4H71A

Human plk1-pbd in complex with poloxime ((e)-4-(hydroxyimino)-2-isopropyl-5-methylcyclohexa-2,5-dienone)
Total Genus 72
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
72
sequence length
223
structure length
222
Chain Sequence
DCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase/transferase inhibitor
molecule keywords Serine/threonine-protein kinase PLK1
publication title Thymoquinone Blocks pSer/pThr Recognition by Plk1 Polo-Box Domain As a Phosphate Mimic
pubmed doi rcsb
source organism Homo sapiens
total genus 72
structure length 222
sequence length 223
chains with identical sequence B
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2012-09-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4h71A02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4h71A01
4HCOA 4X9WA 2OJXA 3P34A 2OGQA 4O6WA 3HIHA 4J7BB 3HIKA 4O56A 4E9CA 3P36A 4HABA 2N19A 4O9WA 5LHZA 5J19A 1UMWA 4X9VA 4WHHA 4E9DA 3C5LA 4RCPA 4YYPA 3P37A 3BZIA 4WHKA 4LKMA 3FVHA 1Q4OA 4H5XA 4RS6A 4X9RA 5DMSA 5DNJA 5DMVC 3Q1IA 4LKLA 4WHLA 4DFWA 3P2ZA 3P35A 3P2WA 4H71A 4HY2A 4XB0A 3RQ7A 4E67A 1Q4KA
chains in the Genus database with same CATH superfamily
2OGQA 3GYVA 3HIHA 1E2SP 3HIKA 3GYWA 3P36A 1A87A 4HABA 4O9WA 4CXUA 1F32A 1UMWA 4X9VA 3C5LA 4LKMA 1Q4OA 1E1ZP 4H5XA 4X9RA 2UV8G 4WHLA 3P35A 4HY2A 4H71A 4XB0A 1N2KA 4CXKA 3LXQA 1HDHA 4FDIA 1N2LA 2IA9A 4O56A 3FS3A 2N19A 5LHZA 4N9JA 3ED4A 3LM3A 4NKBA 4WHHA 4E9DA 4RCPA 4YYPA 4N7VA 3HFDA 3HMJG 4CYSA 2VKZG 4WHKA 3P34A 5AJ9A 4J7BB 4E9CA 1E3CP 2I9XA 3P37A 2E50A 3FVHA 2I9ZA 4G7NA 5DNJA 5DMVC 3Q1IA 4LKLA 1FSUA 4NK7A 3P2ZA 3P2WA 3RQ7A 3KDRA 4HCOA 4X9WA 2OJXA 4O6WA 1F34B 5DAYA 1E2TA 5J19A 1P49A 3BZIA 1AUKA 2QZUA 4N7ZA 1E33P 4RS6A 5DMSA 4FDJA 4CXSA 4DFWA 4E67A 4CYRA 1Q4KA
chains in the Genus database with same CATH topology
4HCOA 4X9WA 2OJXA 3P34A 2OGQA 4O6WA 3HIHA 4J7BB 3HIKA 4O56A 4E9CA 3P36A 4HABA 2N19A 4O9WA 5LHZA 5J19A 1UMWA 4X9VA 4WHHA 4E9DA 3C5LA 4RCPA 4YYPA 3P37A 3BZIA 4WHKA 4LKMA 3FVHA 1Q4OA 4H5XA 4RS6A 4X9RA 5DMSA 5DNJA 5DMVC 3Q1IA 4LKLA 4WHLA 4DFWA 3P2ZA 3P35A 3P2WA 4H71A 4HY2A 4XB0A 3RQ7A 4E67A 1Q4KA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4HCO A;  4X9W A;  2OJX A;  3P34 A;  2OGQ A;  4O6W A;  3HIH A;  4J7B B;  3HIK A;  4O56 A;  4E9C A;  3P36 A;  4HAB A;  2N19 A;  4O9W A;  5LHZ A;  5J19 A;  1UMW A;  4X9V A;  4WHH A;  4E9D A;  3C5L A;  4RCP A;  4YYP A;  3P37 A;  3BZI A;  4WHK A;  4LKM A;  3FVH A;  1Q4O A;  4H5X A;  4RS6 A;  4X9R A;  5DMS A;  5DNJ A;  5DMV C;  3Q1I A;  4LKL A;  4WHL A;  4DFW A;  3P2Z A;  3P35 A;  3P2W A;  4H71 A;  4HY2 A;  4XB0 A;  3RQ7 A;  4E67 A;  1Q4K A; 
#chains in the Genus database with same CATH topology
 2OGQ A;  3GYV A;  3HIH A;  1E2S P;  3HIK A;  3GYW A;  3P36 A;  1A87 A;  4HAB A;  4O9W A;  4CXU A;  1F32 A;  1UMW A;  4X9V A;  3C5L A;  4LKM A;  1Q4O A;  1E1Z P;  4H5X A;  4X9R A;  2UV8 G;  4WHL A;  3P35 A;  4HY2 A;  4H71 A;  4XB0 A;  1N2K A;  4CXK A;  3LXQ A;  1HDH A;  4FDI A;  1N2L A;  2IA9 A;  4O56 A;  3FS3 A;  2N19 A;  5LHZ A;  4N9J A;  3ED4 A;  3LM3 A;  4NKB A;  4WHH A;  4E9D A;  4RCP A;  4YYP A;  4N7V A;  3HFD A;  3HMJ G;  4CYS A;  2VKZ G;  4WHK A;  3P34 A;  5AJ9 A;  4J7B B;  4E9C A;  1E3C P;  2I9X A;  3P37 A;  2E50 A;  3FVH A;  2I9Z A;  4G7N A;  5DNJ A;  5DMV C;  3Q1I A;  4LKL A;  1FSU A;  4NK7 A;  3P2Z A;  3P2W A;  3RQ7 A;  3KDR A;  4HCO A;  4X9W A;  2OJX A;  4O6W A;  1F34 B;  5DAY A;  1E2T A;  5J19 A;  1P49 A;  3BZI A;  1AUK A;  2QZU A;  4N7Z A;  1E33 P;  4RS6 A;  5DMS A;  4FDJ A;  4CXS A;  4DFW A;  4E67 A;  4CYR A;  1Q4K A; 
#chains in the Genus database with same CATH homology
 4HCO A;  4X9W A;  2OJX A;  3P34 A;  2OGQ A;  4O6W A;  3HIH A;  4J7B B;  3HIK A;  4O56 A;  4E9C A;  3P36 A;  4HAB A;  2N19 A;  4O9W A;  5LHZ A;  5J19 A;  1UMW A;  4X9V A;  4WHH A;  4E9D A;  3C5L A;  4RCP A;  4YYP A;  3P37 A;  3BZI A;  4WHK A;  4LKM A;  3FVH A;  1Q4O A;  4H5X A;  4RS6 A;  4X9R A;  5DMS A;  5DNJ A;  5DMV C;  3Q1I A;  4LKL A;  4WHL A;  4DFW A;  3P2Z A;  3P35 A;  3P2W A;  4H71 A;  4HY2 A;  4XB0 A;  3RQ7 A;  4E67 A;  1Q4K A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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