4HABA

Crystal structure of plk1 polo-box domain in complex with pl-49
Total Genus 73
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
73
sequence length
223
structure length
223
Chain Sequence
DCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Development of cyclic peptomer inhibitors targeting the polo-box domain of polo-like kinase 1.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase/transferase inhibitor
molecule keywords Serine/threonine-protein kinase PLK1
total genus 73
structure length 223
sequence length 223
chains with identical sequence B, C
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2012-09-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4habA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4habA01
1Q4KA 5J19A 4HY2A 4LKLA 3FVHA 5DMVC 4O9WA 3P37A 4E9CA 5LHZA 3P35A 3HIKA 4O6WA 3P2WA 4XB0A 3Q1IA 4LKMA 5DNJA 4RS6A 4X9RA 3P36A 3P34A 4HCOA 4X9VA 1UMWA 3BZIA 2N19A 4RCPA 4O56A 4YYPA 2OGQA 3C5LA 4DFWA 4H71A 3HIHA 4H5XA 1Q4OA 4X9WA 4WHLA 4WHHA 2OJXA 5DMSA 4WHKA 3RQ7A 4J7BB 4E67A 4HABA 3P2ZA 4E9DA
chains in the Genus database with same CATH superfamily
1E2SP 3FVHA 5DMVC 4N7ZA 4FDIA 3HFDA 1AUKA 3P34A 4HCOA 4X9VA 1F34B 3BZIA 2N19A 3KDRA 1E3CP 3C5LA 1E1ZP 1Q4OA 4J7BB 1N2KA 4RCPA 4LKLA 4HY2A 4N7VA 3P37A 4E9CA 2I9XA 5LHZA 3P2WA 2IA9A 4XB0A 3Q1IA 4LKMA 5DNJA 4RS6A 1UMWA 2QZUA 1HDHA 4YYPA 2OGQA 1A87A 2E50A 4H71A 3HIHA 3LM3A 4H5XA 4N9JA 2UV8G 4WHHA 1FSUA 4WHLA 3P2ZA 4E9DA 4CXKA 4O9WA 3GYWA 3P35A 4O6WA 5DAYA 4NKBA 1E33P 3ED4A 3GYVA 4CYRA 4FDJA 4X9RA 5AJ9A 1F32A 4G7NA 4X9WA 2OJXA 5DMSA 4NK7A 4CYSA 1Q4KA 5J19A 3HIKA 3FS3A 2VKZG 4CXUA 1N2LA 3P36A 3HMJG 1P49A 3LXQA 4O56A 2I9ZA 4DFWA 4CXSA 4WHKA 3RQ7A 4E67A 1E2TA 4HABA
chains in the Genus database with same CATH topology
1Q4KA 5J19A 4HY2A 4LKLA 3FVHA 5DMVC 4O9WA 3P37A 4E9CA 5LHZA 3P35A 3HIKA 4O6WA 3P2WA 4XB0A 3Q1IA 4LKMA 5DNJA 4RS6A 4X9RA 3P36A 3P34A 4HCOA 4X9VA 1UMWA 3BZIA 2N19A 4RCPA 4O56A 4YYPA 2OGQA 3C5LA 4DFWA 4H71A 3HIHA 4H5XA 1Q4OA 4X9WA 4WHLA 4WHHA 2OJXA 5DMSA 4WHKA 3RQ7A 4J7BB 4E67A 4HABA 3P2ZA 4E9DA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1Q4K A;  5J19 A;  4HY2 A;  4LKL A;  3FVH A;  5DMV C;  4O9W A;  3P37 A;  4E9C A;  5LHZ A;  3P35 A;  3HIK A;  4O6W A;  3P2W A;  4XB0 A;  3Q1I A;  4LKM A;  5DNJ A;  4RS6 A;  4X9R A;  3P36 A;  3P34 A;  4HCO A;  4X9V A;  1UMW A;  3BZI A;  2N19 A;  4RCP A;  4O56 A;  4YYP A;  2OGQ A;  3C5L A;  4DFW A;  4H71 A;  3HIH A;  4H5X A;  1Q4O A;  4X9W A;  4WHL A;  4WHH A;  2OJX A;  5DMS A;  4WHK A;  3RQ7 A;  4J7B B;  4E67 A;  4HAB A;  3P2Z A;  4E9D A; 
#chains in the Genus database with same CATH topology
 1E2S P;  3FVH A;  5DMV C;  4N7Z A;  4FDI A;  3HFD A;  1AUK A;  3P34 A;  4HCO A;  4X9V A;  1F34 B;  3BZI A;  2N19 A;  3KDR A;  1E3C P;  3C5L A;  1E1Z P;  1Q4O A;  4J7B B;  1N2K A;  4RCP A;  4LKL A;  4HY2 A;  4N7V A;  3P37 A;  4E9C A;  2I9X A;  5LHZ A;  3P2W A;  2IA9 A;  4XB0 A;  3Q1I A;  4LKM A;  5DNJ A;  4RS6 A;  1UMW A;  2QZU A;  1HDH A;  4YYP A;  2OGQ A;  1A87 A;  2E50 A;  4H71 A;  3HIH A;  3LM3 A;  4H5X A;  4N9J A;  2UV8 G;  4WHH A;  1FSU A;  4WHL A;  3P2Z A;  4E9D A;  4CXK A;  4O9W A;  3GYW A;  3P35 A;  4O6W A;  5DAY A;  4NKB A;  1E33 P;  3ED4 A;  3GYV A;  4CYR A;  4FDJ A;  4X9R A;  5AJ9 A;  1F32 A;  4G7N A;  4X9W A;  2OJX A;  5DMS A;  4NK7 A;  4CYS A;  1Q4K A;  5J19 A;  3HIK A;  3FS3 A;  2VKZ G;  4CXU A;  1N2L A;  3P36 A;  3HMJ G;  1P49 A;  3LXQ A;  4O56 A;  2I9Z A;  4DFW A;  4CXS A;  4WHK A;  3RQ7 A;  4E67 A;  1E2T A;  4HAB A; 
#chains in the Genus database with same CATH homology
 1Q4K A;  5J19 A;  4HY2 A;  4LKL A;  3FVH A;  5DMV C;  4O9W A;  3P37 A;  4E9C A;  5LHZ A;  3P35 A;  3HIK A;  4O6W A;  3P2W A;  4XB0 A;  3Q1I A;  4LKM A;  5DNJ A;  4RS6 A;  4X9R A;  3P36 A;  3P34 A;  4HCO A;  4X9V A;  1UMW A;  3BZI A;  2N19 A;  4RCP A;  4O56 A;  4YYP A;  2OGQ A;  3C5L A;  4DFW A;  4H71 A;  3HIH A;  4H5X A;  1Q4O A;  4X9W A;  4WHL A;  4WHH A;  2OJX A;  5DMS A;  4WHK A;  3RQ7 A;  4J7B B;  4E67 A;  4HAB A;  3P2Z A;  4E9D A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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