4H71A

Human plk1-pbd in complex with poloxime ((e)-4-(hydroxyimino)-2-isopropyl-5-methylcyclohexa-2,5-dienone)
Total Genus 72
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
72
sequence length
223
structure length
222
Chain Sequence
DCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Serine/threonine-protein kinase PLK1
publication title Thymoquinone Blocks pSer/pThr Recognition by Plk1 Polo-Box Domain As a Phosphate Mimic
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase/transferase inhibitor
total genus 72
structure length 222
sequence length 223
chains with identical sequence B
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2012-09-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4h71A02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4h71A01
1Q4OA 1Q4KA 4H71A 4XB0A 3HIHA 5DMSA 4HABA 4O56A 4WHKA 5LHZA 3P37A 2N19A 2OJXA 3HIKA 4LKLA 4J7BB 4HCOA 4E67A 2OGQA 4YYPA 3BZIA 4LKMA 3C5LA 3P36A 3P2WA 4E9DA 5DNJA 4E9CA 1UMWA 3FVHA 4RS6A 5J19A 4HY2A 5DMVC 3P34A 4O6WA 4RCPA 4WHHA 4DFWA 3P35A 3Q1IA 3P2ZA 4X9RA 4O9WA 3RQ7A 4X9VA 4WHLA 4X9WA 4H5XA
chains in the Genus database with same CATH superfamily
4XB0A 4N7VA 3P37A 1FSUA 1HDHA 2OGQA 2IA9A 1E33P 4E9DA 3GYWA 4CXKA 5J19A 1E2TA 4RCPA 1N2LA 3P35A 3P2ZA 4X9RA 1N2KA 3RQ7A 4N7ZA 4H71A 4CYRA 5DMSA 4HABA 4NKBA 3GYVA 2OJXA 3HIKA 3KDRA 4LKLA 4J7BB 2I9ZA 4HCOA 1E2SP 5DAYA 3BZIA 1F32A 3P2WA 4CXSA 4HY2A 4FDJA 4X9VA 4H5XA 3HIHA 4FDIA 4O56A 5LHZA 4G7NA 2QZUA 1F34B 3LXQA 4NK7A 4CYSA 2I9XA 4E67A 4LKMA 5DMVC 4O6WA 4WHHA 4DFWA 1E1ZP 1A87A 4O9WA 2UV8G 1Q4OA 1Q4KA 5AJ9A 4WHKA 3ED4A 3LM3A 2N19A 4YYPA 2VKZG 3C5LA 3P36A 4CXUA 5DNJA 4E9CA 1UMWA 3FVHA 3FS3A 4RS6A 2E50A 3P34A 3HMJG 1E3CP 3HFDA 3Q1IA 1P49A 4N9JA 4WHLA 4X9WA 1AUKA
chains in the Genus database with same CATH topology
1Q4OA 1Q4KA 4H71A 4XB0A 3HIHA 5DMSA 4HABA 4O56A 4WHKA 5LHZA 3P37A 2N19A 2OJXA 3HIKA 4LKLA 4J7BB 4HCOA 4E67A 2OGQA 4YYPA 3BZIA 4LKMA 3C5LA 3P36A 3P2WA 4E9DA 5DNJA 4E9CA 1UMWA 3FVHA 4RS6A 5J19A 4HY2A 5DMVC 3P34A 4O6WA 4RCPA 4WHHA 4DFWA 3P35A 3Q1IA 3P2ZA 4X9RA 4O9WA 3RQ7A 4X9VA 4WHLA 4X9WA 4H5XA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1Q4O A;  1Q4K A;  4H71 A;  4XB0 A;  3HIH A;  5DMS A;  4HAB A;  4O56 A;  4WHK A;  5LHZ A;  3P37 A;  2N19 A;  2OJX A;  3HIK A;  4LKL A;  4J7B B;  4HCO A;  4E67 A;  2OGQ A;  4YYP A;  3BZI A;  4LKM A;  3C5L A;  3P36 A;  3P2W A;  4E9D A;  5DNJ A;  4E9C A;  1UMW A;  3FVH A;  4RS6 A;  5J19 A;  4HY2 A;  5DMV C;  3P34 A;  4O6W A;  4RCP A;  4WHH A;  4DFW A;  3P35 A;  3Q1I A;  3P2Z A;  4X9R A;  4O9W A;  3RQ7 A;  4X9V A;  4WHL A;  4X9W A;  4H5X A; 
#chains in the Genus database with same CATH topology
 4XB0 A;  4N7V A;  3P37 A;  1FSU A;  1HDH A;  2OGQ A;  2IA9 A;  1E33 P;  4E9D A;  3GYW A;  4CXK A;  5J19 A;  1E2T A;  4RCP A;  1N2L A;  3P35 A;  3P2Z A;  4X9R A;  1N2K A;  3RQ7 A;  4N7Z A;  4H71 A;  4CYR A;  5DMS A;  4HAB A;  4NKB A;  3GYV A;  2OJX A;  3HIK A;  3KDR A;  4LKL A;  4J7B B;  2I9Z A;  4HCO A;  1E2S P;  5DAY A;  3BZI A;  1F32 A;  3P2W A;  4CXS A;  4HY2 A;  4FDJ A;  4X9V A;  4H5X A;  3HIH A;  4FDI A;  4O56 A;  5LHZ A;  4G7N A;  2QZU A;  1F34 B;  3LXQ A;  4NK7 A;  4CYS A;  2I9X A;  4E67 A;  4LKM A;  5DMV C;  4O6W A;  4WHH A;  4DFW A;  1E1Z P;  1A87 A;  4O9W A;  2UV8 G;  1Q4O A;  1Q4K A;  5AJ9 A;  4WHK A;  3ED4 A;  3LM3 A;  2N19 A;  4YYP A;  2VKZ G;  3C5L A;  3P36 A;  4CXU A;  5DNJ A;  4E9C A;  1UMW A;  3FVH A;  3FS3 A;  4RS6 A;  2E50 A;  3P34 A;  3HMJ G;  1E3C P;  3HFD A;  3Q1I A;  1P49 A;  4N9J A;  4WHL A;  4X9W A;  1AUK A; 
#chains in the Genus database with same CATH homology
 1Q4O A;  1Q4K A;  4H71 A;  4XB0 A;  3HIH A;  5DMS A;  4HAB A;  4O56 A;  4WHK A;  5LHZ A;  3P37 A;  2N19 A;  2OJX A;  3HIK A;  4LKL A;  4J7B B;  4HCO A;  4E67 A;  2OGQ A;  4YYP A;  3BZI A;  4LKM A;  3C5L A;  3P36 A;  3P2W A;  4E9D A;  5DNJ A;  4E9C A;  1UMW A;  3FVH A;  4RS6 A;  5J19 A;  4HY2 A;  5DMV C;  3P34 A;  4O6W A;  4RCP A;  4WHH A;  4DFW A;  3P35 A;  3Q1I A;  3P2Z A;  4X9R A;  4O9W A;  3RQ7 A;  4X9V A;  4WHL A;  4X9W A;  4H5X A; 
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similar chains in the Genus database (?% sequence similarity)
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