4HABA

Crystal structure of plk1 polo-box domain in complex with pl-49
Total Genus 73
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
73
sequence length
223
structure length
223
Chain Sequence
DCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Serine/threonine-protein kinase PLK1
publication title Development of cyclic peptomer inhibitors targeting the polo-box domain of polo-like kinase 1.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase/transferase inhibitor
total genus 73
structure length 223
sequence length 223
chains with identical sequence B, C
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2012-09-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4habA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4habA01
4O6WA 3P34A 3Q1IA 4E9DA 4E67A 4WHKA 4WHLA 5LHZA 3P37A 1Q4OA 2OGQA 4HABA 4LKLA 3P36A 4H5XA 4HY2A 4YYPA 4RS6A 3P35A 3RQ7A 4X9VA 1UMWA 4E9CA 4WHHA 3HIHA 5DMSA 2OJXA 3FVHA 4X9RA 1Q4KA 4XB0A 5DNJA 4O9WA 4X9WA 4H71A 3BZIA 2N19A 4O56A 4DFWA 3P2WA 4RCPA 5DMVC 5J19A 3P2ZA 4HCOA 4J7BB 3C5LA 3HIKA 4LKMA
chains in the Genus database with same CATH superfamily
3LXQA 3Q1IA 1P49A 5AJ9A 2I9XA 4WHLA 5LHZA 1Q4OA 3P37A 4LKLA 3HMJG 3P36A 1F32A 4CXKA 1AUKA 3RQ7A 1E2SP 2UV8G 2E50A 3LM3A 5DMSA 4CYRA 4X9RA 1FSUA 1E3CP 3ED4A 5DNJA 4X9WA 3P2WA 5DMVC 4NK7A 4NKBA 4N9JA 1N2KA 4HABA 4HY2A 4CXUA 4YYPA 1F34B 1E33P 4XB0A 3GYWA 1E2TA 3GYVA 1A87A 3FS3A 5J19A 3P2ZA 4HCOA 3HIKA 4LKMA 2QZUA 3P34A 1HDHA 4WHKA 3HFDA 4CXSA 2OGQA 4N7VA 4H5XA 4RS6A 1N2LA 1E1ZP 2IA9A 2VKZG 1UMWA 4WHHA 3HIHA 2OJXA 3FVHA 4CYSA 1Q4KA 4FDIA 2I9ZA 4O56A 4G7NA 3C5LA 4O6WA 4E9DA 4E67A 3KDRA 5DAYA 3P35A 4X9VA 4E9CA 4N7ZA 4O9WA 4FDJA 4H71A 3BZIA 2N19A 4DFWA 4RCPA 4J7BB
chains in the Genus database with same CATH topology
4O6WA 3P34A 3Q1IA 4E9DA 4E67A 4WHKA 4WHLA 5LHZA 3P37A 1Q4OA 2OGQA 4HABA 4LKLA 3P36A 4H5XA 4HY2A 4YYPA 4RS6A 3P35A 3RQ7A 4X9VA 1UMWA 4E9CA 4WHHA 3HIHA 5DMSA 2OJXA 3FVHA 4X9RA 1Q4KA 4XB0A 5DNJA 4O9WA 4X9WA 4H71A 3BZIA 2N19A 4O56A 4DFWA 3P2WA 4RCPA 5DMVC 5J19A 3P2ZA 4HCOA 4J7BB 3C5LA 3HIKA 4LKMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4O6W A;  3P34 A;  3Q1I A;  4E9D A;  4E67 A;  4WHK A;  4WHL A;  5LHZ A;  3P37 A;  1Q4O A;  2OGQ A;  4HAB A;  4LKL A;  3P36 A;  4H5X A;  4HY2 A;  4YYP A;  4RS6 A;  3P35 A;  3RQ7 A;  4X9V A;  1UMW A;  4E9C A;  4WHH A;  3HIH A;  5DMS A;  2OJX A;  3FVH A;  4X9R A;  1Q4K A;  4XB0 A;  5DNJ A;  4O9W A;  4X9W A;  4H71 A;  3BZI A;  2N19 A;  4O56 A;  4DFW A;  3P2W A;  4RCP A;  5DMV C;  5J19 A;  3P2Z A;  4HCO A;  4J7B B;  3C5L A;  3HIK A;  4LKM A; 
#chains in the Genus database with same CATH topology
 3LXQ A;  3Q1I A;  1P49 A;  5AJ9 A;  2I9X A;  4WHL A;  5LHZ A;  1Q4O A;  3P37 A;  4LKL A;  3HMJ G;  3P36 A;  1F32 A;  4CXK A;  1AUK A;  3RQ7 A;  1E2S P;  2UV8 G;  2E50 A;  3LM3 A;  5DMS A;  4CYR A;  4X9R A;  1FSU A;  1E3C P;  3ED4 A;  5DNJ A;  4X9W A;  3P2W A;  5DMV C;  4NK7 A;  4NKB A;  4N9J A;  1N2K A;  4HAB A;  4HY2 A;  4CXU A;  4YYP A;  1F34 B;  1E33 P;  4XB0 A;  3GYW A;  1E2T A;  3GYV A;  1A87 A;  3FS3 A;  5J19 A;  3P2Z A;  4HCO A;  3HIK A;  4LKM A;  2QZU A;  3P34 A;  1HDH A;  4WHK A;  3HFD A;  4CXS A;  2OGQ A;  4N7V A;  4H5X A;  4RS6 A;  1N2L A;  1E1Z P;  2IA9 A;  2VKZ G;  1UMW A;  4WHH A;  3HIH A;  2OJX A;  3FVH A;  4CYS A;  1Q4K A;  4FDI A;  2I9Z A;  4O56 A;  4G7N A;  3C5L A;  4O6W A;  4E9D A;  4E67 A;  3KDR A;  5DAY A;  3P35 A;  4X9V A;  4E9C A;  4N7Z A;  4O9W A;  4FDJ A;  4H71 A;  3BZI A;  2N19 A;  4DFW A;  4RCP A;  4J7B B; 
#chains in the Genus database with same CATH homology
 4O6W A;  3P34 A;  3Q1I A;  4E9D A;  4E67 A;  4WHK A;  4WHL A;  5LHZ A;  3P37 A;  1Q4O A;  2OGQ A;  4HAB A;  4LKL A;  3P36 A;  4H5X A;  4HY2 A;  4YYP A;  4RS6 A;  3P35 A;  3RQ7 A;  4X9V A;  1UMW A;  4E9C A;  4WHH A;  3HIH A;  5DMS A;  2OJX A;  3FVH A;  4X9R A;  1Q4K A;  4XB0 A;  5DNJ A;  4O9W A;  4X9W A;  4H71 A;  3BZI A;  2N19 A;  4O56 A;  4DFW A;  3P2W A;  4RCP A;  5DMV C;  5J19 A;  3P2Z A;  4HCO A;  4J7B B;  3C5L A;  3HIK A;  4LKM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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