4E9CA

The structure of the polo-box domain (pbd) of polo-like kinase 1 (plk1) in complex with ldpplhspta phosphopeptide
Total Genus 74
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
74
sequence length
223
structure length
223
Chain Sequence
CHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title High-throughput interrogation of ligand binding mode using a fluorescence-based assay.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase/transferase inhibitor
molecule keywords Serine/threonine-protein kinase PLK1
total genus 74
structure length 223
sequence length 223
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2012-03-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4e9cA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 4e9cA01
4J7BB 1Q4KA 4X9VA 3P2ZA 4WHKA 4HABA 3C5LA 4HY2A 4E9DA 3HIHA 4X9WA 5DMVC 4H5XA 5LHZA 4H71A 4LKMA 2OJXA 3P37A 3BZIA 4WHLA 3Q1IA 4E9CA 3FVHA 5DMSA 5DNJA 5J19A 4LKLA 3P34A 4YYPA 3P2WA 4O56A 2N19A 4XB0A 4WHHA 3RQ7A 1Q4OA 4X9RA 4O9WA 4HCOA 3HIKA 4RCPA 4O6WA 4DFWA 1UMWA 2OGQA 3P35A 4E67A 4RS6A 3P36A
chains in the Genus database with same CATH superfamily
4J7BB 3HFDA 2I9XA 4HY2A 4E9DA 2UV8G 5DMVC 3FS3A 3HMJG 1N2KA 4CXSA 1HDHA 5DNJA 5J19A 4O56A 4O9WA 4O6WA 5AJ9A 1F34B 1UMWA 2IA9A 3GYVA 3P35A 4FDIA 3P36A 1Q4KA 3P2ZA 1E2TA 4H71A 3P37A 3BZIA 4CXUA 4NKBA 4N7ZA 3RQ7A 2N19A 3HIKA 4CYRA 3KDRA 1FSUA 4N9JA 4X9VA 4WHKA 4HABA 3C5LA 3HIHA 4X9WA 1P49A 4G7NA 2QZUA 4WHLA 3FVHA 4NK7A 1F32A 3P2WA 4WHHA 4FDJA 3LXQA 4HCOA 4RCPA 2I9ZA 1E33P 4DFWA 2OGQA 3ED4A 4E67A 3GYWA 4RS6A 4E9CA 1E3CP 3LM3A 2VKZG 4H5XA 1N2LA 5LHZA 4LKMA 2OJXA 4N7VA 2E50A 4CXKA 3Q1IA 4CYSA 5DMSA 1A87A 4LKLA 1AUKA 3P34A 4YYPA 4XB0A 1Q4OA 4X9RA 5DAYA 1E1ZP 1E2SP
chains in the Genus database with same CATH topology
4J7BB 1Q4KA 4X9VA 3P2ZA 4WHKA 4HABA 3C5LA 4HY2A 4E9DA 3HIHA 4X9WA 5DMVC 4H5XA 5LHZA 4H71A 4LKMA 2OJXA 3P37A 3BZIA 4WHLA 3Q1IA 4E9CA 3FVHA 5DMSA 5DNJA 5J19A 4LKLA 3P34A 4YYPA 3P2WA 4O56A 2N19A 4XB0A 4WHHA 3RQ7A 1Q4OA 4X9RA 4O9WA 4HCOA 3HIKA 4RCPA 4O6WA 4DFWA 1UMWA 2OGQA 3P35A 4E67A 4RS6A 3P36A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4J7B B;  1Q4K A;  4X9V A;  3P2Z A;  4WHK A;  4HAB A;  3C5L A;  4HY2 A;  4E9D A;  3HIH A;  4X9W A;  5DMV C;  4H5X A;  5LHZ A;  4H71 A;  4LKM A;  2OJX A;  3P37 A;  3BZI A;  4WHL A;  3Q1I A;  4E9C A;  3FVH A;  5DMS A;  5DNJ A;  5J19 A;  4LKL A;  3P34 A;  4YYP A;  3P2W A;  4O56 A;  2N19 A;  4XB0 A;  4WHH A;  3RQ7 A;  1Q4O A;  4X9R A;  4O9W A;  4HCO A;  3HIK A;  4RCP A;  4O6W A;  4DFW A;  1UMW A;  2OGQ A;  3P35 A;  4E67 A;  4RS6 A;  3P36 A; 
#chains in the Genus database with same CATH topology
 4J7B B;  3HFD A;  2I9X A;  4HY2 A;  4E9D A;  2UV8 G;  5DMV C;  3FS3 A;  3HMJ G;  1N2K A;  4CXS A;  1HDH A;  5DNJ A;  5J19 A;  4O56 A;  4O9W A;  4O6W A;  5AJ9 A;  1F34 B;  1UMW A;  2IA9 A;  3GYV A;  3P35 A;  4FDI A;  3P36 A;  1Q4K A;  3P2Z A;  1E2T A;  4H71 A;  3P37 A;  3BZI A;  4CXU A;  4NKB A;  4N7Z A;  3RQ7 A;  2N19 A;  3HIK A;  4CYR A;  3KDR A;  1FSU A;  4N9J A;  4X9V A;  4WHK A;  4HAB A;  3C5L A;  3HIH A;  4X9W A;  1P49 A;  4G7N A;  2QZU A;  4WHL A;  3FVH A;  4NK7 A;  1F32 A;  3P2W A;  4WHH A;  4FDJ A;  3LXQ A;  4HCO A;  4RCP A;  2I9Z A;  1E33 P;  4DFW A;  2OGQ A;  3ED4 A;  4E67 A;  3GYW A;  4RS6 A;  4E9C A;  1E3C P;  3LM3 A;  2VKZ G;  4H5X A;  1N2L A;  5LHZ A;  4LKM A;  2OJX A;  4N7V A;  2E50 A;  4CXK A;  3Q1I A;  4CYS A;  5DMS A;  1A87 A;  4LKL A;  1AUK A;  3P34 A;  4YYP A;  4XB0 A;  1Q4O A;  4X9R A;  5DAY A;  1E1Z P;  1E2S P; 
#chains in the Genus database with same CATH homology
 4J7B B;  1Q4K A;  4X9V A;  3P2Z A;  4WHK A;  4HAB A;  3C5L A;  4HY2 A;  4E9D A;  3HIH A;  4X9W A;  5DMV C;  4H5X A;  5LHZ A;  4H71 A;  4LKM A;  2OJX A;  3P37 A;  3BZI A;  4WHL A;  3Q1I A;  4E9C A;  3FVH A;  5DMS A;  5DNJ A;  5J19 A;  4LKL A;  3P34 A;  4YYP A;  3P2W A;  4O56 A;  2N19 A;  4XB0 A;  4WHH A;  3RQ7 A;  1Q4O A;  4X9R A;  4O9W A;  4HCO A;  3HIK A;  4RCP A;  4O6W A;  4DFW A;  1UMW A;  2OGQ A;  3P35 A;  4E67 A;  4RS6 A;  3P36 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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