6A 4WHKA 3P37A 4H5XA 3GYWA 4RCPA 1Q4OA 1E33P 5DMSA 4WHLA 4J7BB 3HMJG 4WHHA 3FS3A 1UMWA 3LM3A 4O9WA 2OJXA 2QZUA 5LHZA 1HDHA 5DAYA 2I9ZA 1N2KA 4HY2A 4G7NA 4FDJA 4DFWA 2N19A 1N2LA 3HIKA 4LKLA 1FSUA 4H71A 3Q1IA 5AJ9A 4N7VA 3GYVA 1P49A 1Q4KA 3HFDA 4YYPA 4NKBA 5DNJA 2I9XA 3KDRA 1E3CP 4N7ZA 4E9DA 3FVHA 3BZIA 4XB0A 3LXQA 4E67A 3C5LA 1F34B 3RQ7A 4X9RA 2UV8G 3P36A 4HCOA 2VKZG 3HIHA 4CXKA 4HABA 4E9CA 3P34A 3ED4A 4X9VA 2E50A 3P2WA 5J19A 4CXUA 4N9JA 4NK7A 4CYSA 4O6WA 4X9WA 1E2SP 5DMVC 3P35A 3P2ZA 1E2TA 2OGQA 1F32A 4O56A 2IA9A 4LKMA 1E1ZP 4CXSA
chains in the Genus database with same CATH topology
4X9RA 4J7BB 3P36A 4H71A 4HCOA 3Q1IA 4WHHA 3HIHA 4RS6A 1UMWA 4WHKA 4HABA 4E9CA 3P34A 4X9VA 4O9WA 3P37A 1Q4KA 4H5XA 2OJXA 4YYPA 3RQ7A 3P2WA 5LHZA 5J19A 5DNJA 4O6WA 4X9WA 4HY2A 4RCPA 4E9DA 3P35A 5DMVC 3P2ZA 1Q4OA 3FVHA 4DFWA 2N19A 2OGQA 4O56A 3BZIA 4XB0A 5DMSA 4E67A 4LKMA 3HIKA 3C5LA 4WHLA 4LKLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4X9R A;  4J7B B;  3P36 A;  4H71 A;  4HCO A;  3Q1I A;  4WHH A;  3HIH A;  4RS6 A;  1UMW A;  4WHK A;  4HAB A;  4E9C A;  3P34 A;  4X9V A;  4O9W A;  3P37 A;  1Q4K A;  4H5X A;  2OJX A;  4YYP A;  3RQ7 A;  3P2W A;  5LHZ A;  5J19 A;  5DNJ A;  4O6W A;  4X9W A;  4HY2 A;  4RCP A;  4E9D A;  3P35 A;  5DMV C;  3P2Z A;  1Q4O A;  3FVH A;  4DFW A;  2N19 A;  2OGQ A;  4O56 A;  3BZI A;  4XB0 A;  5DMS A;  4E67 A;  4LKM A;  3HIK A;  3C5L A;  4WHL A;  4LKL A; 
#chains in the Genus database with same CATH topology
 1AUK A;  4FDI A;  4CYR A;  1A87 A;  4RS6 A;  4WHK A;  3P37 A;  4H5X A;  3GYW A;  4RCP A;  1Q4O A;  1E33 P;  5DMS A;  4WHL A;  4J7B B;  3HMJ G;  4WHH A;  3FS3 A;  1UMW A;  3LM3 A;  4O9W A;  2OJX A;  2QZU A;  5LHZ A;  1HDH A;  5DAY A;  2I9Z A;  1N2K A;  4HY2 A;  4G7N A;  4FDJ A;  4DFW A;  2N19 A;  1N2L A;  3HIK A;  4LKL A;  1FSU A;  4H71 A;  3Q1I A;  5AJ9 A;  4N7V A;  3GYV A;  1P49 A;  1Q4K A;  3HFD A;  4YYP A;  4NKB A;  5DNJ A;  2I9X A;  3KDR A;  1E3C P;  4N7Z A;  4E9D A;  3FVH A;  3BZI A;  4XB0 A;  3LXQ A;  4E67 A;  3C5L A;  1F34 B;  3RQ7 A;  4X9R A;  2UV8 G;  3P36 A;  4HCO A;  2VKZ G;  3HIH A;  4CXK A;  4HAB A;  4E9C A;  3P34 A;  3ED4 A;  4X9V A;  2E50 A;  3P2W A;  5J19 A;  4CXU A;  4N9J A;  4NK7 A;  4CYS A;  4O6W A;  4X9W A;  1E2S P;  5DMV C;  3P35 A;  3P2Z A;  1E2T A;  2OGQ A;  1F32 A;  4O56 A;  2IA9 A;  4LKM A;  1E1Z P;  4CXS A; 
#chains in the Genus database with same CATH homology
 4X9R A;  4J7B B;  3P36 A;  4H71 A;  4HCO A;  3Q1I A;  4WHH A;  3HIH A;  4RS6 A;  1UMW A;  4WHK A;  4HAB A;  4E9C A;  3P34 A;  4X9V A;  4O9W A;  3P37 A;  1Q4K A;  4H5X A;  2OJX A;  4YYP A;  3RQ7 A;  3P2W A;  5LHZ A;  5J19 A;  5DNJ A;  4O6W A;  4X9W A;  4HY2 A;  4RCP A;  4E9D A;  3P35 A;  5DMV C;  3P2Z A;  1Q4O A;  3FVH A;  4DFW A;  2N19 A;  2OGQ A;  4O56 A;  3BZI A;  4XB0 A;  5DMS A;  4E67 A;  4LKM A;  3HIK A;  3C5L A;  4WHL A;  4LKL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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