4E9CA

The structure of the polo-box domain (pbd) of polo-like kinase 1 (plk1) in complex with ldpplhspta phosphopeptide
Total Genus 74
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
74
sequence length
223
structure length
223
Chain Sequence
CHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase/transferase inhibitor
molecule keywords Serine/threonine-protein kinase PLK1
publication title High-throughput interrogation of ligand binding mode using a fluorescence-based assay.
pubmed doi rcsb
source organism Homo sapiens
total genus 74
structure length 223
sequence length 223
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2012-03-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4e9cA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4e9cA01
4X9WA 1Q4KA 3P34A 3P36A 5DNJA 4H5XA 4E9CA 4WHHA 2OGQA 2N19A 1UMWA 4X9VA 4X9RA 4WHKA 4RCPA 4YYPA 3P37A 4WHLA 4O9WA 5DMVC 4H71A 4J7BB 4HY2A 4O6WA 3RQ7A 4O56A 3HIKA 3P2ZA 4HCOA 4E9DA 4E67A 4LKMA 4LKLA 3BZIA 3C5LA 3FVHA 2OJXA 3Q1IA 4XB0A 3P35A 1Q4OA 4RS6A 5J19A 4DFWA 4HABA 5LHZA 5DMSA 3P2WA 3HIHA
chains in the Genus database with same CATH superfamily
2I9XA 1Q4KA 4WHHA 2OGQA 4N7VA 1E33P 1P49A 5DMVC 4H71A 4J7BB 4NK7A 4NKBA 2VKZG 3C5LA 2OJXA 4DFWA 4HABA 4H5XA 2E50A 1E2SP 2QZUA 4CXUA 1F34B 3P36A 1FSUA 2N19A 4X9VA 3FS3A 4RCPA 4YYPA 3P37A 3HMJG 1HDHA 4O9WA 4FDIA 4O6WA 1E1ZP 4HCOA 4E9DA 4E67A 4LKLA 3FVHA 3P35A 1N2LA 1AUKA 4X9WA 3HIHA 1E3CP 3P34A 5DAYA 4N7ZA 4N9JA 3GYVA 3HFDA 4FDJA 3KDRA 1A87A 4CYSA 4HY2A 3RQ7A 4O56A 3HIKA 4CYRA 1E2TA 2IA9A 3Q1IA 3LXQA 1N2KA 5J19A 5DMSA 3GYWA 2I9ZA 2UV8G 4E9CA 1F32A 1UMWA 4CXKA 4X9RA 4CXSA 4WHKA 4WHLA 4G7NA 5AJ9A 3P2ZA 3ED4A 4LKMA 3BZIA 4XB0A 1Q4OA 4RS6A 3LM3A 5LHZA 3P2WA 5DNJA
chains in the Genus database with same CATH topology
4X9WA 1Q4KA 3P34A 3P36A 5DNJA 4H5XA 4E9CA 4WHHA 2OGQA 2N19A 1UMWA 4X9VA 4X9RA 4WHKA 4RCPA 4YYPA 3P37A 4WHLA 4O9WA 5DMVC 4H71A 4J7BB 4HY2A 4O6WA 3RQ7A 4O56A 3HIKA 3P2ZA 4HCOA 4E9DA 4E67A 4LKMA 4LKLA 3BZIA 3C5LA 3FVHA 2OJXA 3Q1IA 4XB0A 3P35A 1Q4OA 4RS6A 5J19A 4DFWA 4HABA 5LHZA 5DMSA 3P2WA 3HIHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4X9W A;  1Q4K A;  3P34 A;  3P36 A;  5DNJ A;  4H5X A;  4E9C A;  4WHH A;  2OGQ A;  2N19 A;  1UMW A;  4X9V A;  4X9R A;  4WHK A;  4RCP A;  4YYP A;  3P37 A;  4WHL A;  4O9W A;  5DMV C;  4H71 A;  4J7B B;  4HY2 A;  4O6W A;  3RQ7 A;  4O56 A;  3HIK A;  3P2Z A;  4HCO A;  4E9D A;  4E67 A;  4LKM A;  4LKL A;  3BZI A;  3C5L A;  3FVH A;  2OJX A;  3Q1I A;  4XB0 A;  3P35 A;  1Q4O A;  4RS6 A;  5J19 A;  4DFW A;  4HAB A;  5LHZ A;  5DMS A;  3P2W A;  3HIH A; 
#chains in the Genus database with same CATH topology
 2I9X A;  1Q4K A;  4WHH A;  2OGQ A;  4N7V A;  1E33 P;  1P49 A;  5DMV C;  4H71 A;  4J7B B;  4NK7 A;  4NKB A;  2VKZ G;  3C5L A;  2OJX A;  4DFW A;  4HAB A;  4H5X A;  2E50 A;  1E2S P;  2QZU A;  4CXU A;  1F34 B;  3P36 A;  1FSU A;  2N19 A;  4X9V A;  3FS3 A;  4RCP A;  4YYP A;  3P37 A;  3HMJ G;  1HDH A;  4O9W A;  4FDI A;  4O6W A;  1E1Z P;  4HCO A;  4E9D A;  4E67 A;  4LKL A;  3FVH A;  3P35 A;  1N2L A;  1AUK A;  4X9W A;  3HIH A;  1E3C P;  3P34 A;  5DAY A;  4N7Z A;  4N9J A;  3GYV A;  3HFD A;  4FDJ A;  3KDR A;  1A87 A;  4CYS A;  4HY2 A;  3RQ7 A;  4O56 A;  3HIK A;  4CYR A;  1E2T A;  2IA9 A;  3Q1I A;  3LXQ A;  1N2K A;  5J19 A;  5DMS A;  3GYW A;  2I9Z A;  2UV8 G;  4E9C A;  1F32 A;  1UMW A;  4CXK A;  4X9R A;  4CXS A;  4WHK A;  4WHL A;  4G7N A;  5AJ9 A;  3P2Z A;  3ED4 A;  4LKM A;  3BZI A;  4XB0 A;  1Q4O A;  4RS6 A;  3LM3 A;  5LHZ A;  3P2W A;  5DNJ A; 
#chains in the Genus database with same CATH homology
 4X9W A;  1Q4K A;  3P34 A;  3P36 A;  5DNJ A;  4H5X A;  4E9C A;  4WHH A;  2OGQ A;  2N19 A;  1UMW A;  4X9V A;  4X9R A;  4WHK A;  4RCP A;  4YYP A;  3P37 A;  4WHL A;  4O9W A;  5DMV C;  4H71 A;  4J7B B;  4HY2 A;  4O6W A;  3RQ7 A;  4O56 A;  3HIK A;  3P2Z A;  4HCO A;  4E9D A;  4E67 A;  4LKM A;  4LKL A;  3BZI A;  3C5L A;  3FVH A;  2OJX A;  3Q1I A;  4XB0 A;  3P35 A;  1Q4O A;  4RS6 A;  5J19 A;  4DFW A;  4HAB A;  5LHZ A;  5DMS A;  3P2W A;  3HIH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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