4E9CA

The structure of the polo-box domain (pbd) of polo-like kinase 1 (plk1) in complex with ldpplhspta phosphopeptide
Total Genus 74
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
74
sequence length
223
structure length
223
Chain Sequence
b'CHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSR'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Serine/threonine-protein kinase PLK1
publication title High-throughput interrogation of ligand binding mode using a fluorescence-based assay.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase/transferase inhibitor
total genus 74
structure length 223
sequence length 223
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2012-03-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4e9cA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4e9cA01
5DMSA 4HABA 5LHZA 2OJXA 4RS6A 4RCPA 4J7BB 3HIHA 4H71A 4WHLA 3P36A 3P37A 4DFWA 4E67A 4WHKA 2OGQA 4O56A 4YYPA 4H5XA 4LKLA 3P2WA 1Q4KA 1UMWA 3RQ7A 3P34A 4X9WA 4E9CA 4E9DA 4X9VA 4HCOA 4WHHA 4LKMA 4O9WA 3HIKA 3C5LA 3FVHA 4HY2A 4XB0A 3BZIA 5J19A 3Q1IA 4O6WA 5DNJA 5DMVC 3P2ZA 2N19A 4X9RA 1Q4OA 3P35A
chains in the Genus database with same CATH superfamily
1HDHA 2E50A 4NK7A 4WHKA 3FS3A 4CXUA 4H5XA 4CYSA 5DAYA 4X9VA 4HY2A 4XB0A 1AUKA 4O6WA 4X9RA 1Q4OA 1FSUA 5DMSA 3HIHA 1E2TA 4H71A 3P36A 2UV8G 3P37A 4E67A 4CXSA 4LKLA 1Q4KA 1UMWA 3ED4A 2VKZG 3P2WA 2I9XA 4FDJA 1N2KA 4O9WA 4NKBA 3C5LA 3FVHA 1A87A 4G7NA 4N9JA 5J19A 2QZUA 5DMVC 2I9ZA 3P35A 3HFDA 1F32A 2OJXA 4RS6A 4RCPA 3LM3A 1N2LA 2OGQA 1P49A 3HMJG 1E3CP 4E9CA 4N7ZA 1E2SP 3GYVA 3LXQA 3BZIA 1E33P 5DNJA 2N19A 4HABA 5LHZA 1F34B 4J7BB 4WHLA 4DFWA 4O56A 4YYPA 1E1ZP 3RQ7A 3P34A 4X9WA 4N7VA 4CYRA 4E9DA 3GYWA 5AJ9A 4HCOA 4WHHA 4LKMA 3KDRA 3HIKA 2IA9A 3Q1IA 3P2ZA 4CXKA 4FDIA
chains in the Genus database with same CATH topology
5DMSA 4HABA 5LHZA 2OJXA 4RS6A 4RCPA 4J7BB 3HIHA 4H71A 4WHLA 3P36A 3P37A 4DFWA 4E67A 4WHKA 2OGQA 4O56A 4YYPA 4H5XA 4LKLA 3P2WA 1Q4KA 1UMWA 3RQ7A 3P34A 4X9WA 4E9CA 4E9DA 4X9VA 4HCOA 4WHHA 4LKMA 4O9WA 3HIKA 3C5LA 3FVHA 4HY2A 4XB0A 3BZIA 5J19A 3Q1IA 4O6WA 5DNJA 5DMVC 3P2ZA 2N19A 4X9RA 1Q4OA 3P35A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5DMS A;  4HAB A;  5LHZ A;  2OJX A;  4RS6 A;  4RCP A;  4J7B B;  3HIH A;  4H71 A;  4WHL A;  3P36 A;  3P37 A;  4DFW A;  4E67 A;  4WHK A;  2OGQ A;  4O56 A;  4YYP A;  4H5X A;  4LKL A;  3P2W A;  1Q4K A;  1UMW A;  3RQ7 A;  3P34 A;  4X9W A;  4E9C A;  4E9D A;  4X9V A;  4HCO A;  4WHH A;  4LKM A;  4O9W A;  3HIK A;  3C5L A;  3FVH A;  4HY2 A;  4XB0 A;  3BZI A;  5J19 A;  3Q1I A;  4O6W A;  5DNJ A;  5DMV C;  3P2Z A;  2N19 A;  4X9R A;  1Q4O A;  3P35 A; 
#chains in the Genus database with same CATH topology
 1HDH A;  2E50 A;  4NK7 A;  4WHK A;  3FS3 A;  4CXU A;  4H5X A;  4CYS A;  5DAY A;  4X9V A;  4HY2 A;  4XB0 A;  1AUK A;  4O6W A;  4X9R A;  1Q4O A;  1FSU A;  5DMS A;  3HIH A;  1E2T A;  4H71 A;  3P36 A;  2UV8 G;  3P37 A;  4E67 A;  4CXS A;  4LKL A;  1Q4K A;  1UMW A;  3ED4 A;  2VKZ G;  3P2W A;  2I9X A;  4FDJ A;  1N2K A;  4O9W A;  4NKB A;  3C5L A;  3FVH A;  1A87 A;  4G7N A;  4N9J A;  5J19 A;  2QZU A;  5DMV C;  2I9Z A;  3P35 A;  3HFD A;  1F32 A;  2OJX A;  4RS6 A;  4RCP A;  3LM3 A;  1N2L A;  2OGQ A;  1P49 A;  3HMJ G;  1E3C P;  4E9C A;  4N7Z A;  1E2S P;  3GYV A;  3LXQ A;  3BZI A;  1E33 P;  5DNJ A;  2N19 A;  4HAB A;  5LHZ A;  1F34 B;  4J7B B;  4WHL A;  4DFW A;  4O56 A;  4YYP A;  1E1Z P;  3RQ7 A;  3P34 A;  4X9W A;  4N7V A;  4CYR A;  4E9D A;  3GYW A;  5AJ9 A;  4HCO A;  4WHH A;  4LKM A;  3KDR A;  3HIK A;  2IA9 A;  3Q1I A;  3P2Z A;  4CXK A;  4FDI A; 
#chains in the Genus database with same CATH homology
 5DMS A;  4HAB A;  5LHZ A;  2OJX A;  4RS6 A;  4RCP A;  4J7B B;  3HIH A;  4H71 A;  4WHL A;  3P36 A;  3P37 A;  4DFW A;  4E67 A;  4WHK A;  2OGQ A;  4O56 A;  4YYP A;  4H5X A;  4LKL A;  3P2W A;  1Q4K A;  1UMW A;  3RQ7 A;  3P34 A;  4X9W A;  4E9C A;  4E9D A;  4X9V A;  4HCO A;  4WHH A;  4LKM A;  4O9W A;  3HIK A;  3C5L A;  3FVH A;  4HY2 A;  4XB0 A;  3BZI A;  5J19 A;  3Q1I A;  4O6W A;  5DNJ A;  5DMV C;  3P2Z A;  2N19 A;  4X9R A;  1Q4O A;  3P35 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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