4H71A

Human plk1-pbd in complex with poloxime ((e)-4-(hydroxyimino)-2-isopropyl-5-methylcyclohexa-2,5-dienone)
Total Genus 72
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
72
sequence length
223
structure length
222
Chain Sequence
b'DCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSS'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Serine/threonine-protein kinase PLK1
publication title Thymoquinone Blocks pSer/pThr Recognition by Plk1 Polo-Box Domain As a Phosphate Mimic
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase/transferase inhibitor
total genus 72
structure length 222
sequence length 223
chains with identical sequence B
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2012-09-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4h71A02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4h71A01
1Q4OA 3Q1IA 3P36A 4E67A 3P2ZA 4X9RA 4YYPA 1Q4KA 2OGQA 1UMWA 3BZIA 4H5XA 4RS6A 5DNJA 4E9DA 4H71A 3HIHA 4O9WA 4HABA 4WHHA 4E9CA 2OJXA 5J19A 4WHLA 4X9VA 4HY2A 3HIKA 4RCPA 4O6WA 4X9WA 4WHKA 3P2WA 3C5LA 3FVHA 3P34A 5DMVC 4O56A 4J7BB 4HCOA 5LHZA 4XB0A 3P35A 4DFWA 4LKLA 5DMSA 3P37A 4LKMA 2N19A 3RQ7A
chains in the Genus database with same CATH superfamily
3Q1IA 1P49A 4X9RA 4FDIA 4N7ZA 3BZIA 1A87A 2E50A 4O9WA 4WHHA 3HMJG 2I9ZA 4X9VA 3HIKA 4WHKA 3C5LA 3P34A 4CXSA 4N7VA 5DMSA 3P37A 1FSUA 3RQ7A 1Q4OA 2I9XA 1Q4KA 2OGQA 4CYSA 4H71A 3HIHA 4HABA 2OJXA 4X9WA 3P2WA 4FDJA 1E1ZP 3GYVA 4CYRA 1N2LA 1E3CP 1N2KA 4XB0A 3P35A 4DFWA 4LKLA 3LM3A 1HDHA 1E2SP 3P36A 1E2TA 3GYWA 2VKZG 3LXQA 4G7NA 4H5XA 4E9DA 4CXKA 1AUKA 5J19A 4HY2A 4O6WA 3FVHA 4O56A 1F34B 4J7BB 3KDRA 4LKMA 3HFDA 2QZUA 2IA9A 4E67A 3P2ZA 4YYPA 1UMWA 4RS6A 4NK7A 5DNJA 5DAYA 3ED4A 4E9CA 4WHLA 4RCPA 1E33P 4N9JA 3FS3A 1F32A 5DMVC 2UV8G 5AJ9A 4HCOA 5LHZA 4NKBA 2N19A 4CXUA
chains in the Genus database with same CATH topology
1Q4OA 3Q1IA 3P36A 4E67A 3P2ZA 4X9RA 4YYPA 1Q4KA 2OGQA 1UMWA 3BZIA 4H5XA 4RS6A 5DNJA 4E9DA 4H71A 3HIHA 4O9WA 4HABA 4WHHA 4E9CA 2OJXA 5J19A 4WHLA 4X9VA 4HY2A 3HIKA 4RCPA 4O6WA 4X9WA 4WHKA 3P2WA 3C5LA 3FVHA 3P34A 5DMVC 4O56A 4J7BB 4HCOA 5LHZA 4XB0A 3P35A 4DFWA 4LKLA 5DMSA 3P37A 4LKMA 2N19A 3RQ7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1Q4O A;  3Q1I A;  3P36 A;  4E67 A;  3P2Z A;  4X9R A;  4YYP A;  1Q4K A;  2OGQ A;  1UMW A;  3BZI A;  4H5X A;  4RS6 A;  5DNJ A;  4E9D A;  4H71 A;  3HIH A;  4O9W A;  4HAB A;  4WHH A;  4E9C A;  2OJX A;  5J19 A;  4WHL A;  4X9V A;  4HY2 A;  3HIK A;  4RCP A;  4O6W A;  4X9W A;  4WHK A;  3P2W A;  3C5L A;  3FVH A;  3P34 A;  5DMV C;  4O56 A;  4J7B B;  4HCO A;  5LHZ A;  4XB0 A;  3P35 A;  4DFW A;  4LKL A;  5DMS A;  3P37 A;  4LKM A;  2N19 A;  3RQ7 A; 
#chains in the Genus database with same CATH topology
 3Q1I A;  1P49 A;  4X9R A;  4FDI A;  4N7Z A;  3BZI A;  1A87 A;  2E50 A;  4O9W A;  4WHH A;  3HMJ G;  2I9Z A;  4X9V A;  3HIK A;  4WHK A;  3C5L A;  3P34 A;  4CXS A;  4N7V A;  5DMS A;  3P37 A;  1FSU A;  3RQ7 A;  1Q4O A;  2I9X A;  1Q4K A;  2OGQ A;  4CYS A;  4H71 A;  3HIH A;  4HAB A;  2OJX A;  4X9W A;  3P2W A;  4FDJ A;  1E1Z P;  3GYV A;  4CYR A;  1N2L A;  1E3C P;  1N2K A;  4XB0 A;  3P35 A;  4DFW A;  4LKL A;  3LM3 A;  1HDH A;  1E2S P;  3P36 A;  1E2T A;  3GYW A;  2VKZ G;  3LXQ A;  4G7N A;  4H5X A;  4E9D A;  4CXK A;  1AUK A;  5J19 A;  4HY2 A;  4O6W A;  3FVH A;  4O56 A;  1F34 B;  4J7B B;  3KDR A;  4LKM A;  3HFD A;  2QZU A;  2IA9 A;  4E67 A;  3P2Z A;  4YYP A;  1UMW A;  4RS6 A;  4NK7 A;  5DNJ A;  5DAY A;  3ED4 A;  4E9C A;  4WHL A;  4RCP A;  1E33 P;  4N9J A;  3FS3 A;  1F32 A;  5DMV C;  2UV8 G;  5AJ9 A;  4HCO A;  5LHZ A;  4NKB A;  2N19 A;  4CXU A; 
#chains in the Genus database with same CATH homology
 1Q4O A;  3Q1I A;  3P36 A;  4E67 A;  3P2Z A;  4X9R A;  4YYP A;  1Q4K A;  2OGQ A;  1UMW A;  3BZI A;  4H5X A;  4RS6 A;  5DNJ A;  4E9D A;  4H71 A;  3HIH A;  4O9W A;  4HAB A;  4WHH A;  4E9C A;  2OJX A;  5J19 A;  4WHL A;  4X9V A;  4HY2 A;  3HIK A;  4RCP A;  4O6W A;  4X9W A;  4WHK A;  3P2W A;  3C5L A;  3FVH A;  3P34 A;  5DMV C;  4O56 A;  4J7B B;  4HCO A;  5LHZ A;  4XB0 A;  3P35 A;  4DFW A;  4LKL A;  5DMS A;  3P37 A;  4LKM A;  2N19 A;  3RQ7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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