4E9CA

The structure of the polo-box domain (pbd) of polo-like kinase 1 (plk1) in complex with ldpplhspta phosphopeptide
Total Genus 74
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
74
sequence length
223
structure length
223
Chain Sequence
CHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title High-throughput interrogation of ligand binding mode using a fluorescence-based assay.
pubmed doi rcsb
molecule tags Transferase/transferase inhibitor
source organism Homo sapiens
molecule keywords Serine/threonine-protein kinase PLK1
total genus 74
structure length 223
sequence length 223
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2012-03-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4e9cA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4e9cA01
2N19A 4H5XA 4YYPA 3P34A 4WHKA 3RQ7A 3FVHA 3P2WA 4X9WA 3P2ZA 4O9WA 3C5LA 4WHLA 4XB0A 5DMVC 4HABA 4O6WA 4X9VA 5DNJA 1Q4OA 4E9CA 3HIKA 2OJXA 4DFWA 5DMSA 1Q4KA 3P35A 3P36A 4HCOA 5J19A 3HIHA 4H71A 4LKMA 1UMWA 4WHHA 4X9RA 4E67A 3Q1IA 4RCPA 2OGQA 4HY2A 4J7BB 4RS6A 4LKLA 5LHZA 3P37A 4O56A 4E9DA 3BZIA
chains in the Genus database with same CATH superfamily
2N19A 4G7NA 4WHKA 3FVHA 3P2WA 1N2KA 3ED4A 4XB0A 3KDRA 4CYSA 2I9ZA 4HABA 3FS3A 1Q4OA 3HIKA 3HMJG 3P35A 3P36A 1E1ZP 4H71A 1UMWA 3Q1IA 4CXUA 3LM3A 3P37A 4O56A 4N7VA 5DAYA 3P34A 1FSUA 5AJ9A 3RQ7A 3P2ZA 4O9WA 3C5LA 3HFDA 1F34B 5DMSA 1Q4KA 1E2TA 1E33P 5J19A 4WHHA 4X9RA 4RCPA 1P49A 2UV8G 4NKBA 4LKLA 5LHZA 1AUKA 4FDJA 2QZUA 4CXKA 4X9WA 2E50A 3GYVA 4WHLA 5DMVC 4CXSA 2OJXA 1N2LA 2IA9A 4HCOA 3HIHA 3LXQA 4LKMA 4NK7A 4J7BB 4RS6A 4N9JA 4FDIA 3GYWA 4CYRA 4H5XA 4YYPA 2I9XA 1F32A 1HDHA 4O6WA 4X9VA 2VKZG 5DNJA 4E9CA 4DFWA 4E67A 1A87A 2OGQA 4HY2A 4E9DA 1E2SP 1E3CP 3BZIA 4N7ZA
chains in the Genus database with same CATH topology
2N19A 4H5XA 4YYPA 3P34A 4WHKA 3RQ7A 3FVHA 3P2WA 4X9WA 3P2ZA 4O9WA 3C5LA 4WHLA 4XB0A 5DMVC 4HABA 4O6WA 4X9VA 5DNJA 1Q4OA 4E9CA 3HIKA 2OJXA 4DFWA 5DMSA 1Q4KA 3P35A 3P36A 4HCOA 5J19A 3HIHA 4H71A 4LKMA 1UMWA 4WHHA 4X9RA 4E67A 3Q1IA 4RCPA 2OGQA 4HY2A 4J7BB 4RS6A 4LKLA 5LHZA 3P37A 4O56A 4E9DA 3BZIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2N19 A;  4H5X A;  4YYP A;  3P34 A;  4WHK A;  3RQ7 A;  3FVH A;  3P2W A;  4X9W A;  3P2Z A;  4O9W A;  3C5L A;  4WHL A;  4XB0 A;  5DMV C;  4HAB A;  4O6W A;  4X9V A;  5DNJ A;  1Q4O A;  4E9C A;  3HIK A;  2OJX A;  4DFW A;  5DMS A;  1Q4K A;  3P35 A;  3P36 A;  4HCO A;  5J19 A;  3HIH A;  4H71 A;  4LKM A;  1UMW A;  4WHH A;  4X9R A;  4E67 A;  3Q1I A;  4RCP A;  2OGQ A;  4HY2 A;  4J7B B;  4RS6 A;  4LKL A;  5LHZ A;  3P37 A;  4O56 A;  4E9D A;  3BZI A; 
#chains in the Genus database with same CATH topology
 2N19 A;  4G7N A;  4WHK A;  3FVH A;  3P2W A;  1N2K A;  3ED4 A;  4XB0 A;  3KDR A;  4CYS A;  2I9Z A;  4HAB A;  3FS3 A;  1Q4O A;  3HIK A;  3HMJ G;  3P35 A;  3P36 A;  1E1Z P;  4H71 A;  1UMW A;  3Q1I A;  4CXU A;  3LM3 A;  3P37 A;  4O56 A;  4N7V A;  5DAY A;  3P34 A;  1FSU A;  5AJ9 A;  3RQ7 A;  3P2Z A;  4O9W A;  3C5L A;  3HFD A;  1F34 B;  5DMS A;  1Q4K A;  1E2T A;  1E33 P;  5J19 A;  4WHH A;  4X9R A;  4RCP A;  1P49 A;  2UV8 G;  4NKB A;  4LKL A;  5LHZ A;  1AUK A;  4FDJ A;  2QZU A;  4CXK A;  4X9W A;  2E50 A;  3GYV A;  4WHL A;  5DMV C;  4CXS A;  2OJX A;  1N2L A;  2IA9 A;  4HCO A;  3HIH A;  3LXQ A;  4LKM A;  4NK7 A;  4J7B B;  4RS6 A;  4N9J A;  4FDI A;  3GYW A;  4CYR A;  4H5X A;  4YYP A;  2I9X A;  1F32 A;  1HDH A;  4O6W A;  4X9V A;  2VKZ G;  5DNJ A;  4E9C A;  4DFW A;  4E67 A;  1A87 A;  2OGQ A;  4HY2 A;  4E9D A;  1E2S P;  1E3C P;  3BZI A;  4N7Z A; 
#chains in the Genus database with same CATH homology
 2N19 A;  4H5X A;  4YYP A;  3P34 A;  4WHK A;  3RQ7 A;  3FVH A;  3P2W A;  4X9W A;  3P2Z A;  4O9W A;  3C5L A;  4WHL A;  4XB0 A;  5DMV C;  4HAB A;  4O6W A;  4X9V A;  5DNJ A;  1Q4O A;  4E9C A;  3HIK A;  2OJX A;  4DFW A;  5DMS A;  1Q4K A;  3P35 A;  3P36 A;  4HCO A;  5J19 A;  3HIH A;  4H71 A;  4LKM A;  1UMW A;  4WHH A;  4X9R A;  4E67 A;  3Q1I A;  4RCP A;  2OGQ A;  4HY2 A;  4J7B B;  4RS6 A;  4LKL A;  5LHZ A;  3P37 A;  4O56 A;  4E9D A;  3BZI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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