3HIHA

Structure of human plk1-pbd with glycerol and sulfate in the phophopeptide binding site
Total Genus 74
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
74
sequence length
223
structure length
223
Chain Sequence
DCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Serine/threonine-protein kinase PLK1
publication title Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
total genus 74
structure length 223
sequence length 223
chains with identical sequence B
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2009-05-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 3hihA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 3hihA01
3C5LA 3P34A 5DMVC 4J7BB 5LHZA 2OGQA 3P37A 3P35A 3Q1IA 3HIHA 4O56A 3HIKA 4RS6A 4WHKA 4E67A 5DMSA 4WHLA 3P36A 4LKLA 5J19A 3P2WA 3P2ZA 4H71A 4X9VA 2OJXA 1Q4KA 4LKMA 4H5XA 4X9WA 4O6WA 1Q4OA 4HCOA 4WHHA 2N19A 3RQ7A 4RCPA 4X9RA 4E9DA 5DNJA 4XB0A 4DFWA 4YYPA 4HY2A 4O9WA 1UMWA 3FVHA 4E9CA 4HABA 3BZIA
chains in the Genus database with same CATH superfamily
5LHZA 1N2KA 3P35A 3HIHA 4WHKA 4E67A 2VKZG 3P2ZA 1F34B 4H71A 1Q4KA 4HCOA 1AUKA 2N19A 1A87A 3LM3A 4N7VA 4HABA 4NKBA 4FDJA 3FS3A 3P34A 3P37A 3Q1IA 3GYWA 3HIKA 2I9ZA 4LKLA 5J19A 3P2WA 3ED4A 1FSUA 2UV8G 1P49A 4LKMA 4CXUA 2I9XA 4O6WA 1F32A 1Q4OA 1E3CP 4XB0A 4YYPA 4N9JA 1E1ZP 4O9WA 1UMWA 4E9CA 3BZIA 3C5LA 5DMVC 4J7BB 4CXKA 2QZUA 2IA9A 3P36A 1N2LA 4X9VA 2OJXA 4H5XA 4X9WA 5AJ9A 1E2TA 4X9RA 3HMJG 4E9DA 1E33P 1E2SP 4HY2A 3FVHA 4CYSA 2OGQA 4O56A 2E50A 4RS6A 5DMSA 4WHLA 3LXQA 4NK7A 1HDHA 4WHHA 3RQ7A 4RCPA 4G7NA 4CYRA 5DNJA 3GYVA 3HFDA 3KDRA 4FDIA 4DFWA 5DAYA 4CXSA 4N7ZA
chains in the Genus database with same CATH topology
3C5LA 3P34A 5DMVC 4J7BB 5LHZA 2OGQA 3P37A 3P35A 3Q1IA 3HIHA 4O56A 3HIKA 4RS6A 4WHKA 4E67A 5DMSA 4WHLA 3P36A 4LKLA 5J19A 3P2WA 3P2ZA 4H71A 4X9VA 2OJXA 1Q4KA 4LKMA 4H5XA 4X9WA 4O6WA 1Q4OA 4HCOA 4WHHA 2N19A 3RQ7A 4RCPA 4X9RA 4E9DA 5DNJA 4XB0A 4DFWA 4YYPA 4HY2A 4O9WA 1UMWA 3FVHA 4E9CA 4HABA 3BZIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3C5L A;  3P34 A;  5DMV C;  4J7B B;  5LHZ A;  2OGQ A;  3P37 A;  3P35 A;  3Q1I A;  3HIH A;  4O56 A;  3HIK A;  4RS6 A;  4WHK A;  4E67 A;  5DMS A;  4WHL A;  3P36 A;  4LKL A;  5J19 A;  3P2W A;  3P2Z A;  4H71 A;  4X9V A;  2OJX A;  1Q4K A;  4LKM A;  4H5X A;  4X9W A;  4O6W A;  1Q4O A;  4HCO A;  4WHH A;  2N19 A;  3RQ7 A;  4RCP A;  4X9R A;  4E9D A;  5DNJ A;  4XB0 A;  4DFW A;  4YYP A;  4HY2 A;  4O9W A;  1UMW A;  3FVH A;  4E9C A;  4HAB A;  3BZI A; 
#chains in the Genus database with same CATH topology
 5LHZ A;  1N2K A;  3P35 A;  3HIH A;  4WHK A;  4E67 A;  2VKZ G;  3P2Z A;  1F34 B;  4H71 A;  1Q4K A;  4HCO A;  1AUK A;  2N19 A;  1A87 A;  3LM3 A;  4N7V A;  4HAB A;  4NKB A;  4FDJ A;  3FS3 A;  3P34 A;  3P37 A;  3Q1I A;  3GYW A;  3HIK A;  2I9Z A;  4LKL A;  5J19 A;  3P2W A;  3ED4 A;  1FSU A;  2UV8 G;  1P49 A;  4LKM A;  4CXU A;  2I9X A;  4O6W A;  1F32 A;  1Q4O A;  1E3C P;  4XB0 A;  4YYP A;  4N9J A;  1E1Z P;  4O9W A;  1UMW A;  4E9C A;  3BZI A;  3C5L A;  5DMV C;  4J7B B;  4CXK A;  2QZU A;  2IA9 A;  3P36 A;  1N2L A;  4X9V A;  2OJX A;  4H5X A;  4X9W A;  5AJ9 A;  1E2T A;  4X9R A;  3HMJ G;  4E9D A;  1E33 P;  1E2S P;  4HY2 A;  3FVH A;  4CYS A;  2OGQ A;  4O56 A;  2E50 A;  4RS6 A;  5DMS A;  4WHL A;  3LXQ A;  4NK7 A;  1HDH A;  4WHH A;  3RQ7 A;  4RCP A;  4G7N A;  4CYR A;  5DNJ A;  3GYV A;  3HFD A;  3KDR A;  4FDI A;  4DFW A;  5DAY A;  4CXS A;  4N7Z A; 
#chains in the Genus database with same CATH homology
 3C5L A;  3P34 A;  5DMV C;  4J7B B;  5LHZ A;  2OGQ A;  3P37 A;  3P35 A;  3Q1I A;  3HIH A;  4O56 A;  3HIK A;  4RS6 A;  4WHK A;  4E67 A;  5DMS A;  4WHL A;  3P36 A;  4LKL A;  5J19 A;  3P2W A;  3P2Z A;  4H71 A;  4X9V A;  2OJX A;  1Q4K A;  4LKM A;  4H5X A;  4X9W A;  4O6W A;  1Q4O A;  4HCO A;  4WHH A;  2N19 A;  3RQ7 A;  4RCP A;  4X9R A;  4E9D A;  5DNJ A;  4XB0 A;  4DFW A;  4YYP A;  4HY2 A;  4O9W A;  1UMW A;  3FVH A;  4E9C A;  4HAB A;  3BZI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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