3HIHA

Structure of human plk1-pbd with glycerol and sulfate in the phophopeptide binding site
Total Genus 74
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
74
sequence length
223
structure length
223
Chain Sequence
DCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
molecule keywords Serine/threonine-protein kinase PLK1
publication title Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1.
pubmed doi rcsb
source organism Homo sapiens
total genus 74
structure length 223
sequence length 223
chains with identical sequence B
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2009-05-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 3hihA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 3hihA01
3P34A 1Q4KA 5DNJA 2OGQA 4RCPA 4WHHA 1UMWA 4X9RA 4E9CA 4HY2A 3Q1IA 4E9DA 3P35A 4LKLA 4O9WA 4J7BB 4LKMA 3P2ZA 4RS6A 3P2WA 3RQ7A 4O6WA 3C5LA 3HIKA 4E67A 4H71A 3BZIA 3HIHA 5DMVC 4YYPA 2OJXA 4DFWA 2N19A 5LHZA 3P36A 1Q4OA 3P37A 4O56A 4XB0A 4H5XA 4WHKA 4X9VA 5J19A 5DMSA 4HABA 4HCOA 3FVHA 4X9WA 4WHLA
chains in the Genus database with same CATH superfamily
1Q4KA 4CXSA 4RCPA 5AJ9A 4HY2A 2VKZG 1A87A 4N7VA 3BZIA 3HIHA 4YYPA 1E1ZP 4O56A 5DMSA 1AUKA 3FVHA 3FS3A 4NKBA 2I9ZA 1UMWA 1N2KA 1N2LA 3P35A 4N9JA 3GYVA 4O9WA 4J7BB 4CYSA 4CYRA 4O6WA 3C5LA 5DMVC 4E67A 4H71A 1P49A 5DAYA 2IA9A 2N19A 4CXUA 4H5XA 5J19A 4HABA 1E33P 4G7NA 4WHKA 2I9XA 4X9RA 3HFDA 2QZUA 4LKLA 4LKMA 1HDHA 3P2ZA 4RS6A 3RQ7A 1FSUA 3ED4A 3HIKA 2UV8G 2OJXA 4N7ZA 5LHZA 4NK7A 1Q4OA 4XB0A 3LM3A 4FDIA 4X9WA 4WHLA 3P34A 5DNJA 2E50A 2OGQA 4WHHA 4E9CA 3KDRA 1F34B 3Q1IA 4E9DA 1E2SP 1E3CP 3P2WA 3GYWA 4CXKA 1F32A 4DFWA 3LXQA 3P36A 3P37A 4X9VA 4FDJA 3HMJG 1E2TA 4HCOA
chains in the Genus database with same CATH topology
3P34A 1Q4KA 5DNJA 2OGQA 4RCPA 4WHHA 1UMWA 4X9RA 4E9CA 4HY2A 3Q1IA 4E9DA 3P35A 4LKLA 4O9WA 4J7BB 4LKMA 3P2ZA 4RS6A 3P2WA 3RQ7A 4O6WA 3C5LA 3HIKA 4E67A 4H71A 3BZIA 3HIHA 5DMVC 4YYPA 2OJXA 4DFWA 2N19A 5LHZA 3P36A 1Q4OA 3P37A 4O56A 4XB0A 4H5XA 4WHKA 4X9VA 5J19A 5DMSA 4HABA 4HCOA 3FVHA 4X9WA 4WHLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3P34 A;  1Q4K A;  5DNJ A;  2OGQ A;  4RCP A;  4WHH A;  1UMW A;  4X9R A;  4E9C A;  4HY2 A;  3Q1I A;  4E9D A;  3P35 A;  4LKL A;  4O9W A;  4J7B B;  4LKM A;  3P2Z A;  4RS6 A;  3P2W A;  3RQ7 A;  4O6W A;  3C5L A;  3HIK A;  4E67 A;  4H71 A;  3BZI A;  3HIH A;  5DMV C;  4YYP A;  2OJX A;  4DFW A;  2N19 A;  5LHZ A;  3P36 A;  1Q4O A;  3P37 A;  4O56 A;  4XB0 A;  4H5X A;  4WHK A;  4X9V A;  5J19 A;  5DMS A;  4HAB A;  4HCO A;  3FVH A;  4X9W A;  4WHL A; 
#chains in the Genus database with same CATH topology
 1Q4K A;  4CXS A;  4RCP A;  5AJ9 A;  4HY2 A;  2VKZ G;  1A87 A;  4N7V A;  3BZI A;  3HIH A;  4YYP A;  1E1Z P;  4O56 A;  5DMS A;  1AUK A;  3FVH A;  3FS3 A;  4NKB A;  2I9Z A;  1UMW A;  1N2K A;  1N2L A;  3P35 A;  4N9J A;  3GYV A;  4O9W A;  4J7B B;  4CYS A;  4CYR A;  4O6W A;  3C5L A;  5DMV C;  4E67 A;  4H71 A;  1P49 A;  5DAY A;  2IA9 A;  2N19 A;  4CXU A;  4H5X A;  5J19 A;  4HAB A;  1E33 P;  4G7N A;  4WHK A;  2I9X A;  4X9R A;  3HFD A;  2QZU A;  4LKL A;  4LKM A;  1HDH A;  3P2Z A;  4RS6 A;  3RQ7 A;  1FSU A;  3ED4 A;  3HIK A;  2UV8 G;  2OJX A;  4N7Z A;  5LHZ A;  4NK7 A;  1Q4O A;  4XB0 A;  3LM3 A;  4FDI A;  4X9W A;  4WHL A;  3P34 A;  5DNJ A;  2E50 A;  2OGQ A;  4WHH A;  4E9C A;  3KDR A;  1F34 B;  3Q1I A;  4E9D A;  1E2S P;  1E3C P;  3P2W A;  3GYW A;  4CXK A;  1F32 A;  4DFW A;  3LXQ A;  3P36 A;  3P37 A;  4X9V A;  4FDJ A;  3HMJ G;  1E2T A;  4HCO A; 
#chains in the Genus database with same CATH homology
 3P34 A;  1Q4K A;  5DNJ A;  2OGQ A;  4RCP A;  4WHH A;  1UMW A;  4X9R A;  4E9C A;  4HY2 A;  3Q1I A;  4E9D A;  3P35 A;  4LKL A;  4O9W A;  4J7B B;  4LKM A;  3P2Z A;  4RS6 A;  3P2W A;  3RQ7 A;  4O6W A;  3C5L A;  3HIK A;  4E67 A;  4H71 A;  3BZI A;  3HIH A;  5DMV C;  4YYP A;  2OJX A;  4DFW A;  2N19 A;  5LHZ A;  3P36 A;  1Q4O A;  3P37 A;  4O56 A;  4XB0 A;  4H5X A;  4WHK A;  4X9V A;  5J19 A;  5DMS A;  4HAB A;  4HCO A;  3FVH A;  4X9W A;  4WHL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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